JP2007509070A - チオフェン化合物 - Google Patents

チオフェン化合物 Download PDF

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Publication number
JP2007509070A
JP2007509070A JP2006535584A JP2006535584A JP2007509070A JP 2007509070 A JP2007509070 A JP 2007509070A JP 2006535584 A JP2006535584 A JP 2006535584A JP 2006535584 A JP2006535584 A JP 2006535584A JP 2007509070 A JP2007509070 A JP 2007509070A
Authority
JP
Japan
Prior art keywords
formula
alkyl
compound
group
het
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006535584A
Other languages
English (en)
Japanese (ja)
Inventor
チェウン，ムイ
エミット，カイル，アレン
Original Assignee
スミスクライン ビーチャム コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by スミスクライン ビーチャム コーポレーション filed Critical スミスクライン ビーチャム コーポレーション
Publication of JP2007509070A publication Critical patent/JP2007509070A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2006535584A 2003-10-16 2004-10-12 チオフェン化合物 Pending JP2007509070A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51199103P 2003-10-16 2003-10-16
PCT/US2004/033585 WO2005037827A1 (fr) 2003-10-16 2004-10-12 Procede de preparation de thiophenes de benzimidazole

Publications (1)

Publication Number Publication Date
JP2007509070A true JP2007509070A (ja) 2007-04-12

Family

ID=34465302

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006535584A Pending JP2007509070A (ja) 2003-10-16 2004-10-12 チオフェン化合物

Country Status (4)

Country Link
US (1) US7465807B2 (fr)
EP (1) EP1685128A1 (fr)
JP (1) JP2007509070A (fr)
WO (1) WO2005037827A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007519720A (ja) * 2004-01-28 2007-07-19 スミスクライン ビーチャム コーポレーション チアゾール化合物

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA014111B1 (ru) 2005-09-06 2010-10-29 Смитклайн Бичем Корпорейшн Бензимидазолтиофеновые соединения в качестве ингибиторов polo-подобных киназ (plk)
MX2008003172A (es) * 2005-09-06 2008-03-18 Smithkline Beecham Corp Proceso regioselectivo para la preparacion de bencimidazol-tiofenos.
EP2474546A1 (fr) 2006-01-23 2012-07-11 Vertex Pharmaceuticals Inc. Tiophène-carboxamides utiles en tant qu'inhibiteurs de kinases de protéine
WO2007120760A2 (fr) 2006-04-13 2007-10-25 Vertex Pharmaceuticals Incorporated Thiophène-carboxamides servant d'inhibiteurs de protéines kinases
WO2007139795A1 (fr) 2006-05-23 2007-12-06 Vertex Pharmaceuticals Incorporated Thiophène-carboxamides inhibiteurs des protéines kinases
WO2007139816A2 (fr) 2006-05-23 2007-12-06 Vertex Pharmaceuticals Incorporated Thiophène-carboxamides pouvant être employés en tant qu'inhibiteurs de protéine kinase
EP2032563B1 (fr) * 2006-06-02 2010-06-02 GlaxoSmithKline LLC Composés de benzimidazole thiophène
EP2100894A1 (fr) 2008-03-12 2009-09-16 4Sc Ag Pyridopyrimidinones utilisés comme inhibiteurs de la kinase de type Plk1 (polo-like kinase)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6218388B1 (en) * 1997-08-20 2001-04-17 Warner-Lambert Company Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8701172A1 (es) * 1985-09-30 1986-11-16 Consejo Superior Investigacion Procedimiento para la preparacion de derivados de 3-hidroxi-5-(1-poliazolil)-2-metoxicarboniltiofenos
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
CA2341409A1 (fr) 1998-08-31 2000-03-09 Merck And Co., Inc. Nouveaux inhibiteurs d'angiogenese
GB0005642D0 (en) 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
BR0313160A (pt) 2002-08-08 2005-07-12 Smithkline Beecham Corp Composto, composição farmacêutica, métodos para tratar uma condição e um neoplasmo suscetìvel em um animal em um animal, processo para preparar um composto e uso de um composto
EP1558599A4 (fr) 2002-10-30 2007-06-27 Merck & Co Inc Modulateurs d'heteroarylpiperidine de l'activite des recepteurs de la chimiokine
GB0402809D0 (en) 2004-02-09 2004-03-10 Glaxo Group Ltd Chemical compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6218388B1 (en) * 1997-08-20 2001-04-17 Warner-Lambert Company Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007519720A (ja) * 2004-01-28 2007-07-19 スミスクライン ビーチャム コーポレーション チアゾール化合物

Also Published As

Publication number Publication date
WO2005037827A1 (fr) 2005-04-28
US20070060576A1 (en) 2007-03-15
EP1685128A1 (fr) 2006-08-02
US7465807B2 (en) 2008-12-16

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