JP2015504064A - 細胞内標的分子に対する結合剤 - Google Patents

細胞内標的分子に対する結合剤 Download PDF

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JP2015504064A
JP2015504064A JP2014550707A JP2014550707A JP2015504064A JP 2015504064 A JP2015504064 A JP 2015504064A JP 2014550707 A JP2014550707 A JP 2014550707A JP 2014550707 A JP2014550707 A JP 2014550707A JP 2015504064 A JP2015504064 A JP 2015504064A
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alpha
polypeptide
alpha body
cell
cells
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Inventor
イニャス ラスタルス
イニャス ラスタルス
マルク ヴェック
マルク ヴェック
ジョアン デスメット
ジョアン デスメット
ジャーゲン デバベジ
ジャーゲン デバベジ
サブリーナ デルー
サブリーナ デルー
ステファン ラブリクス
ステファン ラブリクス
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コンプリクス エン ヴェー
コンプリクス エン ヴェー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/102—Coronaviridae (F)
    • C07K16/104—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2]
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/80—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies
    • C07K2317/82—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies functional in the cytoplasm, the inner aspect of the cell membrane, the nucleus or the mitochondria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biochemistry (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
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  • Virology (AREA)
  • Pulmonology (AREA)
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JP2014550707A 2012-01-06 2013-01-04 細胞内標的分子に対する結合剤 Pending JP2015504064A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261583761P 2012-01-06 2012-01-06
US61/583,761 2012-01-06
EP12150406.2 2012-01-06
EP12150406 2012-01-06
US201261716893P 2012-10-22 2012-10-22
US61/716,893 2012-10-22
PCT/EP2013/050101 WO2013102659A2 (en) 2012-01-06 2013-01-04 Binding agents to intracellular target molecules

Publications (1)

Publication Number Publication Date
JP2015504064A true JP2015504064A (ja) 2015-02-05

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JP2014550707A Pending JP2015504064A (ja) 2012-01-06 2013-01-04 細胞内標的分子に対する結合剤

Country Status (9)

Country Link
US (1) US20140363434A1 (2)
EP (1) EP2800759B1 (2)
JP (1) JP2015504064A (2)
CN (1) CN104159913A (2)
AU (1) AU2013207209B2 (2)
BR (1) BR112014016744A2 (2)
CA (1) CA2860666A1 (2)
IN (1) IN2014MN01562A (2)
WO (1) WO2013102659A2 (2)

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JP2016506361A (ja) * 2012-10-22 2016-03-03 コンプリクス エン ヴェー Ｉｌ−２３に特異的に結合するポリペプチド
JP2018534240A (ja) * 2015-08-28 2018-11-22 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｂｆｌ−１と結合するペプチド
US11834520B2 (en) 2017-12-15 2023-12-05 Dana-Farber Cancer Institute, Inc. Selective targeting of apoptosis proteins by structurally-stabilized and/or cysteine-reactive NOXA peptides
US12570698B2 (en) 2015-08-28 2026-03-10 Dana-Farber Cancer Institute, Inc. Stabilized peptides for covalent binding to target protein

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EP2909233B1 (en) * 2012-10-22 2016-12-07 Complix NV Polypeptides capable of cellular internalization
EP3610884B1 (en) * 2013-11-06 2021-08-18 Merck Sharp & Dohme Corp. Peptide containing conjugates for dual molecular delivery of oligonucleotides
US11142554B2 (en) 2015-03-18 2021-10-12 Massachusetts Institute Of Technology Selective Mcl-1 binding peptides
US11198715B2 (en) 2016-07-22 2021-12-14 Massachusetts Institute Of Technology Selective Bfl-1 peptides
EP3805400A4 (en) 2018-06-04 2022-06-29 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule showing changed half-life in cytoplasm
WO2020060975A1 (en) 2018-09-17 2020-03-26 Massachusetts Institute Of Technology Peptides selective for bcl-2 family proteins
EP4036117A1 (en) * 2021-01-27 2022-08-03 Complix NV Mcl-1 binding alphabodies and uses thereof
WO2023203127A1 (en) * 2022-04-20 2023-10-26 Vib Vzw Alphabody-based degrader molecules

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016506361A (ja) * 2012-10-22 2016-03-03 コンプリクス エン ヴェー Ｉｌ−２３に特異的に結合するポリペプチド
JP2018534240A (ja) * 2015-08-28 2018-11-22 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｂｆｌ−１と結合するペプチド
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US20140363434A1 (en) 2014-12-11
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EP2800759B1 (en) 2018-07-18
AU2013207209A1 (en) 2014-08-07
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AU2013207209B2 (en) 2017-02-16
BR112014016744A8 (pt) 2017-07-04

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