JP2000502061A5 - - Google Patents
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- Publication number
- JP2000502061A5 JP2000502061A5 JP1997520757A JP52075797A JP2000502061A5 JP 2000502061 A5 JP2000502061 A5 JP 2000502061A5 JP 1997520757 A JP1997520757 A JP 1997520757A JP 52075797 A JP52075797 A JP 52075797A JP 2000502061 A5 JP2000502061 A5 JP 2000502061A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56575695A | 1995-11-30 | 1995-11-30 | |
| US08/565,756 | 1995-11-30 | ||
| PCT/US1996/019721 WO1997019675A2 (en) | 1995-11-30 | 1996-11-27 | Complex cationic lipids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008078918A Division JP4965489B2 (ja) | 1995-11-30 | 2008-03-25 | カチオン脂質複合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2000502061A JP2000502061A (ja) | 2000-02-22 |
| JP2000502061A5 true JP2000502061A5 (2) | 2004-10-28 |
| JP4430135B2 JP4430135B2 (ja) | 2010-03-10 |
Family
ID=24259963
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52075797A Expired - Fee Related JP4430135B2 (ja) | 1995-11-30 | 1996-11-27 | カチオン脂質複合体 |
| JP2008078918A Expired - Fee Related JP4965489B2 (ja) | 1995-11-30 | 2008-03-25 | カチオン脂質複合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008078918A Expired - Fee Related JP4965489B2 (ja) | 1995-11-30 | 2008-03-25 | カチオン脂質複合体 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US6670332B1 (2) |
| EP (1) | EP0863749A2 (2) |
| JP (2) | JP4430135B2 (2) |
| CA (1) | CA2237316C (2) |
| WO (1) | WO1997019675A2 (2) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6214804B1 (en) | 1989-03-21 | 2001-04-10 | Vical Incorporated | Induction of a protective immune response in a mammal by injecting a DNA sequence |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US6673776B1 (en) | 1989-03-21 | 2004-01-06 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human |
| US6867195B1 (en) | 1989-03-21 | 2005-03-15 | Vical Incorporated | Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected |
| ATE162219T1 (de) | 1989-11-16 | 1998-01-15 | Univ Duke | Transformation von tierischen hautzellen mit hilfe von partikeln |
| US6228844B1 (en) | 1991-11-12 | 2001-05-08 | Vical Incorporated | Stimulating vascular growth by administration of DNA sequences encoding VEGF |
| US6706694B1 (en) | 1990-03-21 | 2004-03-16 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate |
| US7105574B1 (en) | 1999-03-26 | 2006-09-12 | Vical Incorporated | Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines |
| US5641665A (en) * | 1994-11-28 | 1997-06-24 | Vical Incorporated | Plasmids suitable for IL-2 expression |
| WO1997019675A2 (en) * | 1995-11-30 | 1997-06-05 | Vical Incorporated | Complex cationic lipids |
| DE69815707T2 (de) * | 1997-11-20 | 2004-07-01 | Vical, Inc., San Diego | Behandlung von krebs durch verwendung von zytokin-exprimierender polynukleotiden und zusammensetzungen dafür |
| US6043390A (en) | 1998-04-03 | 2000-03-28 | The Regents Of The University Of California | Pentaerythritol lipid derivatives and nucleic-acid complexes |
| EP1070047A2 (en) * | 1998-04-08 | 2001-01-24 | Celltech Chiroscience Limited | Lipids |
| US7078224B1 (en) * | 1999-05-14 | 2006-07-18 | Promega Corporation | Cell concentration and lysate clearance using paramagnetic particles |
| EP1459766B1 (en) * | 1999-03-26 | 2008-06-11 | Vical Incorporated | Adjuvant compositions for enhancing immune responses to polynucleotide-based vaccines |
| DE60039198D1 (de) | 1999-03-26 | 2008-07-24 | Vical Inc | Adjuvanszusammensetzungen zur Erhöhung der Immunantwort bezüglich Polynukleotid-basierenden Impfstoffen |
| DE60016205T2 (de) * | 1999-05-28 | 2005-12-01 | Vical, Inc., San Diego | Cytofectin-dimere und verfahren zu ihrer anwendung |
| US6696424B1 (en) | 1999-05-28 | 2004-02-24 | Vical Incorporated | Cytofectin dimers and methods of use thereof |
| WO2001080897A2 (en) * | 2000-04-21 | 2001-11-01 | Vical Incorporated | Compositions and methods for in vivo delivery of polynucleotide-based therapeutics |
| US7935812B2 (en) * | 2002-02-20 | 2011-05-03 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA) |
| EP1575505A4 (en) * | 2002-09-10 | 2007-01-24 | Vical Inc | CODON OPTIMIZATION-BASED POLYNUCLEOTIDE VACCINES AGAINST BACILLUS ANTHRACIS INFECTION |
| JP4917263B2 (ja) * | 2002-12-23 | 2012-04-18 | バイカル インコーポレイテッド | 核酸/ブロックコポリマー/陽イオン性界面活性剤複合体を凍結乾燥する方法 |
| CA2508281C (en) * | 2002-12-23 | 2011-08-09 | Vical Incorporated | Method for producing sterile polynucleotide based medicaments |
| US8080642B2 (en) * | 2003-05-16 | 2011-12-20 | Vical Incorporated | Severe acute respiratory syndrome DNA compositions and methods of use |
| US20060024670A1 (en) * | 2004-05-18 | 2006-02-02 | Luke Catherine J | Influenza virus vaccine composition and methods of use |
| US7799565B2 (en) | 2004-06-07 | 2010-09-21 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering RNA |
| US20060134221A1 (en) * | 2004-12-03 | 2006-06-22 | Vical Incorporated | Methods for producing block copolymer/amphiphilic particles |
| US7404969B2 (en) * | 2005-02-14 | 2008-07-29 | Sirna Therapeutics, Inc. | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules |
| JP5042863B2 (ja) * | 2005-02-14 | 2012-10-03 | サーナ・セラピューティクス・インコーポレイテッド | 生物学的に活性な分子をデリバリーするための脂質ナノ粒子系組成物および方法 |
| US8030034B2 (en) | 2005-12-09 | 2011-10-04 | Promega Corporation | Nucleic acid purification with a binding matrix |
| US20070249821A1 (en) * | 2006-03-08 | 2007-10-25 | Promega Corporation | Small RNA purification |
| WO2008074487A2 (en) * | 2006-12-19 | 2008-06-26 | Novosom Ag | Lipids and lipid assemblies comprising transfection enhancer elements |
| US20100015218A1 (en) * | 2007-02-16 | 2010-01-21 | Vasant Jadhav | Compositions and methods for potentiated activity of biologically active molecules |
| CA2688346A1 (en) * | 2007-05-23 | 2008-12-04 | Vical Incorporated | Compositions and methods for enhancing immune responses to vaccines |
| WO2009129395A1 (en) * | 2008-04-16 | 2009-10-22 | Abbott Laboratories | Cationic lipids and uses thereof |
| US9018187B2 (en) | 2009-07-01 | 2015-04-28 | Protiva Biotherapeutics, Inc. | Cationic lipids and methods for the delivery of therapeutic agents |
| US8569256B2 (en) | 2009-07-01 | 2013-10-29 | Protiva Biotherapeutics, Inc. | Cationic lipids and methods for the delivery of therapeutic agents |
| US8039613B2 (en) | 2009-08-28 | 2011-10-18 | Promega Corporation | Methods of purifying a nucleic acid and formulation and kit for use in performing such methods |
| US8222397B2 (en) | 2009-08-28 | 2012-07-17 | Promega Corporation | Methods of optimal purification of nucleic acids and kit for use in performing such methods |
| JP5902616B2 (ja) | 2010-04-28 | 2016-04-13 | 協和発酵キリン株式会社 | カチオン性脂質 |
| US20130129811A1 (en) | 2010-04-28 | 2013-05-23 | Takeshi Kuboyama | Cationic lipid |
| WO2012024233A2 (en) * | 2010-08-14 | 2012-02-23 | The Regents Of The University Of California | Zwitterionic lipids |
| JP2013095755A (ja) | 2011-11-02 | 2013-05-20 | Kyowa Hakko Kirin Co Ltd | カチオン性脂質 |
| TWI594767B (zh) | 2011-12-12 | 2017-08-11 | 協和醱酵麒麟有限公司 | 含有陽離子性脂質之藥物傳遞系統用脂質奈米粒子 |
| CA2858694A1 (en) | 2011-12-12 | 2013-06-20 | Kyowa Hakko Kirin Co., Ltd. | Lipid nano particles comprising combination of cationic lipids |
| TW201726600A (zh) | 2012-07-06 | 2017-08-01 | 協和醱酵麒麟有限公司 | 陽離子性脂質 |
| SG11201502954TA (en) | 2012-07-16 | 2015-05-28 | Kyowa Hakko Kirin Co Ltd | Rnai pharmaceutical composition for suppressing expression of kras gene |
| US10525138B2 (en) | 2015-12-25 | 2020-01-07 | Kyowa Hakko Kirin Co., Ltd. | Compound as cationic lipid |
| CN111954542A (zh) * | 2018-02-01 | 2020-11-17 | 塔夫茨大学信托人 | 脂质样纳米复合物及其用途 |
| CA3211623A1 (en) | 2021-05-24 | 2022-12-01 | Bo YING | Lipid compounds and lipid nanoparticle compositions |
| AU2024320276A1 (en) | 2023-08-10 | 2026-03-26 | Haichang Biotech Co., Ltd. | Toll-like receptor agonists and use thereof |
| WO2025036297A1 (zh) | 2023-08-11 | 2025-02-20 | 浙江海昶生物医药技术有限公司 | 一种具有靶向性的脂质组合物及其制备方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2368208A (en) | 1940-12-16 | 1945-01-30 | Emulsol Corp | Chemical compounds and method of preparing same |
| US3265719A (en) | 1959-12-28 | 1966-08-09 | American Cyanamid Co | Betaines |
| US5049386A (en) | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| CA1288774C (en) * | 1985-01-07 | 1991-09-10 | Deborah A. Eppstein | 1,2-dialkoxy-w-trialkylammonium cationic surfactants |
| DE3618517A1 (de) | 1985-06-04 | 1986-12-04 | Lion Corp., Tokio/Tokyo | Emulgiermittel zur emulsionspolymerisation |
| US4864060A (en) | 1987-08-31 | 1989-09-05 | Witco Corporation | Surface active compounds, methods for making same and uses thereof |
| US5068431A (en) | 1987-08-31 | 1991-11-26 | Witco Corporation | Methods of making new surface active compounds |
| JP2801727B2 (ja) * | 1990-03-06 | 1998-09-21 | 花王株式会社 | 低刺激性界面活性剤 |
| US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
| US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| DE4013632A1 (de) | 1990-04-27 | 1991-10-31 | Max Planck Gesellschaft | Liposomen mit positiver ueberschussladung |
| WO1991017424A1 (en) * | 1990-05-03 | 1991-11-14 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
| JPH0525106A (ja) | 1991-07-22 | 1993-02-02 | Kao Corp | カルボキシベタイン誘導体及びこれを含有する化粧料 |
| WO1993012240A1 (en) | 1991-12-17 | 1993-06-24 | The Regents Of The University Of California | Gene therapy for cystic fibrosis transmembrane conductance regulator activity (cftr) |
| US5334761A (en) | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
| WO1995002698A1 (en) * | 1993-07-12 | 1995-01-26 | Life Technologies, Inc. | Composition and methods for transfecting eukaryotic cells |
| NZ277614A (en) | 1993-11-24 | 1998-05-27 | Megabios Corp | Piperazine-containing amphiphiles and their use in liposomes for delivering genetic material intracellularly |
| EP0730405A4 (en) | 1993-11-24 | 1997-02-19 | Megabios Corp | AMPHIPHILE GUANIDINE DERIVATIVES |
| US5928944A (en) | 1994-02-04 | 1999-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Method of adenoviral-medicated cell transfection |
| US6075012A (en) * | 1994-02-11 | 2000-06-13 | Life Technologies, Inc. | Reagents for intracellular delivery of macromolecules |
| US5908635A (en) * | 1994-08-05 | 1999-06-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method for the liposomal delivery of nucleic acids |
| US5780009A (en) | 1995-01-20 | 1998-07-14 | Nexia Biotechnologies, Inc. | Direct gene transfer into the ruminant mammary gland |
| CA2222586A1 (en) * | 1995-06-07 | 1996-12-19 | Gen-Probe Incorporated | Thiocationic lipids, pharmaceutical compositions and methods of use thereof |
| US5739271A (en) | 1995-06-07 | 1998-04-14 | Gen-Probe Incorporated | Thiocationic lipids |
| US5736392A (en) | 1995-06-07 | 1998-04-07 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
| US5711964A (en) * | 1995-06-07 | 1998-01-27 | United States Of America | Method for the intracellular delivery of biomolecules using liposomes containing cationic lipids and vitamin D |
| US5869715A (en) * | 1995-09-27 | 1999-02-09 | The Reagents Of The University Of California | Polyfunctional cationic cytofectins |
| AU7078396A (en) * | 1995-09-27 | 1997-04-30 | Regents Of The University Of California, The | Polyfunctional cationic cytofectins, formulations and methods for generating active cytofectin:polynucleotide transfection complexes |
| WO1997019675A2 (en) | 1995-11-30 | 1997-06-05 | Vical Incorporated | Complex cationic lipids |
| EP0904100B1 (en) * | 1996-02-09 | 2006-07-26 | Pi-Wan Cheng | Cationic lipid and receptor ligand-facilitated delivery of biologically active molecules |
| JP3258900B2 (ja) | 1996-03-22 | 2002-02-18 | 三洋電機株式会社 | 電気炊飯器 |
| US5962429A (en) * | 1996-11-22 | 1999-10-05 | University Of Iowa | Complexes of adenovirus with cationic molecules |
-
1996
- 1996-11-27 WO PCT/US1996/019721 patent/WO1997019675A2/en not_active Ceased
- 1996-11-27 JP JP52075797A patent/JP4430135B2/ja not_active Expired - Fee Related
- 1996-11-27 EP EP96943691A patent/EP0863749A2/en not_active Ceased
- 1996-11-27 CA CA2237316A patent/CA2237316C/en not_active Expired - Fee Related
-
1998
- 1998-06-05 US US09/092,486 patent/US6670332B1/en not_active Expired - Fee Related
-
2003
- 2003-12-30 US US10/748,853 patent/US8541628B2/en not_active Expired - Fee Related
-
2008
- 2008-03-25 JP JP2008078918A patent/JP4965489B2/ja not_active Expired - Fee Related