JO3689B1 - صيغ من الباراسيتامول قابلة للحقن - Google Patents
صيغ من الباراسيتامول قابلة للحقنInfo
- Publication number
- JO3689B1 JO3689B1 JOP/2015/0303A JOP20150303A JO3689B1 JO 3689 B1 JO3689 B1 JO 3689B1 JO P20150303 A JOP20150303 A JO P20150303A JO 3689 B1 JO3689 B1 JO 3689B1
- Authority
- JO
- Jordan
- Prior art keywords
- paracetamol
- formulations
- pharmaceutically acceptable
- acceptable salt
- slow
- Prior art date
Links
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title abstract 3
- 229960005489 paracetamol Drugs 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000001990 intravenous administration Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 238000001802 infusion Methods 0.000 abstract 1
- 239000007972 injectable composition Substances 0.000 abstract 1
- 238000007918 intramuscular administration Methods 0.000 abstract 1
- 238000010253 intravenous injection Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000001297 phlebitis Diseases 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
<span dir="RTL">يتعلق الاختراع الحالي بحقن من الباراسيتامول منخفضة الكمية تعطى من خلال الوريد و ملحه المقبول دوائيا و طريقة تحضيره. توفر الصيغ تركيزا مرتفعا من الباراسيتامول أو ملحه المقبول دوائيا في نظام مذيب من الاختراع الحالي و الذي يمكن إعطاؤه ليس فقط من خلال مسار الإدخال في العضل أو الوريد بل أيضا يتناسب الإعطاء البطيء للأقراص عن طريق الوريد بعد حلها مع سوائل مائية إلى حجم نهائي لا يتجاوز 20 مل لتر. و تبقى هذه الصيغ القابلة للحقن مستقرة و تكون مناسبة أيضا للإعطاء من خلال المسار الوريدي البطيء مع آثار جانبية منخفضة (مثل التهاب الوريد، الألم، الخ).</span>
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN4102MU2014 | 2014-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO3689B1 true JO3689B1 (ar) | 2020-08-27 |
Family
ID=55022620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2015/0303A JO3689B1 (ar) | 2014-12-20 | 2015-12-09 | صيغ من الباراسيتامول قابلة للحقن |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US20180000940A1 (ar) |
| EP (1) | EP3233055B1 (ar) |
| JP (1) | JP2017538762A (ar) |
| KR (1) | KR20170099911A (ar) |
| CN (1) | CN107205924A (ar) |
| AR (1) | AR103188A1 (ar) |
| AU (1) | AU2015365533A1 (ar) |
| BR (1) | BR112017012975B1 (ar) |
| CA (1) | CA2969303A1 (ar) |
| CL (1) | CL2017001629A1 (ar) |
| CO (1) | CO2017006268A2 (ar) |
| CU (1) | CU20170088A7 (ar) |
| DO (1) | DOP2017000134A (ar) |
| EA (1) | EA201791409A1 (ar) |
| EC (1) | ECSP17038668A (ar) |
| ES (1) | ES3009433T3 (ar) |
| HU (1) | HUE070091T2 (ar) |
| IL (1) | IL252729A0 (ar) |
| JO (1) | JO3689B1 (ar) |
| MA (1) | MA40599A1 (ar) |
| MD (1) | MD20170071A2 (ar) |
| MX (1) | MX383557B (ar) |
| MY (1) | MY203965A (ar) |
| PE (1) | PE20171305A1 (ar) |
| PH (1) | PH12017501005B1 (ar) |
| PL (1) | PL3233055T3 (ar) |
| SG (1) | SG11201704435PA (ar) |
| TN (1) | TN2017000232A1 (ar) |
| TW (1) | TWI649097B (ar) |
| UA (1) | UA122136C2 (ar) |
| UY (1) | UY36466A (ar) |
| WO (1) | WO2016097899A1 (ar) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107229455B (zh) | 2016-03-24 | 2019-09-17 | 阿里巴巴集团控股有限公司 | 一种业务处理方法、装置及系统 |
| GR1011104B (el) * | 2024-12-18 | 2026-01-16 | Ιουλια Τσετη | Προγεμισμενη συριγγα υδατικου διαλυματος παρακεταμολης καταλληλη για ενεσιμη χορηγηση |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2751875B1 (fr) | 1996-08-05 | 1998-12-24 | Scr Newpharm | Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation |
| IT1301976B1 (it) | 1998-07-31 | 2000-07-20 | Angelini Ricerche Spa | Composizione farmaceutica iniettabile a base di paracetamolo |
| IT1313579B1 (it) | 1999-07-30 | 2002-09-09 | Acraf | Composizione farmaceutica liquida a base di paracetamolo. |
| ITMI20012135A1 (it) | 2001-10-16 | 2003-04-16 | Bioren S A | Soluzioni iniettabili pronte all'uso di paracetamolo |
| BRPI0611170A2 (pt) * | 2005-05-27 | 2010-08-17 | Panacea Biotec Ltd | composições injetáveis e processo para o preparo de tais composições |
| DK1973527T3 (da) * | 2005-12-15 | 2010-02-01 | Acusphere Inc | Fremgangsmåder til fremstilling af partikelbaserede farmaceutiske formulationer til parenteral indgivelse |
| AR067048A1 (es) | 2007-06-18 | 2009-09-30 | Combino Pharm Sl | Formulaciones acuosas de acetaminofen para inyeccion. |
| WO2009098716A2 (en) | 2008-01-17 | 2009-08-13 | Aptuit Laurus Private Limited | Stable pharmaceutical aqueous compositions |
| US20120115958A1 (en) * | 2008-10-09 | 2012-05-10 | Aziende Chim. Riun. Ang. Franc. A.C.R.A.F. S.P.A. | Liquid pharmaceutical formulation containing paracetamol |
| US9616128B2 (en) * | 2010-06-30 | 2017-04-11 | Troikaa Pharmaceuticals Ltd | Pharmaceutical compositions comprising paracetamol and process for preparing the same |
| TWI577377B (zh) * | 2010-09-16 | 2017-04-11 | Viiv醫療保健公司 | 醫藥組合物 |
| CN102258485A (zh) * | 2011-01-11 | 2011-11-30 | 北京润德康医药技术有限公司 | 一种含对乙酰氨基酚的注射用制剂及其应用 |
| CN102600068A (zh) * | 2011-01-24 | 2012-07-25 | 联康药业克雷恩特塞提斯制药实验室有限责任公司 | 稳定即用的可注射扑热息痛制剂 |
-
2015
- 2015-11-17 US US15/537,642 patent/US20180000940A1/en not_active Abandoned
- 2015-11-17 MD MDA20170071A patent/MD20170071A2/ro not_active Application Discontinuation
- 2015-11-17 PH PH1/2017/501005A patent/PH12017501005B1/en unknown
- 2015-11-17 BR BR112017012975-2A patent/BR112017012975B1/pt active IP Right Grant
- 2015-11-17 MX MX2017008264A patent/MX383557B/es unknown
- 2015-11-17 MA MA40599A patent/MA40599A1/fr unknown
- 2015-11-17 JP JP2017533277A patent/JP2017538762A/ja active Pending
- 2015-11-17 SG SG11201704435PA patent/SG11201704435PA/en unknown
- 2015-11-17 CA CA2969303A patent/CA2969303A1/en not_active Abandoned
- 2015-11-17 HU HUE15816228A patent/HUE070091T2/hu unknown
- 2015-11-17 TN TN2017000232A patent/TN2017000232A1/en unknown
- 2015-11-17 PE PE2017001066A patent/PE20171305A1/es unknown
- 2015-11-17 WO PCT/IB2015/058876 patent/WO2016097899A1/en not_active Ceased
- 2015-11-17 EA EA201791409A patent/EA201791409A1/ru unknown
- 2015-11-17 ES ES15816228T patent/ES3009433T3/es active Active
- 2015-11-17 KR KR1020177017759A patent/KR20170099911A/ko not_active Ceased
- 2015-11-17 CU CUP2017000088A patent/CU20170088A7/es unknown
- 2015-11-17 EP EP15816228.9A patent/EP3233055B1/en active Active
- 2015-11-17 CN CN201580069391.5A patent/CN107205924A/zh active Pending
- 2015-11-17 PL PL15816228.9T patent/PL3233055T3/pl unknown
- 2015-11-17 UA UAA201706668A patent/UA122136C2/uk unknown
- 2015-11-17 MY MYPI2017701979A patent/MY203965A/en unknown
- 2015-11-17 AU AU2015365533A patent/AU2015365533A1/en not_active Abandoned
- 2015-11-27 TW TW104139783A patent/TWI649097B/zh not_active IP Right Cessation
- 2015-12-09 JO JOP/2015/0303A patent/JO3689B1/ar active
- 2015-12-21 UY UY0001036466A patent/UY36466A/es unknown
- 2015-12-21 AR ARP150104211A patent/AR103188A1/es unknown
-
2017
- 2017-06-06 IL IL252729A patent/IL252729A0/en unknown
- 2017-06-09 DO DO2017000134A patent/DOP2017000134A/es unknown
- 2017-06-20 CL CL2017001629A patent/CL2017001629A1/es unknown
- 2017-06-20 EC ECIEPI201738668A patent/ECSP17038668A/es unknown
- 2017-06-23 CO CONC2017/0006268A patent/CO2017006268A2/es unknown
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