JP2000508908A - 分泌蛋白およびそれらをコードしているポリヌクレオチド - Google Patents

分泌蛋白およびそれらをコードしているポリヌクレオチド

Info

Publication number: JP2000508908A
Authority: JP; Japan
Prior art keywords: seq; amino acid; protein; polynucleotide; acid sequence
Prior art date: 1996-04-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP9538135A

Other languages

English (en)

Japanese (ja)

Inventor

ジェイコブズ，ケネス

マッコイ，ジョン・エム

レイシー，リサ・エイ

ラバリー，エドワード・アール

マーバーグ，デイビッド

スパルディング，ビッキー

Original Assignee

ジェネティックス・インスチチュート・インコーポレーテッド

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-19

Filing date

1997-04-14

Publication date

2000-07-18

1997-04-14 Application filed by ジェネティックス・インスチチュート・インコーポレーテッド filed Critical ジェネティックス・インスチチュート・インコーポレーテッド

2000-07-18 Publication of JP2000508908A publication Critical patent/JP2000508908A/ja

Status Pending legal-status Critical Current

Links

108090000623 proteins and genes Proteins 0.000 title claims description 419
102000004169 proteins and genes Human genes 0.000 title claims description 405
108091033319 polynucleotide Proteins 0.000 title claims description 219
102000040430 polynucleotide Human genes 0.000 title claims description 219
239000002157 polynucleotide Substances 0.000 title claims description 219
239000002773 nucleotide Substances 0.000 claims abstract description 201
125000003729 nucleotide group Chemical group 0.000 claims abstract description 201
125000003275 alpha amino acid group Chemical group 0.000 claims abstract description 146
210000004027 cell Anatomy 0.000 claims abstract description 83
238000000034 method Methods 0.000 claims abstract description 60
239000002299 complementary DNA Substances 0.000 claims abstract description 56
239000000203 mixture Substances 0.000 claims description 69
150000001413 amino acids Chemical class 0.000 claims description 64
108091026890 Coding region Proteins 0.000 claims description 46
108090000765 processed proteins & peptides Proteins 0.000 claims description 36
239000012634 fragment Substances 0.000 claims description 30
230000004071 biological effect Effects 0.000 claims description 19
108020004414 DNA Proteins 0.000 claims description 14
102000004196 processed proteins & peptides Human genes 0.000 claims description 14
238000004519 manufacturing process Methods 0.000 claims description 10
229920001184 polypeptide Polymers 0.000 claims description 10
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 9
230000015572 biosynthetic process Effects 0.000 claims description 7
108091028043 Nucleic acid sequence Proteins 0.000 claims description 6
239000003937 drug carrier Substances 0.000 claims description 5
210000004962 mammalian cell Anatomy 0.000 claims description 5
238000003786 synthesis reaction Methods 0.000 claims description 5
101150112497 26 gene Proteins 0.000 claims 1
101150072006 33 gene Proteins 0.000 claims 1
101150002210 34 gene Proteins 0.000 claims 1
101150005355 36 gene Proteins 0.000 claims 1
102000040739 Secretory proteins Human genes 0.000 abstract description 6
108091058545 Secretory proteins Proteins 0.000 abstract description 6
210000003819 peripheral blood mononuclear cell Anatomy 0.000 abstract description 6
238000012216 screening Methods 0.000 abstract description 5
208000005017 glioblastoma Diseases 0.000 abstract description 2
235000018102 proteins Nutrition 0.000 description 334
230000000694 effects Effects 0.000 description 68
235000001014 amino acid Nutrition 0.000 description 49
210000001519 tissue Anatomy 0.000 description 34
210000001744 T-lymphocyte Anatomy 0.000 description 31
238000003556 assay Methods 0.000 description 31
238000011282 treatment Methods 0.000 description 24
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 22
206010028980 Neoplasm Diseases 0.000 description 21
239000000427 antigen Substances 0.000 description 20
102000036639 antigens Human genes 0.000 description 19
108091007433 antigens Proteins 0.000 description 19
102000004127 Cytokines Human genes 0.000 description 18
108090000695 Cytokines Proteins 0.000 description 18
239000008194 pharmaceutical composition Substances 0.000 description 18
108020003175 receptors Proteins 0.000 description 18
102000005962 receptors Human genes 0.000 description 18
239000003446 ligand Substances 0.000 description 17
201000010099 disease Diseases 0.000 description 16
230000028993 immune response Effects 0.000 description 15
210000000988 bone and bone Anatomy 0.000 description 14
239000003795 chemical substances by application Substances 0.000 description 14
102100026445 A-kinase anchor protein 17A Human genes 0.000 description 12
101000718019 Homo sapiens A-kinase anchor protein 17A Proteins 0.000 description 12
230000006870 function Effects 0.000 description 11
230000035755 proliferation Effects 0.000 description 11
230000000903 blocking effect Effects 0.000 description 10
230000003993 interaction Effects 0.000 description 10
210000004881 tumor cell Anatomy 0.000 description 10
241000282412 Homo Species 0.000 description 9
239000002253 acid Substances 0.000 description 9
230000004069 differentiation Effects 0.000 description 9
239000011159 matrix material Substances 0.000 description 9
239000000047 product Substances 0.000 description 9
239000000523 sample Substances 0.000 description 9
241000894007 species Species 0.000 description 9
230000001580 bacterial effect Effects 0.000 description 8
239000003153 chemical reaction reagent Substances 0.000 description 8
230000006378 damage Effects 0.000 description 8
230000003394 haemopoietic effect Effects 0.000 description 8
210000003041 ligament Anatomy 0.000 description 8
230000001225 therapeutic effect Effects 0.000 description 8
102000002746 Inhibins Human genes 0.000 description 7
108010004250 Inhibins Proteins 0.000 description 7
108010074338 Lymphokines Proteins 0.000 description 7
102000008072 Lymphokines Human genes 0.000 description 7
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
210000000845 cartilage Anatomy 0.000 description 7
230000035605 chemotaxis Effects 0.000 description 7
238000010367 cloning Methods 0.000 description 7
230000001419 dependent effect Effects 0.000 description 7
230000006698 induction Effects 0.000 description 7
239000000893 inhibin Substances 0.000 description 7
239000000463 material Substances 0.000 description 7
208000024891 symptom Diseases 0.000 description 7
241001465754 Metazoa Species 0.000 description 6
240000004808 Saccharomyces cerevisiae Species 0.000 description 6
-1 TN F Proteins 0.000 description 6
208000027418 Wounds and injury Diseases 0.000 description 6
239000003146 anticoagulant agent Substances 0.000 description 6
210000003719 b-lymphocyte Anatomy 0.000 description 6
238000009472 formulation Methods 0.000 description 6
230000012010 growth Effects 0.000 description 6
238000009396 hybridization Methods 0.000 description 6
230000001506 immunosuppresive effect Effects 0.000 description 6
238000001727 in vivo Methods 0.000 description 6
239000003112 inhibitor Substances 0.000 description 6
208000014674 injury Diseases 0.000 description 6
230000001404 mediated effect Effects 0.000 description 6
102000039446 nucleic acids Human genes 0.000 description 6
108020004707 nucleic acids Proteins 0.000 description 6
150000007523 nucleic acids Chemical class 0.000 description 6
230000008569 process Effects 0.000 description 6
230000001737 promoting effect Effects 0.000 description 6
230000004044 response Effects 0.000 description 6
239000000243 solution Substances 0.000 description 6
230000004936 stimulating effect Effects 0.000 description 6
230000002537 thrombolytic effect Effects 0.000 description 6
208000023275 Autoimmune disease Diseases 0.000 description 5
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
102000012673 Follicle Stimulating Hormone Human genes 0.000 description 5
108010079345 Follicle Stimulating Hormone Proteins 0.000 description 5
208000009329 Graft vs Host Disease Diseases 0.000 description 5
241000238631 Hexapoda Species 0.000 description 5
108060003951 Immunoglobulin Proteins 0.000 description 5
102000043131 MHC class II family Human genes 0.000 description 5
108091054438 MHC class II family Proteins 0.000 description 5
241000124008 Mammalia Species 0.000 description 5
241000699670 Mus sp. Species 0.000 description 5
239000004480 active ingredient Substances 0.000 description 5
201000011510 cancer Diseases 0.000 description 5
230000007547 defect Effects 0.000 description 5
238000011161 development Methods 0.000 description 5
230000018109 developmental process Effects 0.000 description 5
208000035475 disorder Diseases 0.000 description 5
239000003814 drug Substances 0.000 description 5
229940028334 follicle stimulating hormone Drugs 0.000 description 5
208000024908 graft versus host disease Diseases 0.000 description 5
102000018358 immunoglobulin Human genes 0.000 description 5
230000002401 inhibitory effect Effects 0.000 description 5
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 5
238000001990 intravenous administration Methods 0.000 description 5
239000002609 medium Substances 0.000 description 5
210000000056 organ Anatomy 0.000 description 5
208000033808 peripheral neuropathy Diseases 0.000 description 5
238000011160 research Methods 0.000 description 5
239000003352 sequestering agent Substances 0.000 description 5
210000003491 skin Anatomy 0.000 description 5
210000000130 stem cell Anatomy 0.000 description 5
230000017423 tissue regeneration Effects 0.000 description 5
102000005606 Activins Human genes 0.000 description 4
108010059616 Activins Proteins 0.000 description 4
241000894006 Bacteria Species 0.000 description 4
108020004635 Complementary DNA Proteins 0.000 description 4
206010062016 Immunosuppression Diseases 0.000 description 4
108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 4
108010076504 Protein Sorting Signals Proteins 0.000 description 4
241000700159 Rattus Species 0.000 description 4
230000005867 T cell response Effects 0.000 description 4
208000007536 Thrombosis Diseases 0.000 description 4
206010052428 Wound Diseases 0.000 description 4
239000000488 activin Substances 0.000 description 4
230000002785 anti-thrombosis Effects 0.000 description 4
238000002512 chemotherapy Methods 0.000 description 4
230000007812 deficiency Effects 0.000 description 4
102000037865 fusion proteins Human genes 0.000 description 4
108020001507 fusion proteins Proteins 0.000 description 4
238000001415 gene therapy Methods 0.000 description 4
230000035876 healing Effects 0.000 description 4
230000001900 immune effect Effects 0.000 description 4
238000000338 in vitro Methods 0.000 description 4
230000004054 inflammatory process Effects 0.000 description 4
238000002347 injection Methods 0.000 description 4
239000007924 injection Substances 0.000 description 4
238000002372 labelling Methods 0.000 description 4
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
239000007788 liquid Substances 0.000 description 4
210000004698 lymphocyte Anatomy 0.000 description 4
239000012528 membrane Substances 0.000 description 4
238000000746 purification Methods 0.000 description 4
230000001105 regulatory effect Effects 0.000 description 4
239000000126 substance Substances 0.000 description 4
230000009885 systemic effect Effects 0.000 description 4
238000002054 transplantation Methods 0.000 description 4
230000008733 trauma Effects 0.000 description 4
230000000472 traumatic effect Effects 0.000 description 4
229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
108020005187 Oligonucleotide Probes Proteins 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
102000013275 Somatomedins Human genes 0.000 description 3
241000700605 Viruses Species 0.000 description 3
239000000654 additive Substances 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
230000003110 anti-inflammatory effect Effects 0.000 description 3
208000006673 asthma Diseases 0.000 description 3
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
210000004369 blood Anatomy 0.000 description 3
239000008280 blood Substances 0.000 description 3
238000009395 breeding Methods 0.000 description 3
239000002775 capsule Substances 0.000 description 3
230000003915 cell function Effects 0.000 description 3
230000001413 cellular effect Effects 0.000 description 3
230000010002 chemokinesis Effects 0.000 description 3
230000003399 chemotactic effect Effects 0.000 description 3
210000000078 claw Anatomy 0.000 description 3
238000012258 culturing Methods 0.000 description 3
238000012217 deletion Methods 0.000 description 3
230000037430 deletion Effects 0.000 description 3
239000008121 dextrose Substances 0.000 description 3
239000013604 expression vector Substances 0.000 description 3
230000035558 fertility Effects 0.000 description 3
230000004927 fusion Effects 0.000 description 3
210000003958 hematopoietic stem cell Anatomy 0.000 description 3
230000011132 hemopoiesis Effects 0.000 description 3
239000000833 heterodimer Substances 0.000 description 3
229910052588 hydroxylapatite Inorganic materials 0.000 description 3
210000002865 immune cell Anatomy 0.000 description 3
230000036039 immunity Effects 0.000 description 3
230000001939 inductive effect Effects 0.000 description 3
208000015181 infectious disease Diseases 0.000 description 3
238000003780 insertion Methods 0.000 description 3
230000037431 insertion Effects 0.000 description 3
239000002502 liposome Substances 0.000 description 3
239000003550 marker Substances 0.000 description 3
230000004048 modification Effects 0.000 description 3
238000012986 modification Methods 0.000 description 3
210000001616 monocyte Anatomy 0.000 description 3
210000000944 nerve tissue Anatomy 0.000 description 3
210000002569 neuron Anatomy 0.000 description 3
201000001119 neuropathy Diseases 0.000 description 3
230000007823 neuropathy Effects 0.000 description 3
239000003921 oil Substances 0.000 description 3
235000019198 oils Nutrition 0.000 description 3
239000002751 oligonucleotide probe Substances 0.000 description 3
210000005009 osteogenic cell Anatomy 0.000 description 3
239000002245 particle Substances 0.000 description 3
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 3
239000002243 precursor Substances 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
230000002265 prevention Effects 0.000 description 3
230000004952 protein activity Effects 0.000 description 3
230000008929 regeneration Effects 0.000 description 3
238000011069 regeneration method Methods 0.000 description 3
230000008439 repair process Effects 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
238000010254 subcutaneous injection Methods 0.000 description 3
239000003826 tablet Substances 0.000 description 3
238000001890 transfection Methods 0.000 description 3
230000004614 tumor growth Effects 0.000 description 3
230000003827 upregulation Effects 0.000 description 3
230000003612 virological effect Effects 0.000 description 3
230000029663 wound healing Effects 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
241000283690 Bos taurus Species 0.000 description 2
241000222120 Candida <Saccharomycetales> Species 0.000 description 2
206010007710 Cartilage injury Diseases 0.000 description 2
108010035532 Collagen Proteins 0.000 description 2
102000008186 Collagen Human genes 0.000 description 2
241000588724 Escherichia coli Species 0.000 description 2
206010017533 Fungal infection Diseases 0.000 description 2
241000233866 Fungi Species 0.000 description 2
102000018713 Histocompatibility Antigens Class II Human genes 0.000 description 2
108010027412 Histocompatibility Antigens Class II Proteins 0.000 description 2
206010020751 Hypersensitivity Diseases 0.000 description 2
208000026350 Inborn Genetic disease Diseases 0.000 description 2
206010061218 Inflammation Diseases 0.000 description 2
108010002352 Interleukin-1 Proteins 0.000 description 2
208000034693 Laceration Diseases 0.000 description 2
241001529936 Murinae Species 0.000 description 2
208000031888 Mycoses Diseases 0.000 description 2
108091034117 Oligonucleotide Proteins 0.000 description 2
241001494479 Pecora Species 0.000 description 2
102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 2
108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 2
102000007056 Recombinant Fusion Proteins Human genes 0.000 description 2
108010008281 Recombinant Fusion Proteins Proteins 0.000 description 2
206010063837 Reperfusion injury Diseases 0.000 description 2
241000282887 Suidae Species 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 description 2
108091008874 T cell receptors Proteins 0.000 description 2
102000016266 T-Cell Antigen Receptors Human genes 0.000 description 2
102000002933 Thioredoxin Human genes 0.000 description 2
206010052779 Transplant rejections Diseases 0.000 description 2
208000025865 Ulcer Diseases 0.000 description 2
230000009471 action Effects 0.000 description 2
230000004913 activation Effects 0.000 description 2
230000002730 additional effect Effects 0.000 description 2
230000000996 additive effect Effects 0.000 description 2
239000000556 agonist Substances 0.000 description 2
229960000723 ampicillin Drugs 0.000 description 2
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 2
238000010171 animal model Methods 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
230000001363 autoimmune Effects 0.000 description 2
230000037396 body weight Effects 0.000 description 2
230000008468 bone growth Effects 0.000 description 2
230000001488 breeding effect Effects 0.000 description 2
239000000872 buffer Substances 0.000 description 2
239000001506 calcium phosphate Substances 0.000 description 2
150000001720 carbohydrates Chemical class 0.000 description 2
239000001768 carboxy methyl cellulose Substances 0.000 description 2
235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
239000008112 carboxymethyl-cellulose Substances 0.000 description 2
230000024245 cell differentiation Effects 0.000 description 2
238000001516 cell proliferation assay Methods 0.000 description 2
230000008614 cellular interaction Effects 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
210000003169 central nervous system Anatomy 0.000 description 2
210000001175 cerebrospinal fluid Anatomy 0.000 description 2
210000000349 chromosome Anatomy 0.000 description 2
229920001436 collagen Polymers 0.000 description 2
230000000295 complement effect Effects 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
230000000139 costimulatory effect Effects 0.000 description 2
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 2
210000004443 dendritic cell Anatomy 0.000 description 2
230000002222 downregulating effect Effects 0.000 description 2
229940079593 drug Drugs 0.000 description 2
210000001671 embryonic stem cell Anatomy 0.000 description 2
210000003038 endothelium Anatomy 0.000 description 2
230000002708 enhancing effect Effects 0.000 description 2
238000001400 expression cloning Methods 0.000 description 2
239000003925 fat Substances 0.000 description 2
239000000499 gel Substances 0.000 description 2
208000016361 genetic disease Diseases 0.000 description 2
230000002068 genetic effect Effects 0.000 description 2
239000003102 growth factor Substances 0.000 description 2
230000023597 hemostasis Effects 0.000 description 2
230000002439 hemostatic effect Effects 0.000 description 2
230000003053 immunization Effects 0.000 description 2
230000002163 immunogen Effects 0.000 description 2
230000003308 immunostimulating effect Effects 0.000 description 2
230000001965 increasing effect Effects 0.000 description 2
239000012678 infectious agent Substances 0.000 description 2
208000000509 infertility Diseases 0.000 description 2
230000036512 infertility Effects 0.000 description 2
231100000535 infertility Toxicity 0.000 description 2
230000002757 inflammatory effect Effects 0.000 description 2
230000005764 inhibitory process Effects 0.000 description 2
230000002452 interceptive effect Effects 0.000 description 2
210000000936 intestine Anatomy 0.000 description 2
230000003834 intracellular effect Effects 0.000 description 2
238000010253 intravenous injection Methods 0.000 description 2
238000002955 isolation Methods 0.000 description 2
210000003734 kidney Anatomy 0.000 description 2
239000004310 lactic acid Substances 0.000 description 2
235000014655 lactic acid Nutrition 0.000 description 2
150000002632 lipids Chemical class 0.000 description 2
210000004185 liver Anatomy 0.000 description 2
244000144972 livestock Species 0.000 description 2
230000033001 locomotion Effects 0.000 description 2
230000007774 longterm Effects 0.000 description 2
230000003472 neutralizing effect Effects 0.000 description 2
210000000440 neutrophil Anatomy 0.000 description 2
230000011164 ossification Effects 0.000 description 2
230000036961 partial effect Effects 0.000 description 2
229920000747 poly(lactic acid) Polymers 0.000 description 2
229920001223 polyethylene glycol Polymers 0.000 description 2
239000004626 polylactic acid Substances 0.000 description 2
239000000843 powder Substances 0.000 description 2
238000001959 radiotherapy Methods 0.000 description 2
238000002271 resection Methods 0.000 description 2
239000007787 solid Substances 0.000 description 2
210000004989 spleen cell Anatomy 0.000 description 2
239000003381 stabilizer Substances 0.000 description 2
238000003756 stirring Methods 0.000 description 2
239000007929 subcutaneous injection Substances 0.000 description 2
238000006467 substitution reaction Methods 0.000 description 2
230000008093 supporting effect Effects 0.000 description 2
230000004083 survival effect Effects 0.000 description 2
208000011580 syndromic disease Diseases 0.000 description 2
238000012360 testing method Methods 0.000 description 2
229940124597 therapeutic agent Drugs 0.000 description 2
108060008226 thioredoxin Proteins 0.000 description 2
229940094937 thioredoxin Drugs 0.000 description 2
238000012549 training Methods 0.000 description 2
238000012546 transfer Methods 0.000 description 2
230000009261 transgenic effect Effects 0.000 description 2
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
229940078499 tricalcium phosphate Drugs 0.000 description 2
229910000391 tricalcium phosphate Inorganic materials 0.000 description 2
235000019731 tricalcium phosphate Nutrition 0.000 description 2
231100000397 ulcer Toxicity 0.000 description 2
230000002792 vascular Effects 0.000 description 2
239000013598 vector Substances 0.000 description 2
UBWXUGDQUBIEIZ-UHFFFAOYSA-N (13-methyl-3-oxo-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl) 3-phenylpropanoate Chemical compound CC12CCC(C3CCC(=O)C=C3CC3)C3C1CCC2OC(=O)CCC1=CC=CC=C1 UBWXUGDQUBIEIZ-UHFFFAOYSA-N 0.000 description 1
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
229920000936 Agarose Polymers 0.000 description 1
206010001488 Aggression Diseases 0.000 description 1
102000040717 Alpha family Human genes 0.000 description 1
108091071248 Alpha family Proteins 0.000 description 1
208000024827 Alzheimer disease Diseases 0.000 description 1
206010002198 Anaphylactic reaction Diseases 0.000 description 1
208000032467 Aplastic anaemia Diseases 0.000 description 1
208000034172 Autoimmune Experimental Myasthenia Gravis Diseases 0.000 description 1
208000030767 Autoimmune encephalitis Diseases 0.000 description 1
102000019260 B-Cell Antigen Receptors Human genes 0.000 description 1
108010012919 B-Cell Antigen Receptors Proteins 0.000 description 1
244000063299 Bacillus subtilis Species 0.000 description 1
235000014469 Bacillus subtilis Nutrition 0.000 description 1
208000035143 Bacterial infection Diseases 0.000 description 1
206010065553 Bone marrow failure Diseases 0.000 description 1
241000244203 Caenorhabditis elegans Species 0.000 description 1
241000283707 Capra Species 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
201000009030 Carcinoma Diseases 0.000 description 1
102000014914 Carrier Proteins Human genes 0.000 description 1
108010067225 Cell Adhesion Molecules Proteins 0.000 description 1
102000016289 Cell Adhesion Molecules Human genes 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
108010012236 Chemokines Proteins 0.000 description 1
102000019034 Chemokines Human genes 0.000 description 1
208000003044 Closed Fractures Diseases 0.000 description 1
206010053567 Coagulopathies Diseases 0.000 description 1
108020004705 Codon Proteins 0.000 description 1
102000029816 Collagenase Human genes 0.000 description 1
108060005980 Collagenase Proteins 0.000 description 1
208000035473 Communicable disease Diseases 0.000 description 1
206010010356 Congenital anomaly Diseases 0.000 description 1
206010010904 Convulsion Diseases 0.000 description 1
241000699802 Cricetulus griseus Species 0.000 description 1
208000011231 Crohn disease Diseases 0.000 description 1
238000001712 DNA sequencing Methods 0.000 description 1
206010011985 Decubitus ulcer Diseases 0.000 description 1
208000020401 Depressive disease Diseases 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
102100025137 Early activation antigen CD69 Human genes 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
102000003951 Erythropoietin Human genes 0.000 description 1
108090000394 Erythropoietin Proteins 0.000 description 1
239000001856 Ethyl cellulose Substances 0.000 description 1
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
208000009386 Experimental Arthritis Diseases 0.000 description 1
108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
206010015866 Extravasation Diseases 0.000 description 1
206010017076 Fracture Diseases 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
102000006395 Globulins Human genes 0.000 description 1
108010044091 Globulins Proteins 0.000 description 1
108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 1
102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 1
108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 1
102100031547 HLA class II histocompatibility antigen, DO alpha chain Human genes 0.000 description 1
208000030836 Hashimoto thyroiditis Diseases 0.000 description 1
206010019196 Head injury Diseases 0.000 description 1
102000001554 Hemoglobins Human genes 0.000 description 1
108010054147 Hemoglobins Proteins 0.000 description 1
208000031220 Hemophilia Diseases 0.000 description 1
208000009292 Hemophilia A Diseases 0.000 description 1
206010019668 Hepatic fibrosis Diseases 0.000 description 1
101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 description 1
101000866278 Homo sapiens HLA class II histocompatibility antigen, DO alpha chain Proteins 0.000 description 1
101000964562 Homo sapiens Zinc finger FYVE domain-containing protein 9 Proteins 0.000 description 1
208000023105 Huntington disease Diseases 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
206010061598 Immunodeficiency Diseases 0.000 description 1
208000029462 Immunodeficiency disease Diseases 0.000 description 1
206010061216 Infarction Diseases 0.000 description 1
208000022559 Inflammatory bowel disease Diseases 0.000 description 1
102100037852 Insulin-like growth factor I Human genes 0.000 description 1
108010050904 Interferons Proteins 0.000 description 1
102000014150 Interferons Human genes 0.000 description 1
108090000174 Interleukin-10 Proteins 0.000 description 1
108090000177 Interleukin-11 Proteins 0.000 description 1
108010065805 Interleukin-12 Proteins 0.000 description 1
108090000176 Interleukin-13 Proteins 0.000 description 1
108010002350 Interleukin-2 Proteins 0.000 description 1
108010002386 Interleukin-3 Proteins 0.000 description 1
108090000978 Interleukin-4 Proteins 0.000 description 1
108010002616 Interleukin-5 Proteins 0.000 description 1
108090001005 Interleukin-6 Proteins 0.000 description 1
108010002586 Interleukin-7 Proteins 0.000 description 1
108090001007 Interleukin-8 Proteins 0.000 description 1
108010002335 Interleukin-9 Proteins 0.000 description 1
241000235649 Kluyveromyces Species 0.000 description 1
101710142063 Lactose-binding protein Proteins 0.000 description 1
241000222722 Leishmania <genus> Species 0.000 description 1
206010024774 Localised infection Diseases 0.000 description 1
208000004852 Lung Injury Diseases 0.000 description 1
206010025323 Lymphomas Diseases 0.000 description 1
108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
108091061960 Naked DNA Proteins 0.000 description 1
206010029260 Neuroblastoma Diseases 0.000 description 1
239000005642 Oleic acid Substances 0.000 description 1
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
208000002565 Open Fractures Diseases 0.000 description 1
208000001132 Osteoporosis Diseases 0.000 description 1
101710160107 Outer membrane protein A Proteins 0.000 description 1
101150036326 PMT2 gene Proteins 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
208000018737 Parkinson disease Diseases 0.000 description 1
235000019483 Peanut oil Nutrition 0.000 description 1
208000010886 Peripheral nerve injury Diseases 0.000 description 1
102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
208000013544 Platelet disease Diseases 0.000 description 1
206010035664 Pneumonia Diseases 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
229920002732 Polyanhydride Polymers 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
102400000745 Potential peptide Human genes 0.000 description 1
101800001357 Potential peptide Proteins 0.000 description 1
208000004210 Pressure Ulcer Diseases 0.000 description 1
241000288906 Primates Species 0.000 description 1
102000002067 Protein Subunits Human genes 0.000 description 1
108010001267 Protein Subunits Proteins 0.000 description 1
201000004681 Psoriasis Diseases 0.000 description 1
108091005682 Receptor kinases Proteins 0.000 description 1
241000235070 Saccharomyces Species 0.000 description 1
241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
206010039491 Sarcoma Diseases 0.000 description 1
241000235347 Schizosaccharomyces pombe Species 0.000 description 1
101100043108 Schizosaccharomyces pombe (strain 972 / ATCC 24843) spb1 gene Proteins 0.000 description 1
208000034189 Sclerosis Diseases 0.000 description 1
206010040047 Sepsis Diseases 0.000 description 1
206010040070 Septic Shock Diseases 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
208000029033 Spinal Cord disease Diseases 0.000 description 1
230000006044 T cell activation Effects 0.000 description 1
230000020385 T cell costimulation Effects 0.000 description 1
230000024932 T cell mediated immunity Effects 0.000 description 1
239000004098 Tetracycline Substances 0.000 description 1
102000036693 Thrombopoietin Human genes 0.000 description 1
108010041111 Thrombopoietin Proteins 0.000 description 1
102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
102000009618 Transforming Growth Factors Human genes 0.000 description 1
108010009583 Transforming Growth Factors Proteins 0.000 description 1
102400001320 Transforming growth factor alpha Human genes 0.000 description 1
101800004564 Transforming growth factor alpha Proteins 0.000 description 1
206010069363 Traumatic lung injury Diseases 0.000 description 1
206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
208000036142 Viral infection Diseases 0.000 description 1
108010006886 Vitrogen Proteins 0.000 description 1
102100040801 Zinc finger FYVE domain-containing protein 9 Human genes 0.000 description 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
238000002814 agar dilution Methods 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
201000009961 allergic asthma Diseases 0.000 description 1
208000026935 allergic disease Diseases 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
230000001668 ameliorated effect Effects 0.000 description 1
125000000539 amino acid group Chemical group 0.000 description 1
230000003321 amplification Effects 0.000 description 1
230000000202 analgesic effect Effects 0.000 description 1
230000036783 anaphylactic response Effects 0.000 description 1
208000003455 anaphylaxis Diseases 0.000 description 1
208000007502 anemia Diseases 0.000 description 1
230000033115 angiogenesis Effects 0.000 description 1
230000002491 angiogenic effect Effects 0.000 description 1
230000003172 anti-dna Effects 0.000 description 1
229940121363 anti-inflammatory agent Drugs 0.000 description 1
239000002260 anti-inflammatory agent Substances 0.000 description 1
229940124599 anti-inflammatory drug Drugs 0.000 description 1
230000000692 anti-sense effect Effects 0.000 description 1
230000000259 anti-tumor effect Effects 0.000 description 1
230000002155 anti-virotic effect Effects 0.000 description 1
230000005875 antibody response Effects 0.000 description 1
230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 description 1
230000030741 antigen processing and presentation Effects 0.000 description 1
230000000890 antigenic effect Effects 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
230000003078 antioxidant effect Effects 0.000 description 1
230000007416 antiviral immune response Effects 0.000 description 1
238000003782 apoptosis assay Methods 0.000 description 1
230000006907 apoptotic process Effects 0.000 description 1
230000036528 appetite Effects 0.000 description 1
235000019789 appetite Nutrition 0.000 description 1
206010003246 arthritis Diseases 0.000 description 1
230000003416 augmentation Effects 0.000 description 1
238000000376 autoradiography Methods 0.000 description 1
208000022362 bacterial infectious disease Diseases 0.000 description 1
OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
230000006399 behavior Effects 0.000 description 1
230000003542 behavioural effect Effects 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000008901 benefit Effects 0.000 description 1
239000003613 bile acid Substances 0.000 description 1
108091008324 binding proteins Proteins 0.000 description 1
239000003462 bioceramic Substances 0.000 description 1
239000005312 bioglass Substances 0.000 description 1
239000013060 biological fluid Substances 0.000 description 1
229960000182 blood factors Drugs 0.000 description 1
210000002798 bone marrow cell Anatomy 0.000 description 1
210000005013 brain tissue Anatomy 0.000 description 1
210000000481 breast Anatomy 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
230000000747 cardiac effect Effects 0.000 description 1
208000003295 carpal tunnel syndrome Diseases 0.000 description 1
239000000969 carrier Substances 0.000 description 1
230000022159 cartilage development Effects 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
238000004113 cell culture Methods 0.000 description 1
230000010261 cell growth Effects 0.000 description 1
230000004663 cell proliferation Effects 0.000 description 1
208000015114 central nervous system disease Diseases 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
208000026106 cerebrovascular disease Diseases 0.000 description 1
238000012512 characterization method Methods 0.000 description 1
239000003610 charcoal Substances 0.000 description 1
230000001659 chemokinetic effect Effects 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
238000012761 co-transfection Methods 0.000 description 1
230000019771 cognition Effects 0.000 description 1
208000010877 cognitive disease Diseases 0.000 description 1
230000001149 cognitive effect Effects 0.000 description 1
229960002424 collagenase Drugs 0.000 description 1
230000001332 colony forming effect Effects 0.000 description 1
238000010276 construction Methods 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
238000002316 cosmetic surgery Methods 0.000 description 1
230000016396 cytokine production Effects 0.000 description 1
108010057085 cytokine receptors Proteins 0.000 description 1
102000003675 cytokine receptors Human genes 0.000 description 1
230000009089 cytolysis Effects 0.000 description 1
230000001461 cytolytic effect Effects 0.000 description 1
230000003013 cytotoxicity Effects 0.000 description 1
231100000135 cytotoxicity Toxicity 0.000 description 1
230000034994 death Effects 0.000 description 1
230000006735 deficit Effects 0.000 description 1
230000007850 degeneration Effects 0.000 description 1
238000004925 denaturation Methods 0.000 description 1
230000036425 denaturation Effects 0.000 description 1
238000000151 deposition Methods 0.000 description 1
238000001212 derivatisation Methods 0.000 description 1
238000013461 design Methods 0.000 description 1
238000003795 desorption Methods 0.000 description 1
230000001066 destructive effect Effects 0.000 description 1
206010012601 diabetes mellitus Diseases 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000037213 diet Effects 0.000 description 1
230000029087 digestion Effects 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical compound C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 description 1
210000001840 diploid cell Anatomy 0.000 description 1
POLCUAVZOMRGSN-UHFFFAOYSA-N dipropyl ether Chemical compound CCCOCCC POLCUAVZOMRGSN-UHFFFAOYSA-N 0.000 description 1
238000010494 dissociation reaction Methods 0.000 description 1
230000005593 dissociations Effects 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
230000010091 embryonic hemopoiesis Effects 0.000 description 1
206010014599 encephalitis Diseases 0.000 description 1
230000002124 endocrine Effects 0.000 description 1
210000002889 endothelial cell Anatomy 0.000 description 1
210000003989 endothelium vascular Anatomy 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
238000006911 enzymatic reaction Methods 0.000 description 1
229940088598 enzyme Drugs 0.000 description 1
210000003979 eosinophil Anatomy 0.000 description 1
230000000925 erythroid effect Effects 0.000 description 1
210000003013 erythroid precursor cell Anatomy 0.000 description 1
229940105423 erythropoietin Drugs 0.000 description 1
229920001249 ethyl cellulose Polymers 0.000 description 1
235000019325 ethyl cellulose Nutrition 0.000 description 1
210000003527 eukaryotic cell Anatomy 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
210000002744 extracellular matrix Anatomy 0.000 description 1
230000036251 extravasation Effects 0.000 description 1
208000030533 eye disease Diseases 0.000 description 1
230000020764 fibrinolysis Effects 0.000 description 1
230000003176 fibrotic effect Effects 0.000 description 1
239000000945 filler Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
235000013305 food Nutrition 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
238000002523 gelfiltration Methods 0.000 description 1
238000002682 general surgery Methods 0.000 description 1
238000009650 gentamicin protection assay Methods 0.000 description 1
210000004602 germ cell Anatomy 0.000 description 1
230000013595 glycosylation Effects 0.000 description 1
238000006206 glycosylation reaction Methods 0.000 description 1
210000003714 granulocyte Anatomy 0.000 description 1
230000009036 growth inhibition Effects 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
230000037308 hair color Effects 0.000 description 1
208000006454 hepatitis Diseases 0.000 description 1
231100000283 hepatitis Toxicity 0.000 description 1
238000013537 high throughput screening Methods 0.000 description 1
210000003630 histaminocyte Anatomy 0.000 description 1
230000013632 homeostatic process Effects 0.000 description 1
239000000710 homodimer Substances 0.000 description 1
230000003054 hormonal effect Effects 0.000 description 1
230000028996 humoral immune response Effects 0.000 description 1
229920002674 hyaluronan Polymers 0.000 description 1
229960003160 hyaluronic acid Drugs 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
238000004191 hydrophobic interaction chromatography Methods 0.000 description 1
229920013821 hydroxy alkyl cellulose Polymers 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
230000003463 hyperproliferative effect Effects 0.000 description 1
230000009610 hypersensitivity Effects 0.000 description 1
210000000987 immune system Anatomy 0.000 description 1
238000002649 immunization Methods 0.000 description 1
230000007813 immunodeficiency Effects 0.000 description 1
230000016784 immunoglobulin production Effects 0.000 description 1
229960003444 immunosuppressant agent Drugs 0.000 description 1
230000001861 immunosuppressant effect Effects 0.000 description 1
239000003018 immunosuppressive agent Substances 0.000 description 1
239000007943 implant Substances 0.000 description 1
230000006872 improvement Effects 0.000 description 1
230000007574 infarction Effects 0.000 description 1
230000028709 inflammatory response Effects 0.000 description 1
206010022000 influenza Diseases 0.000 description 1
238000001802 infusion Methods 0.000 description 1
239000013546 insoluble monolayer Substances 0.000 description 1
102000006495 integrins Human genes 0.000 description 1
108010044426 integrins Proteins 0.000 description 1
230000008611 intercellular interaction Effects 0.000 description 1
229940047124 interferons Drugs 0.000 description 1
238000004255 ion exchange chromatography Methods 0.000 description 1
208000012947 ischemia reperfusion injury Diseases 0.000 description 1
210000004153 islets of langerhan Anatomy 0.000 description 1
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
206010023332 keratitis Diseases 0.000 description 1
230000002147 killing effect Effects 0.000 description 1
102000033736 lactose binding proteins Human genes 0.000 description 1
239000010410 layer Substances 0.000 description 1
208000032839 leukemia Diseases 0.000 description 1
210000000265 leukocyte Anatomy 0.000 description 1
210000004523 ligament cell Anatomy 0.000 description 1
238000004811 liquid chromatography Methods 0.000 description 1
239000004973 liquid crystal related substance Substances 0.000 description 1
239000012669 liquid formulation Substances 0.000 description 1
231100000515 lung injury Toxicity 0.000 description 1
210000001165 lymph node Anatomy 0.000 description 1
230000002912 lymphogenic effect Effects 0.000 description 1
230000002101 lytic effect Effects 0.000 description 1
210000002540 macrophage Anatomy 0.000 description 1
201000004792 malaria Diseases 0.000 description 1
230000035800 maturation Effects 0.000 description 1
238000013160 medical therapy Methods 0.000 description 1
201000001441 melanoma Diseases 0.000 description 1
230000001394 metastastic effect Effects 0.000 description 1
206010061289 metastatic neoplasm Diseases 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
244000005700 microbiome Species 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
239000008267 milk Substances 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
238000007799 mixed lymphocyte reaction assay Methods 0.000 description 1
238000010369 molecular cloning Methods 0.000 description 1
230000000877 morphologic effect Effects 0.000 description 1
201000006417 multiple sclerosis Diseases 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
206010028417 myasthenia gravis Diseases 0.000 description 1
208000010125 myocardial infarction Diseases 0.000 description 1
201000009240 nasopharyngitis Diseases 0.000 description 1
201000008383 nephritis Diseases 0.000 description 1
210000005036 nerve Anatomy 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
210000003924 normoblast Anatomy 0.000 description 1
238000003199 nucleic acid amplification method Methods 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
230000000771 oncological effect Effects 0.000 description 1
201000008482 osteoarthritis Diseases 0.000 description 1
210000002997 osteoclast Anatomy 0.000 description 1
230000002188 osteogenic effect Effects 0.000 description 1
210000001672 ovary Anatomy 0.000 description 1
238000012261 overproduction Methods 0.000 description 1
229940094443 oxytocics prostaglandins Drugs 0.000 description 1
210000000496 pancreas Anatomy 0.000 description 1
244000045947 parasite Species 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
208000028169 periodontal disease Diseases 0.000 description 1
210000001428 peripheral nervous system Anatomy 0.000 description 1
208000027232 peripheral nervous system disease Diseases 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
150000003904 phospholipids Chemical class 0.000 description 1
230000026731 phosphorylation Effects 0.000 description 1
238000006366 phosphorylation reaction Methods 0.000 description 1
230000037081 physical activity Effects 0.000 description 1
230000019612 pigmentation Effects 0.000 description 1
239000006187 pill Substances 0.000 description 1
230000001817 pituitary effect Effects 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
239000011148 porous material Substances 0.000 description 1
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
210000001236 prokaryotic cell Anatomy 0.000 description 1
150000003180 prostaglandins Chemical class 0.000 description 1
238000001742 protein purification Methods 0.000 description 1
239000012460 protein solution Substances 0.000 description 1
208000005069 pulmonary fibrosis Diseases 0.000 description 1
230000005855 radiation Effects 0.000 description 1
230000001172 regenerating effect Effects 0.000 description 1
230000002629 repopulating effect Effects 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
208000023504 respiratory system disease Diseases 0.000 description 1
238000004007 reversed phase HPLC Methods 0.000 description 1
206010039073 rheumatoid arthritis Diseases 0.000 description 1
102200082402 rs751610198 Human genes 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
229930182490 saponin Natural products 0.000 description 1
150000007949 saponins Chemical class 0.000 description 1
235000017709 saponins Nutrition 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
230000037390 scarring Effects 0.000 description 1
230000003248 secreting effect Effects 0.000 description 1
230000036303 septic shock Effects 0.000 description 1
238000012163 sequencing technique Methods 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
230000001568 sexual effect Effects 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
150000003384 small molecules Chemical class 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
239000002904 solvent Substances 0.000 description 1
210000001082 somatic cell Anatomy 0.000 description 1
230000000392 somatic effect Effects 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
230000021595 spermatogenesis Effects 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000013589 supplement Substances 0.000 description 1
230000001629 suppression Effects 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
210000002435 tendon Anatomy 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 1
206010043554 thrombocytopenia Diseases 0.000 description 1
230000000451 tissue damage Effects 0.000 description 1
231100000827 tissue damage Toxicity 0.000 description 1
230000009772 tissue formation Effects 0.000 description 1
230000008467 tissue growth Effects 0.000 description 1
208000037816 tissue injury Diseases 0.000 description 1
238000004448 titration Methods 0.000 description 1
239000003440 toxic substance Substances 0.000 description 1
238000013519 translation Methods 0.000 description 1
230000005945 translocation Effects 0.000 description 1
230000032258 transport Effects 0.000 description 1
230000001875 tumorinhibitory effect Effects 0.000 description 1
241000701447 unidentified baculovirus Species 0.000 description 1
241001529453 unidentified herpesvirus Species 0.000 description 1
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
229960005486 vaccine Drugs 0.000 description 1
230000006492 vascular dysfunction Effects 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
230000035899 viability Effects 0.000 description 1
230000009385 viral infection Effects 0.000 description 1
239000013603 viral vector Substances 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
210000005253 yeast cell Anatomy 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

JP9538135A 1996-04-19 1997-04-14 分泌蛋白およびそれらをコードしているポリヌクレオチド Pending JP2000508908A (ja)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US63531196A	1996-04-19	1996-04-19
US08/635,311		1996-04-19
US78122697A	1997-01-10	1997-01-10
US08/781,226		1997-01-10
PCT/US1997/006125 WO1997040151A2 (en)	1996-04-19	1997-04-14	Secreted proteins and polynucleotides encoding them

Publications (1)

Publication Number	Publication Date
JP2000508908A true JP2000508908A (ja)	2000-07-18

Family

ID=27092348

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP9538135A Pending JP2000508908A (ja)	1996-04-19	1997-04-14	分泌蛋白およびそれらをコードしているポリヌクレオチド

Country Status (5)

Country	Link
EP (1)	EP0954577A2 (de)
JP (1)	JP2000508908A (de)
AU (1)	AU2728697A (de)
CA (1)	CA2251934A1 (de)
WO (1)	WO1997040151A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8101349B2 (en)	1997-12-23	2012-01-24	Novartis Vaccines And Diagnostics, Inc.	Gene products differentially expressed in cancerous cells and their methods of use II
MXPA01009491A (es) *	1999-03-25	2002-06-04	Squibb Bristol Myers Co	Moleculas de acido desoxirribonucleico (adn) que codifican para proteinas clax humanas y sus proteinas de fusion solubles.
AU6069300A (en) *	1999-07-02	2001-01-22	Chiron Corporation	Novel human genes and gene expression products
US7939282B2 (en) *	2004-10-21	2011-05-10	Rhode Island Hospital	Methods for detecting sepsis
US7842467B1 (en)	2005-05-12	2010-11-30	Celera Corporation	Breast disease targets and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5536637A (en) *	1993-04-07	1996-07-16	Genetics Institute, Inc.	Method of screening for cDNA encoding novel secreted mammalian proteins in yeast

1997
- 1997-04-14 EP EP97921171A patent/EP0954577A2/de not_active Withdrawn
- 1997-04-14 AU AU27286/97A patent/AU2728697A/en not_active Abandoned
- 1997-04-14 JP JP9538135A patent/JP2000508908A/ja active Pending
- 1997-04-14 WO PCT/US1997/006125 patent/WO1997040151A2/en not_active Ceased
- 1997-04-14 CA CA 2251934 patent/CA2251934A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP0954577A2 (de)	1999-11-10
WO1997040151A3 (en)	1998-02-05
AU2728697A (en)	1997-11-12
CA2251934A1 (en)	1997-10-30
WO1997040151A2 (en)	1997-10-30

Publication	Publication Date	Title
JP2001501460A (ja)	2001-02-06	分泌蛋白およびそれらをコードするポリヌクレオチド
JP2000516815A (ja)	2000-12-19	分泌蛋白およびそれらをコードするポリヌクレオチド
JP2001518793A (ja)	2001-10-16	分泌発現配列タグ（ｓＥＳＴｓ）
JP2002514066A (ja)	2002-05-14	分泌タンパク質およびそれをコードするポリヌクレオチド
JP2001501813A (ja)	2001-02-13	分泌蛋白およびそれらをコードするポリヌクレオチド
JP2002512517A (ja)	2002-04-23	分泌蛋白およびそれらをコードするポリヌクレオチド
JP2001527392A (ja)	2001-12-25	分泌蛋白およびそれらをコードするポリヌクレオチド
JP2000515747A (ja)	2000-11-28	分泌蛋白およびそれらをコードするポリヌクレオチド
JP2002514073A (ja)	2002-05-14	分泌蛋白およびそれらをコードするポリヌクレオチド
JP2000512505A (ja)	2000-09-26	分泌蛋白をコードするポリヌクレオチド
JP2000513930A (ja)	2000-10-24	分泌蛋白をコードするヒト胎児脳からのポリヌクレオチド
JP2001523950A (ja)	2001-11-27	分泌蛋白およびそれらをコードするポリヌクレオチド
JP2000508909A (ja)	2000-07-18	分泌蛋白およびそれらをコードしているポリヌクレオチド
JP2000515726A (ja)	2000-11-28	分泌蛋白をコードする成人ｐｂｍｃ由来のポリヌクレオチド
JP2000508908A (ja)	2000-07-18	分泌蛋白およびそれらをコードしているポリヌクレオチド
JP2001508295A (ja)	2001-06-26	分泌蛋白およびそれらをコードするポリヌクレオチド
JP2001509004A (ja)	2001-07-10	分泌蛋白
JP2001514520A (ja)	2001-09-11	分泌蛋白およびそれらをコードするポリヌクレオチド
JP2002515753A (ja)	2002-05-28	分泌蛋白およびそれらをコードしているポリヌクレオチド
JP2002510312A (ja)	2002-04-02	分泌蛋白
JP2002514058A (ja)	2002-05-14	分泌蛋白およびそれらをコードするポリヌクレオチド
JP2000513572A (ja)	2000-10-17	ヒト樹状細胞由来の分泌蛋白をコードしているポリヌクレオチド
JP2002512503A (ja)	2002-04-23	分泌蛋白およびそれらをコードするポリヌクレオチド
JP2000516816A (ja)	2000-12-19	分泌蛋白およびそれらをコードするポリヌクレオチド
JP2000513931A (ja)	2000-10-24	ヒトｐｂｍｃ由来の分泌蛋白をコードするポリヌクレオチド