JP2005225769A5 - - Google Patents

Description

The present invention relates to an external composition for skin , and more particularly, to an external composition for skin suitable for gel cosmetics having a moisturizing action.

Gel preparations using aqueous polymers are applied to various cosmetics such as basic cosmetics and makeup cosmetics because of their fresh feeling. In particular, it has been widely applied to cosmetics intended for young people with oily skin because of its property of containing almost no oil component. In such a formulation, as the gelling agent in the aqueous employed widely used those acrylic, as the aqueous gelling agent of the acrylic acid, carboxyvinyl polymer, alkyl acrylate acrylic acid Copolymers, alkyl methacrylate / methacrylic acid copolymers, alkyl acrylate / acrylic acid crosspolymers and salts thereof are used. The gel structure produced by such an aqueous gelling agent itself contains a lot of moisture, so that it has moderate water retention, but it has almost no occlusive property compared to cosmetics containing oily ingredients. Therefore, there was a problem in maintaining water retention. That is, there has been a demand for a preparation that maintains a moisturizing action for a long time in an aqueous gel cosmetic.

A component of the aqueous, as a component which is excellent in moisture retention, trehalose, sulfuric trehalose and salts thereof, 1,3-glucans, heparinoid, urea, hyaluronic acid and its salts that are known (e.g., Patent Document 1 Patent Document 2, Patent Document 3, Patent Document 4, Patent Document 5, and Patent Document 6 ). However, among these, 1) a carboxyvinyl polymer and / or a salt thereof which may have an alkyl group having 10 to 30 carbon atoms or a crosslinked structure, and 2) be sulfated. There is no combination of good trehalose and / or its salt with 3) a water-absorbing polymer, nor is there any disclosure or suggestion that such a combination can provide excellent moisture retention. As a technique for obtaining a moisturizing gel by combining two or more kinds of copolymers, a technique for combining two kinds of acrylic acid copolymers is already known ( see, for example, Patent Document 7, Patent Document 8, and Patent Document 9). ), also have an alkyl group having 10 to 30 carbon atoms, and good carboxyvinyl polymer and / or a salt thereof have a crosslinked structure, combining a water-absorbing polymer is disclosed or suggested also been Not.

JP 2000-143547 A Japanese Patent Laid-Open No. 05-230313 Japanese translation of PCT publication No. 2003-503316 Japanese Patent Laid-Open No. 2002-47168 Japanese Patent Laid-Open No. 06-145037 JP 2001-131015 A JP 2002-212047 A Japanese Patent Laid-Open No. 2002-212052 JP 2000-327516 A

This invention is made | formed under such a condition, and makes it a subject to provide the aqueous | water-based gel-form skin external composition which is excellent in the maintenance property of a moisturizing effect.

In view of such a situation, the results of such a situation have been made, and as a result of intensive research efforts to find an aqueous gel-like external composition for skin having excellent moisturizing effect, 1) carbon 2) Carboxyvinyl polymer and / or its salt which may have an alkyl group of several tens to 30 or may have a crosslinked structure 2) Trehalose and / or its salt which may be sulfated 3) The inventors have found that an external composition for skin containing a water-absorbing polymer has such characteristics, and has completed the invention. That is, this invention relates to the technique shown below.
(1) 1) Carboxyvinyl polymer and / or its salt which may have a C10-30 alkyl group or a crosslinked structure, and 2) Trehalose which may be sulfated and / or Or the salt and 3) Water-absorbing polymer, The composition for external use of the skin characterized by the above-mentioned.
(2) The external composition for skin according to (1), which is a gel preparation.
(3) The external composition for skin according to (1) or (2), which is a cosmetic .
(4) The external composition for skin according to (1) or (2), further comprising 0.01 to 0.1% by mass of dipotassium glycyrrhizinate.
(5) The external composition for skin according to (4), wherein the composition is a quasi-drug that promotes anti-inflammatory action.

ADVANTAGE OF THE INVENTION According to this invention, the aqueous gel-form skin external composition which is excellent in the maintenance property of a moisturizing effect can be provided.

(1) Carboxyvinyl polymer and / or salt thereof which may have a C10-30 alkyl group, which is an essential component of the composition for external use of the present invention, or may have a crosslinked structure The external composition for skin contains a carboxyvinyl polymer and / or a salt thereof which may have an alkyl group having 10 to 30 carbon atoms or may have a crosslinked structure. Carboxyvinyl polymer is widely used in the field of cosmetics as a gelling agent in a composition for external use on skin, and is “Carbopol” (provided that “Carbopol” is sold by Goodrich). 1382 ”),“ Hibiswako ”series sold by Wako Pure Chemical Industries, Ltd., etc., which can be purchased and used. As a carboxyvinyl polymer having an alkyl group having 10 to 30 carbon atoms and having a crosslinked structure, for example, “Carbopol 1382” (acrylic acid (C10-30) alkyl / methacrylic acid sold by Goodrich Corporation. Crosslinked (crosslinked) copolymer), “Pemlen TR-1” (stearyl acrylate / methacrylic acid crosslinked (crosslinked) copolymer), etc., and carboxyvinyl polymers having an alkyl group are also from Goodrich “Pemlen TR-2” (acrylic acid (C10-30) alkyl / acrylic acid copolymer) and the like are available. Since these are all sold as cosmetic raw materials, they can be purchased and used. Examples of these salts include alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium and magnesium, organic amine salts such as ammonium salt, triethanolamine salt and triethylamine salt, lysine salt and arginine. Preferred examples include basic amino acid salts such as salts. In the composition for external use of the skin of the present invention, the carboxyvinyl polymer which may have these alkyl groups having 10 to 30 carbon atoms or may have a crosslinked structure and / or a salt thereof contains only one kind. It can also be included, and it can also contain it in combination of 2 or more types. In the composition for external use of the skin of the present invention, the preferred content of the carboxyvinyl polymer which may have an alkyl group having 10 to 30 carbon atoms or may have a crosslinked structure and / or a salt thereof is the total amount. And it is 0.05-5 mass% with respect to the skin external composition whole quantity, More preferably, it is 0.1-1 mass%. In the composition for external use of the skin according to the present invention, such a component exhibits an action of constructing a gel structure excellent in water retention.

(2) Water-absorbing polymer and / or salt thereof, which is an essential component of the composition for external use of the present invention
The composition for external skin of the present invention is a composition for external skin containing a carboxyvinyl polymer and / or a salt thereof, which may have an alkyl group having 10 to 30 carbon atoms or may have a crosslinked structure. The water-absorbing polymer and / or salt thereof is contained as an essential component. The water-absorbing polymer that can be used in the present invention is not particularly limited and can be used as long as it has an acrylic acid structure as a main component of the polymer and can contain moisture twice or more of its own weight. Specific examples include, for example, cross-linked polyacrylic acid and / or a salt thereof, polyacrylic acid / starch graft polymer and / or a salt thereof, and these are already commercially available. Among such commercially available products, preferred are Sunfresh ST500DC, ST500MPS, polyacrylic acid / starch graft polymer and / or salt, which are cross-linked polyacrylic acid and / or salt, Sunfresh ST100, ST100MPS, An example is ST100SP. These are all commercially available from Sanyo Chemical Industries. These can be used as a salt at the time of use, or as a free form by an acid or the like. At this time, as long as it is physiologically acceptable as a salt, it can be applied without any particular limitation. For example, an alkali metal salt such as sodium or potassium, or an alkaline earth such as magnesium. Preferred examples include metal salts, ammonium salts, organic amine salts, basic amino acid salts and the like. Further, it is possible to contain only one species, or it is possible to contain two or more species in combination. The total content of these water-absorbing polymers in the external composition for skin of the present invention is preferably 0.01% by mass to 5% by mass, and more preferably 0.02 to 0.5% by mass. In this content, these may have an alkyl group having 10 to 30 carbon atoms or may have a cross-linked structure. Has the effect of maintaining water retention for a long time. That is, if the content of these water-absorbing polymers is too small, the effect cannot be exhibited, and the maintenance time of water retention may be shortened, and if it is too large, it has an alkyl group having 10 to 30 carbon atoms. This is because the stability due to the carboxyvinyl polymer, which may have a crosslinked structure, may be hindered. Further, such a component may have a secondary effect of increasing the salt resistance of the gel structure of the carboxyvinyl polymer salt, which may have a C10-30 alkyl group or a crosslinked structure. .

(3) Trehalose which may be sulfated and / or salt thereof, which is an essential component of the composition for external use of the present invention The composition for external use of skin of the present invention contains sulfated trehalose and / or a salt thereof. Features. Trehalose is originally resurrected and has excellent water retention properties in a dry state. Such sulfation of trehalose may be performed according to a conventional method, and examples thereof include a method of Schweiger RG et al. (See, for example, Schweiger RG, Carbohydrate Reserch 21 219-229 , 1972 ). Hereinafter, the outline for which, for example, N in a nitrogen gas stream, N - advance trehalose swollen in dimethylformamide (DMF), anhydrous sulfuric acid were prepared therefrom separately - was added dropwise DMF complex, 4 hours at room temperature, The reaction is performed at 70 ° C. for about 30 minutes. After neutralization with NaOH, the reaction is precipitated with an organic solvent such as methanol and collected by suction filtration. The precipitate was dissolved in distilled water and then purified by ion chromatography. The degree of substitution of sulfate groups in the obtained sulfated trehalose is determined by conducting an electric conductivity titration method with an aqueous sodium hydroxide solution of an appropriate concentration, and the ratio of the number of moles of sulfate groups to the number of moles of monosaccharides constituting trehalose Express as For example , the sulfuric acid substitution degree of sulfated trehalose obtained by the above method is about 0.05 to 4.0. Moreover, this thing exists as what is marketed as a raw material for cosmetics, and it can also be purchased and utilized. As such a commercially available product, for example, “trehalose S” (manufactured by Hayashibara Laboratories) and the like can be preferably exemplified. Such sulfated trehalose can be used as a salt together with the aforementioned alkali. In the composition for external use of the skin of the present invention, trehalose and / or a salt thereof which may be sulfated may be used alone or in combination of two or more. Such an ingredient has an action of increasing and maintaining the moisture content in the skin in the external composition for skin of the present invention. By combining with the water-absorbing polymer and / or salt thereof, the water gel retains its water retentivity for an extremely long time. The preferable content of such trehalose in the external composition for skin of the present invention is 0.01 to 1% by mass, more preferably 0.02 to 0.1% by mass. This is because if the amount is too small, the above-mentioned effect may not be achieved, and if the amount is too large, a sticky feeling of carbohydrates may appear and the usability may be impaired.

(4) external composition for skin external composition for skin of the Invention The present invention is characterized by containing the essential components, preferably characterized in that a gel formulation of the aqueous. In the composition for external use of the skin of the present invention, in addition to the above-mentioned components, any components that are usually used in cosmetics can be contained within a range not impairing the effects of the present invention. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oils such as hardened oil, mole, hardened castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, waxes, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum , Hydrocarbons such as microcrystalline wax, higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, cetyl alcohol, stearyl alcohol, isostearyl Alcohol, behenyl alcohol, octyldodecanol, higher alcohol such as myristyl alcohol, cetostearyl alcohol, cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate, dimethylpolysiloxane, methylphenylpoly Loxane, linear polysiloxane such as diphenylpolysiloxane, cyclic polysiloxane such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oil such as modified polysiloxane such as fluorine-modified polysiloxane, anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfate, chloride Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride, laurylamine oxide, imidazoline-based amphoteric surfactants (2-cocoyl-2-imida Zolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), amphoteric surfactants such as acylmethyltaurine, sorbitan fatty acid esters (sorbitan) Monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (glyceryl monostearate, etc.), propylene glycol fatty acid esters (propylene glycol monostearate, etc.), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid ester Tells (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonylphenyl) Ethers, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), Nonionic surfactants such as sucrose fatty acid ester and alkyl glucoside, polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene Polyols such as recall, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexylene glycol, 1,2-hexanediol, 1,2-octanediol, pyrrolidone carboxylic acid Moisturizing ingredients such as sodium, lactic acid, sodium lactate, guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, curdlan, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylhydroxypropylcellulose, chondroitin sulfate , Dermatan sulfate, glycogen, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate, hyaluronan Droxyethyl guar gum, carboxymethyl guar gum, dextran, keratosulfuric acid, locust bean gum, succinoglucan, carolinic acid, chitin, chitosan, carboxymethylchitin, agar, polyvinyl alcohol, polyvinylpyrrolidone, sodium polyacrylate, polyethylene glycol, bentonite Thickeners such as mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, barium sulfate, etc. May be treated, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments, surface may be treated, titanium mica, fish phosphorus foil, Pearl agents such as bismuth oxychloride, raked Red 202, Red 228, Red 226, Yellow 4, Blue 404, Yellow 5, Red 505, Red 230, Red 223, Orange 201, Red 213, Yellow 204 No., yellow No. 203, blue No. 1, green No. 201, purple No. 201, red No. 204, organic dyes such as polyethylene powder,
Organic powders such as polymethyl methacrylate, nylon powder, organopolysiloxane elastomer, paraaminobenzoic acid UV absorber, anthranilic acid UV absorber, salicylic acid UV absorber, cinnamic acid UV absorber, benzophenone UV Absorbers, sugar-based ultraviolet absorbers, ultraviolet absorbers such as 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy-4′-t-butyldibenzoylmethane, ethanol, Lower alcohols such as isopropanol, vitamin A or its derivatives, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or its derivatives, vitamin B such as vitamin B12, vitamin B15 or its derivatives, α- Tocopherol, β-tocopherol, γ-tokov Roll, vitamin E such as vitamin E acetate, vitamin D, vitamin H, pantothenic acid, pantethine, and vitamins pyrroloquinoline quinone or the like can preferably be mentioned. The external composition for skin of the present invention can be produced by treating such components according to a conventional method.

The composition for external use of the skin of the present invention can be used according to the purpose to which cosmetics are usually applied, and can take a pharmaceutical dosage form for that purpose. For example, in the case of basic cosmetics intended for skin conditioning, ingredients for skin conditioning can be further added to make quasi drugs, and such a form is particularly preferred. In particular, it is preferable to contain water-soluble active ingredients that are ionized. Since it is not necessary to contain an oily component, it is possible to prevent the aqueous component from being trapped in the oil or the like and not absorbed, and according to the characteristics of the present invention, even if an electrolyte is added, the carboxyvinyl polymers There are two reasons why the gel structure can exist stably. Examples of such components include ascorbic acid and / or a salt thereof, ascorbic acid phosphate and / or a salt thereof, which are melanin production inhibitors, such as glycyrrhizic acid dipotassium salt and glycyrrhetinic acid stearyl sodium salt which are anti-inflammatory components Ascorbic acid glucoside and / or a salt thereof can be suitably exemplified. Such components can contain only one species, but can also contain two or more species. Particularly preferred is a quasi-drug containing dipotassium glycyrrhizinate and appealing for anti-inflammation. The preferable content of such components in the external composition for skin of the present invention is 0.01 to 5% by mass, more preferably 0.02 to 4% by mass, based on the total amount of the external composition for skin. is there. This can be done by legal quantification, in which case the legal indication such as “quasi-drug”, “anti-inflammatory action”, “dipotassium glycyrrhizinate as an anti-inflammatory ingredient” is clearly made, It is preferable to specify a legal dosage dose such as “apply appropriate amount to inflamed place several times a day”. With such a display, it can be clearly distinguished from cosmetics.

<Example 1>
The cosmetic of the present invention was prepared according to the formulation shown below. That is, each of the ingredients of A and B is heated to 80 ° C., solubilized, gradually added to A while stirring under reduced pressure, cooled with stirring, and water gel cosmetic 1 (appealing anti-inflammatory effect) Quasi-drug). Similarly, Comparative Example 1 in which the trehalose of the aqueous gel cosmetic 1 was replaced with “Sunfresh ST100” and Comparative Example 2 in which “Sunfresh ST100” was replaced with trehalose were also prepared. Using these cosmetics, the maintenance of moisture retention was tested. The maintainability of the moisture retention was evaluated by the change over time (5 panelists) of TEWL (transcutaneously dissipated moisture amount; measured by SBC II manufactured by IBS Inc.). In addition, five expert panelists also performed a sensory evaluation of “easy to spread”, which indicates the ease of disintegration of the gel by salt such as sweat during use. “Ease of extension” teeth were scored according to the following evaluation criteria. Score 1: When cosmetics are placed on the skin, the structure breaks down and spreads and is difficult to use. Score 2: When scratching, the structure breaks down and is slightly difficult to use. Score 3: Easy to spread. It was a standard that score 4: the structure was gradually broken and easily extended according to scratching, and score 5: the structure was strong and very easy to extend. These averages are shown in Table 1. From this, it can be seen that the composition for external use of the present invention is excellent in usability and moisture retention.

<Example 3>
In the same manner as in Example 1, an aqueous gel cosmetic 3 as a quasi-drug was prepared. This was also evaluated in the same manner as in Example 1. The results are shown in Table 3. Also here, it can be seen that the external composition for skin of the present invention is excellent in usability and moisture retention. As the sulfated trehalose, “trehalose S” was used.

<Example 4>
In the same manner as in Example 1, an aqueous gel cosmetic 4 which is a quasi-drug was prepared. This was also evaluated in the same manner as in Example 1. The results are shown in Table 4. Also here, it can be seen that the external composition for skin of the present invention is excellent in usability and moisture retention.

<Example 5>
In the same manner as in Example 1, an aqueous gel cosmetic 5 which is a quasi-drug was prepared. This was also evaluated in the same manner as in Example 1. The results are shown in Table 5. Also here, it can be seen that the external composition for skin of the present invention is excellent in usability and moisture retention.

INDUSTRIAL APPLICABILITY The present invention can be applied to an aqueous gel-like external composition for skin having excellent moisture retention and usability.

Claims (5)

1) a carboxyvinyl polymer and / or a salt thereof which may have an alkyl group having 10 to 30 carbon atoms or a crosslinked structure; and 2) trehalose and / or a salt thereof which may be sulfated. And 3) a composition for external use comprising a water-absorbing polymer. The composition for external use on skin according to claim 1, wherein the composition is a gel preparation. The composition for external use on skin according to claim 1 or 2, wherein the composition is a cosmetic . Furthermore, 0.01-0.1 mass% of glycyrrhizic acid dipotassium salt is contained, The external composition for skin of Claim 1 or 2 characterized by the above-mentioned. The composition for external use on skin according to claim 4 , wherein the composition is a quasi-drug that promotes anti-inflammatory action.