JO3243B1 - عملية لتصنيع الديغارليكس ومركباته الوسيطة - Google Patents
عملية لتصنيع الديغارليكس ومركباته الوسيطةInfo
- Publication number
- JO3243B1 JO3243B1 JOP/2011/0318A JOP20110318A JO3243B1 JO 3243 B1 JO3243 B1 JO 3243B1 JO P20110318 A JOP20110318 A JO P20110318A JO 3243 B1 JO3243 B1 JO 3243B1
- Authority
- JO
- Jordan
- Prior art keywords
- degarelix
- amino protecting
- protecting group
- protecting groups
- hydrogen
- Prior art date
Links
- 108010052004 acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide Proteins 0.000 title abstract 5
- MEUCPCLKGZSHTA-XYAYPHGZSA-N degarelix Chemical compound C([C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CC=1C=CC(NC(=O)[C@H]2NC(=O)NC(=O)C2)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(NC(N)=O)C=C1 MEUCPCLKGZSHTA-XYAYPHGZSA-N 0.000 title abstract 5
- 229960002272 degarelix Drugs 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 125000006239 protecting group Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000002243 precursor Substances 0.000 abstract 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C07K1/023—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution using racemisation inhibiting agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
يتعلق الاختراع الحالي بعملية تصنيع في الطور السائل (أو محلول) لتحضير الديكا ببتيد دِجاريليكس، والمادة المُنتجة المحمية الخاصة به، ومركبات وسيطة أخرى مفيدة. يتعلق الاختراع أيضاً ببولي ببتيدات مفيدة في عملية التصنيع في الطور السائل وبتنقية الدِجاريليكس نفسه. يمكن الحصول على الدِجاريليكس بواسطة إخضاع مادة منتجة للدِجاريليكس وفقاً للصيغة II: أو ملح أو ذوابة منه، إلى عملية معالجة بعامل انشطار في مذيب عضوي، حيث تكونP1 عبارة عن مجموعات حماية من الأمينو؛ يفضل الأسيتيل؛ تكون P4 عبارة عن مجموعات حماية من الهيدروجين أو الهيدروكسيل، يفضل مجموعة حماية من الهيدروكسيل؛ تكون P6 عبارة عن مجموعات حماية من الهيدروجين أو الأمينو؛ يفضل مجموعات حماية من الأمينو؛ وتكون P8 عبارة عن مجموعة حماية من الأمينو.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10189032A EP2447276A1 (en) | 2010-10-27 | 2010-10-27 | Process for the manufacture of Degarelix and its intermediates |
| US40930410P | 2010-11-02 | 2010-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO3243B1 true JO3243B1 (ar) | 2018-03-08 |
Family
ID=43531147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2011/0318A JO3243B1 (ar) | 2010-10-27 | 2011-10-24 | عملية لتصنيع الديغارليكس ومركباته الوسيطة |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US9090656B2 (ar) |
| EP (2) | EP2447276A1 (ar) |
| JP (1) | JP6007187B2 (ar) |
| KR (1) | KR101904808B1 (ar) |
| CN (1) | CN103180335B (ar) |
| AU (1) | AU2011322618B2 (ar) |
| BR (1) | BR112013010360B1 (ar) |
| CA (1) | CA2815270A1 (ar) |
| DK (1) | DK2632935T3 (ar) |
| ES (1) | ES2606753T3 (ar) |
| HR (1) | HRP20161315T1 (ar) |
| HU (1) | HUE030184T2 (ar) |
| IL (1) | IL225687A (ar) |
| JO (1) | JO3243B1 (ar) |
| LT (1) | LT2632935T (ar) |
| MX (1) | MX343058B (ar) |
| NZ (1) | NZ609064A (ar) |
| PL (1) | PL2632935T3 (ar) |
| PT (1) | PT2632935T (ar) |
| RS (1) | RS55193B1 (ar) |
| RU (1) | RU2602042C2 (ar) |
| SA (1) | SA111320880B1 (ar) |
| SI (1) | SI2632935T1 (ar) |
| TW (1) | TWI515201B (ar) |
| WO (1) | WO2012055905A1 (ar) |
| ZA (1) | ZA201302670B (ar) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0117057D0 (en) * | 2001-07-12 | 2001-09-05 | Ferring Bv | Pharmaceutical composition |
| JOP20090061B1 (ar) | 2008-02-11 | 2021-08-17 | Ferring Int Center Sa | طريقة معالجة سرطان البروستاتا بمضادات الهرمونات التناسلية GnRH |
| AU2010243273B2 (en) * | 2009-05-01 | 2016-06-16 | Ferring B.V. | Composition for the treatment of prostate cancer |
| US20110039787A1 (en) * | 2009-07-06 | 2011-02-17 | Ferring International Center S.A. | Compositions, kits and methods for treating benign prostate hyperplasia |
| EP2447276A1 (en) | 2010-10-27 | 2012-05-02 | Ferring B.V. | Process for the manufacture of Degarelix and its intermediates |
| PT2632934T (pt) | 2010-10-27 | 2017-01-06 | Ferring Bv | Processo para o fabrico de degarelix e seus intermediários |
| JO3755B1 (ar) | 2011-01-26 | 2021-01-31 | Ferring Bv | تركيبات تستوستيرون |
| KR102140982B1 (ko) | 2012-06-01 | 2020-08-05 | 훼링 비.브이. | 데가렐릭스의 제조 방법 |
| CN103992378A (zh) * | 2013-11-01 | 2014-08-20 | 杭州诺泰制药技术有限公司 | 一种制备醋酸地加瑞克的方法 |
| CN106589071B (zh) * | 2016-12-12 | 2020-09-08 | 江苏诺泰澳赛诺生物制药股份有限公司 | 一种地加瑞克的合成方法 |
| CN109748954B (zh) * | 2017-11-06 | 2022-03-01 | 正大天晴药业集团股份有限公司 | 一种地加瑞克的纯化方法 |
| CN107955061B (zh) * | 2017-11-15 | 2021-07-30 | 连云港恒运药业有限公司 | 地加瑞克关键中间体的制备方法 |
| CN109929007B (zh) * | 2017-12-15 | 2023-07-28 | 连云港恒运药业有限公司 | 地加瑞克关键二肽中间体的制备方法 |
| CN110330552B (zh) * | 2019-08-14 | 2021-03-16 | 凯莱英生命科学技术(天津)有限公司 | 醋酸地加瑞克的合成方法 |
| TWI854108B (zh) * | 2020-03-09 | 2024-09-01 | 美商西格馬 奧爾德里奇有限責任公司 | 經由共同中間物有效率地製備尾海兔素及奧瑞他汀類似物 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| DE2862341D1 (en) | 1977-12-26 | 1983-11-24 | Ihara Chemical Ind Co | Process for producing aromatic monocarboxylic acid |
| DE593491T1 (de) | 1991-04-25 | 1994-11-17 | Romano S.-Cergue Deghenghi | LHRH-Antagonisten. |
| EP0556034B2 (en) | 1992-02-12 | 2004-07-21 | Daikyo Gomu Seiko Ltd. | A medical instrument |
| SI9300468A (en) | 1992-10-14 | 1994-06-30 | Hoffmann La Roche | Injectable composition for the sustained release of biologically active compounds |
| US5506207A (en) | 1994-03-18 | 1996-04-09 | The Salk Institute For Biological Studies | GNRH antagonists XIII |
| US5595760A (en) | 1994-09-02 | 1997-01-21 | Delab | Sustained release of peptides from pharmaceutical compositions |
| US5710247A (en) * | 1996-03-19 | 1998-01-20 | Abbott Laboratories | Process and intermediates for the synthesis of LHRH antagonists |
| US5710246A (en) * | 1996-03-19 | 1998-01-20 | Abbott Laboratories | Process for intermediates for the synthesis of LHRH antagonists |
| US5860957A (en) | 1997-02-07 | 1999-01-19 | Sarcos, Inc. | Multipathway electronically-controlled drug delivery system |
| US5925730A (en) | 1997-04-11 | 1999-07-20 | Ferring Bv | GnRH antagonists |
| US5821230A (en) | 1997-04-11 | 1998-10-13 | Ferring Bv | GnRH antagonist decapeptides |
| WO1999026964A1 (en) | 1997-11-20 | 1999-06-03 | Ortho-Mcneil Pharmaceutical, Inc. | LIQUID PHASE PROCESS FOR THE PREPARATION OF GnRH PEPTIDES |
| FR2776520B1 (fr) | 1998-03-25 | 2000-05-05 | Sod Conseils Rech Applic | Nouvelles compositions pharmaceutiques destinees a la liberation prolongee de peptides et leur procede de preparation |
| US20040198706A1 (en) | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
| US20020103131A1 (en) | 2001-01-26 | 2002-08-01 | Jacobson Jill D. | Prevention of diabetes by administration of GnRH antagonists |
| GB0117057D0 (en) | 2001-07-12 | 2001-09-05 | Ferring Bv | Pharmaceutical composition |
| SE0104463D0 (sv) * | 2001-12-29 | 2001-12-29 | Carlbiotech Ltd As | Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister |
| CN1411803A (zh) | 2002-08-29 | 2003-04-23 | 四川大学 | 制备前体脂质体的方法及其装置 |
| AR042815A1 (es) | 2002-12-26 | 2005-07-06 | Alza Corp | Dispositivo de suministro de agente activo que tiene miembros compuestos |
| EP1674082A1 (de) | 2004-12-22 | 2006-06-28 | Zentaris GmbH | Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel |
| WO2007130809A2 (en) | 2006-05-06 | 2007-11-15 | Volodymyr Brodskyy | An automatic injectable drug mixing device |
| GB0616111D0 (en) * | 2006-06-16 | 2006-09-20 | Ardana Bioscience Ltd | Agents, methods and uses |
| EP1891964A1 (en) | 2006-08-08 | 2008-02-27 | AEterna Zentaris GmbH | Application of initial doses of LHRH analogues and maintenance doses of LHRH antagonists for the treatment of hormone-dependent cancers and corresponding pharmaceutical kits |
| EP1967202A1 (en) | 2007-03-05 | 2008-09-10 | AEterna Zentaris GmbH | Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity |
| IL182922A0 (en) | 2007-05-02 | 2007-09-20 | Medimop Medical Projects Ltd | Automatic liquid drug reconstitution apparatus |
| WO2009102720A1 (en) | 2008-02-11 | 2009-08-20 | Safety Syringes, Inc. | Reconstitution means for safety device |
| JOP20090061B1 (ar) | 2008-02-11 | 2021-08-17 | Ferring Int Center Sa | طريقة معالجة سرطان البروستاتا بمضادات الهرمونات التناسلية GnRH |
| NZ595888A (en) * | 2009-04-24 | 2013-05-31 | Polypeptide Laboratories As | Method for the manufacture of degarelix |
| AU2010243273B2 (en) | 2009-05-01 | 2016-06-16 | Ferring B.V. | Composition for the treatment of prostate cancer |
| TW201043221A (en) | 2009-05-06 | 2010-12-16 | Ferring Int Ct Sa | Kit and method for preparation of a Degarelix solution |
| US20110039787A1 (en) | 2009-07-06 | 2011-02-17 | Ferring International Center S.A. | Compositions, kits and methods for treating benign prostate hyperplasia |
| EP2447276A1 (en) | 2010-10-27 | 2012-05-02 | Ferring B.V. | Process for the manufacture of Degarelix and its intermediates |
| PT2632934T (pt) | 2010-10-27 | 2017-01-06 | Ferring Bv | Processo para o fabrico de degarelix e seus intermediários |
| JO3755B1 (ar) | 2011-01-26 | 2021-01-31 | Ferring Bv | تركيبات تستوستيرون |
| CA2841751A1 (en) | 2011-07-15 | 2013-01-24 | Raymond E. Joseph | Method for timing a colonoscopy wherein a picosulate composition is administered |
-
2010
- 2010-10-27 EP EP10189032A patent/EP2447276A1/en not_active Ceased
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2011
- 2011-10-24 JO JOP/2011/0318A patent/JO3243B1/ar active
- 2011-10-26 WO PCT/EP2011/068735 patent/WO2012055905A1/en not_active Ceased
- 2011-10-26 RU RU2013118446/04A patent/RU2602042C2/ru active
- 2011-10-26 US US13/881,744 patent/US9090656B2/en active Active
- 2011-10-26 JP JP2013535414A patent/JP6007187B2/ja active Active
- 2011-10-26 HR HRP20161315TT patent/HRP20161315T1/hr unknown
- 2011-10-26 CN CN201180051147.8A patent/CN103180335B/zh active Active
- 2011-10-26 NZ NZ609064A patent/NZ609064A/en unknown
- 2011-10-26 SI SI201130984A patent/SI2632935T1/sl unknown
- 2011-10-26 PL PL11776745T patent/PL2632935T3/pl unknown
- 2011-10-26 HU HUE11776745A patent/HUE030184T2/en unknown
- 2011-10-26 ES ES11776745.9T patent/ES2606753T3/es active Active
- 2011-10-26 KR KR1020137010251A patent/KR101904808B1/ko active Active
- 2011-10-26 TW TW100138937A patent/TWI515201B/zh active
- 2011-10-26 CA CA2815270A patent/CA2815270A1/en not_active Abandoned
- 2011-10-26 SA SA111320880A patent/SA111320880B1/ar unknown
- 2011-10-26 RS RS20160822A patent/RS55193B1/sr unknown
- 2011-10-26 BR BR112013010360-4A patent/BR112013010360B1/pt active IP Right Grant
- 2011-10-26 EP EP11776745.9A patent/EP2632935B1/en active Active
- 2011-10-26 LT LTEP11776745.9T patent/LT2632935T/lt unknown
- 2011-10-26 AU AU2011322618A patent/AU2011322618B2/en active Active
- 2011-10-26 PT PT117767459T patent/PT2632935T/pt unknown
- 2011-10-26 DK DK11776745.9T patent/DK2632935T3/en active
- 2011-10-26 MX MX2013004320A patent/MX343058B/es active IP Right Grant
-
2013
- 2013-04-10 IL IL225687A patent/IL225687A/en active IP Right Grant
- 2013-04-12 ZA ZA2013/02670A patent/ZA201302670B/en unknown
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2015
- 2015-06-23 US US14/747,218 patent/US9822146B2/en active Active
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