JOP20210331A1 - مُعَدِّلات مُستقبِل نمدا (nmda) - Google Patents

مُعَدِّلات مُستقبِل نمدا (nmda)

Info

Publication number
JOP20210331A1
JOP20210331A1 JOP/2021/0331A JOP20210331A JOP20210331A1 JO P20210331 A1 JOP20210331 A1 JO P20210331A1 JO P20210331 A JOP20210331 A JO P20210331A JO P20210331 A1 JOP20210331 A1 JO P20210331A1
Authority
JO
Jordan
Prior art keywords
nmda receptor
receptor modulators
compounds
directed
inventions
Prior art date
Application number
JOP/2021/0331A
Other languages
English (en)
Inventor
Mauro Marigo
Erhad Ascic
Laurent David
John Paul Kilburn
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of JOP20210331A1 publication Critical patent/JOP20210331A1/ar

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B62—LAND VEHICLES FOR TRAVELLING OTHERWISE THAN ON RAILS
    • B62D—MOTOR VEHICLES; TRAILERS
    • B62D15/00—Steering not otherwise provided for
    • B62D15/02—Steering position indicators ; Steering position determination; Steering aids
    • B62D15/027—Parking aids, e.g. instruction means
    • B62D15/0285—Parking performed automatically
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60W—CONJOINT CONTROL OF VEHICLE SUB-UNITS OF DIFFERENT TYPE OR DIFFERENT FUNCTION; CONTROL SYSTEMS SPECIALLY ADAPTED FOR HYBRID VEHICLES; ROAD VEHICLE DRIVE CONTROL SYSTEMS FOR PURPOSES NOT RELATED TO THE CONTROL OF A PARTICULAR SUB-UNIT
    • B60W30/00—Purposes of road vehicle drive control systems not related to the control of a particular sub-unit, e.g. of systems using conjoint control of vehicle sub-units
    • B60W30/06—Automatic manoeuvring for parking
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60W—CONJOINT CONTROL OF VEHICLE SUB-UNITS OF DIFFERENT TYPE OR DIFFERENT FUNCTION; CONTROL SYSTEMS SPECIALLY ADAPTED FOR HYBRID VEHICLES; ROAD VEHICLE DRIVE CONTROL SYSTEMS FOR PURPOSES NOT RELATED TO THE CONTROL OF A PARTICULAR SUB-UNIT
    • B60W60/00—Drive control systems specially adapted for autonomous road vehicles
    • B60W60/001—Planning or execution of driving tasks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60W—CONJOINT CONTROL OF VEHICLE SUB-UNITS OF DIFFERENT TYPE OR DIFFERENT FUNCTION; CONTROL SYSTEMS SPECIALLY ADAPTED FOR HYBRID VEHICLES; ROAD VEHICLE DRIVE CONTROL SYSTEMS FOR PURPOSES NOT RELATED TO THE CONTROL OF A PARTICULAR SUB-UNIT
    • B60W2510/00—Input parameters relating to a particular sub-units
    • B60W2510/20—Steering systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Mechanical Engineering (AREA)
  • Transportation (AREA)
  • Automation & Control Theory (AREA)
  • Epidemiology (AREA)
  • Human Computer Interaction (AREA)
  • Combustion & Propulsion (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

يتعلق هذا الاختراع بإعداد مُعَدِّلات جديدة لمستقبل نمدا (NMDA). وُجِّهَت مظاهر منفصلة لهذا الاختراع إلى تركيبات صيدلية تتضمن المركبات المذكورة واستخدامات المركبات في علاج الاضطرابات العصبية والاضطرابات النفسية العصبية مثل الاكتئاب.
JOP/2021/0331A 2019-07-03 2021-12-14 مُعَدِّلات مُستقبِل نمدا (nmda) JOP20210331A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201900821 2019-07-03
PCT/EP2020/068522 WO2021001423A1 (en) 2019-07-03 2020-07-01 Modulators of the nmda receptor

Publications (1)

Publication Number Publication Date
JOP20210331A1 true JOP20210331A1 (ar) 2021-12-14

Family

ID=74065626

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2021/0331A JOP20210331A1 (ar) 2019-07-03 2021-12-14 مُعَدِّلات مُستقبِل نمدا (nmda)

Country Status (21)

Country Link
US (1) US11466027B2 (ar)
EP (1) EP3994141A1 (ar)
JP (1) JP2022539197A (ar)
KR (1) KR20220029568A (ar)
CN (1) CN114008054A (ar)
AR (1) AR119340A1 (ar)
AU (1) AU2020299992A1 (ar)
BR (1) BR112021003928A2 (ar)
CA (1) CA3144304A1 (ar)
CL (1) CL2021003557A1 (ar)
CO (1) CO2021017142A2 (ar)
CR (1) CR20210662A (ar)
EC (1) ECSP22003596A (ar)
IL (1) IL289575A (ar)
JO (1) JOP20210331A1 (ar)
MA (1) MA56451A (ar)
MX (1) MX2021015742A (ar)
PE (1) PE20220137A1 (ar)
PH (1) PH12021553286A1 (ar)
TW (1) TW202116779A (ar)
WO (1) WO2021001423A1 (ar)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021000297A1 (en) 2019-07-03 2021-01-07 Merck Sharp & Dohme Corp. Compounds and methods of use thereof as antibacterial agents
US11358971B2 (en) 2019-07-03 2022-06-14 H. Lundbeck A/S Prodrugs of modulators of the NMDA receptor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5026700A (en) 1989-05-16 1991-06-25 Merrell Dow Pharmaceuticals Certain quinolines and thienopyridines as excitatory amino acid antagonists
US5252581A (en) 1992-07-20 1993-10-12 Hoechst-Roussel Pharmaceuticals Inc. Substituted aminothienopyridines, pharmaceutical composition and use
US6071970A (en) 1993-02-08 2000-06-06 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
KR100366745B1 (ko) 1994-02-08 2003-04-18 엔피에스 파마슈티칼즈, 인코포레이티드 신경 질환 및 신경 질병의 치료에 유용한 수용체-작동된 칼슘채널의 신규 부위에서 활성인 화합물
JP2002511835A (ja) 1996-06-07 2002-04-16 エヌピーエス・ファーマシウティカルズ・インコーポレイテッド 神経障害および神経病の治療に有用な受容体作動性カルシウムチャネル上の新規部位で活性な化合物
WO1998056752A1 (en) 1997-06-11 1998-12-17 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
CL2003002287A1 (es) 2002-11-25 2005-01-14 Wyeth Corp COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS
GB0401332D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
GB0420719D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
US9340555B2 (en) 2009-09-03 2016-05-17 Allergan, Inc. Compounds as tyrosine kinase modulators
JP5860417B2 (ja) * 2010-03-04 2016-02-16 メルク・シャープ・エンド・ドーム・コーポレイション カテコールｏ−メチルトランスフェラーゼの阻害剤および精神障害の治療におけるその使用
US11358971B2 (en) 2019-07-03 2022-06-14 H. Lundbeck A/S Prodrugs of modulators of the NMDA receptor

Also Published As

Publication number Publication date
MA56451A (fr) 2022-05-11
CL2021003557A1 (es) 2022-08-19
CA3144304A1 (en) 2021-01-07
TW202116779A (zh) 2021-05-01
ECSP22003596A (es) 2022-02-25
PE20220137A1 (es) 2022-01-27
AR119340A1 (es) 2021-12-09
AU2020299992A1 (en) 2022-02-24
CN114008054A (zh) 2022-02-01
BR112021003928A2 (pt) 2021-05-18
PH12021553286A1 (en) 2022-08-01
CR20210662A (es) 2022-03-02
US11466027B2 (en) 2022-10-11
JP2022539197A (ja) 2022-09-07
IL289575A (en) 2022-03-01
CO2021017142A2 (es) 2022-01-17
KR20220029568A (ko) 2022-03-08
WO2021001423A1 (en) 2021-01-07
US20210002292A1 (en) 2021-01-07
MX2021015742A (es) 2022-01-27
EP3994141A1 (en) 2022-05-11

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