JP2009249366A - Collagen production promotor and anti-aging skin preparation for external use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new collagen production promotor and an anti-aging skin preparation for external use. <P>SOLUTION: This collagen production promotor comprises an extract of Pluchea indica Less of Compositae fanily as an active ingredient, and the anti-aging skin preparation for external use comprises the above collagen production promotor as an active ingredient. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a novel collagen production promoter and an anti-aging skin external preparation containing the promoter as an active ingredient.

  There are various causes of skin aging, and one of them is a decrease in the amount of collagen in the dermis and a decrease in function due to degeneration of the collagen itself. Collagen constitutes the deep dermis of the skin and has the action of giving the skin firmness and suppressing sagging, etc., but the ability to produce collagen in the body decreases due to aging and ultraviolet irradiation, or the collagen itself is denatured The function is reduced, the skin is not firm, wrinkles and sagging occur, and it is recognized as skin aging in appearance. Since collagen is produced by fibroblasts present in the dermis, agents that activate the fibroblasts, such as magnesium ascorbate phosphate (VC-PMg), are effective as an anti-aging skin external preparation. Conventionally used as an ingredient. However, in order to meet the higher demands of the market, it is desired to provide a novel agent exhibiting a superior collagen production promoting action.

On the other hand, since an external preparation for skin is directly applied to the skin, high safety is required for a medicinal agent used as an active ingredient. Therefore, conventionally, the medicinal effects of various plant extracts have been studied. It has been reported that Asteraceae (Pluchea indica Less) has a tyrosinase inhibitory action and the like (Patent Documents 1 to 4). However, an activator action on fibroblasts and a collagen production promoting action have been conventionally used. unknown.
JP 09-087197 A JP-A-11-005975 JP-A-11-106311 JP 2000-095663 A

  An object of the present invention is to provide a novel collagen production promoter having good safety, and an anti-aging skin external preparation containing the promoter as an active ingredient.

As a result of intensive studies by the present inventor, the extract of Asteraceae laevis has a high activation effect on fibroblasts, and further exhibits an excellent collagen production promoting action, and further, the collagen production promoting action is It has been found that even when blended with an external preparation for skin, it can be effectively exhibited, and based on this finding, the present invention has been completed.
That is, the present invention provides a collagen production promoter containing an extract of Asteraceae daisies as an active ingredient and an anti-aging skin external preparation containing the collagen production promoter as an active ingredient in order to solve the above-mentioned problems. .
From another point of view, according to the present invention, there is provided a method of promoting collagen production in the dermis by applying an extract of Asteraceae daisies to the skin (except for a method for human treatment).

  ADVANTAGE OF THE INVENTION According to this invention, the novel collagen production promoter with favorable safety | security and the skin external preparation for anti-aging which contains the said promoter as an active ingredient can be provided.

Hereinafter, the present invention will be described in detail. In the present specification, “to” means a range including numerical values before and after.
TECHNICAL FIELD The present invention relates to a collagen production promoter comprising an extract of Asteraceae daisies (hereinafter sometimes referred to as “a daisies extract”) as an active ingredient. Asteraceae, Hilatagiku, is a plant of the scientific name Pluchea indica Less, called Belantas, inhabiting Java Island and cultivated for food.

  The daisies extract used in the present invention can be prepared by a general method. For example, it may be an extract of any part of the roots, stems, stems, leaves, flowers, etc. of daisies, and an extract obtained from two or more parts may be mixed or used. Two or more kinds of extracts extracted with different solvents from more than one part may be used. Although it does not specifically limit as an extraction solvent, For example, Water; Lower monohydric alcohols, such as methyl alcohol and ethyl alcohol; Liquid polyhydric alcohols, such as glycerol, propylene glycol, and 1, 3- butylene glycol; Ketones, such as acetone; Ethyl One or more of ethers such as ether; esters such as ethyl acetate; and the like can be used. It is preferable to use a mixed solution of water and a lower monohydric alcohol. The extraction can be performed by immersing the daisies in a solvent at room temperature or under heating for a predetermined time. Moreover, pre-processing, such as drying, shredding, pressing or fermentation, can also be performed before extraction.

  The said daisies extract can be used as a collagen production promoter as it is after preparation. Further, if desired, it can be used as a collagen production promoter after being left to mature for an appropriate period. If necessary, it can be used after being subjected to a purification treatment such as deodorization and decolorization by filtration or ion exchange resin within a range that does not affect the effect of the present invention. Further, a fraction having high activity can be taken out and used by using a separation means such as liquid chromatography.

  Examples of preferred methods for preparing the daisies extract include daisies roots, stems, leaves, flowers, etc. as they are or dried, or chopped and crushed, etc. Monohydric alcohol; polyhydric alcohol such as glycerin, propylene glycol, 1,3-butylene glycol; etc .; heated in a hydrophilic polar solvent or a mixed solvent of two or more of these or soaked at room temperature, and then extracted Can be obtained. However, the extraction method is not limited to this.

  The daisies extract may be in any form such as liquid, paste or gel. The liquid extract containing the extraction solvent can also be used after it is solidified by drying under reduced pressure or freeze drying. It can also be dried by spray drying or the like and used as a powder.

  The present invention also relates to an anti-aging skin external preparation containing, as an active ingredient, a daisy extract that is a collagen production promoter of the present invention. The external preparation for skin of the present invention exhibits an excellent anti-aging effect due to the collagen production-promoting action of the daisies extract. Collagen production promoting action of the daisies extract is considered to be mainly due to the activation action on fibroblasts, but the daisies extract is compared with conventional fibroblast activators (for example, VC-PMg). The collagen production promoting action is particularly high. Therefore, the external preparation for skin of the present invention has a particularly excellent preventive effect against skin aging caused by a decrease in the amount of collagen in the dermis and aging of the collagen in the dermis. The content of the leeky extract in the external preparation for skin of the present invention is preferably 0.00001 to 2% by mass (hereinafter simply referred to as “%”), more preferably 0.0001 to 1 as a solid content. %. If it exists in this range, the said extract can be mix | blended stably and the high anti-aging effect can be exhibited.

  The external preparation for skin of the present invention can be prepared by blending the collagen production promoter with various forms of bases according to a conventional method. Further, by adding the collagen production promoter in combination with one or more of other medicinal agents, a skin external preparation that further enhances the collagen production promoting effect or exhibits other medicinal effects together with the collagen production promoting effect. Can be prepared. Examples of other medicinal agents include, but are not limited to, whitening agents, UV protection agents, antibacterial agents, anti-inflammatory agents, cell activators, active oxygen scavengers, and humectants.

  Examples of whitening agents include ascorbic acid or derivatives thereof, arbutin, ellagic acid, linoleic acid, vitamin E and derivatives thereof, glycyrrhizic acid and derivatives thereof, tranexamic acid, placenta extract, chamomile extract, licorice extract, age extract , Ogon extract, seaweed extract, cucumber extract, caquette extract, gokahi extract, rice bran extract, wheat germ extract, saicin extract, hawthorn extract, sun penz extract, shirayuri extract, peony extract Sempukuka extract, soybean extract, tea extract, molasses extract, sandalwood extract, grape extract, hop extract, micaika extract, mokka extract, yukinoshita extract and the like.

  Examples of the UV protection agent include paramethoxycinnamate-2-ethylhexyl, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5 sodium sulfate, 4-t-butyl-4′- Examples thereof include methoxydibenzoylmethane, 2-phenyl-benzimidazole-5-sulfuric acid, titanium oxide, and zinc oxide.

  Examples of the antibacterial agent include benzoic acid, sodium benzoate, p-hydroxybenzoate ester, benzalkonium chloride, phenoxyethanol, isopropylmethylphenol, and the like.

  Anti-inflammatory agents include, for example, sulfur and its derivatives, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, artea extract, ashitaba extract, arnica extract, ginseng extract, nettle extract, buckwheat extract, hypericum Examples include extracts, chamomile extracts, goldfish extract, watercress extract, comfrey extract, salvia extract, sicon extract, perilla extract, birch extract, gentian extract and the like.

  Examples of cell activators include caffeine, chicken crown extract, shell extract, shell extract, royal jelly, silk protein and its degradation products or derivatives thereof, lactoferrin or degradation products thereof, chondroitin sulfate, hyaluronic acid, etc. Mucopolysaccharides or their salts, collagen, yeast extract, lactic acid bacteria extract, bifidobacteria extract, fermentation metabolic extract, ginkgo biloba extract, barley extract, assembly extract, peanut extract, carrot extract, rosemary Extracts, glycolic acid, citric acid, lactic acid, malic acid, tartaric acid, succinic acid and the like are included.

  The active oxygen scavenger has an action such as suppression of lipid peroxide production. For example, superoxide dismutase, mannitol, quercetin, catechin and derivatives thereof, rutin and derivatives thereof, button pi extract, yashajitsu extract, melissa extract , Lanahan fruit extract, retinol and its derivatives, vitamin A such as carotenoid, thiamine and its derivative, riboflavin and its derivative, pyridoxine and its derivative, vitamin B such as nicotinic acid and its derivative, tocopherol and its derivative, etc. Vitamin E, dibutylhydroxytoluene, butylhydroxyanisole, etc. are mentioned.

  Examples of the humectant include proteins such as elastin and keratin or derivatives thereof, hydrolysates and salts thereof, amino acids such as glycine, serine, aspartic acid, glutamic acid, arginine and theanine and derivatives thereof, sorbitol, erythritol, Trehalose, inositol, glucose, sucrose and derivatives thereof, dextrin and derivatives thereof, saccharides such as honey, D-panthenol and derivatives thereof, urea, phospholipid, ceramide, auren extract, ginger extract, diautum extract, sensyu extract Product, mallow extract, gypsophila extract, dokudami extract, hamamelis extract, bodaige extract, maronier extract, quince extract and the like.

  Moreover, arbitrary components other than the collagen production promoter of this invention can be mix | blended with the skin external preparation of this invention. Examples of such components include, but are not limited to, physiologically active substances such as amino acids, lipids, sugars, hormones, enzymes, and nucleic acids. In addition, components that are usually used in the production of cosmetics, quasi-drugs, skin external preparations and the like, for example, water (purified water, hot spring water, deep water, etc.), oil agents, Surfactant, metal soap, gelling agent, powder, alcohol, water-soluble polymer, film-forming agent, resin, inclusion compound, fragrance, deodorant, salt, pH adjuster, refreshing agent, plant / animal -Extracts derived from microorganisms, blood circulation promoters, astringents, antiseborrheic agents, chelating agents, keratolytic agents, enzymes, hormones, other vitamins and the like can be used as necessary.

  The external preparation for skin of the present invention has various forms such as powders such as powder and powder foundation; solids such as soap and lipstick; emulsions such as cream, emulsion and cream foundation; It is preferable that it is a cosmetic composition. However, it is not limited to these.

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples. However, the scope of the present invention is not limited to the following examples.
[Example 1: Preparation of leeks extract]
The dried product of the stems and leaves of daisies was pulverized, and 1,000 mL of a 50% by volume aqueous ethanol solution was added to 100 g of the pulverized product, followed by stirring and extraction at room temperature for 7 days. This was centrifuged and filtered under pressure to obtain 900 g of an extract (the amount of dry solid at this time was 0.8 g).

[Example 2: Collagen production test of leeks extract]
As a medium, Dulbecco's modified Eagle's MEM medium (DMEM, Nissui) containing 10% calf serum (FBS) was used, and human neonatal fibroblasts NB1RGB were added to 3 × 10 ⁵ cells / well (12-well plate). Sowing). The amount of medium in one well was 400 μL. After cell fixation, Dulbecco's modified Eagle MEM containing 5% calf serum (FBS) added with daisies extract prepared in Example 1 at concentrations of 0, 0.1 and 1% by volume with respect to the medium. Medium was added and cultured for 4 days. Four days later, the cell culture medium was collected, and the amount of collagen produced in the culture medium and the cell number ratio were measured and calculated by the following method.
In addition, as a positive control, a medium sample containing 0.01% by volume of VC-PMg, which is known to have an activating effect on fibroblasts, instead of the dairy extract was also cultured in the same manner. Thereafter, the amount of collagen and the cell number ratio were similarly determined.

(Measurement and calculation of collagen content)
The amount of collagen in each sample medium was quantified using a collagen analysis kit (SicrolCollagenassaykit; manufactured by Sircol) using a dye that specifically binds to soluble collagen. Specifically, 150 μL of the medium from each sample medium was transferred to a tube, 1.0 mL of the collagen analysis kit test solution (SircolDyeReagent) was added, and the mixture was mixed at a temperature of 37 ° C. for 30 minutes. The mixture was centrifuged at 1500 rpm for 10 minutes, and the supernatant was removed. Again, 1.0 mL of the collagen analysis kit test solution was added and mixed slowly, and then the absorbance at a wavelength of 540 nm was measured.
The following table shows the amount of collagen production C calculated from the measured values.

(Measurement and calculation of cell number ratio)
The number of cells in each sample medium is replaced with a fresh medium, cultured with MTT assay reagent added, the absorbance of the culture solution measured at a wavelength of 490 nm, and calculated based on the amount of formazan calculated from the measured value. did. The results are shown in the following table. The values in the table are values calculated as a cell number ratio M with respect to 100 as the number of cells in the sample medium to which no sample solution is added.

(Correction value for collagen production)
Further, the following table also shows the value obtained by dividing the amount of collagen C produced in each sample medium by the cell number ratio M calculated by the above method. This correction value C / M serves as an index of the amount of collagen production per fibroblast of the same number, and is a value that directly indicates the collagen production promoting action on the fibroblasts of the sample solution.

  From the results shown in the above table, it can be understood that the daisies extract shows a higher collagen production promoting effect than VC-PMg known as a cell activator. In particular, when the correction value C / M obtained by dividing the collagen production amount C by the cell number ratio M is compared, it can be understood that the action of accelerating the collagen production by the hilaragi extract is remarkably high.

[Example 3: Preparation of cleansing cream]
A cleansing cream having the following composition was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (9) are dissolved by heating and maintained at 70 ° C.
B. The following components (10) to (14) are dissolved by heating and maintained at 70 ° C.
C. A is added to B and emulsified.
D. After cooling C, the following components (15) and (16) were added and mixed to obtain a cleansing cream.
(Ingredient) (%)
(1) Stearic acid 2.0
(2) Stearyl alcohol 3.0
(3) Lipophilic glyceryl monostearate 2.0
(4) Beeswax 1.5
(5) Vaseline 6.0
(6) Liquid paraffin 40.0
(7) Dimethylpolysiloxane (100CS) 0.5
(8) Sorbitan sesquioleate 1.0
(9) Preservative appropriate amount (10) Triethanolamine 1.0
(11) Propylene glycol 10.0
(12) Polyethylene glycol 20000 0.5
(13) Carboxyvinyl polymer 1% solution 5.0
(14) Purified water Remaining amount (15) Hilaragiku extract * 1 0.1
(16) Perfume appropriate amount * 1 Extract prepared in Example 1

  The prepared cleansing cream had a good fit with makeup stains, clean makeup stains removed, moderate moisture and emollient on the skin, and was a non-sticky cleansing cream.

[Example 4: Preparation of face wash]
A face wash having the following composition was produced by the following method.
(Manufacturing method)
A. The following components (1) to (5) are dissolved by heating.
B. The following components (6) and (7) are dissolved by heating.
C. The following components (8) to (11) are dissolved by heating.
D. Add B to A and mix, then add C and mix.
E. After cooling D, the following components (12), (13) and (14) were added and mixed to obtain a face wash.
(Ingredient)%
(1) Lauric acid 5.0
(2) Myristic acid 18.5
(3) Stearic acid 6.0
(4) Glycerin 12.0
(5) Polyethylene glycol 1500 5.0
(6) Potassium hydroxide 6.5
(7) Purified water remaining amount (8) Palm oil fatty acid diethanolamide 5.0
(9) Palm oil fatty acid methyl taurine sodium 1.8
(10) Polyoxyethylene (7.5E.O.) lauryl ether 2.0
(11) Ethylene glycol distearate 1.0
(12) Hydroxypropyl methylcellulose 1% aqueous solution 5.0
(13) Hilaragiku extract * 1 0.1
(14) Perfume appropriate amount * 1 Extract prepared in Example 1

  The prepared face wash was rich and rich in foaming, had good stain removal, washes cleanly, and remained moist on the skin.

[Example 5: Preparation example of lotion 1]
A lotion 1 having the following composition was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (7) are mixed and dissolved.
B. The following components (8) to (11) are mixed and dissolved.
C. B was added to A and mixed to obtain a skin lotion.
(Ingredient)%
(1) Citric acid 0.05
(2) Sodium citrate 0.2
(3) Sodium pyrrolidonecarboxylate (50%) solution 0.5
(4) Hilaragiku extract * 1 0.05
(5) Glycerin 3.0
(6) 1,3-butylene glycol 8.0
(7) Purified water remaining amount (8) Ethyl alcohol 10.0
(9) Perfume Appropriate amount (10) Preservative Appropriate amount (11) Polyoxyethylene monooleate (20E.O.)
Sorbitan 0.5
* 1 Extract prepared in Example 1

  The prepared lotion 1 was a lotion that had a fresh feeling of use, was excellent in moisture of the skin, adjusted the texture, and was able to make the skin beautiful and elastic.

[Example 6: Preparation example of lotion 2]
A lotion 2 having the following composition was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (7) are mixed and dissolved.
B. The following components (8) to (12) are mixed and dissolved.
C. A is added to B and mixed to obtain a skin lotion.
(Ingredient)%
(1) Meadow Home Oil 0.05
(2) Jojoba oil 0.05
(3) Perfume appropriate amount (4) preservative appropriate amount (5) polyoxyethylene monooleate (20E.O.)
Sorbitan 0.5
(6) Isostearic acid polyoxyethylene hydrogenated castor oil (50 EO) 1.0
(7) Ethyl alcohol 8.0
(8) Glycerin 5.0
(9) 1,3-butylene glycol 5.0
(10) Polyethylene glycol 1500 0.1
(11) Hilaragiku extract * 1 0.2
(12) Purified water remaining * 1 Extract prepared in Example 1

  The prepared lotion 2 was a lotion that had a smooth feeling of use, was excellent in moisture of the skin, adjusted the texture, and was able to give a beautiful skin with elasticity.

[Example 7: Preparation example of lotion 3]
A lotion 3 having the following composition was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (8) are mixed and dissolved.
B. The following components (9) to (12) are mixed and dissolved.
C. A is added to B and emulsified to obtain a skin lotion.
(Ingredient)%
(1) Glyceryl tri-2-ethylhexanoate 0.08
(2) Squalane 0.02
(3) Sorbitan sesquioleate 0.05
(4) Polyoxyethylene monooleate (20E.O.)
Sorbitan 0.05
(5) Polyoxyethylene (8E.O.) alkyl (12-15)
Ether phosphoric acid 0.1
(6) Preservative appropriate amount (7) perfume appropriate amount (8) ethyl alcohol 8.0
(9) Dipropylene glycol 8.0
(10) Glycerin 4.0
(11) Hilaragiku extract * 1 0.1
(12) Purified water remaining * 1 Extract prepared in Example 1

  The prepared lotion 3 was a lotion that had a fresh and refreshing feeling of use, was excellent in moisture of the skin, adjusted the texture, and was able to make the skin beautiful and elastic.

[Example 8: Preparation of emulsion]
An emulsion having the following composition was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (10) are dissolved by heating and maintained at 70 ° C.
B. The following components (11) to (15) are dissolved by heating and maintained at 70 ° C.
C. B is added to A to emulsify, and the following component (16) is further added and mixed.
D. C is cooled, the following components (17) and (18) are added and mixed to obtain an emulsion.
(Ingredient)%
(1) Stearic acid 1.0
(2) Cetanol 0.5
(3) Lipophilic glyceryl monostearate 0.5
(4) Liquid paraffin 2.0
(5) Squalane 3.0
(6) Jojoba oil 3.0
(7) Cetyl palmitate 0.2
(8) Preservative appropriate amount (9) Sorbitan monostearate 0.3
(10) Polyoxyethylene monooleate (20E.O.)
Sorbitan 0.5
(11) Triethanolamine 0.5
(12) 1,3-butylene glycol 15.0
(13) Glycerin 3.0
(14) Polyethylene glycol 6000 0.5
(15) Purified water Remaining amount (16) Carboxyvinyl polymer 1% solution 8.0
(17) Hilaragiku extract * 1 0.2
(18) Perfume appropriate amount * 1 Extract prepared in Example 1

  The prepared emulsion had a fresh and smooth feeling of use, was excellent in moisture and emollient, had a smooth texture, and was able to give beautiful skin with elasticity.

[Example 9: Preparation example of cream]
The following compositional claims were prepared in the following manner.
(Manufacturing method)
A. The following components (1) to (13) are dissolved by heating and maintained at 70 ° C.
B. The following components (14) to (18) are dissolved by heating and maintained at 70 ° C.
C. B is added to A to emulsify, and the following component (19) is further added and mixed.
D. C is cooled, and the following components (20) and (21) are added and mixed to obtain an emulsion.
(Ingredient)%
(1) Stearic acid 2.5
(2) Cetanol 2.5
(3) Lipophilic glyceryl monostearate 2.0
(4) Vaseline 2.0
(5) Dipentaerythritol fatty acid ester * 1 2.0
(6) Isotridecyl myristate 5.0
(7) Liquid paraffin 8.0
(8) Squalane 5.0
(9) Beeswax 1.0
(10) Cetyl palmitate 2.0
(11) Sorbitan sesquioleate 0.5
(12) Polyoxyethylene monooleate (20E.O.)
Sorbitan 1.5
(13) Preservative appropriate amount (14) Triethanolamine 1.2
(15) 1,3-butylene glycol 8.0
(16) Glycerin 2.0
(17) Polyethylene glycol 20000 0.5
(18) Purified water remaining amount (19) 1% aqueous solution of carboxyvinyl polymer 5.0
(20) Hilaragiku extract * 2 1.0
(21) Fragrance appropriate amount * 1: Cosmol 168AR (Nisshin Oillio Group)
* 2 Extract prepared in Example 1

  The prepared cream was a cream that had a smooth and smooth feeling of use, excellent skin emollient, smoothed texture, and, after all, made beautiful skin with elasticity.

[Example 10: Preparation example of cosmetic liquid]
A serum having the following composition was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (8) are mixed and dissolved.
B. The following components (9) to (17) are mixed and dissolved.
C. A was added to B and mixed to obtain a serum.
(Ingredient)%
(1) Glyceryl tri-2-ethylhexanoate 0.1
(2) Meadow Home Oil 0.05
(3) Jojoba oil 0.05
(4) Preservative appropriate amount (5) perfume appropriate amount (6) polyoxyethylene monooleate (20E.O.)
Sorbitan 0.5
(7) Polyoxyethylene hydrogenated isostearate castor oil (50 EO) 1.5
(8) Ethyl alcohol 5.0
(9) Glycerin 4.0
(10) Dipropylene glycol 8.0
(11) 1,3-butylene glycol 8.0
(12) Sodium lactate 0.5
(13) Sodium pyrrolidonecarboxylate (50%) solution 0.5
(14) Hydroxyethyl cellulose 0.08
(15) Sodium alginate 0.05
(16) Hilaragiku extract * 1 0.1
(17) Purified water remaining * 1 Extract prepared in Example 1

  The prepared essence had a fresh, smooth and mild feel, was excellent in moisture and emollient, had a smooth texture, and was able to give glossy and beautiful skin.

[Example 11: Preparation example of pack]
A pack having the following composition was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (5) are dissolved by heating.
B. The following components (6) to (10) are mixed and dissolved.
C. After cooling A, B and the following (11) were added and mixed to obtain a pack.
(Ingredient)%
(1) Polyvinyl alcohol 12.0
(2) Methylcellulose 0.1
(3) Glycerin 3.0
(4) 1,3-butylene glycol 5.0
(5) Purified water remaining amount (6) perfume appropriate amount (7) preservative appropriate amount (8) glyceryl tri-2-ethylhexanoate 0.1
(9) Polyoxyethylene monooleate (20E.O.)
Sorbitan 1.0
(10) Ethyl alcohol 13.0
(11) Hilaragiku extract * 1 0.1
* 1 Extract prepared in Example 1

  The prepared pack was a pack that stretched well, imparted moderate tension to the skin, did not stick to the skin after peeling off the pack, and was highly moist and sticky.

[Example 12: Preparation example of massage cream]
A massage cream having the following composition was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (9) are dissolved by heating and maintained at 70 ° C.
B. The following components (10) to (13) are dissolved by heating and maintained at 70 ° C.
C. A is added to B and emulsified.
D. After cooling C, the following components (14) and (15) were added and mixed to obtain a massage cream.
(Ingredient)%
(1) Stearic acid 2.0
(2) Stearyl alcohol 2.5
(3) Lipophilic glyceryl monostearate 2.0
(4) Sorbitan sesquioleate 1.0
(5) Cetyl palmitate 1.0
(6) Dipentaerythritol fatty acid ester * 1 4.0
(7) Vaseline 20.0
(8) Liquid paraffin 28.0
(9) Methyl polysiloxane (100CS) 0.5
(10) Sodium hydroxide 0.1
(11) Dipropylene glycol 7.0
(12) 1% solution of carboxyvinyl polymer 5.0
(13) Purified water Remaining amount (14) Hilaragiku extract * 2 0.2
(15) Fragrance appropriate amount * 1: Cosmol 168AR (Nisshin Oillio Group)
* 2: Extract prepared in Example 1

  The prepared massage cream had a smooth and rich feeling of use, had an excellent massage effect, and was highly effective in preventing sagging of the skin and the decrease in elasticity.

[Example 13: Preparation example of cream foundation]
A cream foundation having the following composition was prepared by the following method.
(Manufacturing method)
A: The following components (8) to (13) are mixed.
B: The following components (14) to (19) are mixed.
C: The following components (1) to (7) are added to A and mixed and dispersed.
D: The following components (20) and (21) were added to C to obtain a cream foundation.
(Ingredient)%
(1) Sericite 8.0
(2) Titanium oxide 10.0
(3) Bengala 1.0
(4) Yellow iron oxide 2.2
(5) Mica titanium 2.0
(6) Black iron oxide 0.1
(7) Organic metamorphic bentonite * 1 0.5
(8) Long chain alkyl-containing polyoxyalkylene modified organopolysiloxane * 2 2.0
(9) Polyoxyalkylene-modified organopolysiloxane * 3 2.0
(10) Decamethylcyclopentasiloxane 12.0
(11) Octamethylcyclotetrasiloxane 10.0
(12) Trimethylsiloxysilicic acid silicone solution * 4 3.0
(13) Glyceryl tri-2-ethylhexanoate 5.0
(14) 1,3-butylene glycol 5.0
(15) Diglycerin 2.0
(16) Glycerin 2.0
(17) Xanthan gum 0.2
(18) Sodium chloride 0.2
(19) Purified water Residual amount (20) Hilaragiku extract * 5 0.1
(21) Perfume appropriate amount * 1: Benton 38 (manufactured by NL Endowry)
* 2: Avil EM-90 (Gold Schmidt)
* 3: KF-6017 (manufactured by Shin-Etsu Chemical Co., Ltd.)
* 4: KF-7312J (manufactured by Shin-Etsu Chemical Co., Ltd.)
* 5: Extract prepared in Example 1

  The prepared cream foundation has a smooth, non-sticky feel, excellent adhesion to the skin, a beautiful finish, and gives an emollient feel to the skin to make it beautiful and elastic. It was a cream foundation.

  ADVANTAGE OF THE INVENTION According to this invention, the novel collagen production promoter and anti-aging skin external preparation with favorable safety | security can be provided.

Claims (2)

Collagen production promoter containing as an active ingredient an extract of Asteraceae Hihiragiku (scientific name: Pluchea indica Less). An anti-aging skin external preparation containing the collagen production promoter according to claim 1 as an active ingredient.