JP2014508511A5 - - Google Patents
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- Publication number
- JP2014508511A5 JP2014508511A5 JP2013545325A JP2013545325A JP2014508511A5 JP 2014508511 A5 JP2014508511 A5 JP 2014508511A5 JP 2013545325 A JP2013545325 A JP 2013545325A JP 2013545325 A JP2013545325 A JP 2013545325A JP 2014508511 A5 JP2014508511 A5 JP 2014508511A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- amino acid
- antibody molecule
- seq
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 20
- 102000003810 Interleukin-18 Human genes 0.000 claims 9
- 108090000171 Interleukin-18 Proteins 0.000 claims 9
- 238000006467 substitution reaction Methods 0.000 claims 7
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 101000960954 Homo sapiens Interleukin-18 Proteins 0.000 claims 3
- 102000043959 human IL18 Human genes 0.000 claims 3
- 102000044166 interleukin-18 binding protein Human genes 0.000 claims 3
- 108010070145 interleukin-18 binding protein Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical group 0.000 claims 3
- 102000004557 Interleukin-18 Receptors Human genes 0.000 claims 2
- 108010017537 Interleukin-18 Receptors Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 101100067721 Caenorhabditis elegans gly-3 gene Proteins 0.000 claims 1
- 101100315624 Caenorhabditis elegans tyr-1 gene Proteins 0.000 claims 1
- 102100038796 E3 ubiquitin-protein ligase TRIM13 Human genes 0.000 claims 1
- 101000664589 Homo sapiens E3 ubiquitin-protein ligase TRIM13 Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000004602 germ cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061424920P | 2010-12-20 | 2010-12-20 | |
| US61/424,920 | 2010-12-20 | ||
| PCT/EP2011/073496 WO2012085015A1 (en) | 2010-12-20 | 2011-12-20 | Anti-il-18 antibodies and their uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014508511A JP2014508511A (ja) | 2014-04-10 |
| JP2014508511A5 true JP2014508511A5 (2) | 2015-02-12 |
Family
ID=45372272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013545325A Pending JP2014508511A (ja) | 2010-12-20 | 2011-12-20 | 抗ｉｌ−１８抗体およびそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9255144B2 (2) |
| EP (1) | EP2655416A1 (2) |
| JP (1) | JP2014508511A (2) |
| KR (1) | KR20140003467A (2) |
| CN (1) | CN103339147A (2) |
| AU (2) | AU2011347354A1 (2) |
| BR (1) | BR112013015508B1 (2) |
| CA (1) | CA2822515C (2) |
| MX (1) | MX2013007067A (2) |
| RU (1) | RU2013133846A (2) |
| WO (1) | WO2012085015A1 (2) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9376489B2 (en) * | 2012-09-07 | 2016-06-28 | Novartis Ag | IL-18 binding molecules |
| ES2742413T3 (es) * | 2012-11-21 | 2020-02-14 | Km Biologics Co Ltd | Nuevo anticuerpo humano contra IL-18 |
| CN115925928A (zh) * | 2013-09-05 | 2023-04-07 | Ab2生物股份有限公司 | 炎性疾病中的il-18结合蛋白(il-18bp) |
| WO2015160795A1 (en) * | 2014-04-14 | 2015-10-22 | The Regents Of The University Of California | Compositions and methods for treating inflammation |
| US10882905B2 (en) * | 2015-03-05 | 2021-01-05 | Ab2 Bio Sa | IL-18 binding protein (IL-18BP) and antibodies in inflammatory diseases |
| FI3592384T3 (fi) | 2017-03-09 | 2025-09-29 | Mab Discovery Gmbh | Vasta-aineita, jotka spesifisesti sitoutuvat ihmisen IL-1R7:ään |
| WO2019213686A1 (en) * | 2018-05-10 | 2019-11-14 | The Council Of The Queensland Institute Of Medical Research | Therapeutic compositions and uses therefor |
| US12269874B2 (en) | 2018-12-03 | 2025-04-08 | mAbProtein Co., Ltd. | Antibody that recognizes neoepitope of activated interleukin-18 proteins and application thereof |
| CN109870570A (zh) * | 2018-12-29 | 2019-06-11 | 广东云天抗体生物科技有限公司 | 一种检测猴il-18的酶联免疫试剂盒 |
| GB202007404D0 (en) * | 2020-05-19 | 2020-07-01 | Nasser Syed Muhammad Tahir | Treatment for viral respiratory infections |
| TW202210511A (zh) * | 2020-06-01 | 2022-03-16 | 美商阿法羅醫療股份有限公司 | 涉及il-18抗體之方法及治療 |
| CN112415191A (zh) * | 2020-11-06 | 2021-02-26 | 郑州人福博赛生物技术有限责任公司 | 一种白细胞三烯检测试剂盒 |
| EP4371573A4 (en) | 2021-07-13 | 2025-08-20 | National Univ Corporation Tokai National Higher Education And Research System | MEDICINAL COMPOSITION FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE |
| WO2023067348A1 (en) | 2021-10-21 | 2023-04-27 | Biosirius Ltd | Treatment for virally-induced pneumonia |
| MX2024007616A (es) * | 2021-12-20 | 2024-09-04 | Avalo Therapeutics Inc | Métodos y tratamiento para la enfermedad de still de inicio en la edad adulta y la artritis idiopática juvenil de inicio sistemico que implica anticuerpos contra il-18. |
| PE20251671A1 (es) | 2022-03-15 | 2025-06-30 | Compugen Ltd | Anticuerpos antagonistas de il-18bp y su uso en monoterapia y terapia de combinacion en el tratamiento del cancer |
| CN116236560A (zh) * | 2022-12-13 | 2023-06-09 | 华中科技大学同济医学院附属同济医院 | 人白细胞介素-37b在制备治疗鼻息肉的药品中的应用 |
| AU2024314970A1 (en) | 2023-06-20 | 2026-01-15 | Apollo Ap43 Limited | Anti-il-18 antibody therapy for treating atopic dermatitis |
| TW202515608A (zh) | 2023-06-26 | 2025-04-16 | 以色列商坎布根有限公司 | Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途 |
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| US565332A (en) | 1896-08-04 | Toy for making soap-bubbles | ||
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4318980A (en) | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
| US4424200A (en) | 1979-05-14 | 1984-01-03 | Nuc Med Inc. | Method for radiolabeling proteins with technetium-99m |
| US4479930A (en) | 1982-07-26 | 1984-10-30 | Trustees Of The University Of Massachusetts | Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5185243A (en) | 1988-08-25 | 1993-02-09 | Syntex (U.S.A.) Inc. | Method for detection of specific nucleic acid sequences |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
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| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| GB9206318D0 (en) | 1992-03-24 | 1992-05-06 | Cambridge Antibody Tech | Binding substances |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5962255A (en) | 1992-03-24 | 1999-10-05 | Cambridge Antibody Technology Limited | Methods for producing recombinant vectors |
| US6225447B1 (en) | 1991-05-15 | 2001-05-01 | Cambridge Antibody Technology Ltd. | Methods for producing members of specific binding pairs |
| US5871907A (en) | 1991-05-15 | 1999-02-16 | Medical Research Council | Methods for producing members of specific binding pairs |
| US6492160B1 (en) | 1991-05-15 | 2002-12-10 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| US5858657A (en) | 1992-05-15 | 1999-01-12 | Medical Research Council | Methods for producing members of specific binding pairs |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| US5872215A (en) | 1991-12-02 | 1999-02-16 | Medical Research Council | Specific binding members, materials and methods |
| ES2341666T3 (es) | 1991-12-02 | 2010-06-24 | Medimmune Limited | Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos. |
| GB9203459D0 (en) | 1992-02-19 | 1992-04-08 | Scotgen Ltd | Antibodies with germ-line variable regions |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| ATE199392T1 (de) | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| BR9707495A (pt) | 1996-02-13 | 1999-07-27 | Zeneca Ltd | Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente |
| US6291455B1 (en) | 1996-03-05 | 2001-09-18 | Zeneca Limited | 4-anilinoquinazoline derivatives |
| US5814468A (en) | 1996-03-27 | 1998-09-29 | Coulter International Corp. | Methods of enumerating receptor molecules for specific binding partners on formed bodies and in solution |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| CA2276216A1 (en) | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
| DE69941267D1 (de) | 1998-12-10 | 2009-09-24 | Bristol Myers Squibb Co | Proteingerüste für antikörper-nachahmer und andere bindende proteine |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| AR022952A1 (es) | 1999-03-19 | 2002-09-04 | Smithkline Beecham Corp | ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL |
| TWI335336B (2) * | 2000-02-10 | 2011-01-01 | Abbott Gmbh & Co Kg | |
| ES2253358T3 (es) | 2000-03-31 | 2006-06-01 | Cambridge Antibody Technology Limited | Mejoras en la visualizacion del ribosoma. |
| NZ522074A (en) | 2000-05-31 | 2004-06-25 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| CN1255392C (zh) | 2000-07-07 | 2006-05-10 | 安吉奥金尼药品有限公司 | 作为血管生成抑制剂的秋水仙醇衍生物 |
| IL153484A0 (en) | 2000-07-07 | 2003-07-06 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors |
| MXPA05000511A (es) | 2001-07-12 | 2005-09-30 | Jefferson Foote | Anticuepros super humanizados. |
| AU2004235595C1 (en) | 2003-04-30 | 2009-09-24 | Japan Science And Technology Agency | Human antihuman interleukin-18 antibody, fragment thereof and method of using the same |
| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| US20050100965A1 (en) * | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
| GB0500099D0 (en) | 2005-01-05 | 2005-02-09 | Cambridge Antibody Tech | Methods and means relating to protein variants |
| CN103555733A (zh) | 2005-01-05 | 2014-02-05 | F-星生物技术研究与开发有限公司 | 分子中互补决定区以外的区域中工程改造了的具有结合特性的合成免疫球蛋白结构域 |
| BRPI0822099A2 (pt) * | 2007-12-21 | 2017-05-23 | Medimmune Ltd | membro de ligação isolado, uso de um membro de ligação isolado, método parav tratar um distúrbio, molécula de ácido nucléico isolada, célula hospedeira, e, método para produzir um membro de ligação |
| WO2009099545A1 (en) * | 2008-01-30 | 2009-08-13 | Abbott Laboratories | Compositions and methods for crystallizing antibody fragments |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
-
2011
- 2011-12-20 KR KR1020137018576A patent/KR20140003467A/ko not_active Withdrawn
- 2011-12-20 CA CA2822515A patent/CA2822515C/en active Active
- 2011-12-20 MX MX2013007067A patent/MX2013007067A/es not_active Application Discontinuation
- 2011-12-20 CN CN2011800612426A patent/CN103339147A/zh active Pending
- 2011-12-20 EP EP11799104.2A patent/EP2655416A1/en not_active Withdrawn
- 2011-12-20 WO PCT/EP2011/073496 patent/WO2012085015A1/en not_active Ceased
- 2011-12-20 RU RU2013133846/10A patent/RU2013133846A/ru not_active Application Discontinuation
- 2011-12-20 US US13/993,537 patent/US9255144B2/en active Active
- 2011-12-20 AU AU2011347354A patent/AU2011347354A1/en not_active Abandoned
- 2011-12-20 JP JP2013545325A patent/JP2014508511A/ja active Pending
- 2011-12-20 BR BR112013015508-6A patent/BR112013015508B1/pt active IP Right Grant
-
2017
- 2017-03-06 AU AU2017201512A patent/AU2017201512A1/en not_active Abandoned
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