JO3326B1 - مثبطات إيبوكسي كيتون بروتياز ثلاثي الببتيد - Google Patents

مثبطات إيبوكسي كيتون بروتياز ثلاثي الببتيد

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Publication number
JO3326B1
JO3326B1 JOP/2014/0111A JOP20140111A JO3326B1 JO 3326 B1 JO3326 B1 JO 3326B1 JO P20140111 A JOP20140111 A JO P20140111A JO 3326 B1 JO3326 B1 JO 3326B1
Authority
JO
Jordan
Prior art keywords
protease inhibitors
epoxy ketone
ketone protease
tripeptide epoxy
compositions
Prior art date
Application number
JOP/2014/0111A
Other languages
English (en)
Inventor
Mcminn Dustin
C Moebius David
Bowers Simeon
Johnson Henry
Original Assignee
Onyx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Onyx Therapeutics Inc filed Critical Onyx Therapeutics Inc
Application granted granted Critical
Publication of JO3326B1 publication Critical patent/JO3326B1/ar

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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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Abstract

يتعلق الاختراع الحالي بمثبطات إيبوكسي كيتون بروتياز ثلاثي الببتيد، وطرق لتحضيرها، والتركيبات الصيدلية ذات الصلة، وطرق استخدامها. على سبيل المثال، يتوفر هنا مركبات وفقًا للصيغة (X): وأملاح وتركيبات مقبولة صيدليًا تتضمنها. يمكن استخدام المركبات والتركيبات المتوفرة هنا، على سبيل المثال، في علاج الأمراض وتتضمن أمراض الالتهاب وضمور الأعصاب.
JOP/2014/0111A 2013-03-14 2014-03-16 مثبطات إيبوكسي كيتون بروتياز ثلاثي الببتيد JO3326B1 (ar)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361785608P 2013-03-14 2013-03-14
US201361786086P 2013-03-14 2013-03-14
US201361847780P 2013-07-18 2013-07-18
US201361856847P 2013-07-22 2013-07-22
US201361883798P 2013-09-27 2013-09-27
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