JP2012506896A5 - - Google Patents
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- JP2012506896A5 JP2012506896A5 JP2011533714A JP2011533714A JP2012506896A5 JP 2012506896 A5 JP2012506896 A5 JP 2012506896A5 JP 2011533714 A JP2011533714 A JP 2011533714A JP 2011533714 A JP2011533714 A JP 2011533714A JP 2012506896 A5 JP2012506896 A5 JP 2012506896A5
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- JP
- Japan
- Prior art keywords
- meta
- compound
- och
- formula
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08167982.1 | 2008-10-30 | ||
| EP08167982 | 2008-10-30 | ||
| PCT/EP2009/064243 WO2010049466A1 (en) | 2008-10-30 | 2009-10-29 | Thienotriazolodiazepine derivatives active on apo a |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012506896A JP2012506896A (ja) | 2012-03-22 |
| JP2012506896A5 true JP2012506896A5 (2) | 2012-12-20 |
| JP5490811B2 JP5490811B2 (ja) | 2014-05-14 |
Family
ID=40380148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011533714A Expired - Fee Related JP5490811B2 (ja) | 2008-10-30 | 2009-10-29 | アポａに対して活性なチエノトリアゾロジアゼピン誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8569288B2 (2) |
| EP (1) | EP2362876B1 (2) |
| JP (1) | JP5490811B2 (2) |
| KR (1) | KR101633742B1 (2) |
| CN (1) | CN102292341B (2) |
| AU (1) | AU2009309691B2 (2) |
| BR (1) | BRPI0914406A2 (2) |
| CA (1) | CA2741934C (2) |
| EA (1) | EA018620B1 (2) |
| ES (1) | ES2448567T3 (2) |
| WO (1) | WO2010049466A1 (2) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008092231A1 (en) | 2007-02-01 | 2008-08-07 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular diseases |
| NZ755378A (en) | 2009-03-18 | 2022-07-29 | Resverlogix Corp | Novel quinazolinones and related compounds for use as anti-inflammatory agents |
| KR20190091564A (ko) | 2009-04-22 | 2019-08-06 | 리스버로직스 코퍼레이션 | 신규한 소염제 |
| WO2011143651A1 (en) * | 2010-05-14 | 2011-11-17 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating metabolism |
| CN103180318B (zh) * | 2010-05-14 | 2017-05-10 | 达那-法伯癌症研究所 | 雄性避孕组合物以及使用方法 |
| MX354217B (es) | 2010-05-14 | 2018-02-19 | Dana Farber Cancer Inst Inc | Composiciones y metodos para el tratamiento de leucemia. |
| PL2902030T3 (pl) | 2010-05-14 | 2017-07-31 | Dana-Farber Cancer Institute, Inc. | Związki tienotriazolodiazepinowe do leczenia nowotworu |
| US9249161B2 (en) | 2010-12-02 | 2016-02-02 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| WO2012151512A2 (en) | 2011-05-04 | 2012-11-08 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| EP2721031B1 (en) | 2011-06-17 | 2016-01-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| EP2864336B1 (en) | 2012-06-06 | 2016-11-23 | Constellation Pharmaceuticals, Inc. | Benzo[b]isoxazoloazepine bromodomain inhibitors and uses thereof |
| AU2014292888B2 (en) | 2013-07-25 | 2018-03-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
| CA2929652A1 (en) | 2013-11-08 | 2015-05-14 | Dana-Farber Cancer Institute, Inc. | Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors |
| CA2936865A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
| WO2015117087A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| SG11201607108XA (en) | 2014-02-28 | 2016-09-29 | Tensha Therapeutics Inc | Treatment of conditions associated with hyperinsulinaemia |
| CA2952830C (en) | 2014-06-20 | 2022-11-01 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide |
| KR20170032474A (ko) | 2014-08-08 | 2017-03-22 | 다나-파버 캔서 인스티튜트 인크. | 디히드로프테리디논 유도체 및 그의 용도 |
| CN106715437A (zh) | 2014-08-08 | 2017-05-24 | 达纳-法伯癌症研究所股份有限公司 | 二氮杂环庚烷衍生物及其用途 |
| BR112017008714A2 (pt) | 2014-10-27 | 2017-12-19 | Tensha Therapeutics Inc | inibidores de bromodomínio |
| JO3789B1 (ar) | 2015-03-13 | 2021-01-31 | Resverlogix Corp | التراكيب والوسائل العلاجية المعتمدة لمعالجة الامراض المتعلقة بالمتممة |
| US10702527B2 (en) | 2015-06-12 | 2020-07-07 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| HK1256417A1 (zh) | 2015-09-11 | 2019-09-20 | 达纳-法伯癌症研究所股份有限公司 | 氰基噻吩并三唑并二氮杂环庚三烯及其用途 |
| RU2018112953A (ru) | 2015-09-11 | 2019-10-14 | Дана-Фарбер Кэнсер Инститьют, Инк. | Ацетамидтиенотриазолодиазепины и пути их применения |
| MX2018006499A (es) | 2015-11-25 | 2018-08-01 | Dana Farber Cancer Inst Inc | Inhibidores de bromodominio bivalentes y usos de los mismos. |
| MX2020013608A (es) | 2018-06-13 | 2021-03-09 | Worg Pharmaceuticals Hangzhou Co Ltd | Preparacion de derivados de triazepina condensados y su uso como inhibidores de bet. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4155913A (en) * | 1973-02-08 | 1979-05-22 | Hoffmann-La Roche Inc. | Thienotriazolodiazepine derivatives |
| DE3435973A1 (de) * | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung |
| WO1988009333A1 (fr) | 1987-05-28 | 1988-12-01 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose a base de thieno(triazolo)diazepine et applications medicales de ce compose |
| DK0853480T3 (da) * | 1995-09-09 | 2003-05-05 | Hoffmann La Roche | Anvendelse af en thienotriazolodiazepin til forøgelse af apolipoprotein A-I-niveauer |
| US6444664B1 (en) * | 1997-04-18 | 2002-09-03 | Nederlandse Organisatie Voor Toegepast - Natuurweten Schappelijk Onderzoek (Tno) | Method for controlling the plasma level of lipoproteins to treat alzheimeris disease |
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2009
- 2009-10-29 US US13/126,600 patent/US8569288B2/en not_active Expired - Fee Related
- 2009-10-29 EA EA201100698A patent/EA018620B1/ru not_active IP Right Cessation
- 2009-10-29 ES ES09740899.1T patent/ES2448567T3/es active Active
- 2009-10-29 AU AU2009309691A patent/AU2009309691B2/en not_active Ceased
- 2009-10-29 CN CN200980150891.6A patent/CN102292341B/zh not_active Expired - Fee Related
- 2009-10-29 KR KR1020117012290A patent/KR101633742B1/ko not_active Expired - Fee Related
- 2009-10-29 JP JP2011533714A patent/JP5490811B2/ja not_active Expired - Fee Related
- 2009-10-29 WO PCT/EP2009/064243 patent/WO2010049466A1/en not_active Ceased
- 2009-10-29 EP EP09740899.1A patent/EP2362876B1/en not_active Not-in-force
- 2009-10-29 CA CA2741934A patent/CA2741934C/en not_active Expired - Fee Related
- 2009-10-29 BR BRPI0914406A patent/BRPI0914406A2/pt active Search and Examination