JP2011521930A5 - - Google Patents
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- Publication number
- JP2011521930A5 JP2011521930A5 JP2011511053A JP2011511053A JP2011521930A5 JP 2011521930 A5 JP2011521930 A5 JP 2011521930A5 JP 2011511053 A JP2011511053 A JP 2011511053A JP 2011511053 A JP2011511053 A JP 2011511053A JP 2011521930 A5 JP2011521930 A5 JP 2011521930A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- formula
- natural
- modified
- protected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0802928A FR2931824B1 (fr) | 2008-05-29 | 2008-05-29 | Procede de synthese d'arn par voie chimique. |
| FR0802928 | 2008-05-29 | ||
| PCT/FR2009/000624 WO2009144418A1 (fr) | 2008-05-29 | 2009-05-28 | Procede de synthese d'arn par voie chimique |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011521930A JP2011521930A (ja) | 2011-07-28 |
| JP2011521930A5 true JP2011521930A5 (2) | 2014-07-24 |
| JP5689054B2 JP5689054B2 (ja) | 2015-03-25 |
Family
ID=39712442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011511053A Expired - Fee Related JP5689054B2 (ja) | 2008-05-29 | 2009-05-28 | Ｒｎａ化学合成方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8536318B2 (2) |
| EP (1) | EP2303905B1 (2) |
| JP (1) | JP5689054B2 (2) |
| BR (1) | BRPI0910689A2 (2) |
| CA (1) | CA2726260C (2) |
| FR (1) | FR2931824B1 (2) |
| WO (1) | WO2009144418A1 (2) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011028218A1 (en) | 2009-09-02 | 2011-03-10 | Alnylam Pharmaceuticals, Inc. | Process for triphosphate oligonucleotide synthesis |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2625189B1 (en) | 2010-10-01 | 2018-06-27 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DE19216461T1 (de) | 2011-10-03 | 2021-10-07 | Modernatx, Inc. | Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon |
| CA3018046A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| WO2013151665A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| EP2878604B1 (en) | 2012-07-25 | 2018-08-29 | Kochi University | Monomer for synthesis of rna, method for producing same, and method for producing rna |
| PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| PL221806B1 (pl) | 2013-03-21 | 2016-05-31 | Inst Chemii Bioorg Polskiej Akademii Nauk | Sposób wprowadzania acetalowych i acetaloestrowych grup ochronnych oraz związki do realizacji tego sposobu |
| EP3041934A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| EP3062798B1 (en) | 2013-11-01 | 2020-05-06 | CureVac AG | Modified rna with decreased immunostimulatory properties |
| WO2015062738A1 (en) | 2013-11-01 | 2015-05-07 | Curevac Gmbh | Modified rna with decreased immunostimulatory properties |
| US20170204152A1 (en) | 2014-07-16 | 2017-07-20 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| EP4441066A1 (en) | 2021-11-29 | 2024-10-09 | Hongene Biotech Corporation | Synthesis of 2' acetyl-ester protected nucleosides |
| CN114685572B (zh) * | 2022-06-02 | 2022-08-30 | 上海百力格生物技术有限公司 | 用于mgb核酸探针合成的氧化剂组合物及探针的合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) * | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| EP1386925A1 (en) * | 2002-07-31 | 2004-02-04 | Girindus AG | Method for preparing oligonucleotides |
| CN100484949C (zh) * | 2005-07-18 | 2009-05-06 | 张必良 | 用于rna寡核苷酸合成中的核苷亚磷酰胺及其合成方法 |
-
2008
- 2008-05-29 FR FR0802928A patent/FR2931824B1/fr active Active
-
2009
- 2009-04-28 BR BRPI0910689A patent/BRPI0910689A2/pt not_active IP Right Cessation
- 2009-05-28 US US12/995,001 patent/US8536318B2/en active Active
- 2009-05-28 WO PCT/FR2009/000624 patent/WO2009144418A1/fr not_active Ceased
- 2009-05-28 JP JP2011511053A patent/JP5689054B2/ja not_active Expired - Fee Related
- 2009-05-28 EP EP09754068A patent/EP2303905B1/fr active Active
- 2009-05-28 CA CA2726260A patent/CA2726260C/fr active Active
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