JP2015509380A5 - - Google Patents
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- Publication number
- JP2015509380A5 JP2015509380A5 JP2014561037A JP2014561037A JP2015509380A5 JP 2015509380 A5 JP2015509380 A5 JP 2015509380A5 JP 2014561037 A JP2014561037 A JP 2014561037A JP 2014561037 A JP2014561037 A JP 2014561037A JP 2015509380 A5 JP2015509380 A5 JP 2015509380A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- heavy chain
- mouse
- immunoglobulin heavy
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 41
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 33
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 33
- 239000000427 antigen Substances 0.000 claims description 26
- 102000036639 antigens Human genes 0.000 claims description 26
- 108091007433 antigens Proteins 0.000 claims description 26
- 108060003951 Immunoglobulin Proteins 0.000 claims description 17
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 17
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 17
- 102000018358 immunoglobulin Human genes 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 15
- 241000699666 Mus <mouse, genus> Species 0.000 claims 26
- 210000003719 b-lymphocyte Anatomy 0.000 claims 15
- 102000025171 antigen binding proteins Human genes 0.000 claims 14
- 108091000831 antigen binding proteins Proteins 0.000 claims 14
- 210000004602 germ cell Anatomy 0.000 claims 7
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 4
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 241000699670 Mus sp. Species 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000000392 somatic effect Effects 0.000 claims 1
- 101150039504 6 gene Proteins 0.000 description 1
- 101100370002 Mus musculus Tnfsf14 gene Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/412,936 | 2012-03-06 | ||
| US13/412,936 US20120192300A1 (en) | 2010-02-08 | 2012-03-06 | Common Light Chain Mouse |
| PCT/US2013/029125 WO2013134263A1 (en) | 2012-03-06 | 2013-03-05 | Common light chain mouse |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018088350A Division JP2018138047A (ja) | 2010-02-08 | 2018-05-01 | 共通の軽鎖のマウス |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015509380A JP2015509380A (ja) | 2015-03-30 |
| JP2015509380A5 true JP2015509380A5 (2) | 2016-04-28 |
Family
ID=47998513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014561037A Withdrawn JP2015509380A (ja) | 2012-03-06 | 2013-03-05 | 共通の軽鎖のマウス |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP2822379A1 (2) |
| JP (1) | JP2015509380A (2) |
| KR (1) | KR20140136462A (2) |
| CN (2) | CN104244709B (2) |
| AU (2) | AU2013204140B2 (2) |
| CA (1) | CA2865029A1 (2) |
| HK (1) | HK1205873A1 (2) |
| IL (1) | IL234207A0 (2) |
| IN (1) | IN2014DN08163A (2) |
| MX (1) | MX353278B (2) |
| NZ (1) | NZ630637A (2) |
| RU (1) | RU2683514C2 (2) |
| SG (1) | SG11201405088QA (2) |
| WO (1) | WO2013134263A1 (2) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| DK3622815T3 (da) | 2009-07-08 | 2023-06-26 | Kymab Ltd | Gnavermodeller og terapeutiske molekyler |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| SMT202600080T1 (it) | 2010-02-08 | 2026-03-09 | Regeneron Pharma | Topo con catena leggera comune |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| BR112014006394A2 (pt) | 2011-09-19 | 2017-03-28 | Kymab Ltd | manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| WO2013138681A1 (en) | 2012-03-16 | 2013-09-19 | Regeneron Pharmaceuticals, Inc. | Mice that produce antigen-binding proteins with ph-dependent binding characteristics |
| EP3539374A1 (en) | 2012-03-16 | 2019-09-18 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing ph-sensitive immunoglobulin sequences |
| EP2825036B1 (en) | 2012-03-16 | 2018-05-02 | Regeneron Pharmaceuticals, Inc. | Histidine engineered light chain antibodies and genetically modified rodents for generating the same |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| US9248181B2 (en) | 2012-04-20 | 2016-02-02 | Merus B.V. | Methods and means for the production of Ig-like molecules |
| HK1218550A1 (zh) * | 2013-03-13 | 2017-02-24 | Regeneron Pharmaceuticals, Inc. | 常見輕鏈小鼠 |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| FR3011249A1 (2) * | 2013-10-01 | 2015-04-03 | Kymab Ltd | |
| AU2014330922A1 (en) * | 2013-10-01 | 2016-03-03 | Kymab Limited | Animal models and therapeutic molecules |
| CA3124228C (en) | 2014-03-21 | 2024-05-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
| CA2979702A1 (en) | 2015-03-19 | 2016-09-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| WO2017035274A1 (en) * | 2015-08-27 | 2017-03-02 | Crystal Bioscience Inc. | Transgenic animal for production of antibodies having a common light chain |
| KR20230006929A (ko) | 2016-01-13 | 2023-01-11 | 리제너론 파마슈티칼스 인코포레이티드 | 조작된 중쇄 다양성 영역을 갖는 설치류 |
| JP7269963B2 (ja) | 2018-06-08 | 2023-05-09 | クリスタル バイオサイエンス インコーポレイテッド | 同じ軽鎖ｉを有する多様な抗体を産生するためのトランスジェニック動物 |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| CA3125380A1 (en) | 2019-02-18 | 2020-08-27 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with humanized immunoglobulin locus |
| BR112021016173A2 (pt) | 2019-02-22 | 2021-11-03 | Regeneron Pharma | Roedor geneticamente modificado, métodos de produção de um roedor geneticamente modificado e de produção de um anticorpo anti-nav1.7, célula ou tecido isolado de roedor, linhagem celular imortalizada, embrião de roedor, construto de ácido nucleico de direcionamento, e, hibridoma |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| JP2023529846A (ja) * | 2020-06-02 | 2023-07-12 | バイオサイトジェン ファーマシューティカルズ （ベイジン） カンパニー リミテッド | 共通軽鎖免疫グロブリン遺伝子座を有する遺伝子改変非ヒト動物 |
| US20220090060A1 (en) | 2020-09-11 | 2022-03-24 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| CN116848254B (zh) | 2020-12-16 | 2026-03-17 | 瑞泽恩制药公司 | 表达人源化Fcα受体的小鼠 |
| CA3165366A1 (en) | 2020-12-23 | 2022-06-30 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| IL303865A (en) | 2020-12-23 | 2023-08-01 | Regeneron Pharma | Methods for obtaining antibodies that bind transmembrane proteins and cells that produce them |
| GB202217978D0 (en) | 2022-11-30 | 2023-01-11 | Petmedix Ltd | Rodents expressing a common light chain |
| TW202430641A (zh) | 2023-01-18 | 2024-08-01 | 美商基利科學股份有限公司 | 人類免疫球蛋白二元輕鏈轉殖基因構築體及其用途 |
| WO2026019824A1 (en) | 2024-07-16 | 2026-01-22 | Gilead Sciences, Inc. | Human immunoglobulin common light chain transgene constructs and uses thereof |
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
| WO2026035843A2 (en) | 2024-08-06 | 2026-02-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7084260B1 (en) * | 1996-10-10 | 2006-08-01 | Genpharm International, Inc. | High affinity human antibodies and human antibodies against human antigens |
| US20020062010A1 (en) * | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| DK2314629T4 (da) * | 2002-07-18 | 2023-02-06 | Merus Nv | Rekombinant produktion af blandinger af antistoffer |
| US20100069614A1 (en) * | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| ES2463476T3 (es) | 2004-10-19 | 2014-05-28 | Regeneron Pharmaceuticals, Inc. | Método para generar un ratón homocigótico para una modificación genética |
| JP5307708B2 (ja) | 2006-06-02 | 2013-10-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒトｉｌ−６受容体に対する高親和性抗体 |
| EP2147594B1 (en) * | 2008-06-27 | 2013-11-13 | Merus B.V. | Antibody producing non-human mammals |
| MY192182A (en) | 2009-06-26 | 2022-08-04 | Regeneron Pharma | Readily isolated bispecific antibodies with native immunoglobulin format |
| DK3622815T3 (da) * | 2009-07-08 | 2023-06-26 | Kymab Ltd | Gnavermodeller og terapeutiske molekyler |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| SMT202600080T1 (it) * | 2010-02-08 | 2026-03-09 | Regeneron Pharma | Topo con catena leggera comune |
-
2013
- 2013-03-05 MX MX2014010794A patent/MX353278B/es active IP Right Grant
- 2013-03-05 HK HK15106625.3A patent/HK1205873A1/xx unknown
- 2013-03-05 AU AU2013204140A patent/AU2013204140B2/en active Active
- 2013-03-05 CA CA2865029A patent/CA2865029A1/en not_active Abandoned
- 2013-03-05 IN IN8163DEN2014 patent/IN2014DN08163A/en unknown
- 2013-03-05 RU RU2014140239A patent/RU2683514C2/ru active
- 2013-03-05 CN CN201380012671.3A patent/CN104244709B/zh active Active
- 2013-03-05 EP EP13712618.1A patent/EP2822379A1/en not_active Withdrawn
- 2013-03-05 JP JP2014561037A patent/JP2015509380A/ja not_active Withdrawn
- 2013-03-05 NZ NZ630637A patent/NZ630637A/en unknown
- 2013-03-05 SG SG11201405088QA patent/SG11201405088QA/en unknown
- 2013-03-05 EP EP16203839.2A patent/EP3165086A1/en not_active Withdrawn
- 2013-03-05 WO PCT/US2013/029125 patent/WO2013134263A1/en not_active Ceased
- 2013-03-05 KR KR20147026624A patent/KR20140136462A/ko not_active Ceased
- 2013-03-05 CN CN201611201918.8A patent/CN107090471A/zh active Pending
-
2014
- 2014-08-19 IL IL234207A patent/IL234207A0/en active IP Right Grant
-
2016
- 2016-04-20 AU AU2016202488A patent/AU2016202488C1/en active Active
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