JP2000509394A - 細胞膜を横切って物質を輸送するためのポリペプチド結合体 - Google Patents

細胞膜を横切って物質を輸送するためのポリペプチド結合体

Info

Publication number: JP2000509394A
Authority: JP; Japan
Prior art keywords: polypeptide; acid; composition; compound; terminus
Prior art date: 1996-05-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

JP9539221A

Other languages

English (en)

Japanese (ja)

Other versions

JP2000509394A5 (cs

Inventor

イー．サマートン，ジェームス

ディー．ウェラー，ドワイト

Original Assignee

アンティバイラルズインコーポレイテッド

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-01

Filing date

1997-04-30

Publication date

2000-07-25

1997-04-30 Application filed by アンティバイラルズインコーポレイテッド filed Critical アンティバイラルズインコーポレイテッド

2000-07-25 Publication of JP2000509394A publication Critical patent/JP2000509394A/ja

2004-12-09 Publication of JP2000509394A5 publication Critical patent/JP2000509394A5/ja

Status Ceased legal-status Critical Current

Links

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VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
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229960003048 vinblastine Drugs 0.000 description 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP9539221A 1996-05-01 1997-04-30 細胞膜を横切って物質を輸送するためのポリペプチド結合体 Ceased JP2000509394A (ja)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US1634796P	1996-05-01	1996-05-01
US60/016,347		1996-05-01
US2860996P	1996-10-23	1996-10-23
US60/028,609		1996-10-23
PCT/US1997/007335 WO1997040854A2 (en)	1996-05-01	1997-04-30	Polypeptide conjugates for transporting substances across cell membranes

Publications (2)

Publication Number	Publication Date
JP2000509394A true JP2000509394A (ja)	2000-07-25
JP2000509394A5 JP2000509394A5 (cs)	2004-12-09

Family

ID=26688485

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP9539221A Ceased JP2000509394A (ja)	1996-05-01	1997-04-30	細胞膜を横切って物質を輸送するためのポリペプチド結合体

Country Status (5)

Country	Link
EP (1)	EP0966303A2 (cs)
JP (1)	JP2000509394A (cs)
AU (1)	AU729643B2 (cs)
CA (1)	CA2252706A1 (cs)
WO (1)	WO1997040854A2 (cs)

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JP2004523480A (ja) *	2000-08-22	2004-08-05	ニューリバーファーマシューティカルズ，インコーポレイテッド	活性作用物質送達系ならびに活性作用物質の保護および投与方法
JP2005524677A (ja) *	2002-02-22	2005-08-18	ニューリバーファーマシューティカルズインコーポレイテッド	活性物質送達系及び活性物質を保護し投与する方法
JP2010189419A (ja) *	2000-11-14	2010-09-02	Shire Llc	硫酸アバカビルを含有する新規な薬剤化合物および同化合物の製造ならびに使用方法

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KR20080016992A (ko)	2005-03-03	2008-02-25	레반스 테라퓨틱스, 아이엔씨.	올리고펩티드의 국소 적용 및 경피 전달을 위한 조성물 및방법
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JP5932642B2 (ja)	2009-07-02	2016-06-08	アンジオケムインコーポレーテッド	多量体ペプチドコンジュゲートおよびその使用
KR20200133284A (ko)	2010-05-28	2020-11-26	사렙타 쎄러퓨틱스, 인코퍼레이티드	변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체
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1997
- 1997-04-30 JP JP9539221A patent/JP2000509394A/ja not_active Ceased
- 1997-04-30 AU AU29298/97A patent/AU729643B2/en not_active Ceased
- 1997-04-30 CA CA002252706A patent/CA2252706A1/en not_active Abandoned
- 1997-04-30 WO PCT/US1997/007335 patent/WO1997040854A2/en not_active Ceased
- 1997-04-30 EP EP97923513A patent/EP0966303A2/en not_active Withdrawn

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Publication number	Priority date	Publication date	Assignee	Title
JP2004523480A (ja) *	2000-08-22	2004-08-05	ニューリバーファーマシューティカルズ，インコーポレイテッド	活性作用物質送達系ならびに活性作用物質の保護および投与方法
JP2010189419A (ja) *	2000-11-14	2010-09-02	Shire Llc	硫酸アバカビルを含有する新規な薬剤化合物および同化合物の製造ならびに使用方法
JP2005524677A (ja) *	2002-02-22	2005-08-18	ニューリバーファーマシューティカルズインコーポレイテッド	活性物質送達系及び活性物質を保護し投与する方法

Also Published As

Publication number	Publication date
EP0966303A2 (en)	1999-12-29
WO1997040854A3 (en)	1998-03-12
AU2929897A (en)	1997-11-19
CA2252706A1 (en)	1997-11-06
WO1997040854A2 (en)	1997-11-06
AU729643B2 (en)	2001-02-08

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JP2000509394A - 細胞膜を横切って物質を輸送するためのポリペプチド結合体 - Google Patents

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