JO3772B1 - صيغة جسم مضاد لـ cgrp - Google Patents

صيغة جسم مضاد لـ cgrp

Info

Publication number
JO3772B1
JO3772B1 JOP/2016/0111A JOP20160111A JO3772B1 JO 3772 B1 JO3772 B1 JO 3772B1 JO P20160111 A JOP20160111 A JO P20160111A JO 3772 B1 JO3772 B1 JO 3772B1
Authority
JO
Jordan
Prior art keywords
antibody formulation
cgrp antibody
headaches
episodic
chronic
Prior art date
Application number
JOP/2016/0111A
Other languages
English (en)
Inventor
N Sharma Anant
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of JO3772B1 publication Critical patent/JO3772B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

يتعلق الاختراع الحالي بصيغ صيدلية لأجسام مضادة لـ CGRP، وطرق استخدامها، حيث تكون نافعة كعلاج لأنواع الصداع النصفي، أنواع الصداع العارض، أنواع الصداع المزمن، أنواع الصداع العنقودي المزمن، وأنواع الصداع العنقودي العارض.
JOP/2016/0111A 2015-06-17 2016-06-05 صيغة جسم مضاد لـ cgrp JO3772B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562180905P 2015-06-17 2015-06-17

Publications (1)

Publication Number Publication Date
JO3772B1 true JO3772B1 (ar) 2021-01-31

Family

ID=56131672

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2016/0111A JO3772B1 (ar) 2015-06-17 2016-06-05 صيغة جسم مضاد لـ cgrp

Country Status (31)

Country Link
US (3) US11498959B2 (ar)
EP (2) EP4470557A3 (ar)
JP (1) JP6438599B2 (ar)
KR (1) KR102000867B1 (ar)
CN (4) CN114948847A (ar)
AR (2) AR104847A1 (ar)
AU (1) AU2016280555B2 (ar)
BR (1) BR112017023374A2 (ar)
CA (1) CA2984185A1 (ar)
DK (1) DK3310809T3 (ar)
EA (1) EA037580B1 (ar)
ES (1) ES3000607T3 (ar)
FI (1) FI3310809T3 (ar)
HR (1) HRP20241660T1 (ar)
HU (1) HUE069368T2 (ar)
IL (2) IL292562A (ar)
JO (1) JO3772B1 (ar)
LT (1) LT3310809T (ar)
MA (1) MA49726B1 (ar)
MD (1) MD3310809T2 (ar)
MX (1) MX395147B (ar)
MY (1) MY184266A (ar)
NZ (1) NZ737046A (ar)
PL (1) PL3310809T3 (ar)
PT (1) PT3310809T (ar)
RS (1) RS66243B1 (ar)
SI (1) SI3310809T1 (ar)
TW (1) TWI725973B (ar)
UA (1) UA120881C2 (ar)
WO (1) WO2016205037A1 (ar)
ZA (1) ZA201707324B (ar)

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Also Published As

Publication number Publication date
EA037580B1 (ru) 2021-04-16
DK3310809T3 (da) 2024-12-02
AU2016280555B2 (en) 2018-11-15
US20230159628A1 (en) 2023-05-25
EA201792359A1 (ru) 2018-05-31
RS66243B1 (sr) 2024-12-31
KR102000867B1 (ko) 2019-07-16
EP4470557A2 (en) 2024-12-04
MA49726A (fr) 2020-06-10
EP3310809B1 (en) 2024-10-16
PT3310809T (pt) 2024-12-16
CN107787229A (zh) 2018-03-09
US11498959B2 (en) 2022-11-15
TW201711697A (zh) 2017-04-01
BR112017023374A2 (pt) 2018-07-24
EP4470557A3 (en) 2025-02-26
MD3310809T2 (ro) 2025-03-31
SI3310809T1 (sl) 2025-03-31
JP2018517727A (ja) 2018-07-05
MA49726B1 (fr) 2025-02-28
KR20180002858A (ko) 2018-01-08
LT3310809T (lt) 2025-01-10
MX395147B (es) 2025-03-24
US20220112277A1 (en) 2022-04-14
FI3310809T3 (fi) 2024-12-07
AR133453A2 (es) 2025-10-01
UA120881C2 (uk) 2020-02-25
CN118356393A (zh) 2024-07-19
TWI725973B (zh) 2021-05-01
MX2017016199A (es) 2018-03-01
ZA201707324B (en) 2020-01-29
AR104847A1 (es) 2017-08-16
US20180134772A1 (en) 2018-05-17
WO2016205037A1 (en) 2016-12-22
PL3310809T3 (pl) 2025-01-27
ES3000607T3 (en) 2025-03-03
JP6438599B2 (ja) 2018-12-19
CN122479108A (zh) 2026-07-31
HK1245813A1 (en) 2018-08-31
IL255443B (en) 2022-06-01
EP3310809A1 (en) 2018-04-25
HUE069368T2 (hu) 2025-02-28
NZ737046A (en) 2019-09-27
IL292562A (en) 2022-06-01
AU2016280555A1 (en) 2017-11-16
IL255443A0 (en) 2017-12-31
MY184266A (en) 2021-03-30
CA2984185A1 (en) 2016-12-22
CN114948847A (zh) 2022-08-30
HRP20241660T1 (hr) 2025-02-14

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