JP2010505444A5 - - Google Patents
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- Publication number
- JP2010505444A5 JP2010505444A5 JP2009532369A JP2009532369A JP2010505444A5 JP 2010505444 A5 JP2010505444 A5 JP 2010505444A5 JP 2009532369 A JP2009532369 A JP 2009532369A JP 2009532369 A JP2009532369 A JP 2009532369A JP 2010505444 A5 JP2010505444 A5 JP 2010505444A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- therapeutic agent
- seq
- delivery system
- cartilage tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 229920001184 polypeptide Polymers 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 239000003814 drug Substances 0.000 claims 12
- 229940124597 therapeutic agent Drugs 0.000 claims 11
- 210000000845 cartilage Anatomy 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 5
- 239000012620 biological material Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000002105 nanoparticle Substances 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
- 229920000288 Keratan sulfate Polymers 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 102000000422 Matrix Metalloproteinase 3 Human genes 0.000 claims 1
- 108010016160 Matrix Metalloproteinase 3 Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920000249 biocompatible polymer Polymers 0.000 claims 1
- 229940059329 chondroitin sulfate Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 claims 1
- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 claims 1
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/545,819 US7592009B2 (en) | 2006-10-10 | 2006-10-10 | Polypeptide ligands for targeting cartilage and methods of use thereof |
| PCT/US2007/021529 WO2008063291A2 (en) | 2006-10-10 | 2007-10-09 | Polypeptide ligands for targeting cartilage and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010505444A JP2010505444A (ja) | 2010-02-25 |
| JP2010505444A5 true JP2010505444A5 (2) | 2010-12-02 |
Family
ID=39417214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009532369A Pending JP2010505444A (ja) | 2006-10-10 | 2007-10-09 | 軟骨にターゲティングするためのポリペプチドリガンド及びその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7592009B2 (2) |
| EP (1) | EP2084275A4 (2) |
| JP (1) | JP2010505444A (2) |
| AU (1) | AU2007322346A1 (2) |
| CA (1) | CA2665839A1 (2) |
| IL (1) | IL198120A0 (2) |
| WO (1) | WO2008063291A2 (2) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2008056623A1 (ja) * | 2006-11-09 | 2010-02-25 | 第一三共株式会社 | 核酸導入用組成物 |
| HRP20190691T1 (hr) | 2008-03-27 | 2019-07-12 | Purdue Research Foundation | Sintetički peptidoglikani koji vezuju kolagen, priprema, i postupci upotrebe |
| US8868149B2 (en) * | 2009-07-30 | 2014-10-21 | Oxitone Medical Ltd. | Photoplethysmography device and method |
| MX2012001283A (es) | 2009-07-31 | 2012-06-12 | Amgen Inc | Polipeptidos que se enlazan al inhibidor de tejidos de metaloproteinasa tipo tres (timp-3) composiciones y metodos. |
| US10487148B2 (en) | 2010-01-28 | 2019-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating aging-associated impairments |
| US10626399B2 (en) | 2010-01-28 | 2020-04-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of treating cognitive symptoms of an aging-associated impairment by modulating C-C chemokine receptor type 3 (CCR3) |
| US20160208011A1 (en) | 2010-01-28 | 2016-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same |
| WO2011097342A1 (en) * | 2010-02-04 | 2011-08-11 | University Of Utah Research Foundation | Hydrophobically-modified hyaluronan and methods of making and using thereof |
| US8524662B2 (en) | 2010-12-28 | 2013-09-03 | Depuy Mitek, Llc | Compositions and methods for treating joints |
| US8398611B2 (en) | 2010-12-28 | 2013-03-19 | Depuy Mitek, Inc. | Compositions and methods for treating joints |
| US8455436B2 (en) | 2010-12-28 | 2013-06-04 | Depuy Mitek, Llc | Compositions and methods for treating joints |
| US9173919B2 (en) | 2011-02-16 | 2015-11-03 | Purdue Research Foundation | Collagen-targeted nanoparticles |
| US9161968B2 (en) | 2011-04-08 | 2015-10-20 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists |
| EP3208278B1 (en) | 2011-05-24 | 2018-10-31 | Symic IP, LLC | Hyaluronic acid-binding synthetic peptidoglycans, preparation, and methods of use |
| US8623839B2 (en) | 2011-06-30 | 2014-01-07 | Depuy Mitek, Llc | Compositions and methods for stabilized polysaccharide formulations |
| WO2014063102A1 (en) * | 2012-10-19 | 2014-04-24 | Cornell University | Biomimetic boundary lubricants for articular cartilage |
| JP2016511747A (ja) | 2013-01-04 | 2016-04-21 | マサチューセッツ インスティテュート オブ テクノロジー | ナノ粒子表面結合に基づく薬物の組織への送達 |
| WO2014144969A1 (en) * | 2013-03-15 | 2014-09-18 | Purdue Research Foundation | Extracellular matrix-binding synthetic peptidoglycans |
| EP3021857B1 (en) | 2013-07-19 | 2018-03-21 | The Johns Hopkins University | Biomaterials comprising hyaluronic acid binding peptides and extracellular matrix binding peptides for hyaluronic acid retention and tissue engineering applications |
| US11559580B1 (en) | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
| WO2015075699A1 (en) * | 2013-11-25 | 2015-05-28 | Sanofi | Dotam derivatives for therapeutic use |
| NZ720949A (en) | 2013-12-09 | 2019-03-29 | Univ Leland Stanford Junior | Methods and compositions for treating aging-associated conditions |
| US10905779B2 (en) | 2013-12-09 | 2021-02-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for screening human blood products comprising plasma using immunocompromised rodent models |
| WO2015164822A1 (en) | 2014-04-25 | 2015-10-29 | Purdue Research Foundation | Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction |
| MX382490B (es) | 2014-08-27 | 2025-03-13 | Amgen Inc | Variantes de inhibidor de tejido de metaloproteinasa tipo tres (timp-3), composiciones y metodos |
| US9682099B2 (en) | 2015-01-20 | 2017-06-20 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
| AU2016279804B2 (en) * | 2015-06-15 | 2019-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating aging-associated conditions |
| WO2017044894A2 (en) | 2015-09-09 | 2017-03-16 | Fred Hutchinson Cancer Research Center | Cartilage-homing peptides |
| EP3995141B1 (en) | 2016-04-28 | 2024-01-03 | Alkahest, Inc. | Plasma fractions as therapy for thymic cancer |
| EA039316B1 (ru) | 2016-10-24 | 2022-01-12 | Алкахест, Инк. | Фракции плазмы крови в качестве лечения когнитивных расстройств, связанных со старением |
| WO2018136614A1 (en) | 2017-01-18 | 2018-07-26 | Fred Hutchinson Cancer Research Center | Peptide compositions and methods of use thereof for disrupting tead interactions |
| EP3595699A4 (en) | 2017-03-16 | 2020-12-23 | Blaze Bioscience, Inc. | PEPTIDIC CONJUGATES OF CARTILAGE ECOTROPISM AND THEIR METHODS OF USE |
| MX2019012795A (es) | 2017-04-26 | 2020-02-13 | Alkahest Inc | Régimen de dosificación para el tratamiento de deterioros cognitivos y motores con plasma de sangre y productos de plasma de sangre. |
| US11040068B2 (en) | 2017-04-26 | 2021-06-22 | Alkahest, Inc. | Dosing regimen for treatment of cognitive and motor impairments with blood plasma and blood plasma products |
| EP3638290A4 (en) | 2017-06-15 | 2021-04-07 | Blaze Bioscience, Inc. | KIDNEY HOMING PEPTIDE CONJUGATES AND METHOD OF USING THEREOF |
| AU2018298224B2 (en) | 2017-07-07 | 2024-08-15 | Symic Ip, Llc | Synthetic bioconjugates |
| CA3086040A1 (en) | 2017-12-19 | 2019-06-27 | Blaze Bioscience, Inc. | Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof |
| AU2019233914A1 (en) * | 2018-03-16 | 2020-09-24 | Blaze Bioscience, Inc. | Truncated cartilage-homing peptides and peptide complexes and methods of use thereof |
| CN113166202B (zh) | 2018-10-12 | 2024-09-13 | 治疗调适公司 | 包括β-磷酸三钙-结合序列的多肽及其用途 |
| SG11202103696XA (en) | 2018-10-26 | 2021-05-28 | Alkahest Inc | Use of plasma and plasma fractions for improvement of pain, wound healing, and postoperative recovery |
| JP7471688B2 (ja) * | 2019-12-03 | 2024-04-22 | 中國醫藥大學 | オリゴペプチド、検出キット及び医薬組成物 |
| JP2023525960A (ja) | 2020-04-15 | 2023-06-20 | セラダプティブ インク | 骨に標的治療薬を送達するための組成物および方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2090925A (en) * | 1935-11-25 | 1937-08-24 | Platt Brothers & Co Ltd | Apparatus for opening and cleaning flax straw and such like fibrous materials |
| WO1986005519A1 (en) * | 1985-03-15 | 1986-09-25 | James Summerton | Polynucleotide assay reagent and method |
| US5185444A (en) * | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| US5227165A (en) * | 1989-11-13 | 1993-07-13 | Nova Pharmaceutical Corporation | Liposphere delivery systems for local anesthetics |
| US5410016A (en) * | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
| US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
| US6562596B1 (en) | 1993-10-06 | 2003-05-13 | Amgen Inc. | Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods |
| WO1997022371A1 (en) * | 1995-12-18 | 1997-06-26 | Collagen Corporation | Crosslinked polymer compositions and methods for their use |
| EP0930874A2 (en) * | 1996-10-09 | 1999-07-28 | Takeda Chemical Industries, Ltd. | A method for producing a microparticle |
| US6224794B1 (en) * | 1998-05-06 | 2001-05-01 | Angiotech Pharmaceuticals, Inc. | Methods for microsphere production |
| US20090087878A9 (en) * | 1999-05-06 | 2009-04-02 | La Rosa Thomas J | Nucleic acid molecules associated with plants |
| WO2001044497A2 (en) * | 1999-12-02 | 2001-06-21 | University Of Dundee | Protein kinase regulation |
| US20110131679A2 (en) * | 2000-04-19 | 2011-06-02 | Thomas La Rosa | Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement |
| JP2004520803A (ja) * | 2000-04-21 | 2004-07-15 | コリクサ コーポレイション | 尋常性挫瘡の治療および診断のための組成物および方法 |
| US7630836B2 (en) * | 2001-05-30 | 2009-12-08 | The Kitasato Institute | Polynucleotides |
| US7314974B2 (en) * | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
| AU2003301619A1 (en) * | 2002-10-23 | 2004-05-13 | Exelixis, Inc. | MBMs AS MODIFIERS OF BRANCHING MORPHOGENESIS AND METHODS OF USE |
-
2006
- 2006-10-10 US US11/545,819 patent/US7592009B2/en active Active
-
2007
- 2007-10-09 WO PCT/US2007/021529 patent/WO2008063291A2/en not_active Ceased
- 2007-10-09 AU AU2007322346A patent/AU2007322346A1/en not_active Abandoned
- 2007-10-09 EP EP07870773A patent/EP2084275A4/en active Pending
- 2007-10-09 JP JP2009532369A patent/JP2010505444A/ja active Pending
- 2007-10-09 CA CA002665839A patent/CA2665839A1/en not_active Abandoned
-
2009
- 2009-04-07 IL IL198120A patent/IL198120A0/en unknown
- 2009-09-21 US US12/563,201 patent/US20100080850A1/en not_active Abandoned
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