JO3008B1 - تركيب صيدلي لتخفيف الألم - Google Patents
تركيب صيدلي لتخفيف الألمInfo
- Publication number
- JO3008B1 JO3008B1 JOP/2010/0285A JOP20100285A JO3008B1 JO 3008 B1 JO3008 B1 JO 3008B1 JO P20100285 A JOP20100285 A JO P20100285A JO 3008 B1 JO3008 B1 JO 3008B1
- Authority
- JO
- Jordan
- Prior art keywords
- hyaluronic acid
- pharmaceutical composition
- relieving pain
- carboxyl group
- joint disease
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 5
- 229920002674 hyaluronan Polymers 0.000 abstract 5
- 229960003160 hyaluronic acid Drugs 0.000 abstract 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 208000012659 Joint disease Diseases 0.000 abstract 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 abstract 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 abstract 1
- 230000009435 amidation Effects 0.000 abstract 1
- 238000007112 amidation reaction Methods 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 229930016911 cinnamic acid Natural products 0.000 abstract 1
- 235000013985 cinnamic acid Nutrition 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/738—Cross-linked polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
يتعلق الاختراع الحالي بتركيب صيدلي لتخفيف الألم الناجم عن أمراض تصيب المفاصل, يتضمن حمض الهيالورونيك ومادة حاملة مقبولة صيدلياً, بحيث تتقاطع روابط حمض الهيالورونيك عن طريق حلقنة الرابطة الثنائية في شقّ حمض السناميك لتشكيل حمض هيالورونيك محول إلى أميد جزئياً ممثـل بالصيغة (1): [Ar-CH=CH-COO-(CH2)n-NH-]m-HA, لتشكيل حلقة البيوتان الحلقي, حيث Ar يمثل مجموعة فنيل تحمل بدائل بشكل اختياري, n يمثل عدداً صحيحاً يبلغ 2 أو 3, HA يمثل شق كربوكسي لحمض الهيالورونيك, وm يمثل نسبة أميدة حمض الهيالورونيك إلى إجمالي مجموعة الكربوكسيل والتي تمثل 3 إلى 50? بالنسبة إلى إجمالي مجموعة الكربوكسيل. ويمثل التركيب الصيدلي وفقاً للاختراع الحالي تركيبة تعطى داخل المفصل تبدي تأثيرات مسكنة سريعة بعد الإعطاء, وتظهر تأثيرات طويلة الأمد جداً للأمراض التي تصيب المفاصل عند الإنسان عند الإعطاء المفرد فقط بدلاً من الإعطاءات المتعددة وفقاً للطريقة التقليدية.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009187899 | 2009-08-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO3008B1 true JO3008B1 (ar) | 2016-09-05 |
Family
ID=43586085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2010/0285A JO3008B1 (ar) | 2009-08-13 | 2010-08-10 | تركيب صيدلي لتخفيف الألم |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8828969B2 (ar) |
| EP (2) | EP2918277A1 (ar) |
| JP (4) | JP5788798B2 (ar) |
| KR (2) | KR20180000746A (ar) |
| CN (2) | CN102481313A (ar) |
| AU (1) | AU2010283380B2 (ar) |
| BR (1) | BR112012003149B8 (ar) |
| CA (1) | CA2770583C (ar) |
| ES (1) | ES2537128T3 (ar) |
| JO (1) | JO3008B1 (ar) |
| MX (1) | MX2012001853A (ar) |
| NZ (1) | NZ597680A (ar) |
| RU (1) | RU2558064C2 (ar) |
| TW (2) | TWI612965B (ar) |
| WO (1) | WO2011018902A1 (ar) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5291621B2 (ja) | 2006-12-06 | 2013-09-18 | 生化学工業株式会社 | 関節疾患に対する持続的治療効果を有する薬剤 |
| US20150352142A1 (en) | 2013-01-11 | 2015-12-10 | Carbylan Therapeutics, Inc. | Stabilized compositions comprising hyaluronic acid |
| GB2518405A (en) * | 2013-09-20 | 2015-03-25 | Zeiss Carl Meditec Ag | Composition comprising at least one viscoelastic polymer |
| WO2018048322A1 (ru) * | 2016-09-12 | 2018-03-15 | Леонид Валерьевич КЕЛИН | Композиция для лечения или профилактики вирусных инфекций |
| CN117427182A (zh) | 2017-03-14 | 2024-01-23 | 生化学工业株式会社 | 关节疾病处置用组合物及含有其的试剂盒 |
| MY195178A (en) | 2017-03-14 | 2023-01-11 | Seikagaku Kogyo Co Ltd | Composition for Treating Joint Disease and Kit Containing Same |
| IL269506B2 (en) | 2017-03-22 | 2024-04-01 | Genentech Inc | Hydrogel cross-linked hyaluronic acid prodrug compositions and methods |
| EP3675873A4 (en) * | 2017-09-01 | 2021-06-16 | Pmidg, Llc | Functionalized and crosslinked polymers |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5356883A (en) | 1989-08-01 | 1994-10-18 | Research Foundation Of State University Of N.Y. | Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use |
| JP2855307B2 (ja) * | 1992-02-05 | 1999-02-10 | 生化学工業株式会社 | 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法 |
| US6025444A (en) | 1994-11-17 | 2000-02-15 | Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) | Cinnamic acid derivative |
| JP3308742B2 (ja) | 1994-11-17 | 2002-07-29 | 生化学工業株式会社 | 光架橋性ヒアルロン酸誘導体とその架橋体およびそれらの製造方法 |
| US5690961A (en) | 1994-12-22 | 1997-11-25 | Hercules Incorporated | Acidic polysaccharides crosslinked with polycarboxylic acids and their uses |
| WO1997018244A1 (en) | 1995-11-15 | 1997-05-22 | Seikagaku Corporation | Photocured cross-linked-hyaluronic acid gel and method of preparation thereof |
| DE69822285T2 (de) | 1998-02-27 | 2005-01-27 | Stichting Hyppomedics | Verfahren zur Herstellung von vernetzter Hyaluronsäure |
| AU781105B2 (en) | 2000-02-03 | 2005-05-05 | Denki Kagaku Kogyo Kabushiki Kaisha | Hyaluronic acid gel, process for producing the same, and medical material containing the same |
| DE60117502T2 (de) | 2000-12-19 | 2006-08-24 | Seikagaku Corp. | Photohärtbare Derivate von Hyaluronsäure, Verfahren zu deren Herstellung, vernetztes und photogehärtetes Derivat der Hyaluronsäure und diese enthaltendes medizinisches Material |
| JP4172176B2 (ja) | 2000-12-19 | 2008-10-29 | 生化学工業株式会社 | 光反応性ヒアルロン酸およびその製造方法ならびに光架橋ヒアルロン酸および医用材料 |
| EP2664334B1 (en) | 2004-12-30 | 2015-03-04 | Genzyme Corporation | Regimens for intra-articular viscosupplementation |
| AU2006266741B2 (en) | 2005-07-06 | 2011-09-01 | Seikagaku Corporation | Drug-introduced photo-crosslinked hyaluronic acid derived gel |
| JP5291621B2 (ja) | 2006-12-06 | 2013-09-18 | 生化学工業株式会社 | 関節疾患に対する持続的治療効果を有する薬剤 |
-
2010
- 2010-08-10 JO JOP/2010/0285A patent/JO3008B1/ar active
- 2010-08-13 CN CN2010800352195A patent/CN102481313A/zh active Pending
- 2010-08-13 KR KR1020177036970A patent/KR20180000746A/ko not_active Ceased
- 2010-08-13 RU RU2012109392/15A patent/RU2558064C2/ru active
- 2010-08-13 CA CA2770583A patent/CA2770583C/en active Active
- 2010-08-13 JP JP2011526692A patent/JP5788798B2/ja active Active
- 2010-08-13 CN CN201611263701.XA patent/CN106890131A/zh active Pending
- 2010-08-13 ES ES10808087.0T patent/ES2537128T3/es active Active
- 2010-08-13 MX MX2012001853A patent/MX2012001853A/es active IP Right Grant
- 2010-08-13 BR BR112012003149A patent/BR112012003149B8/pt active IP Right Grant
- 2010-08-13 TW TW105129117A patent/TWI612965B/zh active
- 2010-08-13 EP EP15157125.4A patent/EP2918277A1/en not_active Withdrawn
- 2010-08-13 EP EP10808087.0A patent/EP2465512B1/en active Active
- 2010-08-13 KR KR1020127004612A patent/KR101813487B1/ko active Active
- 2010-08-13 US US13/390,261 patent/US8828969B2/en active Active
- 2010-08-13 WO PCT/JP2010/005060 patent/WO2011018902A1/ja not_active Ceased
- 2010-08-13 NZ NZ597680A patent/NZ597680A/en unknown
- 2010-08-13 TW TW099127068A patent/TWI565470B/zh active
- 2010-08-13 AU AU2010283380A patent/AU2010283380B2/en active Active
-
2014
- 2014-08-05 US US14/452,324 patent/US9579342B2/en active Active
-
2015
- 2015-07-30 JP JP2015150298A patent/JP6058090B2/ja active Active
-
2016
- 2016-12-06 JP JP2016236428A patent/JP6280628B2/ja active Active
- 2016-12-06 US US15/370,442 patent/US10420795B2/en active Active
-
2018
- 2018-01-19 JP JP2018006893A patent/JP6417488B2/ja active Active
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