JP2014532430A5 - - Google Patents
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- Publication number
- JP2014532430A5 JP2014532430A5 JP2014540177A JP2014540177A JP2014532430A5 JP 2014532430 A5 JP2014532430 A5 JP 2014532430A5 JP 2014540177 A JP2014540177 A JP 2014540177A JP 2014540177 A JP2014540177 A JP 2014540177A JP 2014532430 A5 JP2014532430 A5 JP 2014532430A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- binding
- binding partner
- acid complex
- linked
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161556194P | 2011-11-05 | 2011-11-05 | |
| US61/556,194 | 2011-11-05 | ||
| US201261666655P | 2012-06-29 | 2012-06-29 | |
| US61/666,655 | 2012-06-29 | ||
| PCT/US2012/063538 WO2013067489A1 (en) | 2011-11-05 | 2012-11-05 | Nucleic acid-based linkers for detecting and measuring interactions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532430A JP2014532430A (ja) | 2014-12-08 |
| JP2014532430A5 true JP2014532430A5 (2) | 2015-12-24 |
| JP6430253B2 JP6430253B2 (ja) | 2018-11-28 |
Family
ID=48192891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014540177A Active JP6430253B2 (ja) | 2011-11-05 | 2012-11-05 | 相互作用を検出および測定するための核酸ベースのリンカー |
Country Status (3)
| Country | Link |
|---|---|
| US (2) | US9914958B2 (2) |
| JP (1) | JP6430253B2 (2) |
| WO (1) | WO2013067489A1 (2) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6430253B2 (ja) * | 2011-11-05 | 2018-11-28 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 相互作用を検出および測定するための核酸ベースのリンカー |
| AU2014287071A1 (en) | 2013-07-10 | 2016-01-28 | Children's Medical Center Corporation | Compositions and methods relating to nucleic acid-protein complexes |
| EP3594363A1 (en) * | 2014-04-23 | 2020-01-15 | Children's Medical Center Corporation | High-throughput structure determination using nucleic acid calipers |
| US11198900B2 (en) | 2014-12-06 | 2021-12-14 | Children's Medical Center Corporation | Nucleic acid-based linkers for detecting and measuring interactions |
| US11396650B2 (en) | 2015-06-02 | 2022-07-26 | Children's Medical Center Corporation | Nucleic acid complexes for screening barcoded compounds |
| US12077807B2 (en) | 2015-06-27 | 2024-09-03 | The Research Foundation For The State University Of New York | Compositions and methods for analyte detection using nanoswitches |
| EP3356547B1 (en) * | 2015-10-01 | 2020-11-18 | Dynamic Biosensors GmbH | Method for detecting molecular interactions using an immobilized nucleic acid |
| US11713483B2 (en) | 2016-02-09 | 2023-08-01 | Children's Medical Center Corporation | Method for detection of analytes via polymer complexes |
| WO2017147398A1 (en) | 2016-02-25 | 2017-08-31 | Children's Medical Center Corporation | Spinning apparatus for measurement of characteristics relating to molecules |
| EP3426598B1 (en) | 2016-03-11 | 2021-07-28 | Children's Medical Center Corporation | Nucleic acid nanoswitch catenanes |
| US12123869B2 (en) | 2016-03-23 | 2024-10-22 | Children's Medical Center Corporation | Rapid and sensitive detection and quantification of analytes in complex samples using polymer-based methods |
| US10919037B2 (en) | 2016-03-23 | 2021-02-16 | Children's Medical Center Corporation | Systems and apparatus for detecting compounds in human biological samples |
| WO2017189794A1 (en) * | 2016-04-27 | 2017-11-02 | President And Fellows Of Harvard College | Method of secure communication via nucleotide polymers |
| US10823699B2 (en) | 2016-07-29 | 2020-11-03 | Vital Biosciences, Inc. | Gel electrophoresis diagnostic kit and methods of using the same |
| EP3494124B1 (en) | 2016-08-02 | 2022-03-09 | President and Fellows of Harvard College | Crisscross cooperative self-assembly |
| US12252507B2 (en) | 2016-12-05 | 2025-03-18 | Children's Medical Center Corporation | Nucleic acid nanoswitch construction methods |
| WO2018119437A2 (en) | 2016-12-23 | 2018-06-28 | Confer Health, Inc. | Electrophoresis diagnostic methods and kits |
| US11591636B2 (en) | 2017-11-20 | 2023-02-28 | Children's Medical Center Corporation | Force-controlled nanoswitch assays for single-molecule detection in complex biological fluids |
| FR3075820B1 (fr) | 2017-12-21 | 2022-12-30 | Paris Sciences Lettres Quartier Latin | Molecule d'adn double-brin pour la detection et la caracterisation des interactions moleculaires |
| US11561221B2 (en) * | 2018-05-02 | 2023-01-24 | Trustees Of Boston University | Dynamic tracking of captured targets for enhanced digital biosensing |
| WO2019236726A1 (en) | 2018-06-06 | 2019-12-12 | The Regents Of The University Of California | Methods of producing nucleic acid libraries and compositions and kits for practicing same |
| WO2020163397A2 (en) * | 2019-02-04 | 2020-08-13 | Akoya Biosciences, Inc. | Analyte detection by selective labeling of biological samples |
| WO2021174071A1 (en) | 2020-02-29 | 2021-09-02 | President And Fellows Of Harvard College | Nanoswitch caliper trains for high-throughput, high-resolution structural analysis of biomolecules |
| CN111549098B (zh) * | 2020-06-16 | 2024-10-29 | 南开大学 | 测量人端粒精准长度的单分子力学方法 |
| CN111721504B (zh) * | 2020-06-17 | 2022-02-18 | 中国科学院物理研究所 | 在小力下测算磁镊高度转换系数的方法及应用 |
| WO2022099216A1 (en) * | 2020-11-09 | 2022-05-12 | Children's Medical Center Corporation | Systems and methods for high throughput screening of molecular interactions |
| CN119563035A (zh) | 2022-04-01 | 2025-03-04 | 德皮克萨斯股份有限公司 | 筛选化合物的方法 |
| WO2025041065A1 (en) * | 2023-08-21 | 2025-02-27 | Depixus SAS | Device for determining molecular interactions |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9114525D0 (en) | 1991-07-05 | 1991-08-21 | Delnatte Sabine | Homogeneous nucleic acids probe based tests and substances |
| WO1995001365A1 (en) | 1993-07-02 | 1995-01-12 | Lynx Therapeutics, Inc. | Synthesis of branched nucleic acids |
| US5681697A (en) * | 1993-12-08 | 1997-10-28 | Chiron Corporation | Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor |
| US5888731A (en) * | 1995-08-30 | 1999-03-30 | Visible Genetics Inc. | Method for identification of mutations using ligation of multiple oligonucleotide probes |
| EP0938588B1 (en) * | 1996-07-12 | 2003-02-12 | TM Technologies Inc. | Signal amplification method |
| US6251660B1 (en) | 1997-11-25 | 2001-06-26 | Mosaic Technologies, Inc. | Devices and methods for detecting target molecules in biological samples |
| US20020177144A1 (en) | 1997-12-30 | 2002-11-28 | Jose Remacle | Detection and/or quantification method of a target molecule by a binding with a capture molecule fixed on the surface of a disc |
| US6143504A (en) * | 1998-10-27 | 2000-11-07 | Arch Development Corporation | Methods and compositions for the diagnosis of fragile X syndrome |
| GB9827912D0 (en) * | 1998-12-19 | 1999-02-10 | Univ Manchester | Detecting nucleic acids |
| JP3080951B1 (ja) | 1999-03-04 | 2000-08-28 | 株式会社分子バイオホトニクス研究所 | ウイルスを検出する方法 |
| CA2453360A1 (en) | 2001-07-11 | 2003-01-23 | Applera Corporation | Internal calibration standards for electrophoretic analyses |
| US20030143549A1 (en) * | 2002-01-29 | 2003-07-31 | Eastman Kodak Company | Method for DNA sequencing and gene identification |
| US7294513B2 (en) | 2002-07-24 | 2007-11-13 | Wyatt Technology Corporation | Method and apparatus for characterizing solutions of small particles |
| WO2004016767A2 (en) | 2002-08-19 | 2004-02-26 | The President And Fellows Of Harvard College | Evolving new molecular function |
| AU2002952797A0 (en) | 2002-11-20 | 2002-12-05 | Bio-Molecular Holdings Pty Limited | Centrifugal device and method using same |
| CN103396933B (zh) * | 2003-02-26 | 2016-04-20 | 凯利达基因组股份有限公司 | 通过杂交进行的随机阵列dna分析 |
| WO2006041194A1 (ja) | 2004-10-15 | 2006-04-20 | Japan Science And Technology Agency | ｍＲＮＡ－ピューロマイシン－タンパク質連結体作製用リンカー |
| US20070026423A1 (en) * | 2005-03-16 | 2007-02-01 | Thomas Koehler | Method and test kit for the detection of target nucleic acids |
| WO2006128138A2 (en) * | 2005-05-26 | 2006-11-30 | Ensemble Discovery Corportion | Biodetection by nucleic acid-templated chemistry |
| US7842793B2 (en) | 2005-06-14 | 2010-11-30 | The California Institute Of Technology | Methods of making nucleic acid nanostructures |
| WO2007056250A2 (en) | 2005-11-04 | 2007-05-18 | U.S. Genomics, Inc. | Heterogeneous assay of analytes in solution using polymers |
| WO2007076128A2 (en) | 2005-12-23 | 2007-07-05 | Nanostring Technologies, Inc. | Nanoreporters and methods of manufacturing and use thereof |
| EP1987166A4 (en) * | 2006-02-03 | 2010-06-02 | Univ Columbia | BINARY DEOXYRIBOZYM PROBES FOR NUCLEIC ACID ANALYSIS |
| US8685894B2 (en) * | 2006-05-25 | 2014-04-01 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Modified nucleic acid nanoarrays and uses therefor |
| US20090286694A1 (en) | 2006-08-21 | 2009-11-19 | Gafur Zainiev | Nucleic acid array with releaseable nucleic acid probes |
| JP2008259453A (ja) | 2007-04-12 | 2008-10-30 | Toyobo Co Ltd | 核酸の検出方法 |
| US8043810B2 (en) | 2007-05-02 | 2011-10-25 | Eagle Eye Research, Inc. | Analyte detection using autocatalytic chain reactions |
| US8361299B2 (en) | 2008-10-08 | 2013-01-29 | Sage Science, Inc. | Multichannel preparative electrophoresis system |
| US8900549B2 (en) | 2008-10-31 | 2014-12-02 | The General Hospital Corporation | Compositions and methods for delivering a substance to a biological target |
| US8491454B2 (en) | 2008-12-02 | 2013-07-23 | President And Fellows Of Harvard College | Spinning force apparatus |
| CN102549427A (zh) | 2009-07-07 | 2012-07-04 | 新加坡科技研究局 | 鉴定结合配偶体对的方法 |
| WO2011047087A2 (en) * | 2009-10-13 | 2011-04-21 | Nanostring Technologies, Inc. | Protein detection via nanoreporters |
| US9138418B2 (en) | 2009-12-09 | 2015-09-22 | William Marsh Rice University | Therapeutic compositions and methods for delivery of active agents cleavably linked to nanoparticles |
| EP2576074B1 (en) | 2010-06-01 | 2019-03-06 | President and Fellows of Harvard College | Apparatus for measurement of spinning forces relating to molecules |
| WO2012044387A2 (en) | 2010-07-06 | 2012-04-05 | T2 Biosystems, Inc. | Methods and compositions for detection of analytes |
| JP6430253B2 (ja) * | 2011-11-05 | 2018-11-28 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 相互作用を検出および測定するための核酸ベースのリンカー |
| US9182334B2 (en) | 2012-02-24 | 2015-11-10 | Agilent Technologies, Inc. | Method of determining thermodynamic and kinetic parameters from measured off rates |
| WO2013177046A1 (en) | 2012-05-21 | 2013-11-28 | Solulink, Inc. | Methods and/or use of oligonucleotide conjugates for suppressing background due to cross-hybridization |
| US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
| WO2014011800A1 (en) | 2012-07-10 | 2014-01-16 | Pivot Bio, Inc. | Methods for multipart, modular and scarless assembly of dna molecules |
| AU2014287071A1 (en) | 2013-07-10 | 2016-01-28 | Children's Medical Center Corporation | Compositions and methods relating to nucleic acid-protein complexes |
| US9333463B2 (en) | 2013-07-26 | 2016-05-10 | General Electric Company | Devices and systems for elution of biomolecules |
| US9322051B2 (en) | 2013-10-07 | 2016-04-26 | General Electric Company | Probing of biological samples |
| US20150361422A1 (en) | 2014-06-16 | 2015-12-17 | Agilent Technologies, Inc. | High throughput gene assembly in droplets |
| US11198900B2 (en) | 2014-12-06 | 2021-12-14 | Children's Medical Center Corporation | Nucleic acid-based linkers for detecting and measuring interactions |
| US12077807B2 (en) | 2015-06-27 | 2024-09-03 | The Research Foundation For The State University Of New York | Compositions and methods for analyte detection using nanoswitches |
-
2012
- 2012-11-05 JP JP2014540177A patent/JP6430253B2/ja active Active
- 2012-11-05 WO PCT/US2012/063538 patent/WO2013067489A1/en not_active Ceased
- 2012-11-05 US US14/356,282 patent/US9914958B2/en active Active
-
2018
- 2018-02-05 US US15/888,941 patent/US20180291434A1/en not_active Abandoned
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