JP2009504603A - チオトロピウム塩とサルメテロールの塩とを組合せて投与する呼吸困難の治療方法 - Google Patents

チオトロピウム塩とサルメテロールの塩とを組合せて投与する呼吸困難の治療方法 Download PDF

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Publication number: JP2009504603A
Authority: JP; Japan
Prior art keywords: acid; salt; present; salmeterol; tiotropium
Prior art date: 2005-08-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP2008525547A

Other languages

English (en)

Japanese (ja)

Inventor

ピートコルネリセン

Original Assignee

ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-06

Filing date

2006-08-02

Publication date

2009-02-05

2006-08-02 Application filed by ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング filed Critical ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング

2009-02-05 Publication of JP2009504603A publication Critical patent/JP2009504603A/ja

Status Pending legal-status Critical Current

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WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
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230000003993 interaction Effects 0.000 description 1
239000001282 iso-butane Substances 0.000 description 1
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
239000007951 isotonicity adjuster Substances 0.000 description 1
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239000000314 lubricant Substances 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
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235000010355 mannitol Nutrition 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
229940071648 metered dose inhaler Drugs 0.000 description 1
VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical class C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
238000002156 mixing Methods 0.000 description 1
OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
229960002969 oleic acid Drugs 0.000 description 1
229920001542 oligosaccharide Polymers 0.000 description 1
150000002482 oligosaccharides Chemical class 0.000 description 1
239000003002 pH adjusting agent Substances 0.000 description 1
238000010979 pH adjustment Methods 0.000 description 1
244000052769 pathogen Species 0.000 description 1
239000002304 perfume Substances 0.000 description 1
239000008177 pharmaceutical agent Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
230000006461 physiological response Effects 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
229950008882 polysorbate Drugs 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
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230000002335 preservative effect Effects 0.000 description 1
230000008569 process Effects 0.000 description 1
239000001294 propane Substances 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
229960005018 salmeterol xinafoate Drugs 0.000 description 1
230000035807 sensation Effects 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
235000010356 sorbitol Nutrition 0.000 description 1
229940083466 soybean lecithin Drugs 0.000 description 1
229960004793 sucrose Drugs 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
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235000010384 tocopherol Nutrition 0.000 description 1
229960001295 tocopherol Drugs 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
235000019155 vitamin A Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
229950000339 xinafoate Drugs 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

JP2008525547A 2005-08-06 2006-08-02 チオトロピウム塩とサルメテロールの塩とを組合せて投与する呼吸困難の治療方法 Pending JP2009504603A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP05107267		2005-08-06
PCT/EP2006/064957 WO2007017437A1 (fr)	2005-08-06	2006-08-02	Procédé pour le traitement de la dyspnée comprenant l’administration combinée de sels de tiotropium et de sels de salmétérol

Publications (1)

Publication Number	Publication Date
JP2009504603A true JP2009504603A (ja)	2009-02-05

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Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2008525547A Pending JP2009504603A (ja)	2005-08-06	2006-08-02	チオトロピウム塩とサルメテロールの塩とを組合せて投与する呼吸困難の治療方法

Country Status (4)

Country	Link
EP (1)	EP1959942A1 (fr)
JP (1)	JP2009504603A (fr)
CA (1)	CA2617897A1 (fr)
WO (1)	WO2007017437A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7250426B2 (en)	2002-11-29	2007-07-31	Boehringer Ingelheim Pharma Gmbh & Co Kg	Tiotropium-containing pharmaceutical combination for inhalation
CN108451936A (zh) *	2018-06-19	2018-08-28	杭州勃锐思莫生物医药科技有限责任公司	一种噻托溴铵吸入制剂在制备治疗肺癌药物中应用

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JP2004513146A (ja) *	2000-11-13	2004-04-30	ベーリンガー　インゲルハイム　ファルマ　ゲゼルシャフト　ミット　ベシュレンクテル　ハフツング　ウント　コンパニー　コマンディトゲゼルシャフト	チオトロピウム塩及びサルメテロール塩に基づく新規医薬組成物
WO2004058233A1 (fr) *	2002-12-20	2004-07-15	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Medicament pulverulent pour l'inhalation, contenant un sel de tiotropium et du xinafoate de salmeterol
JP2005504076A (ja) *	2001-09-14	2005-02-10	ベーリンガーインゲルハイムファルマゲゼルシャフトミットベシュレンクテルハフツングウントコンパニーコマンディトゲゼルシャフト	新規な吸入用医薬組成物

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US20040002548A1 (en) *	1999-05-12	2004-01-01	Boehringer Ingelheim Pharma Kg	Medicament compositions containing anticholinergically-effective compounds and betamimetics
DE10209243A1 (de) *	2002-03-04	2003-09-18	Boehringer Ingelheim Pharma	Neue Arzneimittelkombination zur Inhalation
DE10145438A1 (de) *	2001-09-14	2003-04-03	Boehringer Ingelheim Pharma	Neue Arzneimittel zur Inhalation
US20040152720A1 (en) *	2002-12-20	2004-08-05	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Powdered medicaments containing a tiotropium salt and salmeterol xinafoate

2006
- 2006-08-02 WO PCT/EP2006/064957 patent/WO2007017437A1/fr not_active Ceased
- 2006-08-02 JP JP2008525547A patent/JP2009504603A/ja active Pending
- 2006-08-02 EP EP06792646A patent/EP1959942A1/fr not_active Withdrawn
- 2006-08-02 CA CA002617897A patent/CA2617897A1/fr not_active Abandoned

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JP2004513146A (ja) *	2000-11-13	2004-04-30	ベーリンガー　インゲルハイム　ファルマ　ゲゼルシャフト　ミット　ベシュレンクテル　ハフツング　ウント　コンパニー　コマンディトゲゼルシャフト	チオトロピウム塩及びサルメテロール塩に基づく新規医薬組成物
JP2005504076A (ja) *	2001-09-14	2005-02-10	ベーリンガーインゲルハイムファルマゲゼルシャフトミットベシュレンクテルハフツングウントコンパニーコマンディトゲゼルシャフト	新規な吸入用医薬組成物
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WO2007017437A1 (fr)	2007-02-15
CA2617897A1 (fr)	2007-02-15
EP1959942A1 (fr)	2008-08-27

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