JO3552B1 - عملية لإنتاج محلول نورادرينالين ذو تركيز منخفض مستقر قابل للحقن - Google Patents
عملية لإنتاج محلول نورادرينالين ذو تركيز منخفض مستقر قابل للحقنInfo
- Publication number
- JO3552B1 JO3552B1 JOP/2015/0031A JOP20150031A JO3552B1 JO 3552 B1 JO3552 B1 JO 3552B1 JO P20150031 A JOP20150031 A JO P20150031A JO 3552 B1 JO3552 B1 JO 3552B1
- Authority
- JO
- Jordan
- Prior art keywords
- noradrenaline
- solution
- production
- stable low
- stable
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
- A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
- A61L2/04—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2103/00—Materials or objects being the target of disinfection or sterilisation
- A61L2103/05—Living organisms or biological materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
في أحد الجوانب، يتعلق الاختراع الحالي إلى عملية لإنتاج محلول قابل للحقن ثابت مع محتوى منخفض من النورادرينالين، الذي يشتمل على تذويب النورادرينالين ويفضل أي مسوغ في مياه غير مؤكسدة أو مفرغ الغاز، وترشيح محلول النورادرينالين الناتج في محتوى غاز النيتروجين، وتوزيع المحلول في محتوى غاز النيتروجين والتعقيم ويفضل التسخين. كما يقدم الاختراع محلول قابل للحقن ثابت بمحتوى منخفض من النُورْأَدْرِنالين، حر بشكل كبير من العوامل مضاد الأكسدة والمواد الحافظة وكذلك استخدامها في المجالات الطبية والصيدلانية.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI20140306 | 2014-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO3552B1 true JO3552B1 (ar) | 2020-07-05 |
Family
ID=50693780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2015/0031A JO3552B1 (ar) | 2014-02-27 | 2015-02-12 | عملية لإنتاج محلول نورادرينالين ذو تركيز منخفض مستقر قابل للحقن |
Country Status (43)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY35988A (es) | 2014-02-27 | 2015-09-30 | Sint Sa | Proceso para la producción de una solución inyectable de noradrenalina de baja concentración |
| EP2990031B1 (en) | 2014-08-28 | 2019-11-13 | Sun Pharmaceutical Industries Ltd | Parenteral dosage form of norepinephrine |
| US20250177328A1 (en) | 2017-01-30 | 2025-06-05 | Nevakar Injectables Inc. | Norepinephrine compositions and methods therefor |
| WO2018140894A1 (en) | 2017-01-30 | 2018-08-02 | Nevakar, Inc | Norepinephrine compositions and methods therefor |
| CN109394683A (zh) * | 2018-12-07 | 2019-03-01 | 远大医药（中国）有限公司 | 一种重酒石酸去甲肾上腺素注射液的制备方法 |
| US10888534B2 (en) * | 2019-04-26 | 2021-01-12 | InfoRLife SA | Storage stable ready-to-use norepinephrine aqueous solutions in flexible plastic bags |
| EP4114336A1 (en) | 2020-03-06 | 2023-01-11 | Baxter International Inc. | Packaged, sealed container system for stable storage of an oxygen sensitive pharmaceutical formulation |
| CA3198908A1 (en) | 2020-10-21 | 2022-04-28 | Sintetica S.A. | Stable, injectable noradrenaline solutions free of antioxidants |
| EP4231996B1 (en) | 2020-10-21 | 2024-09-18 | Sintetica S.A. | Ready to use, noradrenaline drip bags, having low subvisible particle counts |
| US11331266B1 (en) | 2020-10-29 | 2022-05-17 | Medefil, Inc. | Antioxidant free, norepinephrine bitartrate injection in amber glass vials |
| US20220233473A1 (en) * | 2021-01-28 | 2022-07-28 | Cumberland Pharmaceuticals Inc. | Injectable solution of norepinephrine |
| US12564561B2 (en) | 2021-02-15 | 2026-03-03 | Sintetica S.A. | Dilute ready to use large volume containers of phenylephrine |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2809619B1 (fr) * | 2000-06-06 | 2004-09-24 | Pharmatop | Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention |
| FR2832063B1 (fr) * | 2001-11-15 | 2004-08-27 | Aguettant Lab | Procede de production de solutions stables de substances phenoliques et les solutions en resultant |
| MXPA04012507A (es) | 2002-06-20 | 2005-06-08 | Novalar Pharmaceuticals Inc | Formulaciones estabilizadas para antoagonistas del receptor alfa-adrenergico y usos de las mismas. |
| US20040005401A1 (en) | 2002-07-05 | 2004-01-08 | Robert Becker | Method for applying a washcoat to suppport bodies |
| US7078876B2 (en) | 2003-07-07 | 2006-07-18 | Pentadyne Power Corporation | Feedforward controller for synchronous reluctance machines |
| FR2880807B1 (fr) * | 2005-01-19 | 2007-04-13 | Aguettant Sa Lab | Composition pharmaceutique injectable |
| US7465489B2 (en) | 2005-11-15 | 2008-12-16 | Poly-Med, Inc. | Inorganic-organic melted-extruded hybrid filaments and medical applications thereof |
| FR2894154B1 (fr) | 2005-12-06 | 2008-03-14 | Pharmatop Scr | Nouveau procede de stabilisation de substances minerales ou organiques sensibles a l'oxydation. |
| EP2096433A1 (de) | 2008-02-26 | 2009-09-02 | Siemens Aktiengesellschaft | Vorrichtung zur zerstörungsfreien Materialprüfung eines Prüfgegenstands mit Ultraschallwellen |
| US8419689B2 (en) | 2008-09-30 | 2013-04-16 | Covidien Lp | Enclosing package for medical port and cover |
| US8628805B2 (en) | 2009-06-04 | 2014-01-14 | Alk Ag | Stabilized composition comprising at least one adrenergic compound |
| ES2432164T3 (es) * | 2009-06-04 | 2013-12-02 | Alk Ag | Composición estabilizada que comprende al menos un compuesto adrenérgico |
| FR2963237B1 (fr) | 2010-07-28 | 2013-05-17 | Aguettant Lab | Nouvelle composition pharmaceutique utile pour prevenir ou traiter l'hypotension arterielle peroperatoire chez l'etre humain |
| CN102525895B (zh) | 2012-01-04 | 2013-11-06 | 上海禾丰制药有限公司 | 重酒石酸去甲肾上腺素注射液及其制剂工艺 |
| UY35988A (es) | 2014-02-27 | 2015-09-30 | Sint Sa | Proceso para la producción de una solución inyectable de noradrenalina de baja concentración |
| US20160005871A1 (en) * | 2014-07-04 | 2016-01-07 | Semiconductor Energy Laboratory Co., Ltd. | Semiconductor device |
| WO2018140894A1 (en) | 2017-01-30 | 2018-08-02 | Nevakar, Inc | Norepinephrine compositions and methods therefor |
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2015
- 2015-02-10 UY UY0001035988A patent/UY35988A/es unknown
- 2015-02-12 JO JOP/2015/0031A patent/JO3552B1/ar active
- 2015-02-13 AR ARP150100456A patent/AR101148A1/es not_active Application Discontinuation
- 2015-02-24 TW TW104105762A patent/TWI673065B/zh not_active IP Right Cessation
- 2015-02-26 EP EP15712064.3A patent/EP3110399B1/en active Active
- 2015-02-26 AP AP2016009467A patent/AP2016009467A0/en unknown
- 2015-02-26 BR BR112016019804-2A patent/BR112016019804B1/pt active IP Right Grant
- 2015-02-26 PT PT157120643T patent/PT3110399T/pt unknown
- 2015-02-26 SI SI201530205T patent/SI3110399T1/en unknown
- 2015-02-26 CR CR20160420A patent/CR20160420A/es unknown
- 2015-02-26 US US15/118,864 patent/US10251848B2/en not_active Ceased
- 2015-02-26 HU HUE15712064A patent/HUE038738T2/hu unknown
- 2015-02-26 MY MYPI2016703113A patent/MY179942A/en unknown
- 2015-02-26 RS RS20180352A patent/RS57044B1/sr unknown
- 2015-02-26 PE PE2016001537A patent/PE20161375A1/es unknown
- 2015-02-26 GE GEAP201714278A patent/GEP20186829B/en unknown
- 2015-02-26 CN CN201580010039.4A patent/CN106061467B/zh active Active
- 2015-02-26 US US17/006,840 patent/USRE49422E1/en active Active
- 2015-02-26 MA MA39200A patent/MA39200A1/fr unknown
- 2015-02-26 CA CA2940347A patent/CA2940347C/en active Active
- 2015-02-26 ME MEP-2018-88A patent/ME03004B/me unknown
- 2015-02-26 UA UAA201609379A patent/UA118043C2/uk unknown
- 2015-02-26 MD MDA20160103A patent/MD4628C1/ro not_active IP Right Cessation
- 2015-02-26 LT LTEP15712064.3T patent/LT3110399T/lt unknown
- 2015-02-26 US US17/006,838 patent/USRE49443E1/en active Active
- 2015-02-26 KR KR1020167026245A patent/KR102306706B1/ko active Active
- 2015-02-26 HR HRP20180541TT patent/HRP20180541T1/hr unknown
- 2015-02-26 AU AU2015222150A patent/AU2015222150B2/en active Active
- 2015-02-26 EA EA201691734A patent/EA031444B1/ru unknown
- 2015-02-26 PL PL15712064T patent/PL3110399T3/pl unknown
- 2015-02-26 DK DK15712064.3T patent/DK3110399T3/en active
- 2015-02-26 SG SG11201607094WA patent/SG11201607094WA/en unknown
- 2015-02-26 US US17/006,841 patent/USRE49555E1/en active Active
- 2015-02-26 JP JP2016551222A patent/JP6635927B2/ja active Active
- 2015-02-26 SM SM20180239T patent/SMT201800239T1/it unknown
- 2015-02-26 ES ES15712064.3T patent/ES2663817T3/es active Active
- 2015-02-26 MX MX2016011148A patent/MX367148B/es active IP Right Grant
- 2015-02-26 WO PCT/EP2015/054021 patent/WO2015128418A1/en not_active Ceased
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2016
- 2016-08-08 EC ECIEPI201665957A patent/ECSP16065957A/es unknown
- 2016-08-12 DO DO2016000210A patent/DOP2016000210A/es unknown
- 2016-08-17 CL CL2016002073A patent/CL2016002073A1/es unknown
- 2016-08-18 NI NI201600118A patent/NI201600118A/es unknown
- 2016-08-25 IL IL247501A patent/IL247501B/en active IP Right Grant
- 2016-08-26 PH PH12016501703A patent/PH12016501703B1/en unknown
- 2016-08-26 SV SV2016005265A patent/SV2016005265A/es unknown
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2018
- 2018-04-05 CY CY20181100385T patent/CY1120125T1/el unknown
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