JOP20130186B1 - تنقية الجزيئات الشبيهة بالفيروسات - Google Patents
تنقية الجزيئات الشبيهة بالفيروساتInfo
- Publication number
- JOP20130186B1 JOP20130186B1 JOP/2013/0186A JOP20130186A JOP20130186B1 JO P20130186 B1 JOP20130186 B1 JO P20130186B1 JO P20130186 A JOP20130186 A JO P20130186A JO P20130186 B1 JOP20130186 B1 JO P20130186B1
- Authority
- JO
- Jordan
- Prior art keywords
- particles
- virus
- purification
- andnbsp
- methods
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 239000000356 contaminant Substances 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 239000012678 infectious agent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/16011—Caliciviridae
- C12N2770/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/16011—Caliciviridae
- C12N2770/16023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/16011—Caliciviridae
- C12N2770/16051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Analytical Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
يتعلق الاختراع الحالي بطرق تنقية جسيمات تشبه الفيروس (VLPs) والتي تكون خالية الى حد كبير من ملوثات عملية وعوامل معدية. تشتمل الطرق، على سبيل المثال، على معالجة ذات رقم هيدروجيني منخفض أثناء الحصاد و/أو التخميد بواسطة مذيب و/أو منظف أثناء احتجاز VLP.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261663218P | 2012-06-22 | 2012-06-22 | |
| US201361794086P | 2013-03-15 | 2013-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JOP20130186B1 true JOP20130186B1 (ar) | 2021-08-17 |
Family
ID=49769461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2013/0186A JOP20130186B1 (ar) | 2012-06-22 | 2013-06-19 | تنقية الجزيئات الشبيهة بالفيروسات |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10167320B2 (ar) |
| EP (1) | EP2864478B1 (ar) |
| JP (1) | JP6553509B2 (ar) |
| KR (1) | KR102110876B1 (ar) |
| CN (2) | CN114085273B (ar) |
| AR (1) | AR091538A1 (ar) |
| AU (1) | AU2013277959B2 (ar) |
| CA (1) | CA2879815A1 (ar) |
| IN (1) | IN2015DN00089A (ar) |
| JO (1) | JOP20130186B1 (ar) |
| MX (1) | MX366234B (ar) |
| SG (2) | SG11201408459VA (ar) |
| TW (1) | TWI647310B (ar) |
| UY (1) | UY34875A (ar) |
| WO (1) | WO2013192604A1 (ar) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2577833T3 (es) | 2006-09-29 | 2016-07-19 | Takeda Vaccines, Inc. | Formulaciones de vacuna para norovirus |
| HUE028605T2 (en) | 2007-03-14 | 2016-12-28 | Takeda Vaccines Inc | Cleaning virus-like particles |
| SG10201601660YA (en) | 2007-09-18 | 2016-04-28 | Takeda Vaccines Inc | Method of conferring a protective immune response to norovirus |
| EP3299030B1 (en) | 2011-07-11 | 2022-06-08 | Takeda Vaccines, Inc. | Parenteral norovirus vaccine formulations |
| JOP20130186B1 (ar) | 2012-06-22 | 2021-08-17 | Takeda Vaccines Montana Inc | تنقية الجزيئات الشبيهة بالفيروسات |
| CN105339495A (zh) * | 2013-07-11 | 2016-02-17 | 宝生物工程株式会社 | 制备无包膜病毒的方法 |
| AU2014329403B2 (en) | 2013-10-03 | 2020-10-08 | Takeda Vaccines, Inc. | Methods of detection and removal of rhabdoviruses from cell lines |
| CN103981084B (zh) * | 2014-05-29 | 2015-11-18 | 黑龙江省科学院微生物研究所 | 水中病毒分离提取装置及水中札幌病毒的提取方法 |
| CN107109374B (zh) | 2015-01-09 | 2021-04-06 | 宝生物工程株式会社 | 用于生产无包膜病毒颗粒的方法 |
| US10920288B2 (en) | 2015-01-16 | 2021-02-16 | Takeda Vaccines, Inc. | Detection of particle-contained reverse transcriptase activity |
| CN105907729B (zh) * | 2015-05-05 | 2019-08-16 | 广东东阳光药业有限公司 | 一种制备人乳头瘤病毒l1蛋白类病毒样颗粒的方法 |
| CN107034198B (zh) * | 2015-07-15 | 2021-03-09 | 长春百克生物科技股份公司 | 一种嵌合诺如病毒p颗粒及其制备和应用 |
| CA3000329A1 (en) | 2015-08-28 | 2017-03-09 | Ology Bioservices, Inc. | Norovirus vaccine |
| CN105779399A (zh) * | 2016-03-28 | 2016-07-20 | 广西壮族自治区林业科学研究院 | 一种昆虫杆状病毒纯化方法 |
| GB201614050D0 (en) | 2016-08-17 | 2016-09-28 | Glaxosmithkline Ip Dev Ltd | Method for purifying viral vectors |
| KR20190042606A (ko) * | 2016-09-01 | 2019-04-24 | 다케다 백신즈 인코포레이티드 | 백신 제조용 바이러스의 제조 방법 |
| EP3420076B1 (en) * | 2017-03-06 | 2024-02-21 | Guangzhou Realbenefitspot Pharmaceutical Co., Ltd. | Methods of producing and characterizing virus vaccine and virus vaccine composition |
| EP4382183A3 (en) | 2017-03-06 | 2024-08-21 | Guangzhou Realbenefitspot Pharmaceutical Co., Ltd. | Methods of producing and characterizing virus vaccine and virus vaccine composition |
| US11633467B2 (en) | 2018-02-15 | 2023-04-25 | Icon Genetics Gmbh | Immunogenic composition and vaccine for generating an immune response to norovirus |
| CN108676781A (zh) * | 2018-05-18 | 2018-10-19 | 山东信得动物疫苗有限公司 | 一种重组禽流感病毒的工业化纯化方法 |
| CN108776225A (zh) * | 2018-05-23 | 2018-11-09 | 中国农业科学院兰州兽医研究所 | 猪细小病毒VLPs抗体检测试剂盒及其制备方法、应用 |
| US20220152186A1 (en) | 2019-03-12 | 2022-05-19 | Icon Genetics Gmbh | Norovirus-like particles with improved stability |
| US12403164B2 (en) | 2019-09-30 | 2025-09-02 | Bioverativ Therapeutics Inc. | Lentiviral vector formulations |
| EP4340874A1 (en) | 2021-05-21 | 2024-03-27 | Takeda Vaccines, Inc. | Solid composition, freeze-drying method and glass vial |
| EP4362975A4 (en) * | 2021-06-28 | 2025-05-14 | VST LLC dba Medgene Labs | SAPOVIRUS VACCINES |
| CN116789773B (zh) * | 2022-11-30 | 2024-02-20 | 华北制药金坦生物技术股份有限公司 | 一种胞内表达病毒样颗粒的粗纯方法 |
| WO2025077800A1 (en) * | 2023-10-12 | 2025-04-17 | Chengdu Kanghua Biological Products Co., Ltd. | Purification of norovirus virus-like particles (vlps) |
| CN118126202B (zh) * | 2024-05-07 | 2024-07-30 | 上海瑞宙生物科技有限公司 | 一种诺如病毒类病毒颗粒及其应用 |
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| KR101793161B1 (ko) | 2008-08-08 | 2017-11-03 | 다케다 백신즈 인코포레이티드 | 강화된 교차 반응성을 가진 복합체 캡시드 아미노산 서열들을 포함하는 바이러스-유사 입자들 |
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| FI122520B (fi) | 2010-10-15 | 2012-03-15 | Vesna Blazevic | Noroviruksen kapsidi ja rotaviruksen VP6-proteiini käytettäväksi yhdistelmärokotteena |
| CN102260651A (zh) | 2011-06-24 | 2011-11-30 | 华中科技大学同济医学院附属协和医院 | 一种纯化病毒样颗粒蛋白的方法及其应用 |
| JOP20130186B1 (ar) | 2012-06-22 | 2021-08-17 | Takeda Vaccines Montana Inc | تنقية الجزيئات الشبيهة بالفيروسات |
| JP2015015931A (ja) | 2013-07-12 | 2015-01-29 | 株式会社Umnファーマ | ウイルス様粒子を含む培養物の製造方法 |
-
2013
- 2013-06-19 JO JOP/2013/0186A patent/JOP20130186B1/ar active
- 2013-06-21 TW TW102122276A patent/TWI647310B/zh active
- 2013-06-24 SG SG11201408459VA patent/SG11201408459VA/en unknown
- 2013-06-24 AU AU2013277959A patent/AU2013277959B2/en active Active
- 2013-06-24 US US13/925,449 patent/US10167320B2/en active Active
- 2013-06-24 SG SG10201610753YA patent/SG10201610753YA/en unknown
- 2013-06-24 JP JP2015518633A patent/JP6553509B2/ja active Active
- 2013-06-24 MX MX2014015842A patent/MX366234B/es active IP Right Grant
- 2013-06-24 CN CN202111173161.7A patent/CN114085273B/zh active Active
- 2013-06-24 KR KR1020157001131A patent/KR102110876B1/ko active Active
- 2013-06-24 WO PCT/US2013/047249 patent/WO2013192604A1/en not_active Ceased
- 2013-06-24 UY UY0001034875A patent/UY34875A/es active IP Right Grant
- 2013-06-24 AR ARP130102218 patent/AR091538A1/es active IP Right Grant
- 2013-06-24 CN CN201380043618.XA patent/CN104583393A/zh active Pending
- 2013-06-24 CA CA2879815A patent/CA2879815A1/en active Pending
- 2013-06-24 EP EP13807804.3A patent/EP2864478B1/en active Active
-
2015
- 2015-01-06 IN IN89DEN2015 patent/IN2015DN00089A/en unknown
-
2018
- 2018-11-27 US US16/201,073 patent/US11091519B2/en active Active
-
2021
- 2021-08-11 US US17/399,731 patent/US12286456B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6553509B2 (ja) | 2019-07-31 |
| AU2013277959A1 (en) | 2015-01-22 |
| AR091538A1 (es) | 2015-02-11 |
| US12286456B2 (en) | 2025-04-29 |
| EP2864478A1 (en) | 2015-04-29 |
| HK1210210A1 (en) | 2016-04-15 |
| EP2864478B1 (en) | 2020-12-09 |
| US20220213147A1 (en) | 2022-07-07 |
| US10167320B2 (en) | 2019-01-01 |
| MX2014015842A (es) | 2015-09-07 |
| US20190169236A1 (en) | 2019-06-06 |
| MX366234B (es) | 2019-07-03 |
| TWI647310B (zh) | 2019-01-11 |
| TW201406956A (zh) | 2014-02-16 |
| CA2879815A1 (en) | 2013-12-27 |
| JP2015521628A (ja) | 2015-07-30 |
| IN2015DN00089A (ar) | 2015-05-29 |
| AU2013277959B2 (en) | 2019-05-16 |
| SG11201408459VA (en) | 2015-01-29 |
| CN114085273A (zh) | 2022-02-25 |
| CN114085273B (zh) | 2024-07-12 |
| WO2013192604A1 (en) | 2013-12-27 |
| KR102110876B1 (ko) | 2020-05-14 |
| KR20150051988A (ko) | 2015-05-13 |
| US11091519B2 (en) | 2021-08-17 |
| EP2864478A4 (en) | 2015-12-02 |
| UY34875A (es) | 2013-12-31 |
| US20140004145A1 (en) | 2014-01-02 |
| SG10201610753YA (en) | 2017-02-27 |
| CN104583393A (zh) | 2015-04-29 |
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