JO3442B1 - مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5) - Google Patents

مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5)

Info

Publication number
JO3442B1
JO3442B1 JOP/2014/0283A JOP20140283A JO3442B1 JO 3442 B1 JO3442 B1 JO 3442B1 JO P20140283 A JOP20140283 A JO P20140283A JO 3442 B1 JO3442 B1 JO 3442B1
Authority
JO
Jordan
Prior art keywords
sstr5
antagonists
compound
receptor subtype
somatostatin receptor
Prior art date
Application number
JOP/2014/0283A
Other languages
English (en)
Inventor
Shizuo Kasai
Hideki Hirose
Asato Kina
Tohru Yamashita
Yoichi Nishikawa
Takeshi Yamasaki
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Application granted granted Critical
Publication of JO3442B1 publication Critical patent/JO3442B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

<strong>يتعلق الاختراع الحالي بتوفير مركب له فعل مضاد </strong><span dir="LTR">SSTR5</span><strong> واستخدام المركب كدواء. على وجه التحديد، مركب يتم التعبير عنه بواسطة الصيغة التالية:</strong> <span dir="LTR"><img alt="??????? PT38-0003 ?????? 2013-20982620131007----00850075251302101257??20131007102827201310071027595150__________PT_84" src="file:///C:/Users/Darwish.Q/AppData/Local/Temp/msohtmlclip1/01/clip_image002.png" /></span> <strong>حيث يكون كل رمز كما تم التحديد في هذه الوثيقة،</strong> <strong> أو ملح منه، ويتم توفير دواء يشتمل على المركب أو ملح منه، واستخدام المركب أو ملح منه كعامل للوقاية من أو علاج مرض السكر. </strong>
JOP/2014/0283A 2013-10-07 2014-10-02 مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5) JO3442B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2013209826 2013-10-07

Publications (1)

Publication Number Publication Date
JO3442B1 true JO3442B1 (ar) 2019-10-20

Family

ID=51842719

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2014/0283A JO3442B1 (ar) 2013-10-07 2014-10-02 مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5)

Country Status (24)

Country Link
US (2) US9353108B2 (ar)
EP (1) EP3055309B1 (ar)
JP (1) JP6411520B2 (ar)
CN (1) CN105612158B (ar)
AR (1) AR097932A1 (ar)
BR (1) BR112016007620B1 (ar)
CA (1) CA2926544C (ar)
CY (1) CY1121163T1 (ar)
DK (1) DK3055309T3 (ar)
ES (1) ES2687102T3 (ar)
HR (1) HRP20181372T1 (ar)
HU (1) HUE039386T2 (ar)
JO (1) JO3442B1 (ar)
LT (1) LT3055309T (ar)
PL (1) PL3055309T3 (ar)
PT (1) PT3055309T (ar)
RS (1) RS57743B1 (ar)
RU (1) RU2671958C2 (ar)
SI (1) SI3055309T1 (ar)
SM (1) SMT201800461T1 (ar)
TR (1) TR201810506T4 (ar)
TW (1) TWI648276B (ar)
UY (1) UY35774A (ar)
WO (1) WO2015052910A1 (ar)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6247697B2 (ja) * 2013-03-14 2017-12-13 武田薬品工業株式会社 スピロアゼチジンイソキサゾール誘導体及びそのｓｓｔｒ５アンタゴニストとしての使用
EP3227282B1 (en) * 2014-12-02 2019-04-03 F.Hoffmann-La Roche Ag Novel piperidine derivatives
TW201712012A (zh) 2015-06-16 2017-04-01 美國禮來大藥廠 ２－側氧基－１，３，８－三氮雜螺［４．５］癸－３－基羧酸衍生物
KR20220150270A (ko) 2019-10-07 2022-11-10 칼리오페, 인크. Gpr119 효능제
TW202140440A (zh) 2020-02-28 2021-11-01 美商克力歐普股份有限公司 Gpr40激動劑
WO2021230264A1 (ja) * 2020-05-13 2021-11-18 株式会社スコヒアファーマ 胆道系疾患の診断補助・予防・治療剤
WO2021236617A1 (en) 2020-05-19 2021-11-25 Kallyope, Inc. Ampk activators
CN116390925A (zh) 2020-06-26 2023-07-04 卡尔优普公司 Ampk活化剂
CN116354961B (zh) * 2021-12-27 2025-07-25 中国科学院上海药物研究所 生长抑素受体5拮抗剂及其药物组合物及用途
CA3258111A1 (en) * 2022-05-30 2025-04-07 Scinnohub Pharmaceutical Co., Ltd USE OF A TETRAHYDRONAPHTYRIDINE DERIVATIVE FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE PREVENTION AND TREATMENT OF DISEASES RELATED TO ADHESION
WO2024204277A1 (ja) * 2023-03-27 2024-10-03 株式会社スコヒアファーマ 成長ホルモン分泌促進剤

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356906A (en) 1989-10-27 1994-10-18 The Du Pont Merck Pharmaceutical Company (N-phthalimidoalkyl) piperidines useful as treatments for psychosis
CN1072649C (zh) 1995-09-13 2001-10-10 武田药品工业株式会社 苯并氧杂吖庚因化合物,其生产方法和用途
CA2416384A1 (en) 2000-07-17 2003-01-16 Takeda Chemical Industries, Ltd. Sulfone derivatives, their production and use
MXPA04002249A (es) 2001-09-24 2004-06-29 Bayer Pharmaceuticals Corp Preparacion y uso de derivados de 1,5,6,7,-tetrahidro-pirrolo[3,2-c]piridina para el tratamiento de la obesidad.
CN1578781A (zh) * 2001-09-26 2005-02-09 拜尔药品公司 用作抗糖尿病药物的1,8－萘啶衍生物
TW200302225A (en) 2001-12-04 2003-08-01 Bristol Myers Squibb Co Substituted amino methyl factor Xa inhibitors
AU2003278600A1 (en) 2002-11-01 2004-05-25 Takeda Pharmaceutical Company Limited Agent for preventing or treating neuropathy
CA2505322A1 (en) 2002-11-08 2004-05-21 Takeda Pharmaceutical Company Limited Receptor function regulator
US20070004736A1 (en) 2002-11-22 2007-01-04 Keiji Kubo Imidazole derivative, process for producing the same, and use
RU2366655C2 (ru) 2003-03-14 2009-09-10 Оно Фармасьютикал Ко., Лтд. Азотсодержащие гетероциклические производные и лекарственные средства, содержащие их в качестве активного ингредиента
EP1630152A4 (en) 2003-05-30 2009-09-23 Takeda Pharmaceutical CONDENSED CYCLIC COMPOUND
EP1669352A4 (en) 2003-09-30 2008-12-17 Takeda Pharmaceutical THIAZOLINE DERIVATIVE AND ITS USE
KR20060123292A (ko) 2003-11-10 2006-12-01 쉐링 악티엔게젤샤프트 Ｃｃｒ-5 길항제로서 유용한 벤질에테르 아민 화합물
EP1695961A4 (en) 2003-12-17 2007-10-24 Takeda Pharmaceutical UREA DERIVATIVE, METHOD FOR THE PRODUCTION AND THEIR USE
AU2004309271A1 (en) 2003-12-25 2005-07-14 Takeda Pharmaceutical Company Limited 3-(4-benzyloxyphenyl)propanoic acid derivatives
WO2005063725A1 (ja) 2003-12-26 2005-07-14 Takeda Pharmaceutical Company Limited フェニルプロパン酸誘導体
JP4875978B2 (ja) 2004-03-15 2012-02-15 武田薬品工業株式会社 アミノフェニルプロパン酸誘導体
US7517910B2 (en) 2004-03-30 2009-04-14 Takeda Pharmaceutical Company Limited Alkoxyphenylpropanoic acid derivatives
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
US8957070B2 (en) 2005-04-20 2015-02-17 Takeda Pharmaceutical Company Limited Glucokinase activator compounds, methods of activating glucokinase and methods of treating diabetes and obesity
US20090054435A1 (en) 2005-07-29 2009-02-26 Hiroshi Imoto Phenoxyalkanoic Acid Compound
EP1916234B1 (en) 2005-07-29 2014-11-12 Takeda Pharmaceutical Company Limited Cyclopropanecarboxylic acid compound
TW200740435A (en) 2005-08-10 2007-11-01 Takeda Pharmaceuticals Co Therapeutic agent for diabetes
JP2007063225A (ja) 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
RS53230B (sr) 2006-06-27 2014-08-29 Takeda Pharmaceutical Company Limited Kondenzovana ciklična jedinjenja kao modulatori gpr40 receptora
WO2008019967A2 (en) 2006-08-15 2008-02-21 F. Hoffmann-La Roche Ag Phenyl, pyridine and quinoline derivatives
US8492405B2 (en) 2006-10-18 2013-07-23 Takeda Pharmaceutical Company Limited Glucokinase-activating fused heterocyclic compounds and methods of treating diabetes and obesity
RU2454415C9 (ru) 2006-10-19 2013-02-27 Такеда Фармасьютикал Компани Лимитед Производное индола
EP2128138A1 (en) 2007-01-29 2009-12-02 Takeda Pharmaceutical Company Limited Pyrazole compound
JP2010517935A (ja) 2007-02-09 2010-05-27 武田薬品工業株式会社 Ｐｐａｒ−ガンマのパーシャルアゴニストとしての縮合環化合物
US7862825B2 (en) 2007-02-21 2011-01-04 Mladen Vranic Method of controlling tight blood glucose by somatostatin receptor antagonists
US7799806B2 (en) * 2007-04-04 2010-09-21 Hoffmann-La Roche Inc. Substituted n-benzyl piperidines as somatostatin receptor modulators
JPWO2008136428A1 (ja) 2007-04-27 2010-07-29 武田薬品工業株式会社 含窒素５員複素環化合物
US20080306116A1 (en) * 2007-06-08 2008-12-11 Christ Andreas D Aryloxazole, aryloxadiazole and benzimidazole derivatives
WO2008156757A1 (en) 2007-06-19 2008-12-24 Takeda Pharmaceutical Company Limited Indazole compounds for activating glucokinase
TW200918062A (en) 2007-09-12 2009-05-01 Wyeth Corp Azacyclylisoquinolinone and-isoindolinone derivatives as histamine-3 antagonists
JP2012526136A (ja) * 2009-05-07 2012-10-25 メルク・シャープ・エンド・ドーム・コーポレイション 抗糖尿病化合物として有用な置換スピロ環式アミン
WO2012024183A1 (en) 2010-08-18 2012-02-23 Merck Sharp & Dohme Corp. Spiroxazolidinone compounds
WO2012069917A1 (en) 2010-11-26 2012-05-31 Lupin Limited Bicyclic gpr119 modulators
JP6247697B2 (ja) 2013-03-14 2017-12-13 武田薬品工業株式会社 スピロアゼチジンイソキサゾール誘導体及びそのｓｓｔｒ５アンタゴニストとしての使用
AR098215A1 (es) 2013-10-29 2016-05-18 Takeda Pharmaceuticals Co Compuesto heterocíclico

Also Published As

Publication number Publication date
BR112016007620A2 (pt) 2017-08-01
HUE039386T2 (hu) 2018-12-28
ES2687102T3 (es) 2018-10-23
AR097932A1 (es) 2016-04-20
CN105612158B (zh) 2017-06-30
BR112016007620B1 (pt) 2020-05-26
US20160237087A1 (en) 2016-08-18
RU2671958C2 (ru) 2018-11-08
LT3055309T (lt) 2018-08-27
CN105612158A (zh) 2016-05-25
DK3055309T3 (en) 2018-08-27
CA2926544C (en) 2021-07-06
CY1121163T1 (el) 2020-05-29
CA2926544A1 (en) 2015-04-16
SI3055309T1 (sl) 2018-10-30
US20150099777A1 (en) 2015-04-09
EP3055309A1 (en) 2016-08-17
TR201810506T4 (tr) 2018-08-27
SMT201800461T1 (it) 2018-11-09
RS57743B1 (sr) 2018-12-31
JP6411520B2 (ja) 2018-10-24
US9353108B2 (en) 2016-05-31
TWI648276B (zh) 2019-01-21
TW201536784A (zh) 2015-10-01
HRP20181372T1 (hr) 2018-10-19
UY35774A (es) 2015-05-29
US9751878B2 (en) 2017-09-05
PT3055309T (pt) 2018-10-01
EP3055309B1 (en) 2018-06-13
RU2016117732A (ru) 2017-11-15
WO2015052910A1 (en) 2015-04-16
PL3055309T3 (pl) 2018-10-31
JP2016531950A (ja) 2016-10-13

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