|
US5786158A
(en)
*
|
1992-04-30 |
1998-07-28 |
Yale University |
Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
|
|
US20050112121A1
(en)
*
|
1992-04-30 |
2005-05-26 |
Yale University |
Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
|
|
US20030225019A1
(en)
*
|
2002-05-30 |
2003-12-04 |
Freier Susan M. |
Notch1 inhibitors for inducing apoptosis
|
|
EP0861261B9
(en)
*
|
1995-06-28 |
2010-02-24 |
Imperial Cancer Research Technology Limited |
Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
|
|
US20050158859A1
(en)
*
|
1995-09-29 |
2005-07-21 |
Yale University |
Manipulation of non-terminally differentiated cells using the Notch pathway
|
|
US5780300A
(en)
*
|
1995-09-29 |
1998-07-14 |
Yale University |
Manipulation of non-terminally differentiated cells using the notch pathway
|
|
HUP9904567A3
(en)
|
1996-06-20 |
2001-10-29 |
Univ Texas |
Use of azo, thioalkyl, thiocarbonyl derivatives substituted by fused heterocycles and/or phenyl group for the preparation of pharmaceutical compositions stimulating bone growth
|
|
CZ295997B6
(cs)
*
|
1996-11-07 |
2005-12-14 |
Lorantis Limited |
Farmaceutický prostředek s obsahem ligandu Notch a způsob tvorby T-buněk
|
|
US6887475B1
(en)
|
1996-11-07 |
2005-05-03 |
Lorantis Limited |
Notch
|
|
US20060122373A1
(en)
*
|
1997-04-04 |
2006-06-08 |
Millennium Pharmaceuticals, Inc. |
Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
|
|
US6121045A
(en)
*
|
1997-04-04 |
2000-09-19 |
Millennium Biotherapeutics, Inc. |
Human Delta3 nucleic acid molecules
|
|
US6136952A
(en)
|
1997-06-25 |
2000-10-24 |
University Of Washington |
Human jagged polypeptide, encoding nucleic acids and methods of use
|
|
US6692919B1
(en)
|
1997-07-23 |
2004-02-17 |
Yale University |
Activated forms of notch and methods based thereon
|
|
US6436650B1
(en)
|
1997-07-23 |
2002-08-20 |
Yale University |
Activated forms of notch and methods based thereon
|
|
SE9802264D0
(sv)
|
1998-06-25 |
1998-06-25 |
Neuronova Ab |
A method of isolating cells
|
|
US6541247B1
(en)
|
1998-06-25 |
2003-04-01 |
Neuronova Ab |
Method of isolating ependymal neural stem cells
|
|
AU768269B2
(en)
*
|
1998-10-02 |
2003-12-04 |
Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The |
Apoptosis inducing agents and methods
|
|
GB9824045D0
(en)
*
|
1998-11-03 |
1998-12-30 |
European Molecular Biology Lab Embl |
Regulator protein
|
|
WO2001003743A1
(en)
*
|
1999-07-12 |
2001-01-18 |
Walter Gehring |
Manipulation of tissue or organ type using the notch pathway
|
|
US8084258B2
(en)
|
1999-07-12 |
2011-12-27 |
University Of Basel |
Manipulation of tissue of organ type using the notch pathway
|
|
US6720173B1
(en)
|
1999-11-08 |
2004-04-13 |
Lexicon Genetics Incorporated |
Human kinase protein and polynucleotides encoding the same
|
|
US7575921B2
(en)
*
|
1999-12-30 |
2009-08-18 |
Vbi Technologies, L.L.C. |
Spore-like cells and uses thereof
|
|
US7560275B2
(en)
*
|
1999-12-30 |
2009-07-14 |
Vbi Technologies, L.L.C. |
Compositions and methods for generating skin
|
|
WO2001053503A1
(en)
*
|
2000-01-18 |
2001-07-26 |
Cornell Research Foundation, Inc. |
Neural progenitor cells from hippocampal tissue and a method for isolating and purifying them
|
|
US7037493B2
(en)
|
2000-05-01 |
2006-05-02 |
Cornell Research Foundation, Inc. |
Method of inducing neuronal production in the brain and spinal cord
|
|
US7303769B2
(en)
*
|
2000-06-05 |
2007-12-04 |
University Of South Florida |
Method for purifying pluri-differentiated mesenchymal progenitor cells
|
|
US7442390B2
(en)
*
|
2000-06-05 |
2008-10-28 |
University Of South Florida |
Method for enhancing engraftment of cells using mesenchymal progenitor cells
|
|
US6936281B2
(en)
*
|
2001-03-21 |
2005-08-30 |
University Of South Florida |
Human mesenchymal progenitor cell
|
|
WO2001094541A2
(en)
*
|
2000-06-05 |
2001-12-13 |
University Of South Florida |
Human mesenchymal progenitor cell
|
|
US6984522B2
(en)
*
|
2000-08-03 |
2006-01-10 |
Regents Of The University Of Michigan |
Isolation and use of solid tumor stem cells
|
|
US8044259B2
(en)
|
2000-08-03 |
2011-10-25 |
The Regents Of The University Of Michigan |
Determining the capability of a test compound to affect solid tumor stem cells
|
|
GB0019242D0
(en)
*
|
2000-08-04 |
2000-09-27 |
Lorantis Ltd |
Assay
|
|
AU2001284160A1
(en)
*
|
2000-08-19 |
2002-03-04 |
Axordia Limited |
Modulation of stem cell differentiation
|
|
AU2001288628A1
(en)
*
|
2000-08-31 |
2002-03-13 |
Loyola University Chicago |
Method and reagents for treatment of skin disorders by modulating the notch pathway
|
|
US7399633B2
(en)
*
|
2000-10-27 |
2008-07-15 |
Fred Hutchinson Cancer Research Center |
Methods for immortalizing cells
|
|
US20020151050A1
(en)
*
|
2000-10-30 |
2002-10-17 |
Vacanti Charles A. |
Isolation of spore-like cells from tissues exposed to extreme conditions
|
|
US6458588B1
(en)
|
2001-01-31 |
2002-10-01 |
The General Hospital Corporation |
Renal stem cells and uses thereof
|
|
EP1383867A2
(en)
*
|
2001-03-23 |
2004-01-28 |
Axordia Limited |
Stem cell differentiation
|
|
WO2002078449A2
(en)
*
|
2001-04-02 |
2002-10-10 |
Advanced Cell Technology, Inc. |
Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells
|
|
CN1513148A
(zh)
*
|
2001-05-29 |
2004-07-14 |
���µ�����ҵ��ʽ���� |
烹调实绩管理方法、内容管理方法、服务器和烹调设备
|
|
AU2002315337A1
(en)
*
|
2001-06-18 |
2003-01-02 |
Psychiatric Genomics, Inc. |
Method for neural stem cell differentiation using valproate
|
|
US7132287B2
(en)
*
|
2001-06-18 |
2006-11-07 |
Psychiatric Genomics, Inc. |
Method for neural stem cell differentiation using 5HT-1A agonists
|
|
US20050239064A1
(en)
*
|
2001-06-18 |
2005-10-27 |
Spyridon Artavanis-Tsakonas |
Methods and compositions based on protein interactions with mastermind
|
|
WO2003011317A1
(en)
*
|
2001-07-25 |
2003-02-13 |
Lorantis Limited |
Modulators of notch signalling for use in immunotherapy
|
|
US7452532B2
(en)
*
|
2001-09-30 |
2008-11-18 |
Scicotec Gmbh |
Transluminal application of adult stem cells for body organ tissue repair
|
|
US20030119080A1
(en)
*
|
2001-10-15 |
2003-06-26 |
Mangano Joseph A. |
Strategies for the identification and isolation of cancer stem cells and non-cancerous stem cells
|
|
CA2469204A1
(en)
*
|
2001-12-07 |
2003-06-19 |
Regents Of The University Of Michigan |
Prospective identification and characterization of breast cancer stem cells
|
|
DK1479767T3
(da)
*
|
2002-02-06 |
2013-11-25 |
Sanbio Inc |
Fremgangsmåde til differentiering/inducering af stromaceller fra knoglemarv til nerveceller ved overføring af Notch-gen
|
|
WO2003070189A2
(en)
*
|
2002-02-15 |
2003-08-28 |
Cornell Research Foundation, Inc. |
Enhancing neurotrophin-induced neurogenesis by endogenous neural progenitor cells by concurrent overexpression of brain derived neurotrophic factor and an inhibitor of a pro-gliogenic bone morphogenetic protein
|
|
US20050124572A1
(en)
*
|
2002-06-17 |
2005-06-09 |
Freier Susan M. |
Compositions and their uses directed to signal tranducers
|
|
US20040102390A1
(en)
*
|
2002-11-21 |
2004-05-27 |
Isis Pharmaceuticals Inc. |
Modulation of Notch3 expression
|
|
US20040101847A1
(en)
*
|
2002-11-22 |
2004-05-27 |
Isis Pharmaceuticals Inc. |
Modulation of Notch2 expression
|
|
US20040028661A1
(en)
*
|
2002-08-07 |
2004-02-12 |
Bartelmez Stephen H. |
Expansion of cells using thrombopoietin and anti-transforming growth factor-beta
|
|
EP1639090A4
(en)
*
|
2003-06-09 |
2008-04-16 |
Univ Michigan |
COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER
|
|
US8029984B2
(en)
*
|
2003-08-08 |
2011-10-04 |
Licentia, Ltd. |
Materials and methods for colorectal cancer screening, diagnosis and therapy
|
|
US7897384B2
(en)
*
|
2003-09-08 |
2011-03-01 |
Ethicon, Inc. |
Chondrocyte therapeutic delivery system
|
|
US7927599B2
(en)
*
|
2003-09-08 |
2011-04-19 |
Ethicon, Inc. |
Chondrocyte therapeutic delivery system
|
|
US8257963B2
(en)
*
|
2007-06-01 |
2012-09-04 |
Depuy Mitek, Inc. |
Chondrocyte container and method of use
|
|
AU2005209909B8
(en)
*
|
2004-02-03 |
2009-01-15 |
The Regents Of The University Of Michigan |
Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
|
|
US7837993B2
(en)
*
|
2004-03-19 |
2010-11-23 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for regeneration of aged skeletal muscle tissues
|
|
PT1855700E
(pt)
*
|
2005-03-07 |
2013-12-10 |
Sanbio Inc |
Utilização de materiais para tratamento de lesões do sistema nervoso central
|
|
US20060252073A1
(en)
*
|
2005-04-18 |
2006-11-09 |
Regents Of The University Of Michigan |
Compositions and methods for the treatment of cancer
|
|
EP1907858A4
(en)
*
|
2005-06-13 |
2009-04-08 |
Univ Michigan |
COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER
|
|
WO2006135886A2
(en)
*
|
2005-06-13 |
2006-12-21 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
WO2007030693A2
(en)
*
|
2005-09-08 |
2007-03-15 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Methods for promoting stem cell proliferation and survival
|
|
JP5129149B2
(ja)
|
2005-10-31 |
2013-01-23 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
癌を処置および診断するための組成物および方法
|
|
DK2500360T3
(en)
|
2005-10-31 |
2015-10-26 |
Oncomed Pharm Inc |
Compositions and methods for the diagnosis and treatment of cancer
|
|
US7723477B2
(en)
|
2005-10-31 |
2010-05-25 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
|
|
WO2008121102A2
(en)
*
|
2006-02-21 |
2008-10-09 |
The Regents Of The University Of Michigan |
Hedgehog signaling pathway antagonist cancer treatment
|
|
EP2081962B1
(en)
|
2006-10-19 |
2018-10-03 |
Genentech, Inc. |
Novel anti-notch3 antibodies and their use in the detection and diagnosis of disease
|
|
AR063494A1
(es)
*
|
2006-10-19 |
2009-01-28 |
Genentech Inc |
Anticuerpos agonistas anti notch3 y su uso en el tratamiento de las enfermedades relacionadas con el gen notch3
|
|
JP5386364B2
(ja)
*
|
2006-12-18 |
2014-01-15 |
ジェネンテック， インコーポレイテッド |
抗Ｎｏｔｃｈ３アンタゴニスト抗体とＮｏｔｃｈ３関連疾患の予防及び治療におけるその使用
|
|
WO2008092002A2
(en)
|
2007-01-24 |
2008-07-31 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing pancreatic cancer
|
|
PE20090321A1
(es)
|
2007-06-04 |
2009-04-20 |
Genentech Inc |
Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
|
|
AU2008289209A1
(en)
*
|
2007-08-16 |
2009-02-26 |
The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services |
Methods for promoting stem cell proliferation and survival
|
|
CN103002911B
(zh)
|
2008-09-26 |
2015-08-26 |
昂考梅德药品有限公司 |
卷曲蛋白结合药剂及其应用
|
|
PE20120080A1
(es)
*
|
2008-10-01 |
2012-02-17 |
Genentech Inc |
Anticuerpos anti-notch2 y metodos de uso
|
|
US20100125265A1
(en)
*
|
2008-11-20 |
2010-05-20 |
Medtronic Vascular, Inc. |
Cell Delivery System to Induce Cell Growth and Angiogenesis
|
|
JP2013510577A
(ja)
|
2009-11-12 |
2013-03-28 |
ブイビーアイ テクノロジーズ， エルエルシー |
胞子様細胞の亜集団およびその用途
|
|
WO2011063237A2
(en)
|
2009-11-19 |
2011-05-26 |
Oncomed Pharmaceuticals, Inc. |
Jagged-binding agents and uses thereof
|
|
TWI535445B
(zh)
|
2010-01-12 |
2016-06-01 |
安可美德藥物股份有限公司 |
Ｗｎｔ拮抗劑及治療和篩選方法
|
|
CA2794674A1
(en)
|
2010-04-01 |
2011-10-06 |
Oncomed Pharmaceuticals, Inc. |
Frizzled-binding agents and uses thereof
|
|
US20130095080A1
(en)
|
2010-04-09 |
2013-04-18 |
Fred Hutchinson Cancer Reserach Center |
Compositions and methods for providing hematopoietic function
|
|
US20130095079A1
(en)
|
2010-04-09 |
2013-04-18 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for providing hematopoietic function without hla matching
|
|
EP2596119B8
(en)
|
2010-07-23 |
2021-06-02 |
Astellas Institute for Regenerative Medicine |
Methods for detection of rare subpopulations of cells and highly purified compositions of cells
|
|
JP2011019520A
(ja)
*
|
2010-08-13 |
2011-02-03 |
Walter Gehring |
Ｎｏｔｃｈ経路を用いた組織型または器官型の操作
|
|
EP2625264B1
(en)
|
2010-10-08 |
2022-12-07 |
Terumo BCT, Inc. |
Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
|
|
CA2858069C
(en)
|
2011-12-08 |
2020-02-11 |
Novartis Ag |
Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
|
|
WO2013188851A1
(en)
*
|
2012-06-14 |
2013-12-19 |
Fred Hutchinson Cancer Research Center |
Ex vivo expansion of myogenic stem cells by notch activation
|
|
WO2014066328A1
(en)
|
2012-10-23 |
2014-05-01 |
Oncomed Pharmaceuticals, Inc. |
Methods of treating neuroendocrine tumors using wnt pathway-binding agents
|
|
EP2943566A1
(en)
|
2013-01-08 |
2015-11-18 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for expansion of embryonic hematopoietic stem cells
|
|
JP2016510411A
(ja)
|
2013-02-04 |
2016-04-07 |
オンコメッド ファーマシューティカルズ インコーポレイテッド |
Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング
|
|
US9168300B2
(en)
|
2013-03-14 |
2015-10-27 |
Oncomed Pharmaceuticals, Inc. |
MET-binding agents and uses thereof
|
|
WO2015004762A1
(ja)
*
|
2013-07-10 |
2015-01-15 |
株式会社日立製作所 |
細胞培養方法、装置、及び細胞シート
|
|
MX389160B
(es)
|
2013-10-31 |
2025-03-20 |
Hutchinson Fred Cancer Res |
Células no t efectoras y madre/progenitoras hematopoyéticas modificadas y usos de estas.
|
|
JP6633522B2
(ja)
|
2013-11-16 |
2020-01-22 |
テルモ ビーシーティー、インコーポレーテッド |
バイオリアクターにおける細胞増殖
|
|
WO2015148704A1
(en)
|
2014-03-25 |
2015-10-01 |
Terumo Bct, Inc. |
Passive replacement of media
|
|
BR112016028537A2
(pt)
*
|
2014-06-04 |
2017-08-22 |
Hutchinson Fred Cancer Res |
expansão e enxerto de células-tronco utilizando agonistas de notch 1 e/ou de notch 2
|
|
US20160090569A1
(en)
|
2014-09-26 |
2016-03-31 |
Terumo Bct, Inc. |
Scheduled Feed
|
|
AU2016211671B2
(en)
|
2015-01-26 |
2022-05-26 |
Fate Therapeutics, Inc. |
Methods and compositions for inducing hematopoietic cell differentiation
|
|
WO2016138034A1
(en)
*
|
2015-02-24 |
2016-09-01 |
The Regents Of The University Of California |
Binding-triggered transcriptional switches and methods of use thereof
|
|
WO2016176651A2
(en)
|
2015-04-29 |
2016-11-03 |
Fred Hutchinson Cancer Research Center |
Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof
|
|
EP3288570A4
(en)
|
2015-04-29 |
2018-11-21 |
Fred Hutchinson Cancer Research Center |
Modified stem cells and uses thereof
|
|
WO2017004592A1
(en)
|
2015-07-02 |
2017-01-05 |
Terumo Bct, Inc. |
Cell growth with mechanical stimuli
|
|
CA3003152A1
(en)
|
2015-11-04 |
2017-05-11 |
Fate Therapeutics, Inc. |
Methods and compositions for inducing hematopoietic cell differentiation
|
|
JP6928604B2
(ja)
|
2015-11-04 |
2021-09-01 |
フェイト セラピューティクス，インコーポレイテッド |
万能性細胞のゲノム改変
|
|
MX2018006828A
(es)
|
2015-12-04 |
2018-08-09 |
Hutchinson Fred Cancer Res |
Usos de poblaciones expandidas de celulas madre/progenitoras hematopoyeticas.
|
|
WO2017193059A1
(en)
|
2016-05-06 |
2017-11-09 |
The Regents Of The University Of California |
Systems and methods for targeting cancer cells
|
|
JP7034949B2
(ja)
|
2016-05-25 |
2022-03-14 |
テルモ ビーシーティー、インコーポレーテッド |
細胞の増殖
|
|
US11104874B2
(en)
|
2016-06-07 |
2021-08-31 |
Terumo Bct, Inc. |
Coating a bioreactor
|
|
US11685883B2
(en)
|
2016-06-07 |
2023-06-27 |
Terumo Bct, Inc. |
Methods and systems for coating a cell growth surface
|
|
JP7500195B2
(ja)
|
2016-08-23 |
2024-06-17 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法
|
|
US10767164B2
(en)
|
2017-03-30 |
2020-09-08 |
The Research Foundation For The State University Of New York |
Microenvironments for self-assembly of islet organoids from stem cells differentiation
|
|
US11624046B2
(en)
|
2017-03-31 |
2023-04-11 |
Terumo Bct, Inc. |
Cell expansion
|
|
CN117247899A
(zh)
|
2017-03-31 |
2023-12-19 |
泰尔茂比司特公司 |
细胞扩增
|
|
US12234441B2
(en)
|
2017-03-31 |
2025-02-25 |
Terumo Bct, Inc. |
Cell expansion
|
|
CN110055275A
(zh)
*
|
2018-01-19 |
2019-07-26 |
科济生物医药（上海）有限公司 |
一种质粒载体对、其修饰的免疫细胞及其应用
|
|
BR112021003830A2
(pt)
|
2018-08-28 |
2021-07-20 |
Fred Hutchinson Cancer Research Center |
métodos e composições para terapia celular t adotiva incorporando sinalização notch induzida
|
|
EP3849565A4
(en)
|
2018-09-12 |
2022-12-28 |
Fred Hutchinson Cancer Research Center |
REDUCTION OF CD33 EXPRESSION TO SELECTIVELY PROTECT THERAPEUTIC CELLS
|
|
GB2619893A
(en)
|
2021-03-23 |
2023-12-20 |
Terumo Bct Inc |
Cell capture and expansion
|
|
EP4476331A2
(en)
|
2022-02-07 |
2024-12-18 |
Ensoma, Inc. |
Inhibitor-resistant mgmt modifications and modification of mgmt-encoding nucleic acids
|
|
US12152699B2
(en)
|
2022-02-28 |
2024-11-26 |
Terumo Bct, Inc. |
Multiple-tube pinch valve assembly
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CN115925925B
(zh)
*
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2022-08-23 |
2024-02-06 |
江苏芯超生物科技(集团)有限公司 |
一种诱导脐带间充质干细胞分化并生产细胞因子的方法
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USD1099116S1
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2022-09-01 |
2025-10-21 |
Terumo Bct, Inc. |
Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device
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