JOP20220352A1 - العلاج بجسم مضاد لـccr8: واسمات حيوية وعلاجات مركّبة - Google Patents

العلاج بجسم مضاد لـccr8: واسمات حيوية وعلاجات مركّبة

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Publication number
JOP20220352A1
JOP20220352A1 JOJO/P/2022/0352A JOP20220352A JOP20220352A1 JO P20220352 A1 JOP20220352 A1 JO P20220352A1 JO P20220352 A JOP20220352 A JO P20220352A JO P20220352 A1 JOP20220352 A1 JO P20220352A1
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Jordan
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antibodies
human
provides
methods
biomarkers
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JOJO/P/2022/0352A
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English (en)
Inventor
Von Ahsen Oliver
Gritzan Uwe
Weber Ernst
Jones Patrick
Buchmann Pascale
Stelte-Ludwig Beatrix
Paz Pedro
Hoff Sabine
Berndt Sandra
Tseng Su-Yi
Lyn Oh Phaik
Ellinger Philipp
Filarsky Katharina
Bertling Christian
Votsmeier Christian
GORJANACZ Matyas
Trautwein Mark
Pawlowski Nikolaus
Roider Helge
Maria Nadler Wiebke
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Bayer Ag
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Publication of JOP20220352A1 publication Critical patent/JOP20220352A1/ar

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07—ORGANIC CHEMISTRY
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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Abstract

يتعلق الاختراع الحالي بأدوات وطرق لانتاج أجسام مضادة التي تربط على وجه التحديد مستقبلات كيموكين، مثل مستقبلات الكيموكين CC أو CXC. ويتم التزويد بمتعددات الببتيد المعالجة بالكبريت المفصولة ومواد مقنرنة منها، والتي يمكن استخدامها على سبيل المثال كمستضدات أو من أجل تحريك غير مستهدف لتسهيل انتاج أجسام مضادة لمستقبلة مضادة لكيموكين بشري، ربّاحي و/أو فأري، مثلاً لانتاج أجسام مضادة ذات مناطق تحديد تتام CDRs بشرية بالكامل و/أو بخصائص مرغوبة أخرى للاستخدام العلاجي. كما يتعلق الاختراع الحالي أيضاً بأجسام مضادة ومواد مقترنة منها والتي يمكن الحصول عليها عن طريق تطبيق الأدوات والطرق المذكورة سابقاً. ويتم التزويد بأجسام مضادة ترتبط على وجه التحديد بـCCR8 بشري، ربّاحي و/أو فأري ذات خصائص مرغوبة للاستخدام العلاجي، مثلاً الأجسام المضادة متصالبة التفاعل، الأجسام المضادة البشرية بالكامل، الأجسام المضادة منخفضة الاستدخال (تتضمن غير المستدخلة)، والأجسام المضادة التي تحفز بفعالية من السمية الخلوية التي تتوسطها الخلايا المعتمدة على الجسم المضاد ADCC و/أو البلعمة التي تتوسطها الخلايا المعتمدة على الجسم المضاد ADCP في خلايا T التنظيمية Treg. ويتم التزويد أيضاً بالاستخدامات الطبية للأجسام المضادة الجديدة أو مواد مقترنة و/أو طرق علاج تشتمل على اعطاء هذه الأجسام المضادة لمريض أو كائن خاضع للمعالجة، إما لوحدها او في توليفة. ويتم التزويد أخيراً بواسمات حيوية، طرق تتعلق بالتصنيف وطرق تشخيصية تتوقع أو تقيّم قابلية الاستجابة لعلاج أحادي بالجسم المضاد لـCCR8 أو لعلاج مركّب. كما يزوّد الاختراع أيضاً بأدوات
JOJO/P/2022/0352A 2020-06-26 2022-12-27 العلاج بجسم مضاد لـccr8: واسمات حيوية وعلاجات مركّبة JOP20220352A1 (ar)

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US202062705434P 2020-06-26 2020-06-26
US202062705608P 2020-07-07 2020-07-07
EP20205426 2020-11-03
PCT/EP2021/067580 WO2021260210A2 (en) 2020-06-26 2021-06-25 Anti ccr8 antibody therapy: biomarkers & combination therapies

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US (5) US20230250178A1 (ar)
EP (5) EP4172202A2 (ar)
JP (5) JP2023531989A (ar)
KR (2) KR20230028453A (ar)
CN (6) CN116096749A (ar)
AU (2) AU2021295721A1 (ar)
BR (1) BR112022026121A2 (ar)
CA (3) CA3188142A1 (ar)
CL (1) CL2022003747A1 (ar)
IL (2) IL298910A (ar)
JO (1) JOP20220352A1 (ar)
MX (2) MX2022015968A (ar)
PE (1) PE20231200A1 (ar)
TW (1) TW202216771A (ar)
WO (5) WO2021260206A2 (ar)

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