JP2003192526A - Cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an antiaging cosmetic comprising ingredients (A) one or more kinds selected from vegetable extracts having promoting actions on collagen formation and (B) a fish-derived collagen. <P>SOLUTION: This antiaging cosmetic comprises the vegetable extracts having the promoting actions on the collagen formation and a solution of the fish- derived collagen. The resultant cosmetic has excellent stability and exhibits excellent effects on the skin. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an anti-aging cosmetic having an effect of suppressing skin aging.

[0002]

2. Description of the Related Art Skin aging characterized by wrinkle and tarmi is due to a decrease in collagen production of fibroblasts, a decrease in hyaluronic acid synthesis, an increase in collagenase activity due to ultraviolet rays, and a damage due to active oxygen generated from ultraviolet rays and the environment. Is believed to be. Retinol, retinoic acid and the like are used to improve such wrinkles and tarmi. In addition, collagen, plant extracts and the like having a collagen production promoting action are also used.

[0003]

Retinol, retinoic acid and the like have been used to improve wrinkles and tarmi, but they also have strong side effects. In addition, collagen, a plant extract, etc. having a collagen production promoting action are used. However, since each of them has only a weak effect, when they are individually added to cosmetics or the like, sufficient anti-aging, that is, wrinkles The effect of suppressing tarmi was not obtained.

Therefore, it has been desired to develop a highly safe cosmetic composition which has an excellent effect of improving wrinkles and tarmi without side effects.

[0005]

[Means for Solving the Problems] Due to such circumstances,
As a result of intensive studies aimed at suppressing skin aging, the present inventors have found that one or more selected from plant extracts having a collagen production-promoting effect and the content of fish-derived collagen have an excellent skin aging suppression effect. Heading to show,
The present invention has been completed.

That is, the present invention relates to the following components (A) and (B); (A) one or more selected from plant extracts having a collagen production promoting action, and (B) a skin containing fish-derived collagen. It is an anti-aging cosmetic.

The plant extract of the component (A) used in the present invention is not particularly limited as long as it has a collagen production promoting effect, but preferably, kerave, sanbiroto, chemkus, marjoram, peach leaf, tonin, licorice leaf, Examples thereof include olive leaf, goldfish, gentina, hemlock, sponge root, and fuchsonia amiji.

The solvent to be extracted is, for example, water, lower alcohols (methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, etc.), liquid polyhydric alcohol (glycerin, propylene glycol, 1). , 3-butylene glycol, etc.), ketones (acetone, methyl ethyl ketone, etc.), acetonitrile, esters (ethyl acetate, butyl acetate, etc.), hydrocarbons (hexane, heptane, liquid paraffin, etc.), ethers (ethyl ether, propyl, etc.) Ether, tetrahydrofuran, etc.). Water, lower alcohols and liquid polyhydric alcohols are preferable, and water, ethanol, propylene glycol and 1,3-butylene glycol are particularly preferable. These solvents may be used alone or in combination of two or more.

The extracted solutions may be used as they are, or if necessary, they may be subjected to treatments such as concentration, dilution and filtration, and decolorization and deodorization treatment with activated carbon before use. Furthermore, the extracted solution may be concentrated to dryness, spray-dried, freeze-dried and the like and used as a dried product.

The amount of component (A) used in the present invention is not particularly limited, but is preferably 0.0001% by weight in terms of solid content based on the total amount of the cosmetic of the present invention.
The above is preferable, and 0.0005 to 10% by weight is more preferable. If it is less than 0.0001% by weight, it is difficult to exert a sufficient effect. When it is blended in an amount of more than 10% by weight, the effect is not enhanced so much and it is uneconomical. Regarding the method of addition, it may be added in advance or may be added during the production,
It may be selected as appropriate in consideration of workability.

Among these, the component (A) is used alone or in combination of two or more in the cosmetic of the present invention.

The component (B) used in the present invention, which is derived from fish, is not particularly limited, and examples thereof include washing, degreasing, acid filtration, enzyme treatment, and salt folding of skins such as salmon, gold eye bream, codfish, and flounder. The soluble collagen component is extracted through a means such as dialysis, heat treatment, etc., and then obtained. These are generally commercially available as a fish-derived collagen solution and used as a raw material for cosmetics. It may or may not be subjected to an atherotization treatment or a hydrolysis treatment.

The solution may be used as it is, and if necessary,
Concentration, dilution, filtration, etc. and decolorization with activated carbon, etc.
It may be used after being deodorized. Furthermore, the extracted solution may be concentrated to dryness, spray-dried, freeze-dried and the like and used as a dried product.

The blending amount of the component (B) used in the present invention is not particularly limited, but is preferably 0.0001% by weight or more in terms of solid content based on the total amount of the cosmetic of the present invention, and more preferably. Is preferably 0.00001 to 10% by weight. If it is less than 0.00001% by weight, it is difficult to exert a sufficient effect. When it is blended in an amount of more than 10% by weight, the effect is not enhanced so much and it is uneconomical. Regarding the method of addition, it may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability.

As the component (B), one kind or two or more kinds of them are blended in the cosmetic of the present invention.

Oils, waxes, hydrocarbons, fatty acids, which are components used in ordinary cosmetics and quasi drugs, within a range that does not impair the effects of the components (A) and (B).
Alcohols, esters, surfactants, metal soaps, pH
Conditioner, antiseptic, fragrance, moisturizer, powder, UV absorber,
Ingredients such as a thickener, a pigment, an antioxidant, a whitening agent, and a chelating agent can also be added.

The cosmetic of the present invention can be used in both cosmetics and quasi-drugs.
Examples thereof include lotions, creams, emulsions, gels, aerosols, essences, packs, detergents, bath agents, foundations, dusters, lipsticks and the like.

[0018]

EFFECT OF THE INVENTION The cosmetic composition of the present invention has an excellent effect of improving wrinkles and tarmi and an effect of suppressing skin aging.

[0019]

EXAMPLES In order to explain the present invention in detail, examples of production of extracts used in the present invention, prescription examples of the present invention and experimental examples will be given below, but the present invention is not limited thereto. Absent. The parts of the compounding amounts shown in the examples are parts by weight, and% is% by weight.

Production Example 1 Hot water extract of tonin To 400 g of purified water was added to 20 g of dried tonin.
After extracting at 95 to 100 ° C. for 2 hours, the mixture was filtered, and the filtrate was concentrated and freeze-dried to obtain 1.2 g of a hot water extract.

Production Example 2 Ethanol Extract of Kerabe 900 mL of ethanol was added to 100 g of dried matter of Kerabe, and the mixture was extracted at room temperature for 7 days, filtered, and the filtrate was concentrated to dryness to give an ethanol extract of 1. 5 g was obtained.

Production Example 3 Aqueous extract of 1,3-butylene glycol aqueous solution of peach leaf, 1 kg of purified water and 1 kg per 100 g of dried peach leaf.
1,3-butylene glycol was added, and the mixture was extracted at room temperature for 7 days and then filtered to obtain 1.9 g of a 1,3-butylene glycol aqueous solution extract.

Production Example 4 Acid-Soluble Atelolated Collagen Solution Salmon skin is washed, defatted, acid-treated, membrane-filtered, salted-out and dialyzed to obtain an acid-soluble collagen solution. For example, an “acid-soluble atelocollagen collagen solution” (Ihara Suisan: dry residue 1%) can be mentioned.

Production Example 5 Water-Soluble Collagen Solution An acid-soluble collagen solution is obtained through washing treatment, degreasing, acid treatment, membrane filtration, enzyme treatment, salting out, isoelectric focusing and dialysis. For example, "water-soluble collagen solution" (manufactured by Technoble: dry residue 1%) can be mentioned.

Production Example 6 Cattle-derived atelolated collagen solution Cowhide is washed, defatted, acid-treated, membrane-filtered, enzyme-treated, salted-out, isoelectrically precipitated and dialyzed to obtain an acid-soluble collagen solution. For example, an aqueous solution having a dry residue of 1% can be used.

Example 1 Cream 1 formulation Compounding amount 1. Hot water extract of tonin (Production Example 1) 0.05 part 2. Acid-soluble atelo-collagen solution (Production Example 4) 0.1 3. Squalane 5.5 4. Olive oil 3.0 5. Stearic acid 2.0 6. Beeswax 2.0 7. Octyldodecyl myristate 3.5 8. Polyoxyethylene cetyl ether (20 EO) 3.0 9. Behenyl alcohol 1.5 10. Glycerin monostearate 2.5 11. Fragrance 0.1 12.1, 3-butylene glycol 8.5 13. Ethyl paraoxybenzoate 0.05 14. Methyl paraoxybenzoate 0.2 15. [Manufacturing method] The total amount is 100 with purified water. Components 3 to 10 are dissolved by heating and mixed, and 70
Keep at ℃ and use as oil phase. Ingredients 1, 2 and 12-15 are heated and dissolved and mixed, and the mixture is kept at 75 ° C to form an aqueous phase. Add the water phase to the oil phase to emulsify, cool with stirring, add component 11 at 45 ° C, and further cool to 30 ° C to obtain the product.

Comparative Example 1 Conventional Cream 1 A conventional cream 1 was prepared by replacing components 1 and 2 with purified water in Example 1.

Comparative Example 2 Conventional Cream 2 A conventional cream 2 was prepared by replacing the hot water extract of the component 1 in Example 1 with purified water.

Comparative Example 3 Conventional Cream 3 In Example 1, the conventional cream 3 was prepared by replacing the component 2 with purified water.

Example 2 Cosmetic lotion formulation Amount 1. Kerabe ethanol extract (Production Example 2) 0.1 part 2. Acid-soluble atelocollagen collagen solution (Production Example 4) 0.01 3.1,3-butylene glycol 8.0 4. Glycerin 2.0 5. Xanthan gum 0.02 6. Citric acid 0.01 7. Sodium citrate 0.1 8. Ethanol 5.0 9. Methyl paraoxybenzoate 0.1 10. Polyoxyethylene hydrogenated castor oil (40 EO) 0.1 11. Perfume 0.1 12. [Manufacturing method] The total amount is 100 with purified water Components 1 to 7 and 12 and components 8 to 11 are uniformly dissolved, and both are mixed and filtered to obtain a product.

Example 3 Emulsion formulation Compounding amount 1. Kerabe ethanol extract (Production Example 2) 0.5 part 2. Acid soluble atelocollagen collagen solution (Production Example 4) 5.0 3. Squalane 5.0 4. Olive oil 5.0 5. Jojoba oil 5.0 6. Cetanol 1.5 7. Glycerin monostearate 2.0 8. Polyoxyethylene cetyl ether (20 EO) 3.0 9. Polyoxyethylene sorbitan monooleate (20 EO) 2.0 10. Perfume 0.1 11. Propylene glycol 1.0 12. Glycerin 2.0 13. Methyl paraoxybenzoate 0.2 14. [Manufacturing method] The total amount is 100 with purified water. Components 3 to 9 are dissolved by heating and mixed, and the mixture is heated to 70 ° C.
Keep it in the oil phase. Ingredients 1, 2 and 11 to 14 are dissolved by heating and mixed, and the mixture is kept at 75 ° C to form an aqueous phase. The water phase is added to the oil phase to emulsify, and the mixture is cooled with stirring, component 10 is added at 45 ° C, and further cooled to 30 ° C to obtain a product.

[0032]   Example 4 Gel agent Prescription amount 1. Hot water extract of tonin (Production Example 1) 0.1 part 2. Acid-soluble atelo-collagen solution (Production Example 4) 1.0 3. Ethanol 5.0 4. Methyl paraoxybenzoate 0.1 5. Polyoxyethylene hydrogenated castor oil (60EO) 0.1 6. Perfume 0.1 7.1,3-butylene glycol 5.0 8. Glycerin 5.0 9. Xanthan gum 0.1 10. Carboxy vinyl polymer 0.2 11. Potassium hydroxide 0.2 12. Adjust the total volume to 100 with purified water [Production method] Components 1 to 11 are uniformly dissolved to obtain a product.

Example 6 Foundation Formulation Amount 1,3-butylene glycol aqueous solution extract of moon peach leaf (Production Example 3) 1.0 part 2. Acid-soluble atelocollagen solution (Production Example 4) 0.05 3. Stearic acid 2.4 4. Polyoxyethylene sorbitan monostearate (20EO) 1.0 5. Polyoxyethylene cetyl ether (20 EO) 2.0 6. Cetanol 1.0 7. Liquid lanolin 2.0 8. Liquid paraffin 3.0 9. Isopropyl myristate 6.5 10. Butyl paraoxybenzoate 0.1 11. Carboxymethyl cellulose sodium 0.1 12. Bentonite 0.5 13. Propylene glycol 4.0 14. Triethanolamine 1.1 15. Methyl paraoxybenzoate 0.2 16. Titanium dioxide 8.0 17. Talc 4.0 18. Bengal 1.0 19. Yellow iron oxide 2.0 20. Perfume 0.1 21. [Production method] Components 3 to 10 are heated and dissolved in purified water to a total amount of 100 and kept at 80 ° C to form an oil phase. Ingredient 21 is swelled well into ingredient 21, and subsequently ingredients 1, 2 and 12 to 15 are added and mixed uniformly. Components 16 to 19 pulverized and mixed with a pulverizer are added to this, and the mixture is stirred with a homomixer and kept at 75 ° C to form an aqueous phase. Add the oil phase to this water phase while stirring and cool.
Add component 20 at 5 ° C and cool to 30 ° C with stirring to obtain a product.

[0034]   Example 7 Bath agent Prescription amount 1. Extract of a 1,3-butylene glycol aqueous solution of moon peach leaves (Production Example 3)                                                               1.0 copy 2. Water-soluble collagen solution (Production Example 5) 0.1 3. Sodium hydrogen carbonate 50.0 4. Yellow No. 202 (1) 0.1 5. Perfume 0.1 6. Adjust the total amount to 100 with anhydrous sodium sulfate

Next, in order to explain the effects of the present invention in detail, experimental examples will be given.

Experimental Example-1 Effective amount of collagen derived from fish The effective amount of collagen derived from fish against reduction in skin elasticity after ultraviolet irradiation was examined. In the experiment, the back of 6-week-old male mice was irradiated with ultraviolet A waves, and the cream of Comparative Example 1 was applied with or without the hot water extract of tonin and the collagen content varied. Irradiation and application were performed continuously for 30 days, and the skin elasticity was measured after the test was completed.

The results are shown in Table 1. The control shows the elasticity of mouse skin not irradiated with ultraviolet rays. It was effective by adding coltsfoot hot water extract to reduce skin elasticity. The improvement effect of fish-derived collagen depends on its amount,
An excellent effect was shown at 01% or more. However, no enhancement of the effect was observed even if the content was more than 10%.

[0038]

[Table 1]

Experimental Example-2 Collagen production promoting action When 100 μg / mL of the hot water extract of tonin in Production Example-1 was added to cultured skin fibroblasts (NB1RGB), the acid-soluble atelolation in Production Example-4 was added. Collagen solution 1,000
The effect of promoting collagen production was examined in the case of adding μg / mL, in the case of adding both, and in the case of adding both the hot water extract of tonin and the bovine-derived atelocollagen collagen solution of Production Example-6. The amount of promotion of collagen production was evaluated based on the amount of tritium hydroxyproline incorporated, and the ratio was 100 when the amount was not added.

As a result, as shown in Table 2, the collagen production was 150 in the treatment with the hot water extract of tonin.
%, 1 by treatment with acid-soluble atelocollagen solution
20%, and simultaneous treatment of these resulted in an increase of 210%. However, the effect of the hot water extract of tonin was not enhanced by the bovine-derived atelocollagen solution.

[0041]

[Table 2]

Experimental Example-3 Wrinkle and Talmi Improvement Effect Using the cream of Example-1 and the conventional creams of Comparative Examples-1, 2 and 3, 20 women (25 to 25) suffering from skin wrinkles and fine wrinkles. A 40-year-old subject was subjected to a usage test for one month. After use, the effect of improving skin scalp and fine wrinkles was evaluated by self-report.

As a result, as shown in Tables 3 and 4, cosmetics characterized by containing a hot water extract of tonin and an acid-soluble atelolated collagen solution showed an excellent effect of improving wrinkles and tarmi.

[0044]

[Table 3]

[0045]

[Table 4]

The cosmetics obtained in Examples 2 to 7 all showed a sufficient effect of improving wrinkles and tarmi.

[0047]

From the above, the present invention of the present invention comprises one or more of the following components (A) and (B); (A) a plant extract having a collagen production promoting action,
(B) The anti-aging cosmetic composition characterized by containing fish-derived collagen was excellent in stability and showed an excellent effect on the skin.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 7/021 A61K 7/021 7/48 7/48 7/50 7/50 (72) Inventor Makoto Akaza Statement 2-7 Torimicho, Nishi-ku, Nagoya-shi Japan Menard Cosmetics Co., Ltd. Research Institute (72) Inventor Jun Sato 2-7, Torimi-cho, Nishi-ku, Nagoya-shi Japan Menard Cosmetics Research Institute (72) Inventor Tomonori Katata Nishi-ku, Nagoya-shi 2-7 Torimicho Japan Menard Cosmetics Co., Ltd. Research Center F-term (reference) 4C083 AA071 AA072 AA082 AA111 AA112 AA122 AB032 AB232 AB242 AB312 AB352 AB432 AC022 AC072 AC102 AC122 AC182 AC242 AC302 AC332 AC352 AC392 AC402 AC422 AC432 AC442 AC482 AC542 AC842 AC842 AD352 AD431 AD432 BB51 CC02 CC04 CC12 CC25 DD27 DD31 DD41 EE11 EE12

Claims (7)

[Claims] 1. Cosmetics comprising (B) fish-derived collagen and (A) and (B); (A) one or more selected from plant extracts having a collagen production promoting action. Fee 2. A cosmetic according to claim 1, which is an anti-aging cosmetic containing the component according to claim 1. 3. The method according to claim 1, which has an effect of promoting collagen production.
Or 2 cosmetics 4. The amount of component (A) is 0.000 as solid content.
5-10% by weight, amount of component (B) 0.00001-10
% Of cosmetics according to claim 1 or 3. 5. The component (A) is one or more selected from kerab, sanbiroto, chemkus, marjoram, moon peach leaf, tounin, licorice leaf, olive leaf, goldfish, gentina, gentianm, spongeflower, fuchsonia amiji. 4 cosmetics 6. The cosmetics according to claims 1 to 5, wherein the component (A) is selected from keraba, peach leaf and tonin. 7. The cosmetic composition according to claim 1, wherein the component (B) is an acid-soluble atelocollagen collagen solution or a water-soluble collagen solution.