JOP20200050A1 - عوامل RNAi وتركيبات لتثبيط التعبير عن شبيه آنجيوبويتين 3 (ANGPTL3)، وطرق استخدام - Google Patents

عوامل RNAi وتركيبات لتثبيط التعبير عن شبيه آنجيوبويتين 3 (ANGPTL3)، وطرق استخدام

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Publication number
JOP20200050A1
JOP20200050A1 JOP/2020/0050A JOP20200050A JOP20200050A1 JO P20200050 A1 JOP20200050 A1 JO P20200050A1 JO P20200050 A JOP20200050 A JO P20200050A JO P20200050 A1 JOP20200050 A1 JO P20200050A1
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Jordan
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angptl3
rnai agents
angiopoietin
methods
compositions
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JOP/2020/0050A
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English (en)
Inventor
So Wong
Rui Zhu
Zhen Li
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Arrowhead Pharmaceuticals Inc
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Publication of JOP20200050A1 publication Critical patent/JOP20200050A1/ar

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Abstract

يتعلق الكشف الحالي بعوامل RNAi، مثلا، عوامل RNAi مزدوجة الجديلة، قادرة على تثبيط التعبير الجيني عن شبيه آنجيوبويتين 3 (المسماة أيضا ANGPTL3، ANGPL3، بروتين شبيه آنجيوبويتين 3)، وتركيبات تتضمن عوامل ANGPTL3 RNAi. تم أيضا الكشف عن طرق استخدام عوامل ANGPTL3 RNAi وتركيبات. يمكن ترافق عوامل ANGPTL3 RNAi المكشوف عنها هنا مع المركبات الترابطية المستهدفة لتسهيل التوصيل إلى الخلايا، شاملة إلى خلايا الكبد. تم وصف تركيبات صيدلانية تتضمن واحد أو أكثر من عوامل ANGPTL3 RNAi، اختياريا مع واحد أو أكثر من علاجات إضافية. يقوم توصيل عوامل ANGPTL3 RNAi في الكائن الحي بتوفير تثبيط التعبير الجيني عن ANGPTL3، ويمكن أن تؤدي إلى مركبات تراي جليسريد أقل و/أو مستويات الكوليسترول في الخاضع. يمكن استخدام عوامل RNAi في طرق علاج الأمراض والاضطرابات المرتبطة بـ ANGPTL3، شاملة الأمراض القلبية الأيضية مثل زيادة جليسريدات الدم الثلاثية وارتفاع دهون الدم. الشكل 1A
JOP/2020/0050A 2017-09-14 2018-09-13 عوامل RNAi وتركيبات لتثبيط التعبير عن شبيه آنجيوبويتين 3 (ANGPTL3)، وطرق استخدام JOP20200050A1 (ar)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762558819P 2017-09-14 2017-09-14
US201762583919P 2017-11-09 2017-11-09
US201862651284P 2018-04-02 2018-04-02
US201862694976P 2018-07-07 2018-07-07
PCT/US2018/050848 WO2019055633A1 (en) 2017-09-14 2018-09-13 RNAI AGENTS AND COMPOSITIONS FOR INHIBITING ANALOGUE EXPRESSION OF ANGIOPOIETIN 3 (ANGPTL3) AND METHODS OF USE

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JOP20200050A1 true JOP20200050A1 (ar) 2020-03-05

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EP (1) EP3681513A4 (ar)
JP (3) JP7281452B2 (ar)
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AU (2) AU2018331383B2 (ar)
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PE (1) PE20201287A1 (ar)
PH (1) PH12020500309A1 (ar)
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