JP2009281802A - Autoanalyzer and specimen searching system - Google Patents

Abstract

In an automatic analyzer, an item causing a data failure can be searched on the spot and dealt with promptly even during routine work.
A sample probe for measuring various components in a specimen such as a patient sample, a standard solution, and a quality control sample, a reagent probe, a stirring bar, an analysis item for each operation cycle of a mechanical system such as a reaction vessel, a reagent type, In an automatic analyzer equipped with a storage unit for storing the amount of reaction solution, agitation parameters, and reaction vessel number, by setting conditions from among a variety of stored information, for extracting the relevant sample A sample search system for an automatic analyzer that includes a display unit that displays a search screen and a control unit that displays or outputs a screen of the extracted sample.
[Selection] Figure 2

Description

  The present invention relates to an automatic analyzer and a specimen search system that measure biological samples such as blood and urine.

  The automated analyzer can handle a large number of samples at the same time, and can analyze multiple components quickly and with high accuracy, so it can be used not only for biochemical tests but also for immunoserologic tests and pharmaceutical research. It is used for inspections in various fields such as intoxication tests at institutions. Especially in hospital use, the analysis target is a biological fluid sample such as blood or urine of the patient, and the analysis results determine the diagnosis and treatment policy of the disease. Is always sought.

  The automatic analyzer uses a sample probe, reagent probe, stirring mechanism, and common parts such as a reaction vessel and an optical cell to wash a large number of specimens continuously. The fact that a sample or reagent component affects the measured values of other analysis items is called cross contamination. Automatic analysis device with a function to set a cross-contamination avoidance program, such as changing the order of measurement or performing washing with detergent when washing is usually performed when the combination where cross-contamination occurs can be confirmed in advance Equipped with.

  However, in recent automatic analyzers, cross-contamination occurs in combinations that were not known so far in order to measure various analysis items, and the automatic analyzer itself has become faster every year, so the time required for cleaning is increased. Since cross contamination has occurred in combinations that have not occurred so far due to the lack of data, it is difficult to identify the cause when data failure occurs.

  When cross contamination is estimated, it is necessary to perform re-measurement under the same conditions as when data failure occurs, and to follow the dispensing operation one by one and analyze the order of measurement and confirm the data. . Therefore, investigating the cause takes a lot of time and effort. In the case of data failure due to cross contamination, it is a great effort to perform the above analysis for each trouble.

In response to this problem, Patent Document 1 stores the types of samples, analysis items, and reagents measured before analysis of analysis items, and the history of the types of samples, analysis items, and reagents measured before analysis of the analysis items. A technique regarding a method of displaying a list of files is disclosed.
Japanese Patent Laid-Open No. 10-10131

  However, there is a problem that the cause of the data failure cannot be determined only by information on the type of specimen, analysis item, and reagent measured before the analysis item. For example, if data failure occurs due to the presence or absence of the use of the reaction vessel next to the reaction vessel used in the analysis item, or if data failure occurs due to the usage status of the reagent probe before the analysis item, the data I did not know the cause of the defect.

  An object of the present invention is to provide an automatic analyzer that can search for an item causing a data failure on the spot when the data failure occurs and can quickly cope with it even during routine work.

  An automatic analyzer according to the present invention is an automatic analyzer that measures various components in a specimen such as a patient sample, a standard solution, and a quality control sample, and includes a sample probe, a reagent probe, a stirring mechanism, or a reaction system. A storage unit for storing conditions including analysis items, reagent types, reaction liquid amounts, agitation parameters, or reaction vessel numbers for each operation cycle, and a corresponding sample is extracted from the conditions stored in the storage unit Characterized in that it has a sample search system comprising a display unit for displaying a search condition setting screen for setting a search condition for the display, and a control unit for displaying or outputting information on the extracted corresponding sample on the screen To do.

  The sample retrieval system of the present invention is a sample retrieval system for an automatic analyzer that measures various components in a sample such as a patient sample, a standard solution, and a quality control sample, and includes a sample probe and a reagent probe of the automatic analyzer. A storage unit that stores conditions including an analysis item, a reagent type, a reaction liquid amount, a stirring parameter, or a reaction vessel number for each operation cycle of a mechanism system including a stirring mechanism or a reaction vessel, and is stored in the storage unit A display unit for displaying a search condition setting screen for setting a search condition for extracting a corresponding sample from the existing conditions, and a control unit for displaying or outputting information on the extracted corresponding sample on the screen. It is characterized by having.

  According to the present invention, it is possible to search on the spot for the cause when data failure occurs, and to deal with it quickly even during routine work.

  Hereinafter, embodiments of the automatic analyzer of the present invention will be described with reference to the drawings.

  FIG. 1 shows the overall configuration of an automatic analyzer according to an embodiment of the present invention. The automatic analyzer of FIG. 1 includes a sample disk 2 on which a plurality of sample cups 1 can be installed, a sampling mechanism 4 having a sample probe 3 for collecting a predetermined amount of sample, reagent pipetting mechanisms 5a and 5b for dispensing a plurality of reagents, and Reagent disks 6a and 6b, reaction disk 8 holding a plurality of direct photometric reaction containers 7, stirring mechanisms 9a and 9b, reaction container cleaning mechanism 10, photometer 11, and central processing unit for controlling the entire mechanism system (Microcomputer) 12 and the like are mainly configured. The automatic analyzer can measure various components in a specimen such as a patient sample, a standard solution, and a quality control sample as samples that can be analyzed.

  The reaction disk 8 holding a plurality of reaction vessels is controlled to be temporarily stopped by rotating half a turn + 1 reaction vessel every cycle. That is, at the time of stopping every cycle, the reaction vessel 7 of the reaction disk 8 stops in the form of proceeding by one reaction vessel in the counterclockwise direction. As the photometer 11, a multi-wavelength photometer having a plurality of detectors is used. When the reaction disk 8 is in a rotating state as opposed to the light source lamp 13, the row of reaction vessels 7 passes the light beam 14 from the light source lamp 13. Is configured to do. A reaction container cleaning mechanism 10 is disposed between the position of the light beam 14 and the sample discharge position 15.

  Furthermore, it comprises a multiplexer 16 for selecting a wavelength, a logarithmic conversion amplifier 17, an A / D converter 18, a printer 19, a CRT 20, a reagent dispensing mechanism drive circuit 21 and the like, all of which are connected to the central processing unit 12 via an interface 22. It is connected. This central processing unit also performs overall processing including control of the entire mechanical system and data processing such as concentration or enzyme activity value calculation.

  The operation principle in the above configuration will be described below. When the start switch on the operation panel 23 is pressed, the reaction vessel 7 starts to be washed by the reaction vessel washing mechanism 10 and the water blank is measured. This value is a reference for the absorbance measured in the reaction vessel 7 thereafter. When the reaction disk 8 proceeds to the sample discharge position 15 by repeating the operation of one cycle of the reaction disk 8, that is, the operation of moving counterclockwise + 1 reaction container and temporarily stopping, the sample cup 1 moves to the sampling position.

  Similarly, the two reagent disks 6a and 6b are also moved to the reagent pipetting position. During this time, the sampling mechanism 4 operates, and the sample amount of, for example, the analysis item A is sucked from the sample cup 1 by the sample probe 3 and then discharged to the reaction container 7. On the other hand, in the reagent pipetting mechanism 5, when the sampling mechanism discharges the sample to the reaction container 7, the reagent pipetting mechanism 5a starts operating, and the first reagent of the analysis item A installed on the reagent disk 6a is used as the reagent probe 24a. To suck. Next, the reagent probe 24a moves onto the reaction vessel 7 and discharges the sucked reagent, and then the inner wall and outer wall of the probe are washed in the probe washing tank to prepare for the first reagent dispensing of the next analysis item B. Photometry is started after the first reagent is added.

  Photometry is performed when the reaction vessel 7 crosses the light beam 14 when the reaction disk 8 rotates. When the reaction disk rotates twice by two reaction vessels after the first reagent is added, the stirring mechanism 8a is activated to stir the sample and the reagent. When the reaction container 7 moves from the sample dispensing position to the position rotated by 25 rotations + 25 reaction containers, that is, to the second reagent dispensing position, the second reagent is added from the reagent probe 24b, and then stirred by the stirring mechanism 8b.

  By the reaction disk 8, the reaction vessel 7 successively traverses the luminous flux 14, and the absorbance is measured each time. These absorbances are measured 34 times in total for a reaction time of 10 minutes. After completion of photometry, the reaction vessel 7 is washed by the reaction vessel washing mechanism 10 to prepare for the next sample analysis. The measured absorbance is converted into a concentration or enzyme activity value by the central processing unit 12 and the analysis result is output from the printer 19.

Next, one embodiment of the present invention applied to the automatic analyzer of FIG. 1 will be described. First, when a data failure occurs, the operator needs to check whether the same data failure phenomenon has occurred within the same day. It is done.
1) Reagent probe Search for the ones used in a specific order Search for reagent bottles with the number of remaining tests below a certain residual test Search for those that have passed a specific time after calibration 2) Stirring mechanism Search for items that are used in a specific order Search for items that use a specific stirring strength in the next reaction vessel 3) Reaction vessel Search for items that are used in a specific order In the next reaction vessel Search for products using a specific reaction volume Search for products using a reaction vessel at a specific mounting position 4) Sample probe Search for samples used in a specific order

  Therefore, information operating at the same timing in the above apparatus, for example, (1) specimen information when the sample probe is sucked from the sample cup and discharged to the reaction container (analysis item name, standard solution / quality control sample / Specimen type such as patient sample, specimen information such as patient ID number / sample number for patient specimen), (2) Information when reagent probe is aspirated from reagent bottle in reagent disk and discharged to reaction container (analysis item name) , Reagent type such as first reagent / second reagent, reagent remaining amount information, elapsed time since calibration was performed, reaction vessel number), (3) information when the stirring mechanism stirs the reaction solution (analysis) Information such as the item name, reaction vessel number, and stirring intensity in an apparatus that can be set as conditions is stored in a storage device (not shown) by the central processing unit 12.

An example is shown in Table 1 below, but the stored information remains until the operator deletes the patient specimen data. The information is stored in an external storage medium together with the measurement result of the patient specimen so that the information can be used when necessary.

  Next, a method for the operator to search for a specific sample will be described with reference to the flowchart of FIG. To start the search, first, the search screen is displayed by pressing the search button on the operation screen in accordance with the operator's instruction (S1). Subsequently, the operator inputs mechanical items and analysis conditions for searching on the search screen as search conditions (S2), and starts the search (S3). An example of the search condition setting screen is shown in FIG.

  First, the operator selects a mechanism “item” from the list box 31 of the item list. “Items” include mechanical system items such as sample probes, reagent probes, reaction vessels, and stirring mechanisms. Subsequently, the operator sets “analysis condition” in the analysis condition selection field 32. The display of the selected content of “analysis condition” is changed according to the item selected in the item list. For example, when selecting a reaction vessel as an “item” of a mechanical system and searching for items used in a specific order, select the given item and the received item from the list box as the “analysis condition”, and select the list Select the order of use from the box.

In the example of FIG.
Item: “Reaction vessel”
Analysis conditions Given item: “Item F”
Accepted item: “Item B”
Condition: "Order of use"
And the conditions are selected, so that after the reaction container in which the item F is measured, the specimen in which the item B is measured in the same reaction container is searched.

  As another example, in the case of searching for a reagent probe with a number of remaining tests in the reagent bottle equal to or less than a certain remaining test, select the reagent probe as the “item” of the mechanical system as follows, The following search conditions are set as “analysis conditions”.

Item: “Reagent Probe”
Analysis conditions Given item: “Not specified”
Accepted item: “Item D”
Condition: “Number of remaining tests” “10 tests”

  In addition, after selecting the search condition, the update button 33 or the cancel button 34 is pressed. The search condition selected by the operator is displayed in the condition setting list 35, and the search is started by pressing the search start button 37. However, when a plurality of selection conditions are set, each search condition in the condition setting list 35 is set. It is possible to select whether to enable or disable by checking a check box for a condition.

  Subsequently, when the operator presses the search button, the search is started, and the information on the corresponding sample as the search result is displayed (S4). The search result is output to the printer in accordance with the operator's instruction (S5). Subsequently, it is determined whether or not the search result is stored (S6), and if it is stored, it is stored in an external storage medium (S7).

  As shown in the example of FIG. 5, the search result displays sample information such as a patient ID number, a sample type, and a sample set position for each corresponding sample searched in the display column on the left side of the measurement result display column 51. On the right side, information such as an analysis item name corresponding to the sample displayed in the left display column, a measurement result, and an alarm (alarm) indicating a data defect is displayed.

  The operator confirms the measurement result, and if necessary, confirms the reaction time course by pressing the reaction time course button 52. When outputting the result, the operator presses the result output button 53 to output the measurement result. At this time, it is preferable that the output of the result can be selected so that the absorbance on the reaction time course, the graph, or the calibration result information can be output together with the content displayed in the measurement result display column.

  Subsequently, when it is desired to store the search result, the search result is stored in an external storage medium by pressing the save button 54. However, the apparatus stores information from the storage medium so that the search result can be confirmed later. Also be able to read. The search result screen also has a re-search button 55 as a function so that another item can be re-searched and conditions can be reviewed and re-searched.

  If the occurrence of data failure due to cross-contamination can be confirmed from the retrieved measurement results, the cleaning program originally provided in the apparatus, i.e., the sample probe, reagent probe, stirring rod, and reaction vessel, should be There is a function to analyze the item after washing with detergent, and the operator makes settings on the screen for setting the washing program, but this setting is set on the search result screen and the washing program is set. It may be reflected on the screen.

  Next, a method of performing a test for reconfirmation after the operator confirms the measurement result on the search result screen will be described using the flowchart of FIG. First, a retest request screen is displayed according to an instruction from the operator (S11). The retest request screen first lists the search conditions set on the search result screen.

For example,
Condition 1) Reaction vessel: Item C⇒Item G
Condition 2) Reagent probe: Item F⇒Not specified⇒Item B
In this way, after the operator selects a target condition from the condition list (S12), the sample necessary for retest and the position for setting the sample are displayed on the screen. (S13).

  The above information is output to a printer or the like according to the operator's instruction (S14), and after the operator prepares the designated sample at the designated position, the measurement is started according to the operator's instruction (S15). The measured results are not shown in the figure, but the results of this retest and the previous results are arranged side by side so that the operator can see them side by side, and the reaction time course is also displayed by overlapping the current and previous results. Display them in an easy-to-understand manner so that the operator can easily compare them.

  As described above, it is possible to measure and confirm the item causing the data failure on the spot and to quickly cope with it even during routine work.

FIG. 1 is a diagram showing a schematic configuration of an automatic analyzer to which the present invention is applied. FIG. 2 is a diagram showing an example of an operation flow according to claims 1 and 2 of the present invention. FIG. 3 is a diagram showing an example of an operation flow according to claim 3 of the present invention. FIG. 4 is a diagram showing an example of a search condition setting screen in the present invention. FIG. 5 is a diagram showing an example of a search result screen in the present invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Sample cup 2 Sample disk 3 Sample probe 4 Sampling mechanism 5 Reagent pipetting mechanism 6 Reagent disk 7 Reaction container 8 Reaction disk 9 Stirring mechanism 10 Reaction container washing mechanism 11 Photometer 12 Central processing unit 13 Light source lamp 14 Light flux 15 Sample discharge position 16 Multiplexer 17 Logarithmic Conversion Amplifier 18 A / D Converter 19 Printer 20 CRT
21 Reagent Dispensing Mechanism Drive Circuit 22 Interface 23 Operation Panel 24a First Reagent Probe 24b Second Reagent Probe 31 List Box 32 Search Condition Selection Field 33 Update Button 34 Cancel Button 35 Condition Setting List 37 Search Start Button 51 Measurement Result Display Field 52 Reaction time course button 53 Result output button 54 Save button 55 Search again button

Claims (7)

  In automatic analyzers that measure various components in specimens such as patient samples, standard solutions, and quality control samples, analysis items and reagent types for each operation cycle of a mechanism system including a sample probe, reagent probe, stirring mechanism, or reaction vessel , A storage unit for storing conditions including reaction liquid amount, agitation parameter, or reaction vessel number, and a search for setting a search condition for extracting a corresponding specimen from the conditions stored in the storage unit An automatic analyzer comprising a sample search system including a display unit that displays a condition setting screen and a control unit that displays or outputs information on the extracted corresponding sample. The automatic analyzer according to claim 1, wherein
Automatic analysis characterized in that as the search condition in the search screen, the sample probe, the reagent probe, the stirring mechanism of the automatic analyzer, or the mechanical system item of the reaction vessel and the analytical condition for each of the mechanical system item are set. apparatus. The automatic analyzer according to claim 2,
As an analysis condition in the search screen, an automatic analysis device is characterized in that a given item that affects the analysis of the sample, a receiving item that is affected by the analysis of the sample, and a use order of the given item and the receiving item are set. .   4. The automatic analyzer according to claim 1, further comprising means for requesting measurement for reconfirmation of the extracted result, and means for notifying an operator of information on a sample set position of the sample. An automatic analyzer characterized by that.   A sample retrieval system for an automatic analyzer that measures various components in a sample such as a patient sample, a standard solution, and a quality control sample, including a sample probe, a reagent probe, a stirring mechanism, or a reaction vessel of the automatic analyzer A storage unit that stores conditions including analysis items, reagent types, reaction liquid amounts, agitation parameters, or reaction vessel numbers for each system operation cycle, and a corresponding sample is extracted from the conditions stored in the storage unit Specimen search, comprising: a display unit that displays a search condition setting screen for setting a search condition for performing a search, and a control unit that displays or outputs information related to the extracted sample system. The specimen search system according to claim 5, wherein
Specimen search characterized in that as a search condition in the search screen, a sample probe, a reagent probe, a stirring mechanism, or a mechanism system item of a reaction container of an automatic analyzer and an analysis condition for each item of the mechanism system are set. system. The specimen search system according to claim 6, wherein
A sample retrieval system that sets, as analysis conditions in the search screen, a given item that affects the analysis of the sample, a receiving item that is affected by the analysis of the sample, and a use order of the given item and the receiving item .

Images