JP2005509652A - 蛋白質の瘤 - Google Patents

蛋白質の瘤 Download PDF

Info

Publication number
JP2005509652A
JP2005509652A JP2003542901A JP2003542901A JP2005509652A JP 2005509652 A JP2005509652 A JP 2005509652A JP 2003542901 A JP2003542901 A JP 2003542901A JP 2003542901 A JP2003542901 A JP 2003542901A JP 2005509652 A JP2005509652 A JP 2005509652A
Authority
JP
Japan
Prior art keywords
protein
subunit
knob
cysteine
hcg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003542901A
Other languages
English (en)
Japanese (ja)
Inventor
モイル,ウィリアム,アール
シン,ヨンナ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2005509652A publication Critical patent/JP2005509652A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/59Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2003542901A 2001-11-08 2002-11-08 蛋白質の瘤 Pending JP2005509652A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34528301P 2001-11-08 2001-11-08
PCT/US2002/035914 WO2003040695A2 (en) 2001-11-08 2002-11-08 Protein knobs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007265961A Division JP2008110973A (ja) 2001-11-08 2007-10-11 蛋白質の瘤

Publications (1)

Publication Number Publication Date
JP2005509652A true JP2005509652A (ja) 2005-04-14

Family

ID=23354368

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003542901A Pending JP2005509652A (ja) 2001-11-08 2002-11-08 蛋白質の瘤
JP2007265961A Pending JP2008110973A (ja) 2001-11-08 2007-10-11 蛋白質の瘤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007265961A Pending JP2008110973A (ja) 2001-11-08 2007-10-11 蛋白質の瘤

Country Status (13)

Country Link
EP (1) EP1497634A4 (no)
JP (2) JP2005509652A (no)
KR (1) KR20040063928A (no)
CN (1) CN1596304A (no)
CA (1) CA2466595A1 (no)
EA (1) EA200400647A1 (no)
HR (1) HRP20040242A2 (no)
IL (1) IL161804A0 (no)
MX (1) MXPA04004289A (no)
NO (1) NO20042358L (no)
PL (1) PL373566A1 (no)
WO (1) WO2003040695A2 (no)
ZA (1) ZA200404373B (no)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017508967A (ja) * 2014-03-04 2017-03-30 モロジック・リミテッドMologic Limited アッセイ法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005263555B2 (en) * 2004-07-16 2011-01-27 Amgen Research (Munich) Gmbh Expression-enhanced polypeptides
CN112986571B (zh) * 2019-12-12 2023-04-11 中国科学院大连化学物理研究所 一种鉴定Midkine时空网络相互作用蛋白质的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0578328B1 (en) * 1983-11-02 1999-12-29 Applied Research Systems ARS Holding N.V. Material and methods for the production of a heterodimeric human LH with a Met42 Val55 alpha subunit
ES2098261T3 (es) * 1989-02-21 1997-05-01 Univ Washington Formas modificadas de hormonas reproductoras.
US5166322A (en) * 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
WO1997004080A1 (en) * 1995-07-14 1997-02-06 Fuji Yakuhin Kogyo Kabushiki Kaisha Novel protein and monoclonal antibody specific thereto
US6001354A (en) * 1995-11-17 1999-12-14 Washington University GRB2 associating polypeptides and nucleic acids encoding therefor
US5837837A (en) * 1997-02-27 1998-11-17 Millennium Pharmaceuticals, Inc. Nucleic acids molecules encoding Caspase-8h and Caspase-8i
SI0996629T1 (sl) * 1997-06-25 2006-12-31 Applied Research Systems Analogi glikoproteinskega hormona povezanega z disulfidi, priprava in uporaba

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017508967A (ja) * 2014-03-04 2017-03-30 モロジック・リミテッドMologic Limited アッセイ法

Also Published As

Publication number Publication date
CN1596304A (zh) 2005-03-16
JP2008110973A (ja) 2008-05-15
PL373566A1 (en) 2005-09-05
MXPA04004289A (es) 2005-03-31
WO2003040695A3 (en) 2004-11-11
IL161804A0 (en) 2005-11-20
NO20042358L (no) 2004-08-09
EA200400647A1 (ru) 2004-10-28
CA2466595A1 (en) 2003-05-15
HRP20040242A2 (en) 2005-02-28
KR20040063928A (ko) 2004-07-14
EP1497634A2 (en) 2005-01-19
WO2003040695A2 (en) 2003-05-15
ZA200404373B (en) 2005-11-30
EP1497634A4 (en) 2007-02-07

Similar Documents

Publication Publication Date Title
JP4255618B2 (ja) 単鎖二官能性糖タンパク質ホルモン
JP4387625B2 (ja) Her2に結合する化合物
US5958737A (en) Single-chain β subunit dimers of the glycoprotein hormones and recombinant materials related thereto
US6028177A (en) Methods of detecting single-chain forms of the glycoprotein hormone quartet
JPH07508178A (ja) レセプター活性化
JP4278668B2 (ja) ジスルフィド架橋結合した糖タンパク質ホルモン類似体類およびそれらの調製および使用
Moad et al. Selective CGRP and adrenomedullin peptide binding by tethered RAMP‐calcitonin receptor‐like receptor extracellular domain fusion proteins
EP0725795B1 (en) Single-chain forms of the glycoprotein hormone quartet
Cook et al. Study of a synthetic human olfactory receptor 17-4: expression and purification from an inducible mammalian cell line
JP2008110973A (ja) 蛋白質の瘤
US5883073A (en) Single-chain double-alpha peptide
US7442376B2 (en) Glycoprotein hormone compositions containing two β subunits
CA2394332A1 (en) Chimeric neuropeptide y receptors
US20060177894A1 (en) Protein knobs
JP2009050278A (ja) 糖タンパク質ホルモンカルテットの一本鎖形態
AU2002352567A1 (en) Protein knobs
Xing et al. Use of protein knobs to characterize the position of conserved α-subunit regions in lutropin receptor complexes
Rooney et al. Production of platelet-derived growth factor receptor (PDGFR-β) in E. coli: Mapping ligand binding domain
WO2026010814A1 (en) Methods and reagents for cell-based screening of genetically encoded protein binders
CN116769015A (zh) 一种牛IgG Fc受体boFcγRIII的线性配体结合表位
Oh The structure and function ofhCG and the LH/CG receptor
Fralish Towards an understanding of luteinizing hormone receptor binding
Stevis et al. A glutathione-S-transferase-FSHα subunit hybrid associates with FSHβ, retains biological activity, and facilitates purification

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050928

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20050928

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20050928

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070411

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20070709

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20070717

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20070810

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20070817

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20070910

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20070918

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20071221