JP2016525100A5 - - Google Patents

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Publication number: JP2016525100A5
Authority: JP; Japan
Prior art keywords: amino acid; glutamine; residue; mutated; asparagine
Prior art date: 2014-07-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP2016525330A

Other languages

English (en)

Japanese (ja)

Other versions

JP6544809B2 (ja

JP2016525100A (ja

Filing date

2014-07-10

Publication date

2017-08-17

2014-07-10 Application filed filed Critical

2014-07-10 Priority claimed from PCT/SE2014/050882 external-priority patent/WO2015005862A1/en

2016-08-22 Publication of JP2016525100A publication Critical patent/JP2016525100A/ja

2017-08-17 Publication of JP2016525100A5 publication Critical patent/JP2016525100A5/ja

2019-07-17 Application granted granted Critical

2019-07-17 Publication of JP6544809B2 publication Critical patent/JP6544809B2/ja

Status Active legal-status Critical Current

2034-07-10 Anticipated expiration legal-status Critical

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ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 19
235000004554 glutamine Nutrition 0.000 claims 19
229940024606 amino acid Drugs 0.000 claims 15
235000001014 amino acid Nutrition 0.000 claims 15
125000000539 amino acid group Chemical group 0.000 claims 15
150000001413 amino acids Chemical class 0.000 claims 15
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 13
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 13
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 13
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 13
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 13
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 13
235000009582 asparagine Nutrition 0.000 claims 13
229960001230 asparagine Drugs 0.000 claims 13
235000018417 cysteine Nutrition 0.000 claims 13
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 13
235000013930 proline Nutrition 0.000 claims 13
229920001184 polypeptide Polymers 0.000 claims 11
102000004196 processed proteins & peptides Human genes 0.000 claims 11
108090000765 processed proteins & peptides Proteins 0.000 claims 11
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 9
235000004279 alanine Nutrition 0.000 claims 9
125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 8
239000011159 matrix material Substances 0.000 claims 6
238000000926 separation method Methods 0.000 claims 6
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 5
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 3
108060003951 Immunoglobulin Proteins 0.000 claims 3
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 3
239000004472 Lysine Substances 0.000 claims 3
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 3
239000004473 Threonine Substances 0.000 claims 3
235000003704 aspartic acid Nutrition 0.000 claims 3
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 3
238000004140 cleaning Methods 0.000 claims 3
-1 for example Chemical compound 0.000 claims 3
235000013922 glutamic acid Nutrition 0.000 claims 3
239000004220 glutamic acid Substances 0.000 claims 3
125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 3
102000018358 immunoglobulin Human genes 0.000 claims 3
239000007788 liquid Substances 0.000 claims 3
238000000034 method Methods 0.000 claims 3
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
108010088160 Staphylococcal Protein A Proteins 0.000 claims 2
230000035772 mutation Effects 0.000 claims 2
235000004400 serine Nutrition 0.000 claims 2
238000005406 washing Methods 0.000 claims 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
241001481833 Coryphaena hippurus Species 0.000 claims 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
239000003513 alkali Substances 0.000 claims 1
125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
229940072221 immunoglobulins Drugs 0.000 claims 1
108010025221 plasma protein Z Proteins 0.000 claims 1
230000009145 protein modification Effects 0.000 claims 1
102220248493 rs1555542879 Human genes 0.000 claims 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
239000007787 solid Substances 0.000 claims 1
239000004474 valine Substances 0.000 claims 1

JP2016525330A 2013-07-10 2014-07-10 突然変異免疫グロブリン結合ポリペプチド Active JP6544809B2 (ja)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
SE1350859-3		2013-07-10
SE1350860		2013-07-10
SE1350859		2013-07-10
SE1350860-1		2013-07-10
PCT/SE2014/050882 WO2015005862A1 (en)	2013-07-10	2014-07-10	Mutated immunoglobulin-binding polypeptides

Publications (3)

Publication Number	Publication Date
JP2016525100A JP2016525100A (ja)	2016-08-22
JP2016525100A5 true JP2016525100A5 (2)	2017-08-17
JP6544809B2 JP6544809B2 (ja)	2019-07-17

Family

ID=52280382

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
JP2016525329A Active JP6544808B2 (ja)	2013-07-10	2014-07-08	突然変異免疫グロブリン結合ポリペプチド
JP2016525330A Active JP6544809B2 (ja)	2013-07-10	2014-07-10	突然変異免疫グロブリン結合ポリペプチド
JP2019109474A Active JP6862008B2 (ja)	2013-07-10	2019-06-12	突然変異免疫グロブリン結合ポリペプチド

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
JP2016525329A Active JP6544808B2 (ja)	2013-07-10	2014-07-08	突然変異免疫グロブリン結合ポリペプチド

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
JP2019109474A Active JP6862008B2 (ja)	2013-07-10	2019-06-12	突然変異免疫グロブリン結合ポリペプチド

Country Status (5)

Country	Link
US (5)	US9896486B2 (2)
EP (2)	EP3019520B1 (2)
JP (3)	JP6544808B2 (2)
CN (3)	CN111848755A (2)
WO (2)	WO2015005859A1 (2)

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2014
- 2014-07-08 EP EP14823829.8A patent/EP3019520B1/en active Active
- 2014-07-08 CN CN202010728898.XA patent/CN111848755A/zh active Pending
- 2014-07-08 JP JP2016525329A patent/JP6544808B2/ja active Active
- 2014-07-08 WO PCT/SE2014/050872 patent/WO2015005859A1/en not_active Ceased
- 2014-07-08 CN CN201480039292.8A patent/CN105377880B/zh active Active
- 2014-07-08 US US14/903,837 patent/US9896486B2/en active Active
- 2014-07-10 CN CN201480039299.XA patent/CN105377881B/zh active Active
- 2014-07-10 EP EP14823321.6A patent/EP3019519B1/en active Active
- 2014-07-10 WO PCT/SE2014/050882 patent/WO2015005862A1/en not_active Ceased
- 2014-07-10 JP JP2016525330A patent/JP6544809B2/ja active Active
- 2014-07-10 US US14/904,077 patent/US9663558B2/en active Active
2015
- 2015-12-07 US US14/961,164 patent/US10308690B2/en active Active
2017
- 2017-05-18 US US15/598,685 patent/US10112980B2/en active Active
2018
- 2018-02-20 US US15/900,419 patent/US11136359B2/en active Active
2019
- 2019-06-12 JP JP2019109474A patent/JP6862008B2/ja active Active

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JP2016525100A5 (2)	2017-08-17
JP2016523959A5 (2)	2017-08-17
JP2017512063A5 (2)	2018-04-12
RU2017115342A (ru)	2018-12-19	Мутантные иммуноглобулин-связывающие полипептиды
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