JOP20200311A1 - مثبطات صغيرة الجزيئات من فئة الكينازات مزدوجة الوجه (jak) - Google Patents

مثبطات صغيرة الجزيئات من فئة الكينازات مزدوجة الوجه (jak)

Info

Publication number
JOP20200311A1
JOP20200311A1 JOP/2020/0311A JOP20200311A JOP20200311A1 JO P20200311 A1 JOP20200311 A1 JO P20200311A1 JO P20200311 A JOP20200311 A JO P20200311A JO P20200311 A1 JOP20200311 A1 JO P20200311A1
Authority
JO
Jordan
Prior art keywords
kinases
small molecule
molecule inhibitors
jak family
methods
Prior art date
Application number
JOP/2020/0311A
Other languages
English (en)
Inventor
Paul J Krawczuk
Mark S Tichenor
Philippe Fernandes
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of JOP20200311A1 publication Critical patent/JOP20200311A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)

Abstract

مركبات 2-((1r,4r)-4-(إيميدازو[4,5-d]بيرولو[2,3-b]بيريدين-1(6H)-يل)هيكسيل حلقي)أسيتونتريل والتركيبات الدوائية التي تحتوي عليها وطرق صناعتها وطرق استخدامها بما في ذلك طرق علاج حالات المرض والاضطرابات والحالات التي تتدخل بها الكينازات مزدوجة الوجه (JAK).
JOP/2020/0311A 2018-06-15 2019-06-14 مثبطات صغيرة الجزيئات من فئة الكينازات مزدوجة الوجه (jak) JOP20200311A1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862685737P 2018-06-15 2018-06-15
US201962846290P 2019-05-10 2019-05-10
PCT/IB2019/055005 WO2019239387A1 (en) 2018-06-15 2019-06-14 Small molecule inhibitors of the jak family of kinases

Publications (1)

Publication Number Publication Date
JOP20200311A1 true JOP20200311A1 (ar) 2020-11-30

Family

ID=67766195

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2020/0311A JOP20200311A1 (ar) 2018-06-15 2019-06-14 مثبطات صغيرة الجزيئات من فئة الكينازات مزدوجة الوجه (jak)

Country Status (23)

Country Link
US (3) US20200017498A1 (ar)
EP (1) EP3807277A1 (ar)
JP (1) JP2021528391A (ar)
KR (1) KR102768284B1 (ar)
CN (1) CN112313233A (ar)
AU (1) AU2019286641A1 (ar)
BR (1) BR112020024744A2 (ar)
CA (1) CA3101438A1 (ar)
CL (1) CL2020003227A1 (ar)
CO (1) CO2020015396A2 (ar)
CR (1) CR20200603A (ar)
EC (1) ECSP20080817A (ar)
IL (1) IL279314A (ar)
JO (1) JOP20200311A1 (ar)
MA (1) MA52900A (ar)
MX (1) MX2020013688A (ar)
NI (1) NI202000100A (ar)
PE (1) PE20212113A1 (ar)
PH (1) PH12020551984A1 (ar)
SG (1) SG11202011691PA (ar)
TW (1) TW202016110A (ar)
UY (1) UY38262A (ar)
WO (1) WO2019239387A1 (ar)

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* Cited by examiner, † Cited by third party
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JP7291077B2 (ja) 2016-12-16 2023-06-14 ヤンセン ファーマシューティカ エヌ．ベー． Ｊａｋファミリーのキナーゼの低分子阻害物質
TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑
MX2023010642A (es) 2021-03-11 2023-11-28 Janssen Pharmaceutica Nv Lorpucitinib para uso en el tratamiento de trastornos mediados por jak.
CN113292561A (zh) * 2021-05-22 2021-08-24 中国药科大学 一种二吡咯并吡啶结构的化合物、制备方法和医药用途

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AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
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WO2007007919A2 (en) 2005-07-14 2007-01-18 Astellas Pharma Inc. Heterocyclic janus kinase 3 inhibitors
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Also Published As

Publication number Publication date
ECSP20080817A (es) 2021-01-29
US11787807B2 (en) 2023-10-17
IL279314A (en) 2021-01-31
US20200017498A1 (en) 2020-01-16
CL2020003227A1 (es) 2021-05-14
NI202000100A (es) 2021-06-30
MA52900A (fr) 2021-04-21
SG11202011691PA (en) 2020-12-30
WO2019239387A1 (en) 2019-12-19
PE20212113A1 (es) 2021-11-04
CA3101438A1 (en) 2019-12-19
UY38262A (es) 2019-12-31
EP3807277A1 (en) 2021-04-21
KR102768284B1 (ko) 2025-02-13
US11066406B2 (en) 2021-07-20
CN112313233A (zh) 2021-02-02
MX2020013688A (es) 2021-02-26
TW202016110A (zh) 2020-05-01
BR112020024744A2 (pt) 2021-03-23
US20210340144A1 (en) 2021-11-04
CO2020015396A2 (es) 2021-03-08
US20200165250A1 (en) 2020-05-28
PH12020551984A1 (en) 2021-08-02
CR20200603A (es) 2021-01-20
KR20210021342A (ko) 2021-02-25
JP2021528391A (ja) 2021-10-21
AU2019286641A1 (en) 2020-12-10

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