JP2003105371A - Perfume composition for promoting desire of defecation, and perfume-providing article - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a perfume composition for promoting desire of defecation. SOLUTION: This perfume composition for promoting the desire of the defecation contains at least one essential oil selected from the group consisting of a Pogostemon cablin oil, a jasmine oil, a sandalwood oil, a basil oil, a Melissa officinalis L oil, a juniper oil, a lavender oil and a clove oil. The perfume- providing article includes the perfume composition. The desire of the defecation is promoted and the defecation is urged by the perfume composition or the perfume-providing article.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a fragrance composition for promoting stool containing a specific essential oil, and a fragrance product containing the fragrance composition.

[0002]

2. Description of the Related Art In recent years, aromatherapy is awakening, sleep, appetite suppression, appetite promotion, anti-smoking, anti-emetics by rubbing, spraying, inhaling, chewing and the like of an aroma preparation (mainly natural essential oil).
It is attracting attention because it can provide anti-syncope, aphrodisiac, and asexuality effects. And, as the essential oils having an excitatory or wakeful action, hakka, eucalyptus, lemon, salvia, thyme, clove, rosemary, hyssop, etc. are known. Essential oils that have a sedative effect include aloe, chamomile,
Salvia, jasmine, neroli, rose, bergamot, camphor, geranium, sandalwood, ylang-ylang, lavender, hakka, melissa, basil, patchouli, juniper, sage, lemon, eucalyptus and thyme are known.

As described above, many people have long talked about the influence of fragrance on psychology, but in each case, each person felt it individually.
It is used to write and tell legends, and there is hardly anything proved by the methods of modern science. Therefore, as seen in the above-mentioned empirical classification, there is an imbalance that is classified into sedation and excitement such as lemon, almonds, eucalyptus, and thyme.

Recently, changes in eating habits, lack of exercise,
As social stress increases, many people are suffering from constipation. Constipation is particularly common among women, and there are great expectations for its elimination. The mainstream methods of relieving constipation are improving eating habits, preventing light exercise, and treating with drugs. However, it is apt to be shunned by modern people who are busy because it is necessary to continue to improve their eating habits and light exercise every day, and the drug is currently used only in the case of very severe constipation.

Essential oils effective for constipation include black pepper,
Camouflage, rose, marjoram, hyssop oil and rosemary oil are known [practical aromatherapy (Shirley Price, translated by Rintaro Takayama, Fragrance Journal), theory and practice of aromatherapy (aromatherapy) (Robert Tiss) Written by Rand, translated by Ryotaro Takayama, Fragrance Journal).

However, although these essential oils are effective for alleviating constipation symptoms, they maintain a healthy bowel habit and
It is not effective in preventing constipation, such as reducing the number of bowel movements.

[0007]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a fragrance composition that promotes stool and a scented product containing the fragrance composition.

[0008]

Means for Solving the Problems The inventors of the present invention have made extensive studies in view of the above-mentioned problems of the prior art, and as a result, the aroma of a specific essential oil enhances the defecation and further the activity of the digestive tract. The inventors have found that they are promoted and have completed the present invention.
The terms “promotion of defecation” and “improvement of defecation” include meanings such as inducing defecation, strengthening weak defecation, and maintaining a healthy defecation.

That is, the present invention provides the following fragrance composition and fragrance product. Item 1. A scent-accelerating fragrance composition comprising at least one essential oil selected from the group consisting of patchouli oil, jasmine oil, sandalwood oil, basil oil, melissa oil, juniper oil, lavender oil and clove oil. Item 2. A scented product for promoting bowel movement, which comprises the fragrance composition according to Item 1.

[0010]

DETAILED DESCRIPTION OF THE INVENTION The fragrance composition of the present invention comprises at least one selected from the group consisting of patchouli oil, jasmine oil, sandalwood oil, basil oil, melissa oil, juniper oil, lavender oil and clove oil. A fragrance composition containing essential oils for promoting stools. The essential oils listed here are not particularly limited, but briefly described below.

Patchouli oil is, for example, Pogostemon cablin Benth. It can be obtained by steam distillation of leaves and is used as a fragrance for cosmetics or soaps [Hiroshi Kameoka, Chemistry of Essential Oils, 89 (1990), Yukabo].

Jasmine oil is, for example, Jasminum officinale belonging to the family Oleaceae.
L. ) And Taiwan Sokei (Jasminum o)
ficinale L. var. grandiflo
It can be obtained as an absolute by treating the concrete obtained by solvent extraction of the (rum) flower with alcohol. This essential oil is used as a high-grade flavoring agent or a flavoring agent for foods [Hiroshi Kameoka, Chemistry of Essential Oils,
139 (1990), Zenkabo].

[0013] Sandalwood oil is usually Santalum album from East India and E from Australia.
ucarya spicata (or Santalu
mspicatum), Santalum lance
olatum, Eremophila mitchel
Li or East African Osyris tenuif
It can be obtained by chopping wood such as olia and roots and steam-distilling. This essential oil is one of the important ingredients as a fragrance material.
98 (1989), Asakura Shoten].

Basil oil can be obtained, for example, by steam-distilling flowers or whole plants of the perilla family (Ocimum basilicum L.), and is used as a flavor of food and also as a flavoring agent for soaps. [Hiroshi Kameoka, Chemistry of Essential Oils, 90 (1990), Yukabo].

Melissa oil is, for example, M which belongs to Lamiaceae.
It can be obtained by steam distillation of stems or leaves of Elissa officinalis Linne and is used for beverages [Food and Perfumery Handbook, edited by Japan Perfume Industry Association, 383 (1990), Food Chemistry Newspaper].

The juniper oil can be obtained, for example, by steam-distilling the fruit of Juniperus communis L. In addition, this fruit of Euglena is used for flavoring during the production of a gin-type alcoholic beverage, and at that time, juniper oil can be obtained as a by-product. This essential oil is used as a flavor for fragrances, Western liquors, mouth refreshers, etc. [edited by the Japan Fragrance Association, Encyclopedia of Scents, 214 (19)
89), Asakura Shoten].

Lavender oil is, for example, Lav of the Labiatae family.
andula officinalis Chaix.
It can be obtained by steam distillation of flowers and is used as a fragrance for cosmetics such as perfume, lotion, cologne or soap [Hiroshi Kameoka, Chemistry of Essential Oils, 92 (1990), Yukabo].

Clove oil is, for example, a flower bud of Eugenia caryophyllata (or Syzygium aromaticicum), which belongs to the family Myrtaceae,
Can be obtained by steam distillation of flower stems, leaves or twigs,
In addition to mixed fragrances for cosmetics, flavors or pharmaceuticals,
It is also used as a source of synthetic raw materials [Aroma Encyclopedia, 165 (1989), edited by Japan Perfumery Association].

These essential oils may be used alone or 2
You may mix and use 1 or more types. Further, the fragrance composition of the present invention, even if consisting only of the above essential oil,
Components other than the above-mentioned essential oil may be contained within the range where the effect of the present invention is exhibited. As the components other than the essential oil, for example, bases, additives and the like used in perfume compositions can be widely used. When the essential oil and other components are contained, the content of the essential oil is not particularly limited as long as the effects of the present invention are exhibited, but is, for example, 0.1 to 99% (w
/ W).

The fragrance composition of the present invention can be used in various forms. For example, the perfume composition according to the invention can be used in the form of perfume products. The scented product refers to a product or the like which contains the fragrance composition of the present invention for the purpose of scenting, or contains the fragrance composition of the present invention and generates a scent as a result. Examples of the scented products include fragrances, cosmetics, inhalants, textile detergents, foods and the like. Preferred are fragrances, cosmetics, inhalants, and foods, and more preferred are fragrances and cosmetics.

Examples of the fragrance include those conventionally used as fragrances for indoor use, toilet use, automobile use, entrance use, bathroom use, closet use, closet use and the like. Various forms of the fragrance may be used, such as a solid form, a semi-solid form (jelly form, gel form, etc.), a liquid form, and an aerosol form.

In addition to cosmetics, perfumes and cosmetics also include living body cleaners such as soaps and bath agents. Specific examples of the cosmetics include cream, milky lotion, makeup powder, body lotion, hair conditioner, hair wash, soap, body soap, antiperspirant, shampoo, rinse, perfume, lotion, toothpaste, liquid toothpaste. , Mouthwash, mouse pet, sunscreen, kitchen detergent, massage oil, massage cream, skin care oil and the like. In the case of toothpaste, liquid toothpaste, mouthwash, mouthwash, etc., the aroma is inhaled via the mouth.

The inhaled administration agent refers to those which generate aroma in the vicinity of the nose by spraying or volatilization of aroma components and intentionally inhale the aroma, and examples thereof include nasal drops, sprays and inhalants. .

The food includes, for example, the flavor composition of the present invention and is ingested for the purpose of promoting defecation. In order to obtain the effect of aroma efficiently, the one that stays in the mouth for a relatively long time and is inhaled via the mouth, or the one that inhales before entering the mouth, such as tea or flavoring Is preferred. Specific examples include gum, tea, candy, flavoring agents, spices, gummies, yogurt, ice cream and the like. Jasmine tea, basil powder and the like are also included in the food of the present invention as long as they generate the essential oil of the present invention and achieve the enhancement of stool.

Examples of detergents for textile products include anionic, cationic, nonionic or zwitterionic detergents, fabric softeners, fabric softener products, dryer fabric softener products and the like. To be

The content of the fragrance composition of the present invention in the above scented product is not particularly limited, but is, for example, 0.1 to 100% (w / w) in terms of the essential oils listed above. However, since the effect of the fragrance composition of the present invention is affected by age, sex, psychological condition, physical condition, individual difference, etc., the fragrance composition containing less than 0.1 (w / w)% is added. Fragrance products or cosmetics may be used.

The administration of the inhalation administration agent of the present invention is not particularly limited, but it is 5 to 60 seconds per administration and 1 to 1 day per day.
It is preferable to perform 10 times.

In addition to the perfume composition of the present invention, the fragrance may contain components such as bases and additives that have been conventionally used for fragrances. As a base for an aromatic agent, those which are in the form of solid, liquid, semi-solid (jelly, gel, etc.), aerosol, etc. are generally used. For example, water,
Ethanol, solid or liquid anionic, cationic,
Examples thereof include nonionic active agents, polymer agents, oils and fats, guar gum, xanthan gum, gum arabic, gellan gum, carrageenan, gelatin, agar and the like. Furthermore, it can be used in a product form in which a holding carrier such as a solid polymer (for example, polystyrene or polypropylene) or calcium silicate is impregnated.

In addition to the perfume composition of the present invention, the cosmetics may contain components such as bases and additives that have been conventionally used in cosmetics. The base is not particularly limited, and examples thereof include water, ethanol, talc, gelatin and the like. The additive is not particularly limited, and examples thereof include moisturizers, skin softeners, antiseptics, and solubilizers.

When the perfume is a perfume, the perfume composition according to the present invention is used as it is without any addition, or the perfume composition of the present invention is dissolved in alcohol (eg ethyl alcohol) or aqueous alcohol. It can be used as it is. The perfume contains the fragrance composition of the present invention in an amount of 0.1 to 99% by weight in terms of the essential oils listed above. The mixing ratio of water and alcohol is from 50:50 to 0 :.
The range is 100. The colon can contain solubilizers, softeners, humectanes, thickeners, bacteriostats, or other materials commonly used in cosmetics. Using a normal perfuming means, the perfume composition of the present invention is further added with a perfume component to be modulated, and the final perfume, middle note, and base note are appropriately added by adding retention and richness. Can be combined with to prepare a formulation that gives off an attractive aroma over time.

In addition to the perfume composition of the present invention, the inhalation administration preparation may contain components such as bases and additives that have been conventionally used for inhalation administration preparations. Also, when a gas for inhalation is used, the gas used in the conventional inhalation administration agent can be used.

In the detergent for textile products, in addition to the fragrance composition of the present invention, other components conventionally used in detergents for textile products can be used.

[0033]

The effect of the invention is to use at least one essential oil selected from the group consisting of patchouli oil, jasmine oil, sandalwood oil, basil oil, melissa oil, juniper oil, lavender oil and clove oil as a fragrance. Is improved and bowel movements are encouraged. Therefore, the composition of the present invention is effective for those who want to improve diminished bowel movements and those who want to maintain healthy bowel movements.

[0034]

Examples Example 1 The number of feces excreted in 24 hours was measured for each of eight Wistar male rats when exposed to the essential oil prepared for the test and when not exposed. Also, the appearance of those stools was observed. Furthermore, the stools were collected, dried and weighed.

The test essential oils and mixed essential oils were prepared as follows. That is, as a single essential oil, clove oil (trade name: clove hyper), patchouli oil (trade name: patchouli oil), jasmine oil (trade name: Jasmine Absolute Comoros), sandalwood oil (trade name: sandalwood oil), basil Oil (Brand Name: Basil Oil), Melissa Oil (Brand Name: Melissa Oil (Glass), Juniper Oil (Brand Name: Juniper Berry Oil), Lavender Oil (Brand Name: Lavender Oil), Ylang Ylang Oil (Brand Name: Iran) Iran Bourbon), cardamom oil (trade name:
Cardamom oil) and rosemary oil (trade name: rosemary oil) were mixed with dipropylene glycol at 5% (w / w). All of these essential oils were purchased from Ogawa Koryo Co., Ltd.

As a mixed essential oil, a mixed essential oil consisting of basil oil, melissa oil and juniper oil is mixed with dipropylene glycol so that the concentration of each essential oil is 2.5% (w / w). Prepared.

100 μg of the essential oil-containing dipropylene glycol thus prepared was added to an odor paper (7 mm × 5).
0 mm, manufactured by Dai-ichi Yakuhin Sangyo Co., Ltd.), and the odor paper was placed in a glass bottle with a lid in which a certain area was opened in the lid. This glass bottle was placed in a certain place in a rat breeding cage, and the rat was allowed to naturally inhale the odor emitted by the odor paper for 24 hours. Further, an untreated test was conducted in the same manner as the exposure test except that the odor paper impregnated with the essential oil and dipropylene glycol was used instead of the odor paper impregnated with the dipropylene glycol containing the essential oil. The results are shown in Table 1. On the appearance, no diarrhea or loose stool was observed. The number of stools was 1 in comparison with the case of no treatment.
The number of individuals increased by 0% or more, II indicates the number of individuals whose stool number increased by 5% or more and less than 10%, and III indicates that the number of stools was untreated. The number of individuals increased by less than 5% and the number of individuals decreased compared to the case are shown.
The effective rate was calculated from the following formula.

(I individual number + II individual number) / 8 × 10
0

[0039]

[Table 1]

Example 2 The effect of essential oils on the gastrointestinal motility was tested by the blue dextran method using male ddy mice. The specific test method is as follows.

The mice were exposed to the essential oil prepared for the test. That is, dipropylene glycol containing 5% (w / w) of patchouli oil was prepared, and 500 μg of this essential oil-containing dipropylene glycol was added to odor paper (7 mm × 15).
0 mm) was impregnated, and the odor paper was placed in a glass bottle with a lid in which a certain area of the lid was perforated. This glass bottle was placed in a fixed place in a mouse breeding cage, and 8 rats were allowed to naturally inhale the scent of odor paper.

15 minutes after natural inhalation, 0.4 ml of a 2% blue dextran aqueous solution was orally administered. Blue dextran is manufactured by SIGMA. Twenty minutes after oral administration, the mouse was sacrificed by cervical dislocation, the abdomen was opened immediately, and the digestive tract was taken out. The length from the gastric pylorus to the ileocecal region and the most distal part where blue dextran was transported from the gastropylorus Was measured. Gastrointestinal motility (average value of 8 bodies) was defined as the ratio of the length from the gastric pylorus to the ileocecal region to the length of the most distal part where blue dextran was carried from the gastropylorus to The effects of not giving it were compared.

An untreated test was conducted in the same manner as the exposure test, except that an odor paper impregnated with neither essential oil nor dipropylene glycol was used in place of the odor paper impregnated with dipropylene glycol containing essential oil.

The results are shown in Table 2. It was confirmed that the essential oil treatment promoted digestive tract motility.

[0045]

[Table 2]

Example 3 A perfumed product containing the perfume composition of the present invention shown in the following formulation example was prepared.

Formulation Example 1: Liquid fragrance

[0048]

[Table 3]

Formulation 2: Gel fragrance

[0050]

[Table 4]

Prescription Example 3: Aromatic aerosol

[0052]

[Table 5]

Formulation Example 4: Fragrance to be impregnated in unglazed

[0054]

[Table 6]

A carrier (special calcium silicate (Tokuyama, Fluorite RM-90)) was impregnated with a mixture of essential oil and isoparaffin and placed in a bisque-fired container.

Formulation Example 5: Liquid fragrance for inhalation

[0057]

[Table 7]

Prescription example 6: Massage oil

[0059]

[Table 8]

Prescription Example 7: Massage cream

[0061]

[Table 9]

Prescription example 8: candy

[0063]

[Table 10]

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 35/78 A61K 35/78 QW C11D 3/50 C11D 3/50 (72) Inventor Hideki Shiragin Osaka Prefecture 1-30-3 Toyokawa, Ibaraki City Kobayashi Pharmaceutical Co., Ltd. F-term in Central Research Laboratory (reference) 4B018 LB01 MD48 ME11 MF01 4B047 LB03 LE02 LF09 LG12 4C088 AB12 AB38 AB57 AB64 AC01 BA08 MA07 MA59 NA05 NA14 ZA81 4H003 DA01 DA02 DA06 DA17 FA26 4H059. BC23 DA09 EA40

Claims (2)

[Claims] 1. A scent-promoting fragrance composition containing at least one essential oil selected from the group consisting of patchouli oil, jasmine oil, sandalwood oil, basil oil, melissa oil, juniper oil, lavender oil and clove oil. object. 2. A scented product for stool promotion, which comprises the fragrance composition according to claim 1.