JP2006506097A5 - - Google Patents

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Publication number
JP2006506097A5
JP2006506097A5 JP2004570419A JP2004570419A JP2006506097A5 JP 2006506097 A5 JP2006506097 A5 JP 2006506097A5 JP 2004570419 A JP2004570419 A JP 2004570419A JP 2004570419 A JP2004570419 A JP 2004570419A JP 2006506097 A5 JP2006506097 A5 JP 2006506097A5
Authority
JP
Japan
Prior art keywords
polypeptide
conjugate
virus
nucleic acid
host cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004570419A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006506097A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2003/036682 external-priority patent/WO2004046365A2/en
Publication of JP2006506097A publication Critical patent/JP2006506097A/ja
Publication of JP2006506097A5 publication Critical patent/JP2006506097A5/ja
Pending legal-status Critical Current

Links

JP2004570419A 2002-11-18 2003-11-17 インターフェロン−αのポリペプチドおよび結合体 Pending JP2006506097A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42761202P 2002-11-18 2002-11-18
US50256003P 2003-09-12 2003-09-12
PCT/US2003/036682 WO2004046365A2 (en) 2002-11-18 2003-11-17 Interferon-alpha polypeptides and conjugates

Publications (2)

Publication Number Publication Date
JP2006506097A JP2006506097A (ja) 2006-02-23
JP2006506097A5 true JP2006506097A5 (2) 2007-01-11

Family

ID=32329174

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004570419A Pending JP2006506097A (ja) 2002-11-18 2003-11-17 インターフェロン−αのポリペプチドおよび結合体

Country Status (13)

Country Link
US (1) US20040219131A1 (2)
EP (1) EP1565205A4 (2)
JP (1) JP2006506097A (2)
KR (1) KR20050086498A (2)
AU (1) AU2003297285A1 (2)
BR (1) BR0316324A (2)
CA (1) CA2504267A1 (2)
IL (1) IL168049A0 (2)
MX (1) MXPA05005263A (2)
NO (1) NO20052363L (2)
NZ (1) NZ540043A (2)
RU (1) RU2005118998A (2)
WO (1) WO2004046365A2 (2)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2360011A1 (en) 1999-01-05 2000-07-13 Trustees Of Boston University Ordered gene assembly
US7435562B2 (en) 2000-07-21 2008-10-14 Modular Genetics, Inc. Modular vector systems
US7959910B2 (en) * 2000-07-31 2011-06-14 Biolex Therapeutics, Inc. C-terminally truncated interferon alpha variants
DE60332358D1 (de) * 2002-09-09 2010-06-10 Hanall Pharmaceutical Co Ltd Protease-resistente modifizierte interferon alpha polypeptide
JP5207590B2 (ja) 2002-12-26 2013-06-12 マウンテン ビュー ファーマシューティカルズ，インコーポレイテッド 増強された生物学的能力を有するインターフェロン−βのポリマー結合体
GEP20084487B (en) * 2002-12-26 2008-09-25 Mountain View Pharmaceuticals Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof
CA2516552A1 (en) * 2003-02-26 2004-09-10 Intermune, Inc. Polyethylene glycol modified interferon compositions and methods of use thereof
CA2553528C (en) * 2004-01-21 2012-12-04 Nektar Therapeutics Al, Corporation Method of preparing propionic acid-terminated polymers
CN101115769A (zh) * 2004-05-19 2008-01-30 马克西根公司 干扰素-α多肽和偶联物
WO2006004959A2 (en) * 2004-06-30 2006-01-12 Egen Corporation Pegylated interferon alpha-1b
US20060024272A1 (en) * 2004-07-29 2006-02-02 Large Scale Biology Corporation C-terminally truncated interferon
WO2006053131A1 (en) 2004-11-11 2006-05-18 Modular Genetics, Inc. Ladder assembly and system for generating diversity
US9931413B2 (en) * 2005-04-06 2018-04-03 Ibc Pharmaceuticals, Inc. Tetrameric cytokines with improved biological activity
EP1891107B1 (en) * 2005-05-12 2011-07-06 ZymoGenetics, Inc. Compositions and methods for modulating immune responses
EP1888633A4 (en) 2005-05-18 2010-01-27 Maxygen Inc UNFOLDED INTERFERON ALPHA POLYPEPTIDE
US8454948B2 (en) 2006-09-14 2013-06-04 Medgenics Medical Israel Ltd. Long lasting drug formulations
CN102886052B (zh) 2006-09-14 2014-07-30 迈德詹尼克斯医疗以色列有限公司 长效药物制剂
CN1970572A (zh) * 2006-12-21 2007-05-30 北京三元基因工程有限公司 干扰素α突变体及其聚乙二醇衍生物
WO2008124086A2 (en) * 2007-04-05 2008-10-16 President And Fellows Of Harvard College Chimeric activators: quantitatively designed protein therapeutics and uses thereof
US7625555B2 (en) 2007-06-18 2009-12-01 Novagen Holding Corporation Recombinant human interferon-like proteins
CA2802726A1 (en) 2010-06-15 2011-12-22 Medgenics Medical Israel Ltd. Long lasting drug formulations
US20130225789A1 (en) * 2012-02-29 2013-08-29 Yi Sun Polyethylene Glycol Having Hetero Multiple Functional Groups
US20250145680A1 (en) * 2021-08-18 2025-05-08 Remd Biotherapeutics, Inc. Novel interferon variants and bifunctional fusion molecules thereof
CN117417429A (zh) * 2022-07-18 2024-01-19 亚飞（上海）生物医药科技有限公司 肿瘤微环境激活的细胞因子及其应用

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
US6610830B1 (en) * 1980-07-01 2003-08-26 Hoffman-La Roche Inc. Microbial production of mature human leukocyte interferons
US4414150A (en) * 1980-11-10 1983-11-08 Genentech, Inc. Hybrid human leukocyte interferons
US4801685A (en) * 1981-08-14 1989-01-31 Hoffmann-La Roche Inc. Microbial production of mature human leukocyte interferon K and L
US4678751A (en) * 1981-09-25 1987-07-07 Genentech, Inc. Hybrid human leukocyte interferons
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US6936694B1 (en) * 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
EP0205404B1 (en) * 1985-06-11 1992-07-15 Ciba-Geigy Ag Hybrid interferons
US5574138A (en) * 1993-03-08 1996-11-12 Immunex Corporation Epithelium-derived T-cell factor
US6335160B1 (en) * 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
TW517067B (en) * 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
RU2262510C9 (ru) * 1999-05-19 2006-04-20 Лексиген Фармасьютикэлс Корп. Слитый белок, обладающий биологической активностью интерферона-альфа, димерный слитый белок, фармацевтическая композиция, их содержащая, молекула днк (варианты) и способ адресования интерферона-альфа в ткани печени
WO2001025438A2 (en) * 1999-10-07 2001-04-12 Maxygen, Inc. Ifn-alpha homologues
US20020025304A1 (en) * 2000-06-16 2002-02-28 Croze Edward M. Novel interferon for the treatment of multiple sclerosis
WO2002044197A2 (en) * 2000-12-01 2002-06-06 Fish Eleanor N Cytokine receptor binding peptides
ATE337017T1 (de) * 2002-11-15 2006-09-15 Hoffmann La Roche Positionelle isomeren von pegyliertem interferon alpha 2a

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