JP2013514980A5 - - Google Patents

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Publication number: JP2013514980A5
Authority: JP; Japan
Prior art keywords: compound according; group; pharmaceutically acceptable; acceptable salt; compound
Prior art date: 2010-12-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP2012544854A

Other languages

English (en)

Japanese (ja)

Other versions

JP2013514980A (ja

JP5922031B2 (ja

Filing date

2010-12-16

Publication date

2014-02-13

2010-12-16 Application filed filed Critical

2010-12-16 Priority claimed from PCT/US2010/060862 external-priority patent/WO2011084642A1/en

2013-05-02 Publication of JP2013514980A publication Critical patent/JP2013514980A/ja

2014-02-13 Publication of JP2013514980A5 publication Critical patent/JP2013514980A5/ja

2016-05-24 Application granted granted Critical

2016-05-24 Publication of JP5922031B2 publication Critical patent/JP5922031B2/ja

Status Expired - Fee Related legal-status Critical Current

2030-12-16 Anticipated expiration legal-status Critical

Links

150000001875 compounds Chemical class 0.000 claims 14
229910052760 oxygen Inorganic materials 0.000 claims 9
229910052799 carbon Inorganic materials 0.000 claims 8
150000003839 salts Chemical class 0.000 claims 6
229910052717 sulfur Inorganic materials 0.000 claims 6
229910052757 nitrogen Inorganic materials 0.000 claims 4
125000002723 alicyclic group Chemical group 0.000 claims 3
102000019355 Synuclein Human genes 0.000 claims 2
108050006783 Synuclein Proteins 0.000 claims 2
150000001338 aliphatic hydrocarbons Chemical class 0.000 claims 2
125000000217 alkyl group Chemical group 0.000 claims 2
206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
125000004432 carbon atom Chemical group C* 0.000 claims 2
201000010099 disease Diseases 0.000 claims 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
125000001165 hydrophobic group Chemical group 0.000 claims 2
206010012289 Dementia Diseases 0.000 claims 1
201000010374 Down Syndrome Diseases 0.000 claims 1
201000011240 Frontotemporal dementia Diseases 0.000 claims 1
208000009829 Lewy Body Disease Diseases 0.000 claims 1
201000002832 Lewy body dementia Diseases 0.000 claims 1
208000001089 Multiple system atrophy Diseases 0.000 claims 1
208000018737 Parkinson disease Diseases 0.000 claims 1
208000000609 Pick Disease of the Brain Diseases 0.000 claims 1
229910005965 SO 2 Inorganic materials 0.000 claims 1
125000001931 aliphatic group Chemical group 0.000 claims 1
125000003118 aryl group Chemical group 0.000 claims 1
239000003814 drug Substances 0.000 claims 1
125000000623 heterocyclic group Chemical group 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
239000000546 pharmaceutical excipient Substances 0.000 claims 1
239000012453 solvate Substances 0.000 claims 1
208000011580 syndromic disease Diseases 0.000 claims 1
0 CC(*)(*N)NN Chemical compound CC(*)(*N)NN 0.000 description 3
JYXUDLCIDLRXEP-UHFFFAOYSA-N CC1=NC2=CCCC=C2N1 Chemical compound CC1=NC2=CCCC=C2N1 JYXUDLCIDLRXEP-UHFFFAOYSA-N 0.000 description 1

JP2012544854A 2009-12-16 2010-12-16 化合物 Expired - Fee Related JP5922031B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US28708209P	2009-12-16	2009-12-16
US61/287,082		2009-12-16
PCT/US2010/060862 WO2011084642A1 (en)	2009-12-16	2010-12-16	Compound suitable for the treatment of synucleopathies

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2015218140A Division JP2016074679A (ja)	2009-12-16	2015-11-06	化合物

Publications (3)

Publication Number	Publication Date
JP2013514980A JP2013514980A (ja)	2013-05-02
JP2013514980A5 true JP2013514980A5 (2)	2014-02-13
JP5922031B2 JP5922031B2 (ja)	2016-05-24

Family

ID=43629477

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
JP2012544854A Expired - Fee Related JP5922031B2 (ja)	2009-12-16	2010-12-16	化合物
JP2015218140A Withdrawn JP2016074679A (ja)	2009-12-16	2015-11-06	化合物

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
JP2015218140A Withdrawn JP2016074679A (ja)	2009-12-16	2015-11-06	化合物

Country Status (12)

Country	Link
US (2)	US8846682B2 (2)
EP (1)	EP2513090A1 (2)
JP (2)	JP5922031B2 (2)
KR (1)	KR20120112548A (2)
CN (1)	CN102725284A (2)
AU (1)	AU2010339841B2 (2)
BR (1)	BR112012014807A2 (2)
CA (1)	CA2784744A1 (2)
MX (1)	MX335989B (2)
NZ (1)	NZ600449A (2)
RU (1)	RU2012129882A (2)
WO (1)	WO2011084642A1 (2)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX2014011615A (es) *	2012-03-28	2015-01-19	Neuropore Therapies Inc	Derivados de fenil-urea y fenil-carbamato como inhibidores de agregacion de proteina.
CN104703604A (zh)	2012-07-16	2015-06-10	神经孔疗法股份有限公司	作为蛋白质聚集抑制剂的二-和三-杂芳基衍生物
US10022357B2 (en)	2013-04-29	2018-07-17	The General Hospital Corporation	Amyloid precursor protein MRNA blockers for treating Down syndrome and Alzheimer's disease
AP2016009347A0 (en) *	2014-01-29	2016-07-31	Neuropore Therapies Inc	Heteroarly amides as inhibitors of protein aggregation
CN104530013B (zh) *	2014-12-04	2016-06-29	中国农业大学	基于吲哚环的吡唑酰胺类化合物作为农用杀菌剂的用途
EP3328379B1 (en) *	2015-07-29	2021-07-28	UCB Biopharma SRL	Bis-heteroaryl derivatives as modulators of protein aggregation
KR20190112031A (ko) *	2017-01-26	2019-10-02	유씨비 바이오파마 에스피알엘	단백질 응집의 조절제로서의 알콕시 비스-헤테로아릴 유도체
EA201991755A1 (ru)	2017-01-26	2020-01-22	Юсб Байофарма Спрл	Бициклические бисгетероарильные производные в качестве модуляторов агрегации белков
CN110198938B (zh)	2017-01-26	2023-03-14	Ucb生物制药私人有限公司	作为蛋白质聚集调节剂的双-杂芳基衍生物
US12178805B2 (en)	2017-05-11	2024-12-31	Remynd N.V.	Inhibitors of PDE6Delta for use in the prevention and/or treatment of epilepsy and/or neurodegenerative disorders
WO2018206760A1 (en)	2017-05-11	2018-11-15	Remynd N.V.	Compounds for the treatment of epilepsy, neurodegenerative disorders and other cns disorders
WO2023125376A1 (zh) *	2021-12-27	2023-07-06	上海京新生物医药有限公司	作为蛋白质聚集抑制剂的稠合双环杂芳基酰胺化合物
TW202415651A (zh)	2022-07-29	2024-04-16	日商住友製藥股份有限公司	含氮飽和雜環衍生物
TW202412787A (zh)	2022-07-29	2024-04-01	日商住友製藥股份有限公司	2(1h)-吡啶亞胺衍生物
WO2024102758A2 (en) *	2022-11-08	2024-05-16	The General Hospital Corporation	N-(n-aminoalkyl)phenanthridiunium series of chloride-sensitive fluorophores and methods of use thereof
WO2025002040A1 (zh) *	2023-06-25	2025-01-02	上海京新生物医药有限公司	双环杂芳基酰胺化合物的晶型及盐、制备方法和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0726263A3 (en) *	1995-02-08	1996-10-09	American Cyanamid Co	Herbicides (1,3,4) oxadiazoles and thiadiazoles
US5591695A (en) *	1995-02-08	1997-01-07	American Cyanamid Co.	Herbicidal [1,3,4]oxadiazoles and thiadiazoles
EP0946587A2 (en) *	1996-12-16	1999-10-06	Fujisawa Pharmaceutical Co., Ltd.	New amide compounds
US6096688A (en) *	1996-12-27	2000-08-01	American Cyanamid Company	Oxazole carboxamide herbicides
JP2007519753A (ja)	2004-01-30	2007-07-19	スミスクラインビーチャムコーポレーション	化合物
CA2580767A1 (en) *	2004-09-17	2006-03-30	Whitehead Institute For Biomedical Research	Compounds, compositions and methods of inhibiting alpha-synuclein toxicity
DE102004051277A1 (de)	2004-10-21	2006-04-27	Merck Patent Gmbh	Heterocyclische Carbonylverbindungen
KR101394245B1 (ko) *	2005-12-30	2014-05-14	에스케이바이오팜 주식회사	아이속사졸 유도체 및 이의 용도
US8541406B2 (en) *	2006-02-07	2013-09-24	Nv Remynd	Thiadiazole derivatives for the treatment of neurodegenerative diseases
US20100273776A1 (en) *	2006-03-29	2010-10-28	FOLDRx PHARMACEUTICALS, INC	Inhibition of alpha-synuclein toxicity
WO2009129532A1 (en) *	2008-04-18	2009-10-22	University Of Connecticut	Compounds for lysosomal modulation and methods of use
GB0910003D0 (en) *	2009-06-11	2009-07-22	Univ Leuven Kath	Novel compounds for the treatment of neurodegenerative diseases

2010
- 2010-12-16 KR KR1020127018232A patent/KR20120112548A/ko not_active Ceased
- 2010-12-16 CA CA2784744A patent/CA2784744A1/en not_active Abandoned
- 2010-12-16 RU RU2012129882/04A patent/RU2012129882A/ru not_active Application Discontinuation
- 2010-12-16 NZ NZ600449A patent/NZ600449A/en not_active IP Right Cessation
- 2010-12-16 JP JP2012544854A patent/JP5922031B2/ja not_active Expired - Fee Related
- 2010-12-16 BR BR112012014807A patent/BR112012014807A2/pt not_active IP Right Cessation
- 2010-12-16 AU AU2010339841A patent/AU2010339841B2/en not_active Ceased
- 2010-12-16 EP EP10805668A patent/EP2513090A1/en not_active Withdrawn
- 2010-12-16 US US13/516,543 patent/US8846682B2/en active Active
- 2010-12-16 MX MX2012006740A patent/MX335989B/es unknown
- 2010-12-16 CN CN2010800568024A patent/CN102725284A/zh active Pending
- 2010-12-16 WO PCT/US2010/060862 patent/WO2011084642A1/en not_active Ceased
2014
- 2014-08-21 US US14/465,773 patent/US20140364610A1/en not_active Abandoned
2015
- 2015-11-06 JP JP2015218140A patent/JP2016074679A/ja not_active Withdrawn

Publication	Publication Date	Title
JP2013514980A5 (2)	2014-02-13
JP2013510120A5 (2)	2013-11-07
JP2010077141A5 (2)	2012-07-26
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JP2014508804A5 (2)	2015-04-16
WO2009095872A3 (en)	2009-12-03	Labelled analogues of halobenzamides as multimodal radiopharmaceuticals and their precursors
JP2012526808A5 (2)	2013-06-27
TN2013000257A1 (en)	2014-11-10	Immunosuppressant formulations
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JP2013518036A5 (2)	2013-12-05