JP2014237635A5 - - Google Patents
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- Publication number
- JP2014237635A5 JP2014237635A5 JP2014097762A JP2014097762A JP2014237635A5 JP 2014237635 A5 JP2014237635 A5 JP 2014237635A5 JP 2014097762 A JP2014097762 A JP 2014097762A JP 2014097762 A JP2014097762 A JP 2014097762A JP 2014237635 A5 JP2014237635 A5 JP 2014237635A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- represented
- production method
- kaempferol
- caffeoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 claims 17
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims 11
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims 8
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 claims 8
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 6
- 230000003013 cytotoxicity Effects 0.000 claims 6
- 231100000135 cytotoxicity Toxicity 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 6
- JATBXVRRSYYPIL-SKGLXBPESA-N (3'R,4'R)-3'-Epoxyangeloyloxy-4'-acetoxy-3',4'-dihydroseselin Chemical compound CC1OC1(C)C(=O)O[C@H]1C(C)(C)OC(C=CC2=C3OC(=O)C=C2)=C3[C@H]1OC(C)=O JATBXVRRSYYPIL-SKGLXBPESA-N 0.000 claims 5
- JATBXVRRSYYPIL-UHFFFAOYSA-N isoepoxypteryxin Natural products CC1OC1(C)C(=O)OC1C(C)(C)OC(C=CC2=C3OC(=O)C=C2)=C3C1OC(C)=O JATBXVRRSYYPIL-UHFFFAOYSA-N 0.000 claims 5
- 230000000324 neuroprotective effect Effects 0.000 claims 5
- MQVRGDZCYDEQML-UHFFFAOYSA-N Astragalin Natural products C1=CC(OC)=CC=C1C1=C(OC2C(C(O)C(O)C(CO)O2)O)C(=O)C2=C(O)C=C(O)C=C2O1 MQVRGDZCYDEQML-UHFFFAOYSA-N 0.000 claims 4
- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 claims 4
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims 4
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims 4
- HOUHSBKVSRPPGO-UHFFFAOYSA-N UNPD177615 Natural products OCC(O)C1OC(OC2=C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)cc4)C(O)C1O HOUHSBKVSRPPGO-UHFFFAOYSA-N 0.000 claims 4
- 235000008777 kaempferol Nutrition 0.000 claims 4
- JPUKWEQWGBDDQB-QSOFNFLRSA-N kaempferol 3-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=CC(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O JPUKWEQWGBDDQB-QSOFNFLRSA-N 0.000 claims 4
- ZZZILDYSXRHUNY-UHFFFAOYSA-N kaempferol-3-O-glucoside Natural products OC1OC(COC2=C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)cc4)C(O)C(O)C1O ZZZILDYSXRHUNY-UHFFFAOYSA-N 0.000 claims 4
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 claims 4
- 235000005875 quercetin Nutrition 0.000 claims 4
- 229960001285 quercetin Drugs 0.000 claims 4
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 3
- 229960005305 adenosine Drugs 0.000 claims 3
- HFSACQSILLSUII-VXRRTDEQSA-N alpha-glutinol Chemical compound C([C@@H]1[C@@]2(C)CC[C@@]3(C)CCC(C[C@H]3[C@]2(C)CC[C@]11C)(C)C)C=C2[C@H]1CC[C@@H](O)C2(C)C HFSACQSILLSUII-VXRRTDEQSA-N 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- OLWSWWUSGLHFEB-UHFFFAOYSA-N glutinol Natural products CC1C(O)CCC2C1=CCC3C2(C)CCC4(C)C5CC(C)(C)CCC5(C)CCC34C OLWSWWUSGLHFEB-UHFFFAOYSA-N 0.000 claims 3
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 claims 3
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 claims 3
- 235000009498 luteolin Nutrition 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 102000012440 Acetylcholinesterase Human genes 0.000 claims 2
- 108010022752 Acetylcholinesterase Proteins 0.000 claims 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 2
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 claims 2
- 244000000626 Daucus carota Species 0.000 claims 2
- 235000002767 Daucus carota Nutrition 0.000 claims 2
- 241000196324 Embryophyta Species 0.000 claims 2
- RTATXGUCZHCSNG-TYSPDFDMSA-N Kaempferol-3-O-rutinoside Natural products OC1[C@H](O)[C@@H](O)C(C)O[C@H]1OCC1[C@@H](O)[C@@H](O)C(O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=CC(O)=CC=2)=O)O1 RTATXGUCZHCSNG-TYSPDFDMSA-N 0.000 claims 2
- RTATXGUCZHCSNG-QHWHWDPRSA-N Nicotiflorin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=CC(O)=CC=2)=O)O1 RTATXGUCZHCSNG-QHWHWDPRSA-N 0.000 claims 2
- 229940022698 acetylcholinesterase Drugs 0.000 claims 2
- FSLPMRQHCOLESF-UHFFFAOYSA-N alpha-amyrenol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C)C(C)C5C4=CCC3C21C FSLPMRQHCOLESF-UHFFFAOYSA-N 0.000 claims 2
- JFSHUTJDVKUMTJ-QHPUVITPSA-N beta-amyrin Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C JFSHUTJDVKUMTJ-QHPUVITPSA-N 0.000 claims 2
- QQFMRPIKDLHLKB-UHFFFAOYSA-N beta-amyrin Natural products CC1C2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C)CCC1(C)C QQFMRPIKDLHLKB-UHFFFAOYSA-N 0.000 claims 2
- PDNLMONKODEGSE-UHFFFAOYSA-N beta-amyrin acetate Natural products CC(=O)OC1CCC2(C)C(CCC3(C)C4(C)CCC5(C)CCC(C)(C)CC5C4=CCC23C)C1(C)C PDNLMONKODEGSE-UHFFFAOYSA-N 0.000 claims 2
- 231100000433 cytotoxic Toxicity 0.000 claims 2
- 230000001472 cytotoxic effect Effects 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000004090 neuroprotective agent Substances 0.000 claims 2
- RTATXGUCZHCSNG-ZFDPGQBLSA-N nicotiflorin Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC2=C(c3ccc(O)cc3)Oc3c(c(O)cc(O)c3)C2=O)O1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](C)O1 RTATXGUCZHCSNG-ZFDPGQBLSA-N 0.000 claims 2
- RTATXGUCZHCSNG-UHFFFAOYSA-N nicotiflorine Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=CC(O)=CC=2)=O)O1 RTATXGUCZHCSNG-UHFFFAOYSA-N 0.000 claims 2
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 claims 1
- BJCPCZHBNKBBBO-MVVFOYDKSA-N (3R,5R)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid Chemical compound O[C@@H]1CC(O)(C([C@@H](O)C1O)C(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O BJCPCZHBNKBBBO-MVVFOYDKSA-N 0.000 claims 1
- 229940100578 Acetylcholinesterase inhibitor Drugs 0.000 claims 1
- 241000208173 Apiaceae Species 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- OVVGHDNPYGTYIT-ROUHPGRKSA-N alpha-L-Rhap-(1->6)-D-Glcp Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 OVVGHDNPYGTYIT-ROUHPGRKSA-N 0.000 claims 1
- 239000000544 cholinesterase inhibitor Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 0 CC1O*1(C)C(OC([C@](C1)C(C=O)=O)C(C)(C)OC1=CC=C(C=CC(O1)=O)C1=*)=O Chemical compound CC1O*1(C)C(OC([C@](C1)C(C=O)=O)C(C)(C)OC1=CC=C(C=CC(O1)=O)C1=*)=O 0.000 description 3
- XFAOYBPOGKCEOV-UHFFFAOYSA-N CC1c(c(O)cc(O)c2)c2OC(c(cc2)cc(O)c2O)=C1 Chemical compound CC1c(c(O)cc(O)c2)c2OC(c(cc2)cc(O)c2O)=C1 XFAOYBPOGKCEOV-UHFFFAOYSA-N 0.000 description 1
Claims (15)
前記神経保護効果を有する物質を日本山ニンジンから抽出するステップを含む、生産方法。 A production method for producing a substance having a neuroprotective effect,
A production method comprising the step of extracting the substance having a neuroprotective effect from Japanese mountain carrot .
セリ科の植物から抽出物を抽出するステップを含む、生産方法。
A method of production comprising the step of extracting an extract from a plant of the family Apiaceae.
シシウド属の植物から抽出物を抽出するステップを含む、生産方法。
A production method comprising the step of extracting an extract from a plant of the genus Sisius.
日本山ニンジンから抽出物を抽出するステップを含む、生産方法。
A production method comprising the step of extracting an extract from Nihonsan Carrot .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014097762A JP5988058B2 (en) | 2013-05-09 | 2014-05-09 | Production method and neuroprotective agent |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013099714 | 2013-05-09 | ||
| JP2013099714 | 2013-05-09 | ||
| JP2014097762A JP5988058B2 (en) | 2013-05-09 | 2014-05-09 | Production method and neuroprotective agent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014237635A JP2014237635A (en) | 2014-12-18 |
| JP2014237635A5 true JP2014237635A5 (en) | 2016-04-14 |
| JP5988058B2 JP5988058B2 (en) | 2016-09-07 |
Family
ID=52135148
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014097760A Expired - Fee Related JP6065289B2 (en) | 2013-05-09 | 2014-05-09 | Extraction method, method for producing whitening cosmetics and method for producing hair care products |
| JP2014097762A Expired - Fee Related JP5988058B2 (en) | 2013-05-09 | 2014-05-09 | Production method and neuroprotective agent |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014097760A Expired - Fee Related JP6065289B2 (en) | 2013-05-09 | 2014-05-09 | Extraction method, method for producing whitening cosmetics and method for producing hair care products |
Country Status (1)
| Country | Link |
|---|---|
| JP (2) | JP6065289B2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10702571B2 (en) | 2015-12-03 | 2020-07-07 | The University Of North Carolina At Pembroke | Materials for cathepsin B enhancement and methods of use |
| JP2017066145A (en) * | 2016-10-07 | 2017-04-06 | 国立大学法人九州大学 | Hair matrix growth promoter, hair papilla cell growth promoter, alopecia topical medicine and method for producing alopecia topical medicine |
| JP6417514B2 (en) * | 2017-09-13 | 2018-11-07 | 国立大学法人九州大学 | Hair care product production method, hair matrix cell growth promoter, hair papilla cell growth promoter and melanin production promoter |
| JP7089755B2 (en) * | 2018-08-10 | 2022-06-23 | 株式会社東洋マテリアル | Acetylcholinesterase inhibitor |
| JP2024027638A (en) * | 2022-08-18 | 2024-03-01 | 日本メナード化粧品株式会社 | antibacterial agent |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60260520A (en) * | 1984-06-07 | 1985-12-23 | Takagi Koichi | Drug composition |
| JP3122564B2 (en) * | 1993-08-13 | 2001-01-09 | 丸善製薬株式会社 | Method for obtaining 3 '(R), 4' (R) -3'-epoxyangeloyloxy-4'-acetoxy-3 ', 4'-dihydroseserin |
| JP2007051075A (en) * | 2005-08-16 | 2007-03-01 | Keio Gijuku | Plant extract preparation method, plant extract and use thereof |
-
2014
- 2014-05-09 JP JP2014097760A patent/JP6065289B2/en not_active Expired - Fee Related
- 2014-05-09 JP JP2014097762A patent/JP5988058B2/en not_active Expired - Fee Related
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