JP2000212032A - Skin whitening agent - Google Patents

Abstract

(57) [Problem] To provide an external preparation for skin whitening which has a stable and excellent whitening effect by improving the effects inherent in whitening agents and / or anti-inflammatory agents. A skin whitening external preparation containing (A) an acerola extract and (B) a whitening agent and / or an anti-inflammatory agent. The amount of the acerola extract was 0.00005 as dry solids.
-5% by weight, and the amount of the whitening agent is 0.00001-
10% by weight, the compounding amount of the anti-inflammatory agent is 0.00001-20.
% By weight is preferred.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for the skin, and more particularly, to a cosmetic product having an excellent whitening effect on the skin, such as suppressing inflammation such as hot flashes and erythema of the skin after sunburn and preventing the occurrence of pigmentation. And skin external preparations such as external preparations.

[0002]

2. Description of the Related Art Conventionally, an external preparation for skin such as milky lotion, cream, lotion, pack, dispersion, detergent, ointment, cream, liquid for external use, etc. is intended to impart a predetermined medicinal effect to them. As a medicinal ingredient. For example, to prevent phenomena such as darkening of the skin caused by sunburn, spots caused by pigmentation, freckles, etc., such as calamine and the like, ascorbic acids, glutathione, colloidal sulfur, hydroquinone, cinnamaldehyde, placenta extract, etc. A whitening agent has been added. Further, anti-inflammatory agents such as glycyrrhizic acid, indomethacin, aloe extract and chamomile extract are added for the purpose of calming inflammation such as hot flashes and erythema of the skin after sunburn and suppressing the occurrence of pigmentation and the like. ing.

[0003]

However, in skin external preparations such as cosmetics and external preparations containing these whitening agents and / or anti-inflammatory agents, the performance of the whitening agents and / or anti-inflammatory agents is sufficiently exhibited. In many cases, the desired medicinal effect cannot be obtained due to lack of the drug or due to deterioration in the preparation, and the improvement has been desired. The present invention has been made in view of the above circumstances, and a skin external preparation containing a whitening agent and / or an anti-inflammatory agent sufficiently exhibits the performance of the whitening agent and / or the anti-inflammatory agent, and the stability thereof. An object of the present invention is to provide an improved skin external preparation.

[0004]

Means for Solving the Problems The present inventors have conducted intensive studies to improve the efficacy of the medicinal component of a skin external preparation containing a whitening agent and / or an anti-inflammatory agent, and as a result, combined with an acerola extract. As a result, the present inventors have found that the effects of the original whitening agent and / or anti-inflammatory agent are sufficiently exhibited, and completed the present invention.

That is, the present invention is characterized in that it contains one or more of the following components (A) and (B); (A) an acerola extract; and (B) a whitening agent and / or an anti-inflammatory agent. An external preparation for skin whitening.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The acerola extract, which is the component (A) of the skin whitening preparation for external use of the present invention, comprises Malpighia (Ma)
Acerola, scientific name Malpi, a fruit tree of lpighia
ghia emarginataDC; Acerola's scientific name is time, region,
Also, descriptions in papers and the like differ depending on the researcher. Conventionally, Malpighia punicifolia L. and Malpighia glabra L.
Is used as a scientific name for acerola, but Malpighia emarginata DC, described in "TROPICAL AND SUBTROPICAL FRUITS" edited by Steven Nagy et al. In 1980, is currently most appropriate. ) The fruit is extracted using an extraction solvent. The extraction treatment is not particularly limited, but the extraction is carried out at a low temperature or at room temperature or with a suitable solvent.

Examples of the above-mentioned extraction solvent include water; lower monohydric alcohols such as methyl alcohol and ethyl alcohol; one or more kinds of liquid polyhydric alcohols such as glycerin, propylene glycol and 1,3-butylene glycol. Can be used. As an example of a preferable extraction method, after performing extraction at a low temperature using purified water, filtration is performed, and 1,3-butylene glycol is further mixed to a concentration of 20 to 70% (W / W). And a method of performing filtration again.

The amount (content) of the acerola extract in the skin whitening preparation for external use of the present invention is preferably 0.00005 to 5% by weight (hereinafter referred to as "% by weight") as dry solids.
Is simply indicated by “%”), and more preferably 0.00
0.5 to 1%. If the amount (content) of this acerola extract is less than 0.00005%, a sufficient effect may not be obtained, and even if it exceeds 5%, the effect is further increased. Absent.

The component (B) of the skin whitening agent for external use of the present invention is selected from a whitening agent and / or an anti-inflammatory agent. These can be used alone or in combination of two or more. Specific examples of the medicinal agent of the component (B) include the following. As a whitening agent,
Endothelin antagonists, ascorbic acid and its derivatives and their salts, glutathione and its derivatives and their salts, cysteine such as N, N'-diacetylcystine dimethyl and its derivatives and its salts, resorcin and its derivatives and their salts, Hydroquinone and its derivatives and salts thereof, glabridine, glabrene, liquiritin, isoliquiritin and liquorice extract containing them, placenta extract, astaxanthin,
Carotenoids such as lutein and plant and animal extracts containing them, neoagarobiose, agarose oligosaccharide, asparagus extract, ibukitorano extract, pea extract, age extract, gongon extract, ononis extract, Seaweed extract, raspberry extract, jinjin extract, cinnamon extract, gokahi extract, vegetable oil containing linoleic acid such as sesame and perilla, saicin extract, hawthorn extract, sampens extract, white lily extract, peony extract Products, Sempukuka extract, Sophora cinnamon extract, Soybean extract, Tea extracts such as green tea, black tea, oolong tea, Touki extract, molasses extract, Juniper extract, Beech tree extract, Grape seed extract, Flow de Manita extract Thing, hop extract, squid extract, mocca extract, saxifrage extract Things, Coix extract and Lo Han Guo extract, and the like. One or more of these whitening agents can be appropriately selected and blended.

The above ascorbic acid and its derivatives and salts thereof include, for example, L-ascorbic acid, L-ascorbyl palmitate, L-ascorbyl dipalmitate, L-ascorbyl isopalmitate, L-ascorbyl diisopalmitate, Tetraisopalmitic acid L-
Ascorbyl, L-ascorbyl stearate, L-ascorbyl distearate, L-ascorbyl isostearate, L-ascorbyl diisostearate, L-ascorbyl myristate, L-ascorbyl dimyristate, L-ascorbyl isomyristate, diisomyristate L-ascorbyl, L-ascorbyl oleate, L-ascorbyl dioleate, L-ascorbyl 2-ethylhexanoate, sodium L-ascorbate, potassium L-ascorbate, potassium L-ascorbate Magnesium, calcium L-ascorbic acid phosphate,
L-ascorbic acid phosphate aluminum, L-
Sodium ascorbate sulfate, potassium L-ascorbate sulfate, magnesium L-ascorbate sulfate, calcium L-ascorbate sulfate, aluminum L-ascorbate sulfate, sodium L-ascorbate, potassium L-ascorbate, L-magnesium ascorbate, L
-Calcium ascorbate, L-aluminum ascorbate and the like.

Among these whitening agents, particularly preferred are ascorbic acid and its derivatives and salts thereof, astaxanthin, glabridine, glabrene,
Liquiritin, isoliquiritin and liquorice extract containing them, placental extract, neoagarobiose, agarose oligosaccharide, ibukitorano extract,
Seaweed extract, Scutellaria extract, Kokahi extract, Sempens extract, Sempukuka extract, tea extract such as green tea, black tea, oolong tea, molasses extract, syrup extract, grape seed extract, squid extract, mocca extract And yoquinin extract. Examples of the above seaweed extract include kelp, makombu, wakame, hijiki, hibamata, sea urchin, matsumo, mozuku, ishige, habanori, kombumodoki, fukuronori, iwahige, kagomenori, aname,
Brown seaweeds, such as linefish, trollocum, swordfish, swordfish, tiger algae, chigaiso, shrimp, rappamoku, hondawara, gibberish mushroom, giant kelp, etc .; Ushikenori, Asakusanori, Fusanori, Kaginori, Hibiroudo, Katanori, Mukadenori, Matsunori, Tosakamatsu, Funori, Ibaranori, Ogonori,
Red algae such as sponge, darus, igis, egonori, konohanori and himegotake, and marine algae such as Chlorella, Aonori, Donariella, Chlorococcus, Anaoasa, Kawanori, Marimo, Shiogusa, Casanoli, Fudzumo, Tamazumo, Hitoexa, etc. Extract.

Examples of the anti-inflammatory agent include zinc oxide, sulfur and derivatives thereof, glycyrrhizic acid such as glycyrrhizic acid, dipotassium glycyrrhizinate and monoammonium glycyrrhizinate and derivatives thereof and salts thereof, β-glycyrrhetinic acid, stearyl glycyrrhetic acid, and salts thereof. Glycyrrhetinic acid and its derivatives such as disodium succinyloxyglycyrrhetinate and salts thereof, tranexamic acid, chondroitin sulfate, mefenamic acid, phenylbutazone, indomethacin, ibuprofen, ketoprofen, allantoin, guaiazulene and their derivatives and salts thereof, ε-aminocaproic acid, diclofenac sodium, aloe extract, altea extract,
Arnica extract, Ashitaba extract, Cling extract, nettle extract, turmeric extract, oak extract,
Hypericum extract, chamomile extract, goldfish extract, watercress extract, comfrey extract, salvia extract, siconium extract, perilla extract, birch extract, calendula extract, elderberry extract, squirrel extract, Examples include a mud mushroom extract, astragalus extract, mugwort extract and eucalyptus extract. One or two or more of these anti-inflammatory agents can be appropriately selected and blended.

Among these anti-inflammatory agents, particularly preferred are glycyrrhizinic acid, glycyrrhetinic acid, indomethacin, allantoin, guaiazulene and their derivatives, their salts, aloe extract, cinnamon extract, hypericum extract, comfrey Extract, siconium extract, and sage extract.

The content of the above-mentioned component (B), a whitening agent and / or an anti-inflammatory agent, in the external preparation for skin of the present invention varies depending on the type of the agent, but is preferably in the following ranges. That is, the compounding amount (content) of the whitening agent is preferably 0.00001 to 10%, more preferably 0.1%.
0001-5%, and the compounding amount (content) of the anti-inflammatory agent is preferably 0.00001-20%, more preferably 0.0001-10%. When a plant extract or the like is used as it is as an extract, it is an amount in terms of dry solid content. If the content of the whitening agent and / or the anti-inflammatory agent is within the above range, by combining with the acerola extract, the temporal stability of the skin external preparation can be improved without affecting the acerola extract in the skin external preparation. It can improve the whitening effect and anti-inflammatory effect.

The external preparation for skin of the present invention is prepared by blending the essential components (A) and (B) with various types of bases known as ordinary external compositions according to a conventional method. be able to. Examples of the form of the skin external preparation are not particularly limited, for example, milky lotion, cream, lotion, pack,
It can be used as skin care cosmetics such as cleaning agents, cosmetics such as lipsticks, makeup cosmetics, and pharmaceuticals such as ointments, dispersions, creams, and liquids for external use. It can be in the form of a mold, paste, mousse, gel, powder, solution, solubilizing system, emulsifying system, powder dispersion system, or multilayer.

In addition to the components (A) and (B), the external preparation for skin of the present invention usually contains cosmetics, quasi-drugs, and external medicines as long as the effects of the present invention are not impaired. Ingredients used in the formulation, namely water (purified water, hot spring water,
Oils, surfactants, metal soaps, gelling agents, powders, alcohols, water-soluble polymers, film-forming agents,
Resins, UV protective agents, clathrate compounds, antibacterial agents, fragrances, deodorants, salts, PH regulators, cooling agents, extracts from animals and microorganisms, plant extracts, blood circulation promoters, astringents, antiseborrheic agents , Active oxygen scavenger, cell activator, humectant, keratolytic agent, enzyme,
One or two or more hormones, vitamins, and the like can be appropriately added.

The oils may be of any type, such as natural oils, synthetic oils, solids, semi-solids and liquids, as long as they are used in ordinary cosmetics. ,
Any oil agent such as hydrocarbons, waxes, fatty acids, higher alcohols, ester oils, silicone oils, and fluorine-based oils can be used. For example, squalane, squalene, ceresin, paraffin, paraffin wax, liquid paraffin, pristane, polyisobutylene,
Hydrocarbons such as microcrystalline wax and petrolatum; waxes such as beeswax, carnauba wax, candelilla wax, and whale wax; tallow, beef tallow, beef bone fat, hardened tallow, hardened oil, turtle oil, lard, horse fat Animal oils such as lanolin, liquid lanolin, reduced lanolin, lanolin alcohol, hard lanolin, lanolin acetate, lanolin fatty acid isopropyl, POE lanolin alcohol ether, POE lanolin alcohol acetate, lanolin fatty acid polyethylene glycol, POE hydrogen Lanolin derivatives such as added lanolin alcohol ether; lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, oleic acid, arachidonic acid, docosahexaenoic acid (DHA), isostearic acid, 12-hydroxy Fatty acids such as stearic acid.

As an oil agent, lauryl alcohol,
Myristyl alcohol, palmityl alcohol, stearyl alcohol, behenyl alcohol, hexadecyl alcohol, oleyl alcohol, isostearyl alcohol, hexyldecanol, octyldodecanol,
Cetostearyl alcohol, 2-decyltetradecinol, cholesterol, phytosterol, sitosterol, lanosterol, POE cholesterol ether,
Higher alcohols such as monostearyl glycerin ether (batyl alcohol); diisobutyl adipate, 2-hexyldecyl adipate, di-2-adipate
Heptylundecyl, monoisostearate-N-alkyl glycol, isosetyl isostearate, trimethylolpropane triisostearate, ethylene glycol di-2-ethylhexanoate, cetyl 2-ethylhexanoate, trimethylol tri-2-ethylhexanoate Propane, pentaerythritol tetra-2-ethylhexanoate, cetyl octanoate, octyldodecyl gum ester, oleyl oleate, octyldodecyl oleate, decyl oleate, neopentyl glycol dicaprate, triethyl citrate, 2-ethylhexyl succinate , Amyl acetate, ethyl acetate, butyl acetate, isocetyl stearate, butyl stearate, diisopropyl sebacate, di-2-ethylhexyl sebacate,
Cetyl lactate, myristyl lactate, isopropyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, 2-heptylundecyl palmitate, cholesteryl 12-hydroxystearylate, fatty acid ester of dipentaerythritol, isopropyl myristate, isopropyl myristine Octyldodecyl acid, 2-hexyldecyl myristate, myristyl myristate,
Ester oils such as hexyldecyl dimethyloctanoate, ethyl laurate, hexyl laurate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, diisostearyl malate and the like.

Further, as an oil agent, acetoglyceride,
Glyceride triisooctanoate, glyceride triisostearate, glyceride triisopalmitate,
Glyceride oils such as tri-2-ethylhexanoic acid glyceride, monostearic acid glyceride, di-2-heptylundecanoic acid glyceride, and trimyristate glyceride; dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane,
Higher alkoxy-modified silicones such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, tetramethyltetrahydrogencyclotetrasiloxane, and stearoxysilicone; higher fatty acid-modified silicone, silicone resin, silicone rubber, silicone oil And the like; and silicone oils such as perfluoropolyether, perfluorodecalin and perfluorooctane.

As the surfactant, anionic, cationic, nonionic and amphoteric surfactants are used. As anionic surfactants, sodium stearate,
Fatty acid soaps such as triethanolamine palmitate, alkyl ether carboxylic acids and salts thereof, carboxylates such as condensates of amino acids and fatty acids, alkyl sulfonic acids, alkene sulfonates, sulfonates of fatty acid esters, sulfones of fatty acid amides Acid salt, alkyl sulfonate and formalin condensate sulfonate, alkyl sulfate, secondary higher alcohol sulfate, alkyl and allyl ether sulfate, fatty acid ester sulfate, fatty acid alkylolamide Sulfate salts, such as funnel oil,
Alkyl phosphates, ether phosphates, alkyl allyl ether phosphates, amide phosphates, N-acylamino acid-based activators, and the like are included.

Examples of the cationic surfactant include alkylamine salts, amine salts such as polyamines and amino alcohol fatty acid derivatives, alkyl quaternary ammonium salts, aromatic quaternary ammonium salts, pyridium salts, imidazolium salts and the like. As nonionic surfactants, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, polyethylene glycol fatty acid ester, sucrose fatty acid ester, polyoxyethylene alkyl ether, polyoxypropylene alkyl ether,
Polyoxyethylene alkyl phenyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene propylene glycol fatty acid ester, polyoxyethylene castor oil, polyoxy Ethylene hydrogenated castor oil, polyoxyethylene phytostanol ether, polyoxyethylene phytosterol ether, polyoxyethylene cholestanol ether, polyoxyethylene cholesteryl ether, polyoxyalkylene-modified organopolysiloxane, polyoxyalkylene / alkyl co-modified organopolysiloxane, Alkanolamide, sugar ether, sugar amide and the like can be mentioned. Examples of the amphoteric surfactant include betaine, aminocarboxylate, and imidazoline derivative.

Examples of the metal soap include aluminum 12-hydroxystearate, zinc stearate, aluminum stearate, calcium stearate, magnesium stearate, zinc myristate, magnesium myristate, zinc cetyl phosphate, calcium cetyl phosphate, sodium zinc cetyl phosphate, Zinc laurate,
And zinc undecylenate.

As the gelling agent, N-lauroyl-L-
Amino acid derivatives such as glutamic acid and α, γ-di-n-butylamine; dextrin fatty acid esters such as dextrin palmitate, dextrin stearate, dextrin 2-ethylhexanoate palmitate, sucrose palmitate, and sucrose stearin Sucrose fatty acid esters such as acid esters; benzylidene derivatives of sorbitol such as monobenzylidene sorbitol and dibenzylidene sorbitol; and organically modified clay minerals such as dimethylbenzyl dodecyl ammonium montmorillonite clay and dimethyl dioctadecyl ammonium montmorillonite clay.

As the powder, if it is used in ordinary cosmetics, its shape (spherical, needle-like, plate-like, etc.), particle size (fog-like, fine particles, pigment grade, etc.), particle structure ( Porous,
Inorganic powders, organic powders, pigments and the like can be used regardless of whether they are nonporous or not. For example, as inorganic powders, magnesium oxide, barium sulfate, calcium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, talc, synthetic mica, mica, kaolin, sericite, muscovite, synthetic mica, phlogopite, mica, Biotite,
Lithium mica, silicic acid, silicic anhydride, aluminum silicate, magnesium silicate, aluminum magnesium silicate, sulfur-containing aluminum silicate, calcium silicate, barium silicate, strontium silicate, metal tungstate, hydroxyapatite, vermiculite , Hygilite, montmorillonite, zeolite, ceramic powder, dibasic calcium phosphate, alumina, aluminum hydroxide, boron nitride, boron nitride and the like.

As the organic powder, polyamide powder,
Polyester powder, polyethylene powder, polypropylene powder, polystyrene powder, polyurethane, benzoguanamine powder, polymethylbenzoguanamine powder, tetrafluoroethylene powder, polymethyl methacrylate powder, silk powder, nylon powder, 12 nylon, 6 nylon, styrene / acrylic acid Coalesce, divinylbenzene / styrene copolymer, vinyl resin, urea resin, phenolic resin, fluororesin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, microcrystalline fiber powder,
Lauroyl lysine and the like.

Examples of the colored pigments include inorganic red pigments such as iron oxide, iron hydroxide, and iron titanate; inorganic brown pigments such as γ-iron oxide; inorganic yellow pigments such as yellow iron oxide and loess; black iron oxide; Inorganic black pigments such as carbon black, inorganic purple pigments such as manganese violet and cobalt violet, inorganic green pigments such as chromium hydroxide, chromium oxide, cobalt oxide, and cobalt titanate; inorganic blue pigments such as dark blue and ultramarine blue; and tar pigments Pigments obtained by raked pigments, pigments raked by natural pigments, and composite powders obtained by compounding these powders are exemplified. Examples of the pearl pigment include titanium oxide-coated mica, titanium oxide-coated mica, bismuth oxychloride, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, fish scale foil, and titanium oxide-coated colored mica. Examples of the metal powder pigment include aluminum powder, copper powder, and stainless steel powder.

As the tar dyes, red No. 3, red 10
No. 4, Red No. 106, Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red No. 220, Red No. 226
No., Red No. 227, Red No. 228, Red No. 230, Red No. 401, Red No. 505, Yellow No. 4, Yellow No. 5, Yellow No. 2
No. 02, Yellow No. 203, Yellow No. 204, Yellow No. 401,
Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 404, Green No. 3, Green No. 201, Green No. 204, Green No. 205,
Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 20
No. 6, orange No. 207 and the like. Examples of natural dyes include carminic acid, laccaic acid, calsamine, bradylin, crocin, and the like. Powders such as the above-mentioned inorganic powders, organic powders, pigments and tar dyes may be compounded or surface-treated with an oil agent, silicone, or a fluorine compound.

Examples of the ultraviolet protective agent include 2-ethylhexyl paramethoxycinnamate, isopropyl paramethoxycinnamate, diethanolamine salt of paramethoxyhydrocinnamate, and glyceryl diparamethoxycinnamate-mono-2-ethylhexanoate. Cinnamate ultraviolet absorbers such as octyl methoxycinnamate and methyl diisopropylcinnamate; 2-hydroxy-4-methoxybenzophenone;
-Hydroxy-4-methoxybenzophenone-5-sulfate, 2-hydroxy-4-methoxybenzophenone-5
Sodium sulfate, 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxy Benzophenone ultraviolet absorbers such as benzophenone and 2-hydroxy-4-n-octoxybenzophenone;
Para-aminobenzoic acid, ethyl para-aminobenzoate, butyl para-aminobenzoate, para-dimethylaminobenzoic acid
2-ethylhexyl, glyceryl paraaminobenzoate,
Benzoic acid-based ultraviolet absorbers such as amyl paraaminobenzoate are exemplified.

Salicylic acid-2 is used as an ultraviolet ray protective agent.
-Ethylhexyl, triethanolamine salicylate,
Salicylic acid ultraviolet absorbers such as homomenthyl salicylate, dipropylene glycol salicylate, methyl salicylate, ethylene glycol salicylate, phenyl salicylate, amyl salicylate, benzyl salicylate, isopropylbenzyl salicylate, potassium salicylate;
Dibenzoylmethane-based ultraviolet absorbers such as -butyl-4'-methoxydibenzoylmethane, 4-isopropyldibenzoylmethane, 4-methoxydibenzoylmethane, and 4-t-butyl-4'-hydroxydibenzoylmethane;
Menthyl-O-aminobenzoate, 2-phenyl-benzimidazole-5-sulfate, 2-phenyl-5-methylbenzoxazole, 3- (4-methylbenzylidene)
Camphor, 2-ethylhexyl-2-cyano-3,3-
Diphenyl acrylate, 2-ethyl-2-cyano-
Anthranilic acid-based ultraviolet absorbers such as 3,3'-diphenylacrylate, 2- (2'-hydroxy-5-methylphenyl) benzotriazole and menthyl anthranilate; urocanic acid-based ultraviolet absorbers such as ethyl urocanate; titanium oxide , Zirconium oxide, cerium oxide and the like.

Examples of alcohols include lower alcohols such as ethanol and isopropanol, and various alcohols such as glycerin, diglycerin, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, and polyethylene glycol. And hydric alcohols.

As the water-soluble polymer, gum arabic, tragacanth, galactan, carob gum, guar gum,
Vegetable polymers such as karaya gum, carrageenan, pectin, agar, alge colloid, tranto gum, locust bean gum, galactomannan; microbial polymers such as xanthan gum, dextran, succinoglucan, pullulan; animals such as casein, albumin, gelatin Starch polymer such as starch, carboxymethyl starch, methylhydroxypropyl starch; methylcellulose, ethylcellulose, methylhydroxypropylcellulose, carboxymethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, nitrocellulose, sodium cellulose sulfate, sodium carboxymethylcellulose , Crystalline cellulose, cellulosic polymer of cellulose powder; sodium alginate, alginic acid Alginic acid polymers such as pyrene glycol ester; vinyl polymers such as polyvinyl methyl ether, carboxyvinyl polymer and alkyl-modified carboxyvinyl polymer; polyoxyethylene polymers; polyoxyethylene polyoxypropylene copolymer polymers; poly Acrylic polymers such as sodium acrylate, polyethyl acrylate, and polyacrylamide; and inorganic water-soluble polymers such as polyethylene imine, cationic polymers, bentonite, laponite, and hectorite. In addition, film-forming agents such as polyvinyl alcohol and polyvinyl pyrrolidone are also included in these.

Antibacterial agents include benzoic acid, sodium benzoate, carboxylic acid, sorbic acid, potassium sorbate, paraoxybenzoate, parachloromethcresol, hexachlorophene, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide, Photosensitizer,
Examples include bis (2-pyridylthio-1-oxide) zinc, phenoxyethanol and thiantol, and isopropylmethylphenol. Examples of the pH adjuster include potassium carbonate, sodium hydrogen carbonate, and ammonium hydrogen carbonate. Examples of the cooling agent include L-menthol, camphor and the like.

Examples of the cell activator include deoxyribonucleic acid and salts thereof, adenylic acid derivatives such as adenosine triphosphate and adenosine monophosphate and salts thereof, ribonucleic acid and salts thereof, cyclic AMP, cyclic GMP, and flavin adenine. Nucleotides, guanine, adenine, cytosine, thymine, xanthine and their derivatives, such as caffeine, theopherin and their salts, nucleic acid-related substances, calf blood extract, serum deproteinized extract, spleen extract, birds, etc. Egg ingredients, cockscomb extract, shell extract, shellfish extract, royal jelly, silk protein and its degradation products or their derivatives, hemoglobin or its degradation products,
Lactoferrin or its degradation product, mollusc extract such as squid, fish meat extract, etc., mammals, birds, shellfish, insects,
Examples include extracts derived from microorganisms selected from fermentation metabolites such as extracts derived from animals such as fish, molluscs, and crustaceans, yeast extracts, lactic acid bacteria extracts, and bifidobacteria extracts.

As cell activators, vitamin A such as retinol and derivatives thereof (retinol palmitate and retinol acetate), retinal and derivatives thereof, carotenoids such as dehydroretinal and carotene, and thiamines (thiamine hydrochloride, thiamine sulfate and the like) Salts), riboflavins (riboflavin, riboflavin acetate, etc.), pyridoxines (pyridoxine hydrochloride, pyridoxine dioctanoate, etc.), flavin adenine nucleotides, cyanocobalamin, folic acids, nicotinic acids (nicotinamide,
B vitamins such as benzyl nicotinate), cholines, etc.
Apricot extract, ginkgo extract, panax ginseng extract, barley extract, orange extract, cucumber extract, kiwi extract, shiitake extract, horsetail extract, assembly extract, syrup extract, capsicum extract, garlic extract Stuff, carrot extract, bougainvillea extract, peach extract, lettuce extract, lemon extract, ganoderma extract,
Plant-derived extracts such as rosemary extract, hinokitiol, cepharanthin, α- and γ-linolenic acid, eicosapentaenoic acid and their derivatives, estradiol and its derivatives and their salts, glycolic acid, succinic acid, lactic acid, salicylic acid And their derivatives and salts thereof. One or more of the above-mentioned cell activators can be appropriately selected and blended.

Examples of the active oxygen scavenger include superoxide dismutase, mannitol, bilirubin, cholesterol, tryptophan, histidine, quercetin, quercitrin, catechin, catechin derivatives, rutin, rutin derivatives, taurine, thiotaurine, eggshell membrane extract, and gallic acid. , Gallic acid derivatives, yeast extract, ganoderma extract, yasajitsu extract, gennoshoko extract, buttonpi extract, melissa extract, parsley extract and dicopi extract, retinol and its derivatives (retinol palmitate, retinol acetate, etc. ), Retinal and its derivatives, vitamin A such as dehydroretinal; thiamines (thiamine hydrochloride, thiamine sulfate, etc.), riboflavins (riboflavin, riboflavin acetate, etc.), pyridoxines (pyrihydrochloride, etc.) Vitamin B such as toxin, pyridoxine dioctanoate, flavin adenine nucleotide, cyanocobalamin, folate, nicotinic acid (nicotinamide, benzyl nicotinate), choline; ergocalciferol, cholecalciferol, dihydroxysta Vitamins such as nal; tocopherol and its derivatives (dl-α (β, γ) -tocopherol;
Dl-α-tocopherol acetate, nicotinic acid-dl-α
-Tocopherol, linoleic acid-dl-α-tocopherol, dl-α-tocopherol succinate and the like; vitamin Es such as ubiquinones; dibutylhydroxytoluene and butylhydroxyanisole.

Examples of the humectant include mucopolysaccharides such as alkaline simple hot spring water, deep water, hyaluronic acid, chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin and keratan sulfate or salts thereof, and proteins such as collagen, elastin and keratin. Or their derivatives and their salts, soybean and egg-derived phospholipids, glycolipids,
Ceramide, mucin, honey, erythritol, maltose, maltitol, xylitol, xylose, pentaerythritol, fructose, dextrin and derivatives thereof, mannitol, sorbitol, inositol, trehalose, sugars such as glucose, urea, asparagine, aspartic acid, alanine, arginine , Isoleucine, ortinine, glutamine, glycine, glutamic acid and derivatives thereof and salts thereof, cysteine, cystine, citrulline, threonine, serine, tyrosine,
Examples include tryptophan, theanine, valine, histidine, hydroxylysine, hydroxyproline, pyrrolidonecarboxylic acid and salts thereof, amino acids such as proline, phenylalanine, methionine, and lysine, and derivatives or salts thereof.

Further, as humectants, D-panthenol, avocado extract, almond oil, carob extract, rice extract, strawberry extract, fennel extract, usniania oil extract, spinach extract, olive oil, olive oil extract, Cacao butter, oat extract, kizuta extract, kumazasa extract, gardenia extract, grapefruit extract, gennoshoko extract, gentianana extract,
Burdock extract, Kobotoru extract, Sesame extract, Cactus extract, Sophora extract, Ginger extract, Geo extract, Shea butter, Spiraea extract, Senkyu extract, Zeniaoi extract, Tachiko extract, Camellia extract Stuff, corn extract, corn extract, tormentilla extract, dokudami extract, bakmondou extract, locust bean extract, hamamelis extract, mint extract, green peppermint extract, mint extract, parsley extract, rose extract , Sunflower extract, hinoki extract, loofah extract, prune extract, butchers bloom extract, borage oil, button extract, jojoba oil, bodaige extract, hop extract, pine extract, horse chestnut extract, macadamia nut oil , Quince extract,
Murasaki extract, meadow home oil, melissa extract, cornflower extract, lily extract, yuz extract, lime extract, lavender extract, gentian extract, waremokou extract, apple extract and the like. One or two or more of the above-mentioned humectants can be appropriately selected and blended.

As the vitamins, vitamin Ks such as phytonadione, menaquinone, menadione and menadiol;
Vitamin Ps such as eriocitrin and hesperidin, biotin, carcinine, ferulic acid, and the like. As blood circulation promoters, nonylate valenylamide, capsaicin, zingerone, cantharistinc, tintamol, α
-Borneol, inositol hexanicotinate, cyclandate, cinnarizine, tolazoline, acetylcholine, verapamil, γ-oryzanol and the like. Examples of skin astringents include tannic acid and the like, examples of antiseborrheic agents include thiantrol, and examples of enzymes include lipase and papain.

[0039]

EXAMPLES Next, the present invention will be described in more detail with reference to Reference Examples, Test Examples and Examples, but the present invention is not limited thereto.

Reference Example 1 Production of acerola extract Acerola (Acerola, scientific name Malpighia emarginata DC)
Purified water was added to the fruit of No. 1 and the mixture was extracted at low temperature for one day and filtered to obtain an acerola extract (dry solid content 1.7).
%).

Reference Example 2 Production of Plant Extract 70% (v / v) for each 10 g of Licorice (JP), Kujin (Clara) (JP), Touki (JP), Souhakuhi (JP), and Yokuinin (JP) Ethyl alcohol (100 ml) was added, and the mixture was extracted for 3 days with occasional stirring at room temperature, followed by filtration to obtain each plant extract (dry solid content was 2.0%, 1.0%, 1.1%, 1.%, respectively). 0%,
0.8%).

Reference Example 3 Production of chamomile extract 20 g of dried chamomile flowers were minced, 100 ml of 1,3-butylene glycol was added, extraction was performed at room temperature for 5 days with occasional stirring, and filtration was performed to obtain a chamomile extract (dry solids). 0.9%).

Reference Example 4 Production of bovine placenta extract 1 kg of bovine placenta of 3 to 4 months of pregnancy is frozen, thawed to remove impurities after washing, 5 l of purified water is added, extracted under reduced pressure and low temperature for 3 days, and filtered to extract placenta extract (3.5% dry solids).

Test Example 1 Tyrosinase activity inhibition test The acerola extract obtained in Reference Example 1 and the plant extract obtained in Reference Example 2 were examined for tyrosinase activity inhibition rate of a sample alone or in combination thereof by the following method.
That is, an enzyme solution [Sigma, 28,000;
0 units of tyrosinase (10 mg) dissolved in 20 ml of 0.1 M phosphate buffer (pH 6.8)], 0.1 ml was added, and 0.1 M phosphate buffer (pH 6.8) was further added to make 4.0 ml. This was incubated at 25 ° C. for 10 minutes.

Next, the substrate solution [L-DOPA (manufactured by Tokyo Chemical Industry Co., Ltd.), 198.0 mg, previously kept at 25 ° C.
Was dissolved in 100 ml of 0.1 M phosphate buffer (pH 6.8)], and the mixture was reacted for 10 minutes. After the reaction, the absorbance at 475 nm (OD _S ) was measured. Similarly, the absorbance (OD _HE ) and the absorbance (OD _B ) when the reaction was performed using the enzyme inactivated by heating and when no sample was added were measured, and the activity inhibition rate of tyrosinase activity was calculated by the following equation. did. Table 1 shows the results.

[0046]

(Equation 1)

[0047]

[Table 1]

As is clear from Table 1, when the acerola extract and the whitening agent are combined, the tyrosinase activity inhibitory effect is higher than when the acerola extract or the whitening agent is used alone, and a synergistic whitening effect is exhibited. Was.

Test Example 2 Melanin production inhibition test by cell culture According to the following method, for the acerola extract and bovine placenta extract obtained in Reference Example 1 and the plant extract obtained in Reference Example 2,
The melanin production inhibitory effect of the sample alone or in combination was examined. For the cultured cells, using a mouse-derived B16 melanoma cultured cell, an appropriate amount of a medium was taken in two 6-well dishes, and B16 melanoma cells were inoculated at 37 ° C.
Leave still in a carbon dioxide concentration of 5%. On the next day, a sample preparation solution is added and mixed so that the final concentration of each sample becomes 0 (control), 1, 10, and 100 μg / ml. On the fifth day of the culture, the medium is replaced, and the sample preparation solution is added again. On the next day, the medium was removed, and the cells were washed with a phosphate buffer from one petri dish and collected, and the whitening degree of the cultured B16 melanoma cells was evaluated according to the following criteria.

(Criterion) ++: extremely white with respect to the control. +: Clearly white with respect to the control. ±: slightly white with respect to the control. -: Same black as the control.

For the remaining one petri dish, the cells were fixed in formalin and then added to a 1% crystal violet solution for staining. The number of viable cells (A) and the number of control cells (B) for each sample concentration were measured with a monocerator (Olympus), and the cell viability was calculated by the following equation. Table 2 shows the results. Cell viability (%) = (A / B) × 100

[0052]

[Table 2]

As is evident from Table 2, when the acerola extract and the whitening agent are combined, the effect of inhibiting the production of melanin is higher than when the acerola extract or the whitening agent is used alone. And low toxicity to cultured B16 melanoma cells.

Test Example 3 Erythema Inhibition Test The back of colored guinea pigs (15 per group) was shaved and irradiated with ultraviolet light under anesthesia. UV irradiation is performed by FL2 manufactured by Toshiba Corporation.
Irradiate three 0S • BLB lamps and three FL20S • E30 lamps at the same time, and the amount of ultraviolet rays is 4.8 × 10 ⁶ erg /
cm ² . Twenty-four hours before ultraviolet irradiation, immediately after irradiation, and 12 hours after and 24 hours after irradiation, 0.2 ml each of the composition shown in Table 3 and a sample prepared by the following method were applied to four places on the back of the guinea pig. However, before irradiation, the application site was thoroughly washed with warm water. 24 hours after irradiation,
After 7 days, the degree of pigmentation was observed and evaluated according to the following criteria. The results are also shown in Table 3.

[0055]

[Table 3]

(Production method) Components (1)-(6), (10) and (11) are mixed and heated to 70 ° C. B. Mix components (7)-(9) and (12) and heat to 70
Keep at ° C. C. B was added to A, mixed, and cooled to obtain a cream.

(Evaluation Criteria for Erythema Inhibition Effect) <Evaluation> <Contents> Excellent Erythema is not observed at all. Effective Very little erythema is observed. Slightly effective Erythema is observed, but the boundary with the non-irradiated part is unclear. Ineffective Erythema was observed, and the boundary with the non-irradiated part was clear.

(Evaluation Criteria for Pigmentation Inhibition Effect) <Evaluation> <Contents> Excellent No pigmentation was observed at all. Effective Very slight pigmentation is observed. Slightly effective pigmentation is observed, but the boundary with the non-irradiated part is unclear. Ineffective Pigmentation was observed, and the boundary with the non-irradiated part was clear.

As shown in the results of Table 3, the composition of the product 1 of the present invention in which the acerola extract and the stearyl glycyrrhetinate were combined and the composition of the product 2 of the present invention in which the acerola extract and the chamomile extract were combined. It was clarified that by applying these to the skin, erythema and pigmentation caused by ultraviolet rays were effectively suppressed.

Embodiment 1 Preparation Example of Cream A cream was prepared according to the composition shown in Table 4 and the following production method, and the skin effect of combining an acerola extract with a whitening agent and / or an anti-inflammatory agent was examined. Table 4 shows the results.

[0061]

[Table 4]

(Production method) A. Mix components (1) to (6) and (10) and heat to 70 ° C
To keep. B. Mix components (8)-(9) and (12) and heat to 70
Keep at ° C. C. B was added to A, (7) and (11) were mixed, and then cooled to obtain a cream.

(Test Method) 27 per test cream
A panel consisting of 15 women aged 54 to 54
After washing the face for 12 weeks, an appropriate amount of the test cream was applied to the face. The whitening effect of the coating was evaluated according to the following criteria.

(Evaluation Criteria) <Evaluation> <Contents> Effective Skin dullness became inconspicuous. Slightly effective Skin dullness became less noticeable. Ineffective No change from before use.

As shown in the results of Table 4, the composition of the product 1 of the present invention in which an acerola extract and magnesium L-ascorbyl phosphate were combined and the product 2 of the present invention in which an acerola extract and dipotassium glycyrrhizinate were combined were used. Composition,
The composition of the product 3 of the present invention in which the acerola extract is combined with magnesium L-ascorbyl phosphate and dipotassium glycyrrhizinate prevents and improves the occurrence of "dullness" in the skin by applying them to the skin. It became clear that it became a beautiful skin.

Embodiment 2 Preparation Example of Lotion (Prescription) (%) (1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Polyoxyethylene (20EO) Sorbitan 1.2 Monolaurate ( 4) Ethyl alcohol 8.0 (5) Acerola extract * 1 1.0 (6) Astaxanthin * 2 0.001 (7) Preservative appropriate amount (8) Perfume appropriate amount (9) Purified water remaining amount * 1 Reference example 1 * 2 manufactured by Sigma

(Production Method) Components (3), (4), (6), (7) and (8) are mixed and dissolved. B. Components (1), (2), (5) and (9) are mixed and dissolved. C. A and B were mixed and made uniform to obtain a lotion.

Embodiment 3 Preparation Example of Lotion (Prescription) (%) (1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Polyoxyethylene (20EO) Sorbitan 1.2 Monolaurate ( 4) Ethyl alcohol 8.0 (5) Acerola extract * 1 1.0 (6) Oolong tea extract * 2 1.0 (7) Gokahi extract * 3 1.0 (8) Preservative appropriate amount (9) Fragrance Appropriate amount (10) Remaining purified water * 1 Manufactured in Reference Example 1 * 2 Maruzen Pharmaceutical * 3 Maruzen Pharmaceutical

(Production method) Components (3), (4), (8) and (9) are mixed and dissolved. B. Components (1), (2), (5) to (7) and (10) are mixed and dissolved. C. A and B were mixed and made uniform to obtain a lotion.

Embodiment 4 FIG. Preparation Example of Lotion (Prescription) (%) (1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Polyoxyethylene (20EO) Sorbitan 1.2 Monolaurate ( 4) Ethyl alcohol 8.0 (5) Acerola extract * 1 1.0 (6) Aloe extract * 2 1.0 (7) Scutellaria extract * 3 1.0 (8) Preservative appropriate amount (9) Fragrance Appropriate amount (10) Remaining purified water * 1 Manufactured in Reference Example 1 * 2 Maruzen Pharmaceutical * 3 Maruzen Pharmaceutical

(Production Method) Components (3), (4), (8) and (9) are mixed and dissolved. B. Components (1), (2), (5) to (7) and (10) are mixed and dissolved. C. A and B were mixed and made uniform to obtain a lotion.

Embodiment 5 FIG. Preparation Example of Emulsion (Formulation) (%) (1) Polyoxyethylene (10EO) Sorbitan 1.0 Monostearate (2) Polyoxyethylene (60EO) Sorbit 0.5 Tetraoleate (3) ) Glyceryl monostearate 1.0 (4) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Squalane 8.0 (7) Acerola extract * 1 5.0 (8) Ibukitorano extract * 2 0.1 (9) Preservative 0.1 (10) Carboxyvinyl polymer 0.1 (11) Sodium hydroxide 0.05 (12) Ethyl alcohol 5.0 (13) Remaining purified water (14) Perfume appropriate amount * 1 manufactured in Reference Example 1 * 2 manufactured by Koei Kogyo Co., Ltd.

(Production Method) The components (9) to (13) are mixed by heating and kept at 70 ° C. B. Components (1) to (6) are mixed by heating and kept at 70 ° C. C. Add A to B, mix and emulsify uniformly. D. After cooling C, (7), (8) and (14) were added and mixed uniformly to obtain an emulsion.

Embodiment 6 FIG. Preparation Example of Emulsion (Formulation) (%) (1) Polyoxyethylene (10EO) Sorbitan 1.0 Monostearate (2) Polyoxyethylene (60EO) Sorbit 0.5 Tetraoleate (3) ) Glyceryl monostearate 1.0 (4) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Squalane 8.0 (7) Acerola extract * 1 5.0 (8) Mukuroji extract * 2 1 0.0 (9) Preservative 0.1 (10) Carboxyvinyl polymer 0.1 (11) Sodium hydroxide 0.05 (12) Ethyl alcohol 5.0 (13) Remaining purified water (14) Perfume appropriate amount * 1 Manufactured in Reference Example 1 * 2 Maruzen Pharmaceutical Co., Ltd.

(Production Method) The components (9) to (13) are mixed by heating and kept at 70 ° C. B. Components (1) to (6) are mixed by heating and kept at 70 ° C. C. Add A to B, mix and emulsify uniformly. D. After cooling C, the components (7), (8) and (14) were added and mixed uniformly to obtain an emulsion.

Embodiment 7 Preparation Example of Emulsion (Formulation) (%) (1) Polyoxyethylene (10EO) Sorbitan 1.0 Monostearate (2) Polyoxyethylene (60EO) Sorbit 0.5 Tetraoleate (3) ) Glyceryl monostearate 1.0 (4) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Squalane 8.0 (7) Acerola extract * 1 5.0 (8) Sicon extract * 21 0.0 (9) Hypericum extract * 3 1.0 (10) Preservative 0.1 (11) Carboxyvinyl polymer 0.1 (12) Sodium hydroxide 0.05 (13) Ethyl alcohol 5.0 (14) Remaining purified water (15) Suitable amount of perfume * 1 Manufactured in Reference Example 1 * 2 Maruzen Pharmaceutical * 3 Maruzen Pharmaceutical

(Production method) Components (10) to (13) are mixed by heating and kept at 70 ° C. B. Components (1) to (6) are mixed by heating and kept at 70 ° C. C. Add A to B, mix and emulsify uniformly. D. After cooling C, the components (7) to (9) and (14) were added and mixed uniformly to obtain an emulsion.

The lotions of Examples 2, 3 and 4 and the emulsions of Examples 5, 6 and 7 are all excellent in stability over time. It was intended to prevent "dullness", spots and freckles on the skin and to make the skin transparent and beautiful.

Example 8 Preparation Example of Ointment (Formulation) (%) (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Triethanolamine 2.0 (4) Glycerin 5.0 (5) Acerola extract * 1 1.0 (6) Guaiazulene * 2 0.1 (7) Purified water balance * 1 Produced in Reference Example 1 * 2 Sigma

(Production Method) Heat and mix a part of components (3), (4) and (7),
Keep at ° C. B. Heat mix components (1) and (2) and maintain at 75 ° C. C. Add A slowly to B. D. C was cooled and dissolved in the rest of (7) while cooling (5), (6)
Was added to obtain an ointment. The ointment of Example 8 is excellent in stability over time, and is applied to the skin to prevent "stain" and spots and freckles on the skin,
It was intended to make the skin transparent and beautiful.

Example 9. Preparation Example of Pack (Formulation) (%) (1) Polyvinyl alcohol 20.0 (2) Ethyl alcohol 20.0 (3) Glycerin 5.0 (4) Kaolin 6.0 (5) Acerola extract * 1 0.05 (6) Maiden squid extract * 2 0.2 (7) Preservative 0.2 (8) Fragrance 0.1 (9) Remaining purified water * 1 Produced in Reference Example 1 * 2 Maruzen Pharmaceutical

(Production Method) A. Mix components (1), (3), (4) and (9), heat to 70 ° C. and stir. B. Mix components (2), (7) and (8). C. Add the above B to the above A, mix and cool
(5) and (6) were uniformly dispersed to obtain a pack. The pack of Example 9 was excellent in stability over time, and was applied to the skin to prevent the skin from becoming dull and blemishes, and to make the skin transparent and beautiful.

Embodiment 10 FIG. Preparation Example of Cleaning Agent (Formulation) (%) (1) Stearic acid 10.0 (2) Palmitic acid 8.0 (3) Myristic acid 12.0 (4) Lauric acid 4.0 (5) Oleyl alcohol 5 (6) Purified lanolin 1.0 (7) Fragrance 0.1 (8) Preservative 0.2 (9) Glycerin 18.0 (10) Potassium hydroxide 6.0 (11) Acerola extract * 10 5 (12) Indomethacin * 2 0.01 (13) Molasses extract * 3 0.5 (14) Remaining purified water * 1 Produced in Reference Example 1 * 2 Sigma * 3 Taiyo Chemical

(Production Method) A. Mix components (9), (10), (12) and (14) and mix
Heat to 0 ° C. B. Mix components (1)-(6) and (8) and heat to 70 ° C. C. The above B was added to the above A, kept at 70 ° C. for a while, cooled to 50 ° C. after the reaction was completed, and the components (7), (11) and
(13) was added and cooled to obtain a washing agent. The cleansing agent of Example 10 was excellent in stability over time, and when applied to the skin, gave a clear and beautiful skin without dullness.

Embodiment 11 FIG. Preparation Example of Gel Ointment (Prescription) (%) (1) Carboxyvinyl polymer 1.0 (2) Triethanolamine 1.0 (3) 1,3-butylene glycol 10.0 (4) Acerola extract * 1 01 (5) Allantoin * 2 0.02 (6) Remaining purified water * 1 Produced in Reference Example 1 * 2 Merck

(Production Method) Components (1) and (3) to (6) are mixed and dissolved. B. Component (2) was added to A and mixed to obtain a uniform gel ointment. The gel ointment of Example 11 was excellent in stability over time and, when applied to the skin, suppressed erythema due to sunburn and effectively prevented pigmentation.

Embodiment 12 FIG. Preparation Example of Cream (Formulation) (%) (1) Polyoxyethylene (40EO) monostearate 2.0 (2) Glycerin monostearate (self-emulsifying type) 5.0 (3) Stearic acid 5. 0 (4) Behenyl alcohol 0.5 (5) Squalane 15.0 (6) Cetyl isooctanoate 5.0 (7) Preservative appropriate amount (8) 1,3-butylene glycol 5.0 (9) Acerola extract * 1 0.2 (10) Mocca extract * 2 0.5 (11) Remaining purified water (12) Appropriate amount of fragrance * 1 Produced in Reference Example 1 * 2 Manufactured by Maruzen Pharmaceutical Co.

(Production Method) The components (1) to (7) are heated and dissolved at 70 ° C. B. Heat components (8) and (11) to 70 ° C. C. Add A to B, mix (9), (10) and (12) and cool to obtain a cream. The cream of Example 12 was excellent in stability over time, and when applied to the skin, gave a dull, transparent and beautiful skin.

Embodiment 13 FIG. Preparation example of liquid foundation (Formulation) (%) (1) Lanolin 7.0 (2) Liquid paraffin 5.0 (3) Stearic acid 2.0 (4) Cetanol 1.0 (5) Paramethoxycinnamic acid 2-ethylhexyl 3.0 (6) 4-t-butyl-4'-methoxydibenzoylmethane 1.0 (7) glycerin 5.0 (8) triethanolamine 1.0 (9) carboxymethylcellulose 0.7 ( 10) Remaining purified water (11) Mica 15.0 (12) Talc 6.0 (13) Color pigment 6.0 (14) Acerola extract * 1 0.01 (15) Yoquinin extract * 2 0.5 (16) Appropriate amount of fragrance * 1 Produced in Reference Example 1 * 2 Maruzen Pharmaceutical Co., Ltd.

(Production Method) Components (1) to (6) are mixed and dissolved. B. Add components (11) to (13) to A, mix uniformly, and add
Keep at 0 ° C. C. Components (7) to (10) are uniformly dissolved and kept at 70 ° C. D. Add C to B and emulsify uniformly. E. FIG. After cooling D, components (14) to (16) were added to obtain a liquid foundation. The liquid foundation obtained in Example 13 was excellent in stability over time and applied to the skin to prevent blackening of the skin due to sunburn, spots and freckles.

[0091]

According to the present invention, a skin whitening agent and / or an anti-inflammatory agent can be combined with an acerola extract and incorporated into an external preparation for skin to sufficiently enhance the inherent performance of the whitening agent and / or the anti-inflammatory agent. Since it can be exerted, the external preparation for skin has a stable and excellent whitening effect and anti-inflammatory effect, and therefore exhibits a high inhibitory effect on hot flashes due to sunburn, erythema due to ultraviolet irradiation, or pigmentation. It is effective in preventing and improving blackening of skin due to sunburn, spots and freckles. As described above, the skin external preparation of the present invention can sufficiently exhibit the inherent properties of a whitening agent and / or an anti-inflammatory agent, and is therefore extremely useful in cosmetics and medical treatment.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 JKU 7/48 7/48 A61P 17/16 31/00 617J A61K 35 / 78 35/78 C (72) Inventor Yuki Hata 48-18 Sakaemachi, Kita-ku, Tokyo Inside the Kose Research Laboratory (72) Inventor Shizuka Uehara 48-18 Sakaemachi, Kita-ku, Tokyo Kose Research, Inc. Within the headquarters (72) Inventor Ichiro Sasaki 48-18 Sakaemachi, Kita-ku, Tokyo Inside the Kosei Research Headquarters (72) Inventor Kenichi Nagamine 2-5-1-203, Misumi-cho, Higashimurayama-shi, Tokyo (72) Invention Person Takashi Kito 1-21-25-103 Namiki, Kawaguchi City, Saitama Prefecture F-term (reference) 4C083 AA082 AA111 AA112 AB032 AB432 AB442 AC022 AC032 AC072 AC082 AC102 AC122 AC242 AC342 AC402 AC422 AC442 AC472 AC542 AC682 AC852 AD092 AD272 AD512 AD532 AD622 AD642 CC04 CC05 CC07 CC12 EE16 FF01 4C088 AB12 AB16 AB26 AB34 AB40 AB43 AB45 AB51 AB59 AB75 AB86 AC01 BA08 CA06 MA07 MA28 ZA89

Claims (5)

[Claims] 1. An external preparation for skin whitening, comprising: (A) an acerola extract; and (B) a whitening agent and / or an anti-inflammatory agent. 2. A whitening agent comprising an endothelin antagonist, ascorbic acid and its derivatives and their salts, glutathione and its derivatives and their salts, cysteine and its derivatives and their salts, resorcin and its derivatives and their salts, Hydroquinone and its derivatives and their salts, glabridine, glabrene, liquiritin, isoliquiritin and liquorice extract, placenta extract, carotenoids and carotenoids and animal and plant extracts containing these, neoagarobiose, agarose oligosaccharide, asparagus Contains gas extract, Ibukitrano extract, pea extract, Age extract, Japanese gourd extract, Ononis extract, seaweed extract, raspberry extract, kujin extract, kelp extract, gokahi extract, linoleic acid You Vegetable oil, saicin extract, hawthorn extract, sampens extract, white lily extract, peony extract, Sempukuka extract, soybean extract, soybean extract, tea extract, syllium extract, molasses extract, juniper extract, The extract according to claim 1, which is selected from beech extract, grape seed extract, flow de manita extract, hop extract, silkworm extract, mocca extract, saxifrage extract, yokuinin extract and arhat extract. An external preparation for skin whitening. 3. The anti-inflammatory agent includes zinc oxide, sulfur and derivatives thereof, glycyrrhizic acid, glycyrrhetinic acid, tranexamic acid, chondroitin sulfate, mefenamic acid, phenylbutazone, indomethacin, ibuprofen, ketoprofen, allantoin, guaiazulene and derivatives thereof. And salts thereof, ε-aminocaproic acid, diclofenac sodium, aloe extract, Altea extract, Ashitaba extract, Arnica extract, Intinko extract,
Nettle extract, turmeric extract, oak extract, hypericum extract, chamomile extract, goldfish extract,
Watercress extract, Comfrey extract, Salvia extract,
The extract is selected from a radish extract, a perilla extract, a birch extract, a calendula extract, an elder extract, a sea squirt extract, a sapling extract, a vetch plant extract, a mugwort extract and a eucalyptus extract. The skin whitening agent for whitening according to the above. 4. The method according to claim 1, wherein the amount of the acerola extract is 0.00005 to 5% by weight as dry solids, and the amount of the whitening agent is 0.00001 to 10% by weight. The skin whitening agent for whitening according to the above. 5. The composition according to claim 1, wherein the amount of the acerola extract is 0.00005 to 5% by weight as dry solids, and the amount of the anti-inflammatory agent is 0.00001 to 20% by weight. 2. The skin whitening agent for whitening according to item 1.