JP2012515217A5 - - Google Patents
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- Publication number
- JP2012515217A5 JP2012515217A5 JP2011546347A JP2011546347A JP2012515217A5 JP 2012515217 A5 JP2012515217 A5 JP 2012515217A5 JP 2011546347 A JP2011546347 A JP 2011546347A JP 2011546347 A JP2011546347 A JP 2011546347A JP 2012515217 A5 JP2012515217 A5 JP 2012515217A5
- Authority
- JP
- Japan
- Prior art keywords
- lymphoma
- administered
- combination
- cell
- ofatumumab
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims 11
- YTKUWDBFDASYHO-UHFFFAOYSA-N bendamustine Chemical compound ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 YTKUWDBFDASYHO-UHFFFAOYSA-N 0.000 claims 9
- 229960002707 bendamustine Drugs 0.000 claims 9
- 229960002450 ofatumumab Drugs 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 7
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 4
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 4
- 201000003444 follicular lymphoma Diseases 0.000 claims 4
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 206010073478 Anaplastic large-cell lymphoma Diseases 0.000 claims 2
- 208000032004 Large-Cell Anaplastic Lymphoma Diseases 0.000 claims 2
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- 210000003519 mature b lymphocyte Anatomy 0.000 claims 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 1
- 208000030289 Lymphoproliferative disease Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000007452 Plasmacytoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 238000002648 combination therapy Methods 0.000 claims 1
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 1
- 230000003325 follicular Effects 0.000 claims 1
- 201000009277 hairy cell leukemia Diseases 0.000 claims 1
- 230000007813 immunodeficiency Effects 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000011649 lymphoblastic lymphoma Diseases 0.000 claims 1
- 208000003747 lymphoid leukemia Diseases 0.000 claims 1
- 210000003826 marginal zone b cell Anatomy 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000017805 post-transplant lymphoproliferative disease Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 210000001948 pro-b lymphocyte Anatomy 0.000 claims 1
- 210000001978 pro-t lymphocyte Anatomy 0.000 claims 1
- 229960004641 rituximab Drugs 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14521009P | 2009-01-16 | 2009-01-16 | |
| US61/145,210 | 2009-01-16 | ||
| PCT/US2010/021123 WO2010083365A1 (en) | 2009-01-16 | 2010-01-15 | Treatment of a cancer using a combination of bendamustine and an anti-cd20 antibody |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012515217A JP2012515217A (ja) | 2012-07-05 |
| JP2012515217A5 true JP2012515217A5 (2) | 2013-03-07 |
Family
ID=42340093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011546347A Pending JP2012515217A (ja) | 2009-01-16 | 2010-01-15 | ベンダムスチンおよび抗−ｃｄ２０抗体の組合せを用いた癌治療 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20110274697A1 (2) |
| EP (1) | EP2405937A4 (2) |
| JP (1) | JP2012515217A (2) |
| KR (1) | KR20110111303A (2) |
| CN (1) | CN102355907A (2) |
| AU (1) | AU2010204666A1 (2) |
| BR (1) | BRPI1006829A2 (2) |
| CA (1) | CA2749151A1 (2) |
| EA (1) | EA201170940A1 (2) |
| IL (1) | IL213794A0 (2) |
| MX (1) | MX2011007589A (2) |
| SG (1) | SG172792A1 (2) |
| WO (1) | WO2010083365A1 (2) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI409079B (zh) * | 2009-08-14 | 2013-09-21 | Roche Glycart Ag | 非典型岩藻醣化ｃｄ２０抗體與苯達莫斯汀（ｂｅｎｄａｍｕｓｔｉｎｅ）之組合療法 |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2013120302A (ru) | 2010-10-01 | 2014-11-20 | Модерна Терапьютикс, Инк. | Сконструированные нуклеиновые кислоты и способы их применения |
| EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| PL2744515T3 (pl) * | 2011-08-16 | 2022-05-30 | Morphosys Ag | Terapia skojarzona przeciwciałem anty-cd19 i iperytem azotowym |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| FR2980110A1 (fr) * | 2011-09-20 | 2013-03-22 | Lfb Biotechnologies | Combinaison d'anticorps anti-cd20 et de bendamustine |
| RU2648950C2 (ru) | 2011-10-03 | 2018-04-02 | Модерна Терапьютикс, Инк. | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение |
| CN104114572A (zh) | 2011-12-16 | 2014-10-22 | 现代治疗公司 | 经修饰的核苷、核苷酸和核酸组合物 |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| AU2013243948A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins associated with human disease |
| WO2014081507A1 (en) | 2012-11-26 | 2014-05-30 | Moderna Therapeutics, Inc. | Terminally modified rna |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
| WO2018013239A1 (en) * | 2016-07-13 | 2018-01-18 | Takeda Pharmaceutical Company Limited | Combination of spleen tyrosine kinase inhibitors and other therapeutic agents |
| CN110540593B (zh) * | 2018-05-29 | 2022-05-17 | 上海药明生物技术有限公司 | 新型的抗cd3/抗cd20双特异性抗体 |
| WO2019228406A1 (en) * | 2018-05-29 | 2019-12-05 | Wuxi Biologics (Shanghai) Co., Ltd. | A novel anti-cd3/anti-cd20 bispecific antibody |
| JP2022508807A (ja) | 2018-10-16 | 2022-01-19 | ユーエス・ナノ・フード・アンド・ドラッグ・インコーポレーテッド | 腫瘍内注射製剤 |
| US11752165B2 (en) * | 2020-04-13 | 2023-09-12 | US Nano Food & Drug, Inc | Basic chemotherapeutic intratumour injection formulation |
| EP4190352B1 (en) | 2020-07-27 | 2026-03-25 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Formulation of novel bispecific anti-cd3/cd20 polypeptide complex |
| GB202218493D0 (en) * | 2022-12-08 | 2023-01-25 | Oncopeptides Ab | Novel therapeutic combinations |
| EP4674432A1 (en) * | 2023-03-01 | 2026-01-07 | Shanghai JMT-Bio Technology Co., Ltd. | Combination drug containing cd20/cd47 blocking bifunctional fusion protein, and use thereof |
| WO2024263801A2 (en) * | 2023-06-20 | 2024-12-26 | Burzynski Stanislaw R | Compositions comprising antineoplastons and methods of treating ovarian cancer |
| WO2024263804A2 (en) * | 2023-06-20 | 2024-12-26 | Burzynski Stanislaw R | Compositions comprising antineoplastons and methods of treating kidney cancer |
| WO2024263798A1 (en) * | 2023-06-20 | 2024-12-26 | Burzynski Stanislaw R | Compositions comprising antineoplastons and methods of treating prostate cancer |
| EP4731199A2 (en) * | 2023-06-21 | 2026-04-29 | Stanislaw R. Burzynski | Compositions comprising antineoplastons and methods of treating colorectal cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101928344B (zh) * | 2002-10-17 | 2014-08-13 | 根马布股份公司 | 抗cd20的人单克隆抗体 |
| EP1844815B1 (en) * | 2003-11-04 | 2011-09-14 | Novartis Vaccines and Diagnostics, Inc. | Combination therapy comprising anti-CD20 and anti-CD40 antibodies for the treatment of B cell-related cancers |
| JP5377968B2 (ja) * | 2005-11-10 | 2013-12-25 | トポターゲット ユーケー リミテッド | 癌治療のために単独で用いるまたは化学療法薬と併用するヒストンデアセチラーゼ（ｈｄａｃ）阻害剤 |
| US9382327B2 (en) * | 2006-10-10 | 2016-07-05 | Vaccinex, Inc. | Anti-CD20 antibodies and methods of use |
| WO2009083009A2 (en) * | 2008-01-03 | 2009-07-09 | Genmab A/S | Monoclonal antibodies against cd32b |
-
2010
- 2010-01-15 KR KR1020117018826A patent/KR20110111303A/ko not_active Withdrawn
- 2010-01-15 US US13/144,335 patent/US20110274697A1/en not_active Abandoned
- 2010-01-15 MX MX2011007589A patent/MX2011007589A/es not_active Application Discontinuation
- 2010-01-15 AU AU2010204666A patent/AU2010204666A1/en not_active Abandoned
- 2010-01-15 EP EP10732123A patent/EP2405937A4/en not_active Withdrawn
- 2010-01-15 BR BRPI1006829A patent/BRPI1006829A2/pt not_active IP Right Cessation
- 2010-01-15 CN CN2010800123232A patent/CN102355907A/zh active Pending
- 2010-01-15 SG SG2011047107A patent/SG172792A1/en unknown
- 2010-01-15 EA EA201170940A patent/EA201170940A1/ru unknown
- 2010-01-15 WO PCT/US2010/021123 patent/WO2010083365A1/en not_active Ceased
- 2010-01-15 CA CA2749151A patent/CA2749151A1/en not_active Abandoned
- 2010-01-15 JP JP2011546347A patent/JP2012515217A/ja active Pending
-
2011
- 2011-06-27 IL IL213794A patent/IL213794A0/en unknown
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