JP2010526801A5 - - Google Patents

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Publication number: JP2010526801A5
Authority: JP; Japan
Prior art keywords: compound; solvate; pharmaceutically acceptable; acceptable salt; alkyl
Prior art date: 2008-04-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

JP2010507013A

Other languages

English (en)

Japanese (ja)

Other versions

JP2010526801A (ja

Filing date

2008-04-28

Publication date

2010-09-24

2008-04-28 Application filed filed Critical

2008-04-28 Priority claimed from PCT/IB2008/001070 external-priority patent/WO2008139287A1/en

2010-08-05 Publication of JP2010526801A publication Critical patent/JP2010526801A/ja

2010-09-24 Publication of JP2010526801A5 publication Critical patent/JP2010526801A5/ja

Status Withdrawn legal-status Critical Current

Links

LWJGMYMNSNVCEM-UHFFFAOYSA-N 1-(4-fluorobenzoyl)-3-[(6-methoxynaphthalen-2-yl)oxymethyl]azetidine-3-carboxylic acid Chemical compound C1=CC2=CC(OC)=CC=C2C=C1OCC(C1)(C(O)=O)CN1C(=O)C1=CC=C(F)C=C1 LWJGMYMNSNVCEM-UHFFFAOYSA-N 0.000 claims description 2
150000001875 compounds Chemical class 0.000 claims 16
150000003839 salts Chemical class 0.000 claims 12
239000012453 solvate Substances 0.000 claims 12
-1 pyridinylphenyl group Chemical group 0.000 claims 10
125000000217 alkyl group Chemical group 0.000 claims 9
125000003545 alkoxy group Chemical group 0.000 claims 7
125000003118 aryl group Chemical group 0.000 claims 5
206010013935 Dysmenorrhoea Diseases 0.000 claims 4
208000000450 Pelvic Pain Diseases 0.000 claims 4
239000003814 drug Substances 0.000 claims 4
229910052731 fluorine Inorganic materials 0.000 claims 4
201000010260 leiomyoma Diseases 0.000 claims 4
125000001424 substituent group Chemical group 0.000 claims 4
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
239000008194 pharmaceutical composition Substances 0.000 claims 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
208000005641 Adenomyosis Diseases 0.000 claims 2
201000009273 Endometriosis Diseases 0.000 claims 2
206010046798 Uterine leiomyoma Diseases 0.000 claims 2
125000004414 alkyl thio group Chemical group 0.000 claims 2
230000001684 chronic effect Effects 0.000 claims 2
230000013872 defecation Effects 0.000 claims 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
201000009274 endometriosis of uterus Diseases 0.000 claims 2
125000001153 fluoro group Chemical group F* 0.000 claims 2
150000004677 hydrates Chemical class 0.000 claims 2
208000007106 menorrhagia Diseases 0.000 claims 2
208000024891 symptom Diseases 0.000 claims 2
125000001412 tetrahydropyranyl group Chemical group 0.000 claims 2
REAGPRQUVILCCU-UHFFFAOYSA-N 1-(4-fluorophenoxy)carbonyl-3-[(6-methoxynaphthalen-2-yl)oxymethyl]azetidine-3-carboxylic acid Chemical compound C1=CC2=CC(OC)=CC=C2C=C1OCC(C1)(C(O)=O)CN1C(=O)OC1=CC=C(F)C=C1 REAGPRQUVILCCU-UHFFFAOYSA-N 0.000 claims 1
XYEMEUZXCFSFRV-UHFFFAOYSA-N 3-[[4-(4-chlorophenyl)phenoxy]methyl]-1-(4,4-difluorocyclohexanecarbonyl)azetidine-3-carboxylic acid Chemical compound C1N(C(=O)C2CCC(F)(F)CC2)CC1(C(=O)O)COC(C=C1)=CC=C1C1=CC=C(Cl)C=C1 XYEMEUZXCFSFRV-UHFFFAOYSA-N 0.000 claims 1
208000004483 Dyspareunia Diseases 0.000 claims 1
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
208000002193 Pain Diseases 0.000 claims 1
239000002671 adjuvant Substances 0.000 claims 1
230000008485 antagonism Effects 0.000 claims 1
230000009286 beneficial effect Effects 0.000 claims 1
125000006267 biphenyl group Chemical group 0.000 claims 1
239000003085 diluting agent Substances 0.000 claims 1
201000010099 disease Diseases 0.000 claims 1
208000035475 disorder Diseases 0.000 claims 1
229940079593 drug Drugs 0.000 claims 1
125000005842 heteroatom Chemical group 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
125000001624 naphthyl group Chemical group 0.000 claims 1
229910052760 oxygen Inorganic materials 0.000 claims 1
230000036407 pain Effects 0.000 claims 1
230000001568 sexual effect Effects 0.000 claims 1
229910052717 sulfur Inorganic materials 0.000 claims 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
0 **C(N1CC(*)(CO[Al])C1)=O Chemical compound **C(N1CC(*)(CO[Al])C1)=O 0.000 description 2

JP2010507013A 2007-05-10 2008-04-28 プロスタグランジンｅ２拮抗薬としてのアゼチジン誘導体およびその使用 Withdrawn JP2010526801A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US91708107P	2007-05-10	2007-05-10
US1303007P	2007-12-12	2007-12-12
PCT/IB2008/001070 WO2008139287A1 (en)	2007-05-10	2008-04-28	Azetidine derivatives and their use as prostaglandin e2 antagonists

Publications (2)

Publication Number	Publication Date
JP2010526801A JP2010526801A (ja)	2010-08-05
JP2010526801A5 true JP2010526801A5 (2)	2010-09-24

Family

ID=39739736

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2010507013A Withdrawn JP2010526801A (ja)	2007-05-10	2008-04-28	プロスタグランジンｅ２拮抗薬としてのアゼチジン誘導体およびその使用

Country Status (27)

Country	Link
US (1)	US20080280877A1 (2)
EP (1)	EP2155666A1 (2)
JP (1)	JP2010526801A (2)
KR (1)	KR20100009582A (2)
CN (1)	CN101679235A (2)
AP (1)	AP2009005047A0 (2)
AR (1)	AR066524A1 (2)
AU (1)	AU2008249744A1 (2)
BR (1)	BRPI0811444A2 (2)
CA (1)	CA2686517A1 (2)
CL (1)	CL2008001305A1 (2)
CO (1)	CO6260066A2 (2)
CR (1)	CR11101A (2)
DO (1)	DOP2009000256A (2)
EA (1)	EA200901381A1 (2)
EC (1)	ECSP099727A (2)
GT (1)	GT200900293A (2)
IL (1)	IL201874A0 (2)
MA (1)	MA31366B1 (2)
MX (1)	MX2009011998A (2)
PA (1)	PA8779601A1 (2)
PE (1)	PE20090282A1 (2)
SV (1)	SV2009003407A (2)
TN (1)	TN2009000470A1 (2)
TW (1)	TW200904409A (2)
UY (1)	UY31070A1 (2)
WO (1)	WO2008139287A1 (2)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20100256109A1 (en) *	2007-11-15	2010-10-07	Sarah Elizabeth Skerratt	Azetidines As EP2 Antagonists
JP2012508225A (ja) *	2008-11-10	2012-04-05	ファイザー・リミテッド	ピロリジン
AU2010232556A1 (en) *	2009-04-02	2011-11-03	Allergan, Inc.	Prostaglandin E receptor antagonists
DE102009049662A1 (de)	2009-10-13	2011-04-14	Bayer Schering Pharma Aktiengesellschaft	2,5-Disubstituierte 2H-Indazole als EP2-Rezeptor-Antagonisten
JP6263469B2 (ja)	2011-07-15	2018-01-17	ノバルティスアーゲー	アザ二環式ジ−アリールエーテルの塩およびその製造方法またはその前駆体の製造方法
TW201326154A (zh)	2011-11-28	2013-07-01	拜耳知識產權公司	作為ｅｐ２受體拮抗劑之新穎２ｈ－吲唑
EP3237401B1 (en)	2014-12-22	2019-03-06	Pfizer Inc	Antagonists of prostaglandin ep3 receptor
CN110041269A (zh) *	2019-05-16	2019-07-23	海门瑞一医药科技有限公司	一种2-氯-5-羟基嘧啶的制备方法
AU2020388645B2 (en) *	2019-11-21	2026-03-19	University Of Utah Research Foundation	TRPV4 receptor ligands
EP4359399A4 (en) *	2021-06-24	2025-04-23	Reservoir Neuroscience, Inc.	EP2 antagonist compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8300860D0 (en) *	1983-01-13	1983-02-16	Shell Int Research	Azetidine compounds
GB8415614D0 (en) *	1984-06-19	1984-07-25	Shell Int Research	Azetidine derivatives
GB8509746D0 (en) *	1985-04-16	1985-05-22	Shell Int Research	Preparing azetidine derivatives
TW200300757A (en)	2001-11-16	2003-06-16	Schering Corp	Azetidinyl diamines useful as ligands of the nociceptin receptor orl-1
SI1934174T1 (sl) *	2005-10-07	2011-08-31	Exelixis Inc	Inhibitorji MEK in postopki za njihovo uporabo
US8383660B2 (en) *	2006-03-10	2013-02-26	Pfizer Inc.	Dibenzyl amine compounds and derivatives

2008
- 2008-04-28 BR BRPI0811444-7A2A patent/BRPI0811444A2/pt not_active IP Right Cessation
- 2008-04-28 WO PCT/IB2008/001070 patent/WO2008139287A1/en not_active Ceased
- 2008-04-28 KR KR1020097025684A patent/KR20100009582A/ko not_active Ceased
- 2008-04-28 AU AU2008249744A patent/AU2008249744A1/en not_active Abandoned
- 2008-04-28 MX MX2009011998A patent/MX2009011998A/es not_active Application Discontinuation
- 2008-04-28 CN CN200880019555A patent/CN101679235A/zh active Pending
- 2008-04-28 JP JP2010507013A patent/JP2010526801A/ja not_active Withdrawn
- 2008-04-28 EA EA200901381A patent/EA200901381A1/ru unknown
- 2008-04-28 AP AP2009005047A patent/AP2009005047A0/en unknown
- 2008-04-28 CA CA002686517A patent/CA2686517A1/en not_active Abandoned
- 2008-04-28 EP EP08737574A patent/EP2155666A1/en not_active Withdrawn
- 2008-05-05 US US12/115,070 patent/US20080280877A1/en not_active Abandoned
- 2008-05-06 CL CL200801305A patent/CL2008001305A1/es unknown
- 2008-05-08 PE PE2008000813A patent/PE20090282A1/es not_active Application Discontinuation
- 2008-05-08 UY UY31070A patent/UY31070A1/es not_active Application Discontinuation
- 2008-05-08 PA PA20088779601A patent/PA8779601A1/es unknown
- 2008-05-09 TW TW097117225A patent/TW200904409A/zh unknown
- 2008-05-09 AR ARP080101988A patent/AR066524A1/es unknown
2009
- 2009-11-01 IL IL201874A patent/IL201874A0/en unknown
- 2009-11-05 DO DO2009000256A patent/DOP2009000256A/es unknown
- 2009-11-06 TN TNP2009000470A patent/TN2009000470A1/fr unknown
- 2009-11-06 SV SV2009003407A patent/SV2009003407A/es not_active Application Discontinuation
- 2009-11-09 CO CO09126880A patent/CO6260066A2/es not_active Application Discontinuation
- 2009-11-09 CR CR11101A patent/CR11101A/es not_active Application Discontinuation
- 2009-11-10 EC EC2009009727A patent/ECSP099727A/es unknown
- 2009-11-10 GT GT200900293A patent/GT200900293A/es unknown
- 2009-11-10 MA MA32331A patent/MA31366B1/fr unknown

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JP2010526801A5 (2)	2010-09-24
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