JP2002523091A - 異種ｇタンパク質共役受容体の機能を改変する方法 - Google Patents

異種ｇタンパク質共役受容体の機能を改変する方法

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Publication number
JP2002523091A
JP2002523091A JP2000567692A JP2000567692A JP2002523091A JP 2002523091 A JP2002523091 A JP 2002523091A JP 2000567692 A JP2000567692 A JP 2000567692A JP 2000567692 A JP2000567692 A JP 2000567692A JP 2002523091 A JP2002523091 A JP 2002523091A
Authority
JP
Japan
Prior art keywords
receptor
protein
nucleic acid
host cell
coupled receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2000567692A
Other languages
English (en)
Japanese (ja)
Inventor
マーク、ヘンリー、ポウシュ
ユルゲン、ウェス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of JP2002523091A publication Critical patent/JP2002523091A/ja
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2000567692A 1998-09-01 1999-09-01 異種ｇタンパク質共役受容体の機能を改変する方法 Withdrawn JP2002523091A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9870498P 1998-09-01 1998-09-01
US60/098,704 1998-09-01
PCT/US1999/020013 WO2000012705A2 (en) 1998-09-01 1999-09-01 Methods for improving the function of heterologous g protein-coupled receptors

Publications (1)

Publication Number Publication Date
JP2002523091A true JP2002523091A (ja) 2002-07-30

Family

ID=22270543

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000567692A Withdrawn JP2002523091A (ja) 1998-09-01 1999-09-01 異種ｇタンパク質共役受容体の機能を改変する方法
JP2000567691A Withdrawn JP2002523090A (ja) 1998-09-01 1999-09-01 異種ｇタンパク質共役受容体の増強された機能的発現

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2000567691A Withdrawn JP2002523090A (ja) 1998-09-01 1999-09-01 異種ｇタンパク質共役受容体の増強された機能的発現

Country Status (5)

Country Link
EP (2) EP1123391A2 (de)
JP (2) JP2002523091A (de)
AU (2) AU5700999A (de)
CA (2) CA2344591A1 (de)
WO (2) WO2000012705A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528271B1 (en) 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
US5891646A (en) 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
US7541151B2 (en) 1997-06-05 2009-06-02 Duke University Single-cell biosensor for the measurement of GPCR ligands in a test sample
NZ521696A (en) * 2000-04-24 2004-06-25 Wyeth Corp Transgenic animal models for diseases that are regulated by G-protein signalling
CA2426859A1 (en) * 2000-10-26 2002-05-02 The University Of British Columbia A functional assay for g-protein-coupled receptors based on insect cells
EP1331228B1 (de) * 2000-11-01 2007-03-21 Astellas Pharma Inc. VERFAHREN ZUM SCREENEN EINES PLäTTCHENHEMMERS
US7163800B2 (en) 2000-11-03 2007-01-16 Molecular Devices Corporation Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity
US7018812B2 (en) 2000-11-03 2006-03-28 Duke University Modified G-protein coupled receptors
DE10056899A1 (de) 2000-11-16 2002-05-29 Aventis Pharma Gmbh Promotor zur funktionellen Charakterisierung von G-Protein gekoppelten Rezeptoren in der Hefe Saccharomyces cerevisiae
AU2002228844A1 (en) * 2000-12-06 2002-06-18 Deltagen, Inc. Transgenic mice containing targeted gene disruptions
GB0030038D0 (en) * 2000-12-08 2001-01-24 Univ Warwick Yeast-based assay
US7279324B2 (en) 2001-01-23 2007-10-09 Duke University Nucleic acid encoding G-protein coupled receptor with modified DRY motif
EP1336655A1 (de) * 2002-01-12 2003-08-20 Aventis Pharma Deutschland GmbH Verfahren zur Identifikation von konstitutiv aktiven Mutanten
DE10233516A1 (de) * 2002-07-23 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Identifizierung von Substanzen
WO2006104254A1 (ja) * 2005-03-29 2006-10-05 Bio-Energy Corporation レセプター結合性物質のスクリーニング方法
US8354241B2 (en) 2005-04-27 2013-01-15 Arena Pharmaceuticals, Inc. Methods for identifying a GLP-1 secretagogue
AU2006264649A1 (en) 2005-06-30 2007-01-11 Prosidion Limited GPCR agonists
NZ571110A (en) 2006-04-11 2011-03-31 Arena Pharm Inc Methods of using GPR119 receptor to identify Glucose-dependent Insulinotropic Peptide (GIP) secretagogue compounds useful for increasing bone mass in an individual
CL2008000018A1 (es) 2007-01-04 2008-08-01 Prosidion Ltd Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci
EP2114933B1 (de) 2007-01-04 2011-09-07 Prosidion Ltd Piperidin-gpcr-agonisten
PE20081849A1 (es) 2007-01-04 2009-01-26 Prosidion Ltd Derivados de piperidin-4-il-propoxi-benzamida como agonistas de gpcr
GB2456236B8 (en) * 2007-03-22 2009-12-09 Heptares Therapeutics Ltd Stable muscarinic receptor mutants
JP2010539152A (ja) 2007-09-10 2010-12-16 プロシディオン・リミテッド 代謝障害の治療のための化合物
GB0720390D0 (en) 2007-10-18 2007-11-28 Prosidion Ltd G-Protein coupled receptor agonists
GB0720389D0 (en) 2007-10-18 2008-11-12 Prosidion Ltd G-Protein Coupled Receptor Agonists
EP2146210A1 (de) 2008-04-07 2010-01-20 Arena Pharmaceuticals, Inc. Verfahren zur Verwendung eines AG-Protein-gekoppelten Rezeptors zur Identifikation von Peptid-YY (PPY)-Sekretagogen sowie Verbindungen zur Behandlung durch PYY modulierter Leiden
GB0904285D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
GB0904284D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
GB0904287D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
JP7422498B2 (ja) * 2019-07-25 2024-01-26 芳武 村山 ペプチド、細胞遊走抑制剤、細胞浸潤抑制剤、がん細胞転移抑制剤、及び医薬

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5691188A (en) * 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
CA2193809A1 (en) * 1994-06-29 1996-01-11 Catherine D. Strader Modified g-protein coupled receptors
US6255089B1 (en) * 1997-02-27 2001-07-03 Albany Medical College Constitutively activated serotonin receptors

Also Published As

Publication number Publication date
AU5701199A (en) 2000-03-21
WO2000012704A9 (en) 2000-06-08
AU756244B2 (en) 2003-01-09
WO2000012704A3 (en) 2000-11-30
JP2002523090A (ja) 2002-07-30
WO2000012704A2 (en) 2000-03-09
CA2344591A1 (en) 2000-03-09
WO2000012705A9 (en) 2000-07-13
WO2000012705A3 (en) 2000-10-05
EP1123391A2 (de) 2001-08-16
CA2343046A1 (en) 2000-03-09
EP1112359A2 (de) 2001-07-04
WO2000012705A2 (en) 2000-03-09
AU5700999A (en) 2000-03-21

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Effective date: 20061107