JO3108B1 - بيرروليدينونات أروماتية مخلطة مندمجة كمثبطات syk - Google Patents

بيرروليدينونات أروماتية مخلطة مندمجة كمثبطات syk

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Publication number
JO3108B1
JO3108B1 JOP/2010/0471A JOP20100471A JO3108B1 JO 3108 B1 JO3108 B1 JO 3108B1 JO P20100471 A JOP20100471 A JO P20100471A JO 3108 B1 JO3108 B1 JO 3108B1
Authority
JO
Jordan
Prior art keywords
diseases
fused heteroaromatic
syk inhibitors
disorders
formula
Prior art date
Application number
JOP/2010/0471A
Other languages
English (en)
Inventor
Betty Lam
Benjamin Jones
Nie Zhe
Victoria Feher
Christopher Smith
Qing Dong
Masashi Takahashi
Yasuyoshi Arikawa
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43618073&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3108(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Application granted granted Critical
Publication of JO3108B1 publication Critical patent/JO3108B1/ar

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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  • Organic Chemistry (AREA)
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Abstract

يكشف الاختراع الحالي مركبات لها الصيغة 1، وأملاحها المقبولة صيدليا، حيث G، L1، L2، R1، R2، R3، و R4 كما عرفت في الوصف. يتعلق هذا الكشف أيضا بمواد وطرق لتحضير مركبات ذات الصيغة 1، تركيبات صيدلياً محتوية عليها، واستخدامها لمعالجة الاضطرابات، الأمراض، والحالات التي تتضمن على الجهاز المناعي والإلتهاب، مشتملة على إلتهاب المفاصل الروماتيزمي، الأمراض الدموية الخبيثة، أمراض السرطانات الطلائية (أي، الأورام السرطانية (سركوما)) الاضطرابات الأخرى، الأمراض، والحالات التي يستخدم لها مثبط SYK.
JOP/2010/0471A 2009-12-23 2010-12-22 بيرروليدينونات أروماتية مخلطة مندمجة كمثبطات syk JO3108B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28996909P 2009-12-23 2009-12-23
US38696410P 2010-09-27 2010-09-27

Publications (1)

Publication Number Publication Date
JO3108B1 true JO3108B1 (ar) 2017-09-20

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ID=43618073

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2010/0471A JO3108B1 (ar) 2009-12-23 2010-12-22 بيرروليدينونات أروماتية مخلطة مندمجة كمثبطات syk

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TN2012000316A1 (en) 2013-12-12
US20130116260A1 (en) 2013-05-09
CL2012001745A1 (es) 2014-07-18
TWI457339B (zh) 2014-10-21
CN102753548B (zh) 2015-03-11
BR112012015651B1 (pt) 2021-10-26
UA107100C2 (xx) 2014-11-25
KR101790255B1 (ko) 2017-10-26
ES2545616T3 (es) 2015-09-14
EA021568B1 (ru) 2015-07-30
US20220306634A1 (en) 2022-09-29
US20130245031A1 (en) 2013-09-19
JP2017008052A (ja) 2017-01-12
US20110152273A1 (en) 2011-06-23
PT2516434E (pt) 2015-10-05
HK1176054A1 (en) 2013-07-19

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