JP2017205152A - Mold and pattern sheet manufacturing method - Google Patents

Abstract

The present invention provides a mold having good slipperiness and a pattern sheet manufacturing method capable of increasing the throughput of the pattern sheet.
[Solution]
An uneven portion 18 is formed on a part of the back surface 12B of the mold 10 of the embodiment, and the slipperiness with respect to the transparent glass substrate 66 is improved. As a result, the back surface 12 </ b> B of the mold 10 is positioned without sliding on the transparent glass substrate 66 while being in close contact with the transparent glass substrate 66. Therefore, the loss of inspection time caused by the back surface 12B of the mold 10 being in close contact with the transparent glass substrate 66 in the inspection process can be eliminated, so that a reduction in MNA throughput can be prevented.
[Selection] Figure 3

Description

  The present invention relates to a mold and a pattern sheet manufacturing method, and more particularly to a mold and a pattern sheet manufacturing method for manufacturing a microneedle array.

  In recent years, Micro-Needle Array (Micro-Needle Array) has been developed as a new dosage form that can administer drugs such as insulin, vaccine (Vaccines) and human growth hormone (hGH) without causing pain. : Hereinafter abbreviated as “MNA”). MNA includes a drug and a plurality of biodegradable microneedles (also referred to as microneedles or microneedles) arranged in an array. By affixing this MNA to the skin, the microneedle pierces the skin, the microneedle is absorbed in the skin, and the drug contained in the microneedle is administered into the skin.

  As a method for producing such an MNA, a mold having a plurality of needle-like recesses (hereinafter referred to as “concave pattern”) which is a reversal type of microneedles on its surface is manufactured, A method is known in which an MNA is molded by supplying a chemical aqueous solution containing a drug or the like and dried, and then the MNA is peeled from the mold (Patent Document 1).

  The MNA manufacturing process inspects the supply amount of the chemical aqueous solution supplied to the concave pattern between the supply step of supplying the chemical aqueous solution to the concave pattern of the mold and the drying step of drying the chemical aqueous solution to form the MNA. There is an inspection process to do. This inspection process is performed, for example, by placing the back surface of the mold on an inspection table of a high-precision electronic balance. Specifically, the weight of the mold before the supply of the chemical aqueous solution is measured in advance before the supply process, and the weight of the mold after the supply of the chemical aqueous solution is measured in the inspection process to supply the chemical aqueous solution. The supply amount of the aqueous drug solution is obtained by obtaining the weight difference between before and after.

JP2013-162982A

  However, the conventional mold sometimes cannot be easily removed from the inspection table because the back surface of the mold is in close contact with the inspection table of the high-precision electronic balance in the inspection process described above. In particular, a silicone rubber mold adheres strongly to the examination table because it is flexible. Due to such a mold adhesion problem, conventionally, there has been a problem that the throughput (production amount) of MNA cannot be increased.

  This invention is made | formed in view of such a situation, and it aims at providing the manufacturing method of the pattern sheet | seat which can raise the throughput of a pattern sheet | seat which can provide a mold with good slipperiness.

  The mold of one embodiment of the present invention is a mold in which concave patterns including a plurality of concave portions are arranged in an array on the surface of the sheet, and the concave and convex portions are arranged on a part of the back surface of the sheet.

  In one embodiment of the present invention, the concave portion of the mold is preferably a needle-like concave portion.

  One embodiment of the present invention is an area on the back side of the sheet that faces the arrangement area of the concave pattern on the surface of the sheet, the area on the back side of the sheet is a flat surface, and faces the non-arrangement area of the concave pattern on the surface of the sheet. It is preferable that the concavo-convex part is disposed on the surface.

  In one embodiment of the present invention, on the back surface of the sheet, it is preferable that the arrangement region surface of the concavo-convex part protrudes from the region surface excluding the arrangement region surface.

  In one embodiment of the present invention, the Shore A hardness of the mold is preferably 35 or more and 60 or less.

  In one embodiment of the present invention, the mold is preferably made of silicone rubber.

  The pattern sheet manufacturing method according to one aspect of the present invention uses the mold of the present invention to supply a polymer solution to a concave pattern disposed on the surface of the mold sheet, and inspects the back surface of the mold sheet. An inspection process for inspecting the amount of the polymer solution supplied to the concave pattern placed on the table, a drying process for drying the polymer solution to form a pattern sheet, and a pattern sheet for peeling the pattern sheet from the mold And a peeling step.

  According to the mold of the present invention, a mold having good sliding properties can be provided. Moreover, according to the method for producing a pattern sheet of the present invention, the throughput of the pattern sheet can be increased.

Front view of mold of embodiment Rear view of the mold shown in FIG. Sectional view of the mold shown in FIG. Process diagram of mold manufacturing method for manufacturing electroforming mold Process diagram of mold manufacturing method for manufacturing electroforming mold Process diagram of mold manufacturing method for manufacturing electroforming mold Process diagram of mold manufacturing method for manufacturing electroforming mold Process diagram of mold manufacturing method for manufacturing electroforming mold Perspective view of the original Perspective view of mold for producing electroforming mold Process drawing of the manufacturing method of the electroforming mold using the mold of FIG. Process drawing of the manufacturing method of the electroforming mold using the mold of FIG. Process drawing of the manufacturing method of the electroforming mold using the mold of FIG. Process diagram of mold manufacturing method using electroforming mold Process diagram of mold manufacturing method using electroforming mold Process diagram of mold manufacturing method using electroforming mold Process diagram of mold manufacturing method using electroforming mold The perspective view which shows the modification of a mold Flow chart showing the manufacturing process of MNA Process diagram of MNA manufacturing method using mold Process diagram of MNA manufacturing method using mold Process diagram of MNA manufacturing method using mold Process diagram of MNA manufacturing method using mold Process diagram of MNA manufacturing method using mold Process diagram of MNA manufacturing method using mold Process diagram of MNA manufacturing method using mold Configuration diagram of inspection equipment used in the inspection process

  Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings.

  In the embodiment, the MNA is exemplified and described as the pattern sheet of the present invention. However, the pattern sheet of the present invention is not limited to the MNA, and a pattern in which protruding patterns having a plurality of protrusions are arranged in an array on the surface thereof. Any sheet can be applied. That is, the mold of the present invention is not limited to a mold for manufacturing MNA, and can be applied as long as it is a mold for manufacturing a pattern sheet in which protruding patterns are arranged in an array. In addition, MNA is obtained by the number of protrusion patterns from one pattern sheet by cutting the pattern sheet for each protrusion pattern.

[Mold 10]
FIG. 1 is a front view of the front surface of the mold 10 according to the embodiment, FIG. 2 is a rear view of the back surface of the mold 10, and FIG. 3 is a cross-sectional view of the mold 10.

  In the mold 10 shown in FIG. 1, 16 concave patterns 16 including 16 concave portions 14 are arranged in an array on the front surface 12A of a rectangular sheet 12, and as shown in FIG. The concavo-convex part 18 is arranged in the part.

  Moreover, it is preferable that the recessed part 14 of the mold 10 of embodiment is a needle-shaped recessed part as shown in FIG. As shown in FIGS. 1 to 3, the region 22 of the back surface 12 </ b> B of the sheet 12 that faces the arrangement region 20 of the concave pattern 16 on the front surface 12 </ b> A of the sheet 12 is a flat surface, and the concave shape of the front surface 12 </ b> A of the sheet 12. It is preferable that the concavo-convex portion 18 is disposed in the region 26 of the back surface 12B of the sheet 12 facing the non-arranged region 24 of the pattern 16. As shown in FIG. 3, on the back surface 12B of the sheet 12, it is preferable that the arrangement area surface 26A of the concavo-convex portion 18 protrudes about 10 to 100 μm with respect to the area surface 22A excluding the arrangement area surface 26A. In addition, this protrusion amount is equivalent to the height of the top part of the convex part of the uneven | corrugated | grooved part 18 with respect to 22 A of area surfaces. The mold 10 is preferably made of silicone rubber having a Shore A hardness (JIS K6253) of 35 to 60.

  The mold 10 of the embodiment is manufactured by inserting an electroformed mold 30 (see FIG. 15) into a cavity of an injection mold described later and injecting silicone rubber into the cavity. First, a method for manufacturing the electroforming mold 30 will be described.

<Method for manufacturing electroformed mold 30>
4 to 8 are process diagrams showing an example of a method for manufacturing the mold 32 for manufacturing the electroforming mold 30. FIG. FIG. 9 is a perspective view of the original plate 34.

  As shown in FIGS. 4 and 9, a protruding pattern 34 </ b> A is formed on the surface 34 </ b> B of the original 34. The projection pattern 34A of the original 34 is equivalent to the projection pattern of the final product MNA.

  The original 34 is manufactured by machining a metal substrate as a base material using a cutting tool such as a diamond tool. Examples of the metal substrate include stainless steel, aluminum alloy, nickel, and the like.

  The protruding pattern 34A is a form in which a plurality (16 in the embodiment) of protruding portions 36 protruding in a direction away from the surface 34B of the original 34 are arranged on the surface 34B of the original 34 in an array. . The number of the protrusions 36, the arrangement position of the protrusions 36, and the like are not limited. Further, the surface 34B of the original plate 34 may be a complete flat surface or a flat surface at first glance.

  The protrusion 36 of the embodiment is configured in a needle shape that tapers in a direction away from the surface 34B. The protrusion 36 is a so-called cone, and includes a pyramid, a cone, and the like.

  For example, the protrusion 36 preferably has a height of 100 to 2000 μm from the surface 34B of the original plate 34 and a tip diameter of Φ50 μm or less. When it has the some projection part 36, it is preferable that the space | interval of the adjacent projection part 36 is 300-2000 micrometers. Moreover, it is preferable that the aspect ratio (the height of the protrusion 36 / the width of the bottom surface of the protrusion 36) of the protrusion 36 is 1 to 5.

  FIG. 5 is a side view of a thermoplastic resin sheet 38 that is a base material of the mold 32. The thermoplastic resin sheet 38 has a thickness of 0.5 to 2.0 mm and a side length of 100 × 100 to 300 × 300 mm, for example, and a concave pattern 32A described later is formed on the surface 38B. The thickness of the thermoplastic resin sheet 38 is preferably at least the height of the protrusions 36 of the original plate 34.

  As the thermoplastic resin constituting the thermoplastic resin sheet 38, for example, polyethylene terephthalate, polycarbonate, polymethyl methacrylate, polystyrene, polyethylene, liquid crystal polymer, polylactic acid and the like can be suitably used. The thermoplastic resin sheet 38 means a thermoplastic resin that is thin and has a self-supporting property at room temperature. “Self-supporting” refers to the ability to maintain the shape of a single substance without support by other members.

  6 and 7 show that the positioning step, the forming step for forming the concave pattern 32A, and the positioning step and the forming step are repeated.

  As shown in FIG. 6, the original plate 34 and the thermoplastic resin sheet 38 are moved relative to each other, and a position (for example, the region A <b> 1) where the original plate 34 is pressed against the thermoplastic resin sheet 38 is determined. The positioning is performed, for example, by providing an X-axis drive mechanism and a Y-axis drive mechanism that move in a direction orthogonal to each other in a horizontal plane on a table (not shown) that supports the thermoplastic resin sheet 38.

  The original plate 34 is preheated to a temperature at which the thermoplastic resin sheet 38 is softened. The heating method is performed by a heater (not shown). The original 34 is heated to an appropriate temperature in accordance with the thermoplastic resin that constitutes the thermoplastic resin sheet 38.

  Next, the protruding pattern 34A of the heated original plate 34 is pressed and inserted into the region A1 of the surface 38B of the thermoplastic resin sheet 38, and the region A1 of the thermoplastic resin sheet 38 is heated for a certain time.

  Next, the original plate 34 is cooled in a state where the protruding pattern 34A is inserted into the region A1, so that the region A1 is cooled to a softening temperature or lower.

  Next, as shown in FIG. 7, the original plate 34 and the thermoplastic resin sheet 38 are pulled apart. As a result, a concave pattern 32A having a reversed shape of the protruding pattern 34A is formed in the region A1 of the surface 38B of the thermoplastic resin sheet 38.

  The concave pattern 32A refers to a state in which a plurality of needle-like concave portions 38D extending from the front surface 38B to the rear surface 38C of the thermoplastic resin sheet 38 are arranged in an array on the front surface 38B of the thermoplastic resin sheet 38. Since the concave pattern 32A is an inverted shape of the protrusion pattern 34A, the size, number, and arrangement of the needle-like recesses 38D of the concave pattern 32A are equivalent to the size, number, and arrangement of the protrusions 36 of the original plate 34. is there.

  Next, the original plate 34 and the thermoplastic resin sheet 38 are positioned with respect to the region A2 adjacent to the region A1. Next, the protruding pattern 34A of the heated original plate 34 is pressed and inserted into the region A2, and the region A2 is heated for a predetermined time. Next, by cooling the original plate 34, the region A2 is cooled to the softening temperature or lower. Next, the original plate 34 and the thermoplastic resin sheet 38 are pulled apart to form a concave pattern 32A having an inverted shape of the protruding pattern 34A in the region A2.

  Next, the original plate 34 and the thermoplastic resin sheet 38 are positioned with respect to the region A3 adjacent to the region A2, and the protruding pattern 34A of the heated original plate 34 is pressed and inserted into the region A3. A concave pattern 32A is formed in A3.

  Thus, the positioning process of the original plate 34 and the thermoplastic resin sheet 38 described in FIGS. 6 and 7 and the formation process of forming the concave pattern 32A on the thermoplastic resin sheet 38 are repeated. Thereby, as shown in FIG. 8, the mold 32 in which the plurality of concave patterns 32A are formed is manufactured.

  FIG. 10 is a perspective view showing an example of the mold 32. As shown in FIGS. 9 and 10, a resin mold 32 in which 16 concave patterns 32 </ b> A are arranged in an array can be manufactured from an original plate 34 having one protruding pattern 34 </ b> A.

<Method for Producing Electroforming Mold 30 Using Mold 32>
FIGS. 11 to 13 are process diagrams showing the procedure of the method for manufacturing the electroforming mold 30 using the mold 32.

  As shown in FIG. 11, a concave pattern 32 </ b> A is formed on the surface 38 </ b> B of the mold 32.

  FIG. 12 is a process diagram showing an electroforming process in which metal is filled in the concave pattern 32A of the mold 32 by electroforming. In the electroforming process, first, a conductive treatment is performed on the mold 32. A metal (for example, nickel) is sputtered on the mold 32 to adhere the metal to the surface 38B of the mold 32 and the concave pattern 32A.

  Next, the mold 32 subjected to the conductive treatment is held on the cathode. A metal pellet is held in a metal case to serve as an anode. The cathode holding the mold 32 and the anode holding the metal pellet are immersed in the electroforming solution and energized. A metal body 40 to be the electroforming mold 30 is formed by embedding a metal in the concave pattern 32A of the mold 32 by electroforming. The electroforming method refers to a method of depositing metal on the surface of a mold by electroplating.

  FIG. 13 is a process diagram showing a peeling process for peeling the metal body 40 from the mold 32. As shown in FIG. 13, the metal body 40 is peeled from the mold 32. Thereby, the electroforming mold 30 having the protruding pattern 30A can be manufactured. The protruding pattern 30 </ b> A has an inverted shape of the concave pattern 32 </ b> A of the mold 32. That is, the protruding pattern 30A is equivalent to the protruding pattern 34A of the original plate 34 shown in FIG.

[Method for Manufacturing Mold 10 Using Electroforming Mold 30]
14-17 is process drawing which showed the procedure of the manufacturing method of the mold 10 using the electroforming metal mold | die 30. FIG.

  In the mold 10, the electroformed mold 30 is inserted into the cavity 44 of the injection molding mold 42, the uncured silicone rubber 46 is injected into the cavity 44, is thermally cured, and the electroformed mold 30 is peeled from the molded product. It is manufactured by.

  The mold 42 includes a lower mold 48 having a cavity 44 and an upper mold 50 that holds the electroformed mold 30 so that the protruding pattern 30 </ b> A faces the cavity 44.

  By transferring the shape of the electroformed mold 30 by injection molding, the surface 12A of the sheet 12 of the mold 10 is formed. At this time, the shape of the protruding pattern 30A of the electroformed mold 30 is transferred, thereby forming the concave pattern 16. Is formed on the surface 12A. In addition, an uneven portion 52 is provided on a part of the bottom surface 44 </ b> A of the cavity 44 of the lower mold 48. The back surface 12B of the sheet 12 is formed by transferring the shape of the bottom surface 44A of the cavity 44, and the uneven portion 18 is formed on the back surface 12B by transferring the shape of the uneven portion 52 of the bottom surface 44A. The concavo-convex portion 52 has a shape obtained by inverting the concavo-convex portion 18, and is formed on the bottom surface 44 </ b> A by embossing such as sandblasting.

  In the embodiment, as shown in FIGS. 1 to 3, the concavo-convex portion 18 is disposed in the region 26 of the back surface 12 </ b> B of the sheet 12 that faces the non-arranged region 24 of the concave pattern 16 on the front surface 12 </ b> A of the sheet 12. For this reason, the uneven part 52 is provided at a position corresponding to the uneven part 18. Specifically, since the non-arrangement region 24 on the surface 12A of the sheet 12 is a lattice-like region excluding the 16 arrangement regions 20 in the array shape, the uneven portion 52 is also provided in a region corresponding to the lattice-like region. ing.

  The region 26 of the concavo-convex portion 18 is not limited to the lattice-shaped region, and any region of the back surface 12B of the sheet 12 can be provided as long as the back surface 12B of the sheet 12 can be given slidability due to the presence of the concavo-convex portion 18. Any area may be used. For example, like the back surface 12B of the mold 10 in FIG. 18, the region of the concavo-convex portion 18 may be a four-corner region, a central region, or another region.

  Moreover, although the uneven | corrugated | grooved part 18 may be arrange | positioned in the area | region of the back surface 12B of the sheet | seat 12 facing the arrangement | positioning area | region 20 of the concave pattern 16 of the surface 12A of the sheet | seat 12, the optical inspection apparatus 54 mentioned later (refer FIG. 27). According to the inspection process using (1), it is preferable that the uneven portion 18 is disposed in the region 26 facing the non-arranged region 24 and the region 22 facing the disposed region 20 is a flat surface.

  Further, in the back surface 12B of the sheet 12, the arrangement area surface 26A of the uneven portion 18 protrudes about 10 to 100 μm with respect to the area surface 22A excluding the arrangement area surface 26A, so the amount of protrusion of the uneven portion 18 is taken into consideration. Concave and convex portions 52 are formed in the depth.

[Manufacturing method of MNA using mold 32]
FIG. 19 is a flowchart showing the manufacturing process of MNA.

  The manufacturing process of MNA includes a supply process (S (Step) 10) for supplying a polymer solution to the concave pattern 16 disposed on the front surface 12A of the sheet 12 of the mold 10, and a back surface 12B of the sheet 12 of the mold 10 on the inspection table. An inspection step (S20) for inspecting the supply amount of the polymer solution supplied to the concave pattern 16 placed on the transparent glass substrate 66 (see FIG. 27), and drying the polymer solution to form a pattern sheet A drying step (S30), a pattern sheet peeling step (S40) for peeling the pattern sheet from the mold 10, and a cutting step (S50) for cutting the pattern sheet to obtain MNA.

  20 to 26 are process diagrams showing the procedure of the MNA manufacturing method using the mold 10.

  FIG. 20 is a cross-sectional view of the mold 10, and a concave pattern 16 is formed on the surface 12 </ b> B of the mold 10.

  FIG. 21 shows a supplying step (S10) for supplying a polymer solution 60 containing a drug to the concave pattern 16 of the mold 10.

  Here, as a material of the resin polymer used for the polymer solution 60, it is preferable to use a biocompatible resin. Such resins include glucose, maltose, pullulan, sodium chondroitin sulfate, sodium hyaluronate, saccharides such as hydroxyethyl starch and hydroxypropylcellulose, biodegradable proteins such as gelatin, polylactic acid and lactic acid glycolic acid copolymer. It is preferable to use a conductive polymer.

  The chemical | medical agent contained in the polymer solution 60 should just be a substance which has physiological activity, and is not specifically limited. The drug is preferably selected from peptides, proteins, nucleic acids, polysaccharides, vaccines, pharmaceutical compounds, or cosmetic ingredients. Moreover, it is preferable that a pharmaceutical compound belongs to a water-soluble low molecular weight compound. Here, the low molecular compound is a compound having a molecular weight in the range of several hundred to several thousand.

  Although the concentration varies depending on the material, it is preferable that the concentration is such that 10 to 50% by mass of the resin polymer is contained in the polymer solution not containing the drug. Further, the solvent used for dissolution may be volatile even if it is other than warm water, and methyl ethyl ketone, alcohol, or the like can be used. And it is possible to melt | dissolve the chemical | medical agent for supplying in a body according to a use in the solution of a polymer resin. The polymer concentration of the polymer solution 60 containing the drug (when the drug itself is a polymer, the concentration of the polymer excluding the drug) is preferably in the range of 0 to 40% by mass.

  As a method for preparing the polymer solution 60, when a water-soluble polymer (gelatin or the like) is used, a water-soluble powder may be dissolved in water, and a drug may be added after dissolution, or a liquid in which a drug is dissolved. Alternatively, a water-soluble polymer powder may be put in and dissolved. If it is difficult to dissolve in water, it may be dissolved by heating. The temperature can be appropriately selected depending on the type of the polymer material, but it is preferable to heat at a temperature of about 60 ° C. or lower. The viscosity of the polymer resin solution is preferably 100 Pa · s or less, more preferably 10 Pa · s or less, in the case of a solution containing a drug. In the case of a solution that does not contain a drug, it is preferably 2000 Pa · s or less, more preferably 1000 Pa · s or less. By appropriately adjusting the viscosity of the polymer resin solution, the polymer solution 60 can be easily supplied to each recess 14 of the mold 10.

  As a method of supplying the polymer solution 60 in the supplying step (S10), a method of supplying using a spin coater, a method of supplying by moving a squeegee, a method of supplying while moving a slit nozzle, and supplying using a dispenser The method etc. can be mentioned.

  Moreover, since it may be difficult for the polymer solution 60 to enter the recess 14 due to the presence of air, it is desirable to perform the supply step (S10) under a reduced pressure environment. Under reduced pressure environment means a state below atmospheric pressure. For example, the mold 10 is set in a decompression device (not shown), and the polymer solution 60 is supplied to the recesses 14 while drawing the air in the recesses 14 under a decompression environment, so that the polymer solution 60 reaches the tip of the recesses 14. Can be filled. In this case, it is particularly effective that the mold 10 is made of a gas permeable material.

  FIG. 27 is a configuration diagram showing an example of the inspection device 54 used in the inspection step (S20).

  The inspection apparatus 54 includes an imaging unit 72 having a light source 62, an optical system 64, a transparent glass substrate 66, an imaging lens 68, and an imaging unit 70, and an analysis unit that analyzes the image data and detects the supply amount of the polymer solution 60. 74.

  The mold 10 has the back surface 12 </ b> B placed on the transparent glass substrate 66 after the polymer solution 60 is supplied.

  In the polymer solution 60 supplied to the mold 10, water accounts for about 80%, the ratio of the drug is several percent, and the rest is a HES (hydroxyethyl starch) solution or the like. Accordingly, since the polymer solution 60 is about 95% water, HES solution, etc., the water contained in the polymer solution 60 determines the optical properties of the polymer solution 60. For this reason, even if the kind of chemical | medical agent in the polymer solution 60 changes, the optical characteristic of the polymer solution 60 does not change a lot. Therefore, the inspection device 54 pays attention to the light absorption characteristics of water contained in the polymer solution 60 and measures the supply amount of the polymer solution 60 supplied to the recesses 14 of the concave pattern 16.

  That is, in the measurement of the supply amount by the inspection device 54, first, measurement light is vertically incident on the back surface 12B of the mold 10 by the light source 62 and the optical system 64, and is transmitted through each part of the mold 10 (polymer solution 60 and the like). Then, the transmitted light emitted from the surface 12A is imaged by the imaging unit 70 through the imaging lens 68 to obtain image data of the transmitted light. Next, the analysis unit 74 analyzes the image data to detect the transmitted light intensity of the transmitted light. Based on the detection result, the distance through which the transmitted light has passed through the polymer solution 60 in the concave portion 14 of the concave pattern 16 is determined. To detect. By detecting the distance of the transmitted light respectively emitted from the position of the liquid surface 60 a in the concave portion 14 of the concave pattern 16, it is possible to detect the supply amount of the polymer solution 60 supplied into each concave portion 14. it can.

  In this inspection step (S <b> 20), in order to adjust the position of the mold 10 with respect to the optical axis of the imaging lens 68, the mold 10 having the back surface 12 </ b> B placed on the transparent glass substrate 66 is placed on the transparent glass substrate 66. It is necessary to slide and position. Under the present circumstances, the uneven | corrugated | grooved part 18 is formed in a part of back surface 12B of the mold 10 of embodiment, and the slidability with respect to the transparent glass substrate 66 is improved.

  As a result, the back surface 12 </ b> B of the mold 10 is positioned without sliding on the transparent glass substrate 66 while being in close contact with the transparent glass substrate 66. Accordingly, it is possible to eliminate a loss of inspection time due to the back surface 12B of the mold 10 being in close contact with the transparent glass substrate 66 in the inspection step (S20). Therefore, it is possible to prevent a decrease in MNA throughput.

  In the mold 10 of the embodiment, as shown in FIGS. 1 to 3, the region 22 on the back surface 12 </ b> B of the sheet 12 that faces the arrangement region 20 of the concave pattern 16 on the front surface 12 </ b> A of the sheet 12 is a flat surface. ing. As a result, the light incident on the concave pattern 16 of the mold 10 from the light source 62 is not scattered on the back surface 12B of the sheet 12 and is incident as vertical light, so that the supply amount of the polymer solution 60 to the concave portion 14 is accurately measured. be able to. That is, since the uneven portion 18 provided on the back surface 12B of the sheet 12 is provided in the region 26 excluding the region 22, the measurement of the supply amount of the polymer solution 60 is not affected.

  Further, on the back surface 12B of the sheet 12 of the mold 10, the arrangement area surface 26A of the concavo-convex portion 18 protrudes about 10 to 100 μm with respect to the area surface 22A excluding the arrangement area surface 26A. As a result, the concavo-convex portion 18 is placed on the transparent glass substrate 66 and the region surface 22A is held in a state of being separated from the transparent glass substrate 66, so that the region surface 22A is reliably prevented from coming into close contact with the transparent glass substrate 66. can do.

  Furthermore, the mold 10 of the embodiment is made of silicone rubber having a Shore A hardness (JIS K6253) of 35 or more and 60 or less. That is, the problem of adhesion to the inspection table (equivalent to the transparent glass substrate 66) that has occurred due to such a flexible mold 10 is solved by providing the uneven portion 18 on a part of the back surface 12B of the sheet 12. can do.

  FIG. 22 shows a drying step (S30) in which a polymer solution 76 not containing a drug is applied onto the polymer solution 60 containing the drug, and these polymer solutions 60 and 76 are dried to form a pattern sheet 78. )It is shown. In the drying step (S30), the polymer solution 60, 76 is dried by blowing air to the polymer solution 60, 76 supplied to the mold 10. As a result, the pattern sheet 78 is manufactured by the mold 10.

  23 and 24 show a pattern sheet peeling step (S40) for peeling the pattern sheet 78 from the mold 10. FIG. In the peeling process, as shown in FIG. 23, a sheet-like base material 80 may be attached to the back surface 78 </ b> B of the pattern sheet 78. As the base material 80, for example, PET (polyethylene terephthalate), PP (polypropylene), PC (polycarbonate), PE (Polyethylene: polyethylene) and the like can be used.

  Next, as shown in FIG. 24, the substrate 80 and the pattern sheet 78 are simultaneously peeled from the mold 10. Thereby, the pattern sheet 78 in which the plurality of protruding patterns 82 are arranged in an array on the surface 78A can be manufactured. The projecting pattern 82 of the pattern sheet 78 has a reverse shape of the concave pattern 16 of the mold 10.

  25 and 26 show a cutting step (S50) in which the pattern sheet 78 is cut together with the protruding pattern 82 to obtain the MNA 84.

  As shown in FIG. 25, the pattern sheet 78 peeled off from the mold 10 and the base material 80 are set in a cutting device (not shown) and cut together with the protruding pattern 82 to obtain a plurality of MNAs 84. In the embodiment, the example in which the pattern sheet 78 and the substrate 80 are cut at the same time has been shown, but the present invention is not limited to this. For example, the MNA 84 may be obtained by peeling the base material 80 from the pattern sheet 78 peeled from the mold 10 and the base material 80 and cutting the pattern sheet 78.

  Although the present invention has been described with reference to the above-described preferred embodiments, modifications can be made by many techniques without departing from the scope of the present invention, and other embodiments than the embodiments can be used. Accordingly, all modifications within the scope of the present invention are included in the claims.

DESCRIPTION OF SYMBOLS 10 ... Mold 12 ... Sheet 12A ... Front surface 12B ... Back surface 14 ... Concave 16 ... Concave pattern 18 ... Concave portion 20 ... Arrangement area 22 ... Area 22A ... Area surface 24 ... Non-arrangement area 26 ... Area 26A ... Arrangement area surface 30 ... Electricity Casting mold 32 ... mold 32A ... concave pattern 34 ... original plate 34A ... projection pattern 34B ... front surface 36 ... projection 38 ... thermoplastic resin sheet 38B ... front surface 38C ... back surface 38D ... acicular recess 40 ... metal body 42 ... mold 44 ... Cavity 46 ... Silicone rubber 48 ... Lower mold 50 ... Upper mold 52 ... Uneven portion 54 ... Inspection apparatus 60 ... Polymer solution 60a ... Liquid surface 62 ... Light source 64 ... Optical system 66 ... Transparent glass substrate 68 ... Image lens 70 ... Imaging unit 72 ... Imaging unit 74 ... Analysis unit 76 ... Polymer solution 78 ... Pattern sheet 80 ... Base material 82 ... Projection pattern 84 ... MNA

Claims (7)

In the mold in which concave patterns consisting of a plurality of concave portions are arranged in an array on the surface of the sheet,
A mold in which a concavo-convex portion is arranged on a part of the back surface of the sheet.   The mold according to claim 1, wherein the concave portion of the mold is a needle-shaped concave portion. The area of the back surface of the sheet facing the arrangement area of the concave pattern on the surface of the sheet is a flat surface,
3. The mold according to claim 1, wherein the uneven portion is disposed in a region of the back surface of the sheet facing a non-arranged region of the concave pattern on the surface of the sheet.   The mold according to claim 1, 2 or 3, wherein an arrangement area surface of the concavo-convex portion protrudes from an area surface excluding the arrangement area surface on the back surface of the sheet.   The mold according to any one of claims 1 to 4, wherein a Shore A hardness of the mold is 35 or more and 60 or less.   The mold according to any one of claims 1 to 5, wherein the mold is made of silicone rubber. Use the mold according to any one of claims 1 to 6,
A supply step of supplying a polymer solution to the concave pattern disposed on the surface of the sheet of the mold;
An inspection step of inspecting the supply amount of the polymer solution supplied to the concave pattern by placing the back surface of the sheet of the mold on an inspection table;
A drying step of drying the polymer solution to form a pattern sheet;
A pattern sheet peeling step for peeling the pattern sheet from the mold;
The manufacturing method of the pattern sheet containing this.

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