JO3121B1 - مشتقات 1 - ((5-هيتيرورلثيازول-2-يل) أمينوكاربونيل) بيروليدين-2-كربوكساميد كمثبات الفوسفاتديلينوسيتول 3-كيناس (pi3k) مفيدة في علاج الأمراض التصاعدية - Google Patents

مشتقات 1 - ((5-هيتيرورلثيازول-2-يل) أمينوكاربونيل) بيروليدين-2-كربوكساميد كمثبات الفوسفاتديلينوسيتول 3-كيناس (pi3k) مفيدة في علاج الأمراض التصاعدية

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Publication number
JO3121B1
JO3121B1 JOP/2009/0334A JOP20090334A JO3121B1 JO 3121 B1 JO3121 B1 JO 3121B1 JO P20090334 A JOP20090334 A JO P20090334A JO 3121 B1 JO3121 B1 JO 3121B1
Authority
JO
Jordan
Prior art keywords
kinase
treatment
heteroarylthiazol
pi3k
phosphatidylinositol
Prior art date
Application number
JOP/2009/0334A
Other languages
English (en)
Inventor
Imbach Patricia
Furet Pascal
Caravatti Giorgio
Alec Fairhurst Robin
Guagnano Vito
Original Assignee
Novartis Ag
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Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of JO3121B1 publication Critical patent/JO3121B1/ar

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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Abstract

يتعلق الإختراع الحالي بمركب الصيغة (I) (I) أو ملح من ذلك، الذى به المستبدلات كما عرف في الوصف، إلى التراكيب وإستعمال المركبات في معالجة أمراض المحسنة ameloriated بمنع فوسفاتيديل لينوسيتول 3-كينيز.
JOP/2009/0334A 2008-09-10 2009-09-09 مشتقات 1 - ((5-هيتيرورلثيازول-2-يل) أمينوكاربونيل) بيروليدين-2-كربوكساميد كمثبات الفوسفاتديلينوسيتول 3-كيناس (pi3k) مفيدة في علاج الأمراض التصاعدية JO3121B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08164104 2008-09-10
US9667408P 2008-09-12 2008-09-12

Publications (1)

Publication Number Publication Date
JO3121B1 true JO3121B1 (ar) 2017-09-20

Family

ID=40350060

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2009/0334A JO3121B1 (ar) 2008-09-10 2009-09-09 مشتقات 1 - ((5-هيتيرورلثيازول-2-يل) أمينوكاربونيل) بيروليدين-2-كربوكساميد كمثبات الفوسفاتديلينوسيتول 3-كيناس (pi3k) مفيدة في علاج الأمراض التصاعدية

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US (4) US8227462B2 (ar)
EP (1) EP2331537B1 (ar)
JP (1) JP5486601B2 (ar)
KR (1) KR101290844B1 (ar)
CN (1) CN102149711B (ar)
AR (2) AR073369A1 (ar)
AU (1) AU2009290904B2 (ar)
BR (1) BRPI0918750B8 (ar)
CA (1) CA2734819C (ar)
CL (1) CL2011000504A1 (ar)
CO (1) CO6351738A2 (ar)
CR (1) CR20110059A (ar)
CU (1) CU24000B1 (ar)
CY (2) CY1117078T1 (ar)
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DO (1) DOP2011000070A (ar)
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FI (1) FIC20200046I1 (ar)
GE (1) GEP20135991B (ar)
HN (1) HN2011000699A (ar)
HR (1) HRP20160014T1 (ar)
HU (2) HUE025884T2 (ar)
IL (1) IL210976A (ar)
JO (1) JO3121B1 (ar)
LT (1) LTC2331537I2 (ar)
LU (1) LUC00186I2 (ar)
MA (1) MA32604B1 (ar)
ME (1) ME01284B (ar)
MX (1) MX2011002597A (ar)
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PE (1) PE20110796A1 (ar)
PL (1) PL2331537T3 (ar)
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SM (1) SMP201100019B (ar)
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US8293753B2 (en) * 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
BR112013009624A2 (pt) * 2010-11-08 2016-07-12 Novartis Ag uso de derivados de 2-carboxamida cicloamino ureia no tratamento de doenças dependemtes de egfr pu doenças que tenham adquirido resistência a agentes que tenham como alvo membros da família egfr
AU2015203865B2 (en) * 2010-11-08 2016-11-03 Novartis Ag Use of 2-carboxamide cycloamino urea derivatives in the treatment of EGFR dependent diseases or diseases that have acquired resistance to agents that target EGFR family members
UA112539C2 (uk) * 2011-03-03 2016-09-26 Новартіс Аг Спосіб одержання похідних 2-карбоксамідциклоаміносечовини
WO2012148846A1 (en) * 2011-04-25 2012-11-01 Novartis Ag Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor
JP2014517049A (ja) * 2011-06-21 2014-07-17 ノバルティス アーゲー （ｓ）−ピロリジン−１，２−ジカルボン酸２−アミド１−（｛４−メチル−５−［２−（２，２，２−トリフルオロ−１，１−ジメチル−エチル）−ピリジン−４−イル］−チアゾール−２−イル｝−アミドの多形
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CN103764144B (zh) * 2011-08-31 2016-07-20 诺华股份有限公司 Pi3k抑制剂与mek抑制剂的协同组合
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RU2014120792A (ru) * 2011-10-28 2015-12-10 Новартис Аг Способ лечения стромальных опухолей желудочно-кишечного тракта
MX2014005414A (es) * 2011-11-02 2014-09-22 Novartis Ag Derivados de 2-carboxamida-cicloamino-urea para su uso en el tratamiento de las enfermedades dependientes del factor de crecimiento endotelial vascular (vegf).
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