JP2017178902A - Chlorine removing agent and external preparation for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a highly useful chlorine removing agent that has overcome drawbacks of conventional chlorine removing means, particularly a chlorine removing agent and an external preparation for skin or the like for removing residual chlorine in tap water.SOLUTION: An extract obtained by extracting from at least one selected from Brassica Oleracea var. gemmifera and Sukuma wiki.EFFECT: The extract is applied on the skin or hair surface of human as a chlorine removing agent or an external preparation for removing chlorine and can effectively remove chlorine therefrom.SELECTED DRAWING: Figure 2

Description

The present invention relates to a chlorine remover and a skin external preparation that can remove chlorine contained in tap water. Specifically, it relates to the removal of residual chlorine contained in tap water.

In recent years, for sensitive skin with subjective symptoms such as atopic dermatitis, skin itchiness, itching and redness caused by external factors such as the external environment and diet, and internal factors such as lack of sleep, overwork, and stress. The number of people who are worried is increasing. There are various causes that cause such symptoms, and external factors such as environmental pollution caused by nitrogen oxides and ultraviolet rays are considered, and one of them is skin irritation caused by chemical substances such as chlorine. .

Chlorine is a standard established by the national government to ensure the quality of daily water we use, and it is inseparable from our daily lives. . In general, sodium hypochlorite has been frequently used for disinfection of tap water and the like because it is very effective in controlling the pathogenesis of waterborne infectious diseases. A part of hypochlorous acid dissociates in water into hypochlorite ions and hydrogen ions, and these hypochlorous acid and hypochlorite ions are collectively called free residual chlorine or free effective chlorine. These free residual chlorine exerts the effect of sterilization or disinfection by destroying cell membranes and cell walls of pathogenic organisms such as microorganisms and viruses with its strong oxidizing power, and denaturing internal proteins and nucleic acids. On the other hand, when free residual chlorine is combined with amines or amino acids in water, it becomes combined effective chlorine such as monochloramine and dichloroamine, and is called combined residual chlorine. Although this combined residual chlorine is about a fraction of the effect of free residual chlorine, it has a relatively strong sterilizing or disinfecting power derived from oxidizing power. These free residual chlorine and combined residual chlorine are generally residual chlorine. is called. (Non-Patent Document 1).

Residual chlorine has a high disinfection and sterilization effect, but in recent years there have been concerns about the effects on the human body. For example, troubles such as hair becoming crusty or squeaky after entering the pool, or symptoms such as skin tingling when taking the first bath, the residual chlorine contained in the water acts on the proteins that make up the skin and hair It is thought that this happens. In previous studies, it has been reported that residual chlorine contained in water that comes into contact with pools and bathing is an exacerbation factor for atopic dermatitis (Non-patent Document 2). On the other hand, there is a great merit of keeping it, but in recent years, the demerit has gradually become apparent. In response to these trends, removal of residual chlorine is desired, but it is difficult to avoid contact with residual chlorine in daily life unless the user takes active measures to remove chlorine. .

Various methods have already been proposed as means for removing chlorine contained in tap water. As representative methods, ascorbic acid or ascorbic acid derivatives are used as a chlorine neutralizing agent to neutralize residual chlorine. There are a removal method (Patent Document 1) and a hydrophilic adsorbent (Patent Document 2) characterized in that hydrophilic metal oxide particles surface-modified with a silicon compound are attached to a porous body.

However, ascorbic acid and its derivatives may cause irritation and dryness when used at high concentrations, and as such, it is unstable and easily deteriorates, so it is necessary to pay attention to storage. For example, baths containing these In the case of an agent, contact with residual chlorine cannot be avoided particularly when cleaning the head or face that is not immersed in the bathtub.
Moreover, since the hydrophilization adsorbent of patent document 2 is applied as a filter for a water purifier or a shower head, it is necessary to periodically replace the filter, and it is difficult to say that continuous use is easy and limited. Since it is used at a place, chlorine cannot be easily removed at a desired place.

JP 2007-301446 A JP2013-103179A

Cooked food and technology. 2010; 16 (1): 1-14. The Journal of Dermatology. 2003; 30: 196-202.

The present invention has been made in view of the above background, and is a highly useful chlorine remover that has overcome the drawbacks of conventional chlorine removing means, in particular, a chlorine remover for removing residual chlorine in tap water, and a skin external application. The purpose is to provide agents.

In view of the above background, the present inventors have conducted extensive research to suppress the influence of residual chlorine contained in tap water on the skin and hair, and as a result, Brassica Oleracea var. It was found that the extract of gemmifera and sumawiki has a high chlorine removing action, and the present invention has been completed.
That is, the present invention relates to Brassica Oleracea var. A chlorine removing agent comprising one or more selected from gemmifera and sumawiki extract is provided. The present invention also relates to Brassica Oleracea var. The present invention provides an external preparation for skin, a cleansing agent for whole body, a cosmetic for hair, and a bath agent characterized by containing one or more selected from gemmifera and sumawiki extract.

The present invention has excellent chlorine removing ability.

The evaluation standard of the damage suppression effect of hair is shown. The SEM photograph which evaluated the damage inhibitory effect by the chlorine of a plant extract in an Example is shown.

  Hereinafter, the present invention will be described in more detail.

Brassica Oleracea var. Used in the present invention. gemmifera is a hybrid of kale and mecha cabbage, and is commercially available, for example, under the name Petitvale (registered trademark). The site used is not particularly limited. Leaves, flowers, roots, whole plants, etc. are used, but leaves are particularly suitable and show the most remarkable effects. In the evaluation test, leaves are used, but the same effect can be obtained at other sites.

The suma wiki used in the present invention is a Brassicaaceae genus Brassica. Scientific name: Brassica Oleracea var. acephala, a native species native to Africa. The site used is not particularly limited. Leaves, flowers, roots, whole plants, etc. are used, but leaves are particularly suitable and show the most remarkable effects. In the evaluation test, leaves are used, but the same effect can be obtained at other sites.

The preparation of these plant extracts is not particularly limited. For example, the plant extracts are extracted from a low temperature to a warm temperature using various appropriate organic solvents. Examples of the extraction solvent include water; lower monohydric alcohols such as methyl alcohol and ethyl alcohol; liquid polyhydric alcohols such as glycerin, propylene glycol, and 1,3-butylene glycol; ketones such as acetone and methyl ethyl ketone; and ethyl acetate. One or more of alkyl esters; hydrocarbons such as benzene and hexane; ethers such as diethyl ether; and halogenated alkanes such as dichloromethane and chloroform can be used. Among these, water, ethyl alcohol, and one or more mixed solvents of 1,3-butylene glycol are particularly suitable.

Although the extraction method of the plant extract which can be used for this invention is not specifically limited, For example, when using what was dried, 1 to 1000 times amount by mass ratio, especially 10 to 100 times amount of solvent are used, and 0 degreeC or more In particular, it is preferably performed at 20 ° C. to 40 ° C. for 1 hour or longer, particularly 3 to 7 days. Moreover, you may heat-extract for 1 to 4 hours at 60-100 degreeC. A commercially available dry powder may be used. Moreover, extraction is possible even if it is not dried.

Each of the above-mentioned extracts obtained under the above conditions may be used as an extracted solution, but if necessary, the extract, which has been concentrated, decolored, or powdered by filtration, activated carbon, etc. You can use it properly.

Although the compounding quantity in each agent composition of the plant extract which can be used for this invention is not specifically limited, 0.0001-20.0 mass% is preferable converted into dry solid content, and especially 0.001-10. A range of 0% by weight is optimal.

The present invention can be used for cleaning cosmetics, basic cosmetics, hair cosmetics, bath preparations, makeup cosmetics, soaps, facial cleansers, quasi drugs, pharmaceuticals, etc., but the field of use is not particularly limited. Absent.

In the present invention, within the range not impairing the effects of the present invention, components usually used in external preparations for skin and cosmetics such as cosmetics and pharmaceuticals, cleaning agents, such as oils, waxes, hydrocarbon oils, ester oils, higher alcohols, Silicone oil, UV absorber, UV scattering agent, moisturizer, surfactant, water-soluble polymer, thickener, powder, skin protectant, whitening agent, wrinkle improver, anti-aging agent, plant extract, antiseptic Agents, flame retardants, pH adjusters, sequestering agents, antioxidants, stabilizers, fragrances, dyes, pigments, and the like can be appropriately blended as necessary.

INDUSTRIAL APPLICATION This invention can be utilized for the dosage form which mixes these, such as a spraying agent, liquid form, gel form, cream form, solid form, a pack, a bath preparation, etc., or these two types.

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples. However, the present invention is not limited to these examples. Unless otherwise specified, the blending amount is expressed in mass%.

The chlorine removal rates of Examples 1 and 2 and Comparative Examples 1 to 10 were compared.
<Evaluation method>
The evaluation of the chlorine removal rate was performed by measuring the residual chlorine concentration of a sample obtained by adding an aqueous solution of each extraction dry product to a sodium hypochlorite solution having a constant concentration.

<Preparation Example 1>
Brassica Oleracea var. 10 times the mass of water was added to 25 g of Gemifera leaf dry powder and dispersed, followed by extraction at 60 ° C. for 4 hours. Gemifera extract was obtained. The dry solid content was 23%. 10 g of water was added to and dispersed in 25 g of dried Sumawiki leaf powder, followed by extraction at 60 ° C. for 4 hours to obtain a Sumawiki extract. The dry solid content was 22.6%. Water was used as a solvent, and the concentration of dry solids of each extract was adjusted to 10 mg / L and subjected to a residual chlorine concentration measurement test. In addition, the kale leaf extract and mecha cabbage extract used as comparison targets were prepared in the same manner.

Moreover, L-ascorbic acid with a known chlorine removal effect was used as a positive target. First, in order to compare with the dry content of each extract, L-ascorbic acid was compared at a concentration of 10 mg / L (Comparative Example 9) using water as a solvent. Also, Brassica Oleracea var. The amount of L-ascorbic acid contained in the gemmifera extract and the sumawiki extract was determined to be about 0.2% (Table 1). From this, Brassica Oleracea var. L-ascorbic acid was prepared to be 0.02 mg / L (Comparative Example 10) so as to be the same as the L-ascorbic acid content in the gemmifera extract or the Sumawiki extract.

<Residual chlorine concentration measurement test>
(Test Example 1)
Brassica Olacea var. Prepared to 10 mg / L by the method of Preparation Example 1 above. 1. A sodium hypochlorite solution prepared as follows: gemmifera extract or sumawiki extract, plant extract and L-ascorbic acid solution described in Table 2 below as comparison targets, and 0.62 mL, 2 mg / L A sample mixed with 88 mL was used as a sample. The residual chlorine concentration contained in the sample was measured, and the chlorine removal rate was calculated (Table 2).

More specifically, 30 μL of 3 mol / L acetate buffer solution (pH 5.2) containing 0.25% CyDTA was dispensed into a multi-well plate with a culture area of 3.38 cm ² , and 2.5 mL of the sample was mixed therewith. After that, 20 μL of SBT was further mixed, and the absorbance at 655 nm was quickly measured with a microplate reader (TECAN, Infinite (registered trademark) 200PRO). In addition, the chlorine removal rate was calculated | required from the light absorbency measured by the above-mentioned measuring method according to the following formula | equation 1.

<Formula 1>

The results of chlorine removal ability evaluation are shown below.

<Chlorine removal rate of plant extract>

As a result of the test, Brassica Oleracea var. It was confirmed that the residual chlorine was reduced in both the gemmifera extract and the sumawiki extract. On the other hand, in the plant extracts of Comparative Examples 1 to 10, which contain plant polyphenols and vitamins and are known to have antioxidant ability, the chlorine removal effect is low, and in order to exert a sufficient effect in actual use It is conceivable that the blending amount in the cosmetic composition will increase, and further, it is difficult to stably blend into the cosmetic composition due to the increase in blending amount, and there is concern that stability over time will be impaired. Is done.

(Test Example 1)
Evaluation of damage suppression effect of Examples 1 and 2 on hair exposed to residual chlorine <Evaluation Method>
Evaluation of damage-inhibiting effect on hair is performed by observing the hair surface structure with a scanning electron microscope when the hair is immersed in a sample in which an aqueous solution of each extract is added to a sodium hypochlorite solution at a constant concentration. It was.

Brassica Oleracea var. Extracted by the method described in Adjustment Example 1. Gemifera extract was prepared using water as a solvent so that the concentration of dry solids was 60 mg / L. Similarly, the Sumawiki extract extracted by the method described in Preparation Example 1 was used as a solvent. Was adjusted to 40 mg / L. 6.7 mL of each prepared extract and 33.5 mL of sodium hypochlorite solution prepared to 10 mg / L were mixed to prepare a sample. Randomly selected hair (human hair black hair) was immersed in this sample and treated for 30 minutes at room temperature in the dark with stirring. After the dipping treatment, the wet hair was air-dried with a dryer for 5 minutes. After repeating this series of flow until the total immersion time reached 16 hours, a part of the hair was cut out and photographed with a scanning electron microscope (SEM). This SEM photograph is shown in FIG. The condition of the hair in the SEM photograph was evaluated according to the evaluation criteria shown in FIG. For the positive target, the hair of the part not subjected to the immersion treatment was used, and for the negative target, the hair immersed in the sodium hypochlorite solution prepared to be 10 mg / L was used.

The evaluation result of the damage suppression effect in hair is shown in FIG.

As a result of the experiment, as apparent from FIG. 2, Brassica Oleracea var. It was confirmed that the cuticle layer was prevented from peeling off or falling off due to residual chlorine by blending the gemmifera extract and the sumawiki extract.

Hereinafter, formulation examples according to the present invention will be shown. In addition, content is mass%. A manufacturing method is a conventional method. In addition, prescription is a representative example and is not limited to this. For the plant extract incorporated in the formulation examples, see Brassica Olacea var. Both the gemmifera extract dry product and the sumawiki extract dry product use leaves as the extraction site, and the extraction solvent is water. Even when only one plant is blended, the same type of effect has been confirmed when the extract of the other plant and the extract of another part are used.

<Formulation Example 1: Lotion>
Brassica Oleracea var. gemmifera extract dried product 0.01
Polyoxyethylene sorbitan monolaurate (20E.O.) 1.5
1,3-butylene glycol 4.5
Glycerin 3.0
Ethanol 2.0
Sodium hyaluronate (1% aqueous solution) 5.0
Edetate trisodium 0.1
Preservative appropriate amount pH adjuster appropriate amount purified water remaining balance 100

<Prescription Example 2: Face-wash cream>
Brassica Oleracea var. gemmifera extract dried product 3.0
Lauric acid amidopropyl betaine solution 2.0
Hydroxyethyl cellulose 0.7
Sorbitol 1.0
PEG-6 (capryl / capric acid) glyceryl 1.0
Glycerin 16.0
PEG-30 4.0
Stearic acid 8.0
Myristic acid 16.0
Lauric acid 4.0
Glyceryl stearate (SE) 2.0
Jojoba oil 4.0
Hydroxylated Ca 5.2
Preservative Appropriate amount of purified water, remaining balance 100

<Prescription Example 3: Shampoo>
Sumawiki Extract Dried 3.0
Polyquaternium-10 0.4
1,3-butylene glycol 5.0
Cocoyl Methyl Taurine Na 10.5
Lauric acid BG 1.2
Laureth sulfate Na 15.0
Cocamidopropyl betaine 4.0
PEG-18 glyceryl oleate 1.2
Glycol distearate 1.0
Cationized hydroxycellulose 1.0
Preservative appropriate amount pH adjuster appropriate amount purified water remaining balance 100

The preparation of each formulation example was prepared by a conventional method. In both cases, the chlorine removal effect was significantly confirmed.

Claims (5)

A chlorine removing agent comprising one or more selected from Brassica Oleracea var. Gemmifera and Sumawiki extract. Brassica Oleracea var. An external preparation for skin containing one or more selected from gemmifera and sumawiki extract. Brassica Oleracea var. A systemic detergent comprising one or more selected from gemmifera and sumawiki extract. Brassica Oleracea var. A cosmetic for hair containing one or more selected from gemmifera and sumawiki extract. Brassica Oleracea var. The bath agent containing 1 type, or 2 or more types chosen from the extract of gemmifera and Sumawiki.

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