JO3706B1 - مشتقات H4- بيرولو[2,3-c] بيريدين-4- ون - Google Patents

مشتقات H4- بيرولو[2,3-c] بيريدين-4- ون

Info

Publication number
JO3706B1
JO3706B1 JOP/2016/0014A JOP20160014A JO3706B1 JO 3706 B1 JO3706 B1 JO 3706B1 JO P20160014 A JOP20160014 A JO P20160014A JO 3706 B1 JO3706 B1 JO 3706B1
Authority
JO
Jordan
Prior art keywords
pyridine
pyrrole derivatives
pyrrole
derivatives
medicines
Prior art date
Application number
JOP/2016/0014A
Other languages
English (en)
Inventor
Jozsef B?Lint Dr
Keith Graham Dr
Hans Briem Dr
Philip Lienau Dr
Tempel René
Ulrich Klar Dr
Volker Schulze Dr
Gerhard Siemeister Dr
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Application granted granted Critical
Publication of JO3706B1 publication Critical patent/JO3706B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

يتعلق الاختراع الحالي بمركبات الصيغة (I) (I) ، وعمليات لإنتاجها واستخدامها كأدوية.
JOP/2016/0014A 2015-01-28 2016-01-27 مشتقات H4- بيرولو[2,3-c] بيريدين-4- ون JO3706B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15152944 2015-01-28
EP15200407 2015-12-16

Publications (1)

Publication Number Publication Date
JO3706B1 true JO3706B1 (ar) 2021-01-31

Family

ID=55236350

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2016/0014A JO3706B1 (ar) 2015-01-28 2016-01-27 مشتقات H4- بيرولو[2,3-c] بيريدين-4- ون

Country Status (30)

Country Link
US (1) US10428063B2 (ar)
EP (1) EP3250567B1 (ar)
JP (1) JP6704398B2 (ar)
KR (1) KR102544847B1 (ar)
CN (1) CN107406417B (ar)
AU (1) AU2016212230B2 (ar)
BR (1) BR112017016193B1 (ar)
CA (1) CA2974853C (ar)
CL (1) CL2017001930A1 (ar)
CO (1) CO2017007663A2 (ar)
CR (1) CR20170345A (ar)
CU (1) CU20170094A7 (ar)
DO (1) DOP2017000176A (ar)
EA (1) EA032530B1 (ar)
EC (1) ECSP17048527A (ar)
IL (1) IL253284B (ar)
JO (1) JO3706B1 (ar)
MX (1) MX380239B (ar)
MY (1) MY182181A (ar)
NI (1) NI201700096A (ar)
PE (1) PE20171240A1 (ar)
PH (1) PH12017501340A1 (ar)
SG (1) SG11201705908VA (ar)
SV (1) SV2017005487A (ar)
TN (1) TN2017000329A1 (ar)
TW (1) TWI699359B (ar)
UA (1) UA122221C2 (ar)
UY (1) UY36544A (ar)
WO (1) WO2016120196A1 (ar)
ZA (1) ZA201705802B (ar)

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Also Published As

Publication number Publication date
IL253284B (en) 2020-08-31
MX2017009831A (es) 2017-11-02
CN107406417A (zh) 2017-11-28
JP2018503648A (ja) 2018-02-08
SV2017005487A (es) 2019-01-17
CR20170345A (es) 2017-09-29
HK1244804A1 (zh) 2018-08-17
NI201700096A (es) 2017-10-24
SG11201705908VA (en) 2017-08-30
TN2017000329A1 (en) 2019-01-16
MY182181A (en) 2021-01-18
WO2016120196A1 (en) 2016-08-04
ZA201705802B (en) 2019-07-31
TW201639828A (zh) 2016-11-16
DOP2017000176A (es) 2017-08-31
EA201791692A1 (ru) 2018-01-31
ECSP17048527A (es) 2017-10-31
CL2017001930A1 (es) 2018-03-09
EP3250567B1 (en) 2019-10-30
UY36544A (es) 2016-08-31
EA032530B1 (ru) 2019-06-28
US10428063B2 (en) 2019-10-01
CO2017007663A2 (es) 2017-10-10
PH12017501340A1 (en) 2017-12-18
PE20171240A1 (es) 2017-08-24
US20180016272A1 (en) 2018-01-18
EP3250567A1 (en) 2017-12-06
TWI699359B (zh) 2020-07-21
KR20170106452A (ko) 2017-09-20
KR102544847B1 (ko) 2023-06-16
CU20170094A7 (es) 2017-12-08
CA2974853C (en) 2023-02-21
CN107406417B (zh) 2020-06-09
MX380239B (es) 2025-03-12
BR112017016193B1 (pt) 2023-02-23
JP6704398B2 (ja) 2020-06-03
UA122221C2 (uk) 2020-10-12
CA2974853A1 (en) 2016-08-04
BR112017016193A2 (pt) 2018-04-17
IL253284A0 (en) 2017-09-28
AU2016212230B2 (en) 2019-09-19
AU2016212230A1 (en) 2017-07-20

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