JOP20200344A1 - منشطات لاستجابة البروتين غير المطوي - Google Patents
منشطات لاستجابة البروتين غير المطويInfo
- Publication number
- JOP20200344A1 JOP20200344A1 JOP/2020/0344A JOP20200344A JOP20200344A1 JO P20200344 A1 JOP20200344 A1 JO P20200344A1 JO P20200344 A JOP20200344 A JO P20200344A JO P20200344 A1 JOP20200344 A1 JO P20200344A1
- Authority
- JO
- Jordan
- Prior art keywords
- cancer cells
- activators
- small molecules
- resistant
- unfolded protein
- Prior art date
Links
- 239000012190 activator Substances 0.000 title 1
- 230000004906 unfolded protein response Effects 0.000 title 1
- 206010006187 Breast cancer Diseases 0.000 abstract 2
- 208000026310 Breast neoplasm Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 abstract 2
- 150000003384 small molecules Chemical class 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- FABLAHMQSQFDHR-UHFFFAOYSA-N 3,3-bis(4-hydroxyphenyl)-7-methyl-1h-indol-2-one Chemical compound CC1=CC=CC2=C1NC(=O)C2(C=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 FABLAHMQSQFDHR-UHFFFAOYSA-N 0.000 abstract 1
- 206010014733 Endometrial cancer Diseases 0.000 abstract 1
- 206010014759 Endometrial neoplasm Diseases 0.000 abstract 1
- VWUXBMIQPBEWFH-WCCTWKNTSA-N Fulvestrant Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=C1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010061535 Ovarian neoplasm Diseases 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000011443 conventional therapy Methods 0.000 abstract 1
- 238000009261 endocrine therapy Methods 0.000 abstract 1
- 229960002258 fulvestrant Drugs 0.000 abstract 1
- 239000000367 immunologic factor Substances 0.000 abstract 1
- 230000002611 ovarian Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000007420 reactivation Effects 0.000 abstract 1
- 229960001603 tamoxifen Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
يتعلق الاختراع الحالي بمجموعة من المعدلات الحيوية للجزيئات الصغيرة ERa التي تقتل خلايا سرطان الثدي، المبيض، بطانة الرحم المقاومة للعلاج. وتزيد هذه الجزيئات الصغيرة من الطرق العلاجية بسبب زيادة القدرة على قتل خلايا سرطان الثدي المقاومة للعلاج مقارنة بـ BHPI والعلاجات التقليدية الأخرى (علاجات الغدد الصماء، التاموكسيفين وفولفسترانت /ICI). ولا تمنع المركبات الجديدة من تكاثر الخلايا السرطانية فحسب، بل تقتلها أيضاً، مما يمنع إعادة تنشيط الأورام بعد سنوات. الشكل 4ب
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862693641P | 2018-07-03 | 2018-07-03 | |
| PCT/US2019/040058 WO2020009958A1 (en) | 2018-07-03 | 2019-07-01 | Activators of the unfolded protein response |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JOP20200344A1 true JOP20200344A1 (ar) | 2020-12-31 |
Family
ID=69059783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2020/0344A JOP20200344A1 (ar) | 2018-07-03 | 2019-07-01 | منشطات لاستجابة البروتين غير المطوي |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US12180159B2 (ar) |
| EP (1) | EP3817741A4 (ar) |
| JP (1) | JP2021529757A (ar) |
| KR (1) | KR20210027382A (ar) |
| CN (1) | CN112423743A (ar) |
| AU (1) | AU2019299221A1 (ar) |
| BR (1) | BR112020025591A2 (ar) |
| CA (1) | CA3103958A1 (ar) |
| CL (1) | CL2020003423A1 (ar) |
| CO (1) | CO2020016690A2 (ar) |
| CR (1) | CR20210060A (ar) |
| DO (1) | DOP2020000256A (ar) |
| EA (1) | EA202190146A1 (ar) |
| EC (1) | ECSP20084330A (ar) |
| IL (1) | IL279429A (ar) |
| JO (1) | JOP20200344A1 (ar) |
| MA (1) | MA53105A (ar) |
| MX (1) | MX2021000043A (ar) |
| PE (1) | PE20210662A1 (ar) |
| PH (1) | PH12020552223A1 (ar) |
| SG (1) | SG11202012902WA (ar) |
| WO (1) | WO2020009958A1 (ar) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021000043A (es) | 2018-07-03 | 2021-03-25 | Univ Illinois | Activadores de la respuesta a proteinas desplegadas. |
| WO2021222738A1 (en) * | 2020-05-01 | 2021-11-04 | The Board Of Trustees Of The University Of Illinois | Compounds for estrogen receptor positive cancers |
| WO2022020605A1 (en) * | 2020-07-23 | 2022-01-27 | The Board Of Trustees Of The University Of Illinois | Treatment of metastasized estrogen receptor positive breast cancer |
| WO2022032146A1 (en) * | 2020-08-07 | 2022-02-10 | Systems Oncology, Llc | Methods for inhibiting growth of era positive cancers |
| US20230391721A1 (en) * | 2020-10-23 | 2023-12-07 | The Board Of Trustees Of The University Of Illinois | Anticancer compounds selective for er-positive cancers |
| WO2024175114A1 (en) * | 2023-02-23 | 2024-08-29 | Shanghai Yuyao Biotech Ltd. | Boron containing compounds and therapeutic uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003230581A1 (en) | 2002-03-15 | 2003-09-29 | Eli Lilly And Company | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators |
| US20050070718A1 (en) | 2003-09-30 | 2005-03-31 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
| JP4989976B2 (ja) | 2004-02-13 | 2012-08-01 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 翻訳開始阻害剤としての３−３−二置換オキシインドール |
| US7517899B2 (en) | 2004-03-30 | 2009-04-14 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
| BRPI0509745A (pt) * | 2004-04-08 | 2007-09-25 | Topotarget As | compostos de difenil ox-indol-2-ona e seu uso no tratamento de cáncer |
| CA2624220A1 (en) | 2005-09-29 | 2007-04-12 | Wyeth | 1- (1h- indol- 1-yl) -3- (methylamino) -1- phenylpropan-2-ol derivatives and related compounds as modulators of the monoamine reuptake for the treatment of vasomotor symptoms (vms) |
| PA8743601A1 (es) | 2006-08-24 | 2009-02-09 | Wyeth Corp | Proceso para preparar derivados de indonelinona fenilaminopropanol |
| EP2102158A1 (en) | 2006-12-11 | 2009-09-23 | Topo Target A/S | Prodrugs of diphenyl ox- indol- 2 -one compounds for the treatment of cancers |
| CA2684552A1 (en) | 2007-04-24 | 2008-10-30 | Topotarget A/S | Substituted 3-(4-hydroxyphenyl)-indolin-2-one compounds |
| EP2520561B1 (en) | 2007-06-08 | 2016-02-10 | MannKind Corporation | IRE-1A Inhibitors |
| WO2010109008A1 (en) | 2009-03-26 | 2010-09-30 | Topotarget A/S | Prodrugs of substituted 3-(4-hydroxyphenyl)-indolin-2-ones |
| US20160106711A1 (en) | 2012-09-20 | 2016-04-21 | President And Fellows Of Harvard College | 3-3-Di-Substituted-Oxindoles as Inhibitors of Translation Initiation |
| US9316631B1 (en) | 2012-10-19 | 2016-04-19 | Whitehead Institute For Biomedical Research | ER-stress inducing compounds and methods of use thereof |
| AU2014207272A1 (en) * | 2013-01-18 | 2015-07-30 | Neal D. Andruska | Estrogen receptor inhibitors |
| CA2904794C (en) | 2013-03-15 | 2021-11-23 | Peter Walter | Modulators of the eif2alpha pathway |
| TWI653235B (zh) | 2013-05-28 | 2019-03-11 | 阿斯特捷利康公司 | 作為抗癌劑之吲哚衍生物 |
| MX2021000043A (es) | 2018-07-03 | 2021-03-25 | Univ Illinois | Activadores de la respuesta a proteinas desplegadas. |
-
2019
- 2019-07-01 MX MX2021000043A patent/MX2021000043A/es unknown
- 2019-07-01 WO PCT/US2019/040058 patent/WO2020009958A1/en not_active Ceased
- 2019-07-01 SG SG11202012902WA patent/SG11202012902WA/en unknown
- 2019-07-01 PE PE2020002206A patent/PE20210662A1/es unknown
- 2019-07-01 MA MA053105A patent/MA53105A/fr unknown
- 2019-07-01 BR BR112020025591-2A patent/BR112020025591A2/pt not_active IP Right Cessation
- 2019-07-01 US US17/254,771 patent/US12180159B2/en active Active
- 2019-07-01 EA EA202190146A patent/EA202190146A1/ru unknown
- 2019-07-01 KR KR1020217001833A patent/KR20210027382A/ko not_active Withdrawn
- 2019-07-01 EP EP19831532.7A patent/EP3817741A4/en not_active Withdrawn
- 2019-07-01 JP JP2020573046A patent/JP2021529757A/ja active Pending
- 2019-07-01 CN CN201980045131.2A patent/CN112423743A/zh active Pending
- 2019-07-01 CA CA3103958A patent/CA3103958A1/en not_active Abandoned
- 2019-07-01 AU AU2019299221A patent/AU2019299221A1/en not_active Abandoned
- 2019-07-01 CR CR20210060A patent/CR20210060A/es unknown
- 2019-07-01 JO JOP/2020/0344A patent/JOP20200344A1/ar unknown
-
2020
- 2020-02-26 US US16/801,839 patent/US11046647B2/en active Active
- 2020-12-14 IL IL279429A patent/IL279429A/en unknown
- 2020-12-19 PH PH12020552223A patent/PH12020552223A1/en unknown
- 2020-12-29 DO DO2020000256A patent/DOP2020000256A/es unknown
- 2020-12-29 EC ECSENADI202084330A patent/ECSP20084330A/es unknown
- 2020-12-29 CL CL2020003423A patent/CL2020003423A1/es unknown
- 2020-12-30 CO CONC2020/0016690A patent/CO2020016690A2/es unknown
-
2021
- 2021-05-13 US US17/319,447 patent/US11584718B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IL279429A (en) | 2021-01-31 |
| US20210276951A1 (en) | 2021-09-09 |
| PE20210662A1 (es) | 2021-03-31 |
| MX2021000043A (es) | 2021-03-25 |
| US11046647B2 (en) | 2021-06-29 |
| US20200190029A1 (en) | 2020-06-18 |
| US12180159B2 (en) | 2024-12-31 |
| PH12020552223A1 (en) | 2021-06-28 |
| CA3103958A1 (en) | 2020-01-09 |
| KR20210027382A (ko) | 2021-03-10 |
| ECSP20084330A (es) | 2021-01-29 |
| CR20210060A (es) | 2021-04-08 |
| CN112423743A (zh) | 2021-02-26 |
| US11584718B2 (en) | 2023-02-21 |
| CL2020003423A1 (es) | 2021-05-14 |
| CO2020016690A2 (es) | 2021-01-18 |
| MA53105A (fr) | 2021-05-12 |
| US20210340100A1 (en) | 2021-11-04 |
| SG11202012902WA (en) | 2021-01-28 |
| EA202190146A1 (ru) | 2021-04-27 |
| AU2019299221A1 (en) | 2021-02-04 |
| WO2020009958A1 (en) | 2020-01-09 |
| EP3817741A4 (en) | 2022-07-06 |
| EP3817741A1 (en) | 2021-05-12 |
| BR112020025591A2 (pt) | 2021-03-23 |
| JP2021529757A (ja) | 2021-11-04 |
| DOP2020000256A (es) | 2021-03-15 |
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