JP2017503837A5 - - Google Patents

Download PDF

Info

Publication number: JP2017503837A5
Authority: JP; Japan
Prior art keywords: trifluoromethyl; phenyl; tetrahydro; benzo; alkyl
Prior art date: 2015-01-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP2016548133A

Other languages

English (en)

Japanese (ja)

Other versions

JP6526023B2 (ja

JP2017503837A (ja

Filing date

2015-01-23

Publication date

2018-03-01

2015-01-23 Application filed filed Critical

2015-01-23 Priority claimed from PCT/US2015/012591 external-priority patent/WO2015112801A1/en

2017-02-02 Publication of JP2017503837A publication Critical patent/JP2017503837A/ja

2018-03-01 Publication of JP2017503837A5 publication Critical patent/JP2017503837A5/ja

2019-06-05 Application granted granted Critical

2019-06-05 Publication of JP6526023B2 publication Critical patent/JP6526023B2/ja

Status Active legal-status Critical Current

2035-01-23 Anticipated expiration legal-status Critical

Links

125000000217 alkyl group Chemical group 0.000 claims 37
150000001875 compounds Chemical class 0.000 claims 18
150000003839 salts Chemical class 0.000 claims 17
239000012453 solvate Substances 0.000 claims 17
229910052739 hydrogen Inorganic materials 0.000 claims 16
239000001257 hydrogen Substances 0.000 claims 16
-1 azepin-7-yl Chemical group 0.000 claims 11
150000002431 hydrogen Chemical class 0.000 claims 9
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
125000001072 heteroaryl group Chemical group 0.000 claims 7
125000002768 hydroxyalkyl group Chemical group 0.000 claims 7
229910052757 nitrogen Inorganic materials 0.000 claims 6
125000003107 substituted aryl group Chemical group 0.000 claims 6
208000002193 Pain Diseases 0.000 claims 5
125000003282 alkyl amino group Chemical group 0.000 claims 5
125000003710 aryl alkyl group Chemical group 0.000 claims 5
HKSQZEGSMBFHGC-UHFFFAOYSA-N pyrimidine-4-carboxamide Chemical compound NC(=O)C1=CC=NC=N1 HKSQZEGSMBFHGC-UHFFFAOYSA-N 0.000 claims 5
125000005346 substituted cycloalkyl group Chemical group 0.000 claims 5
125000003545 alkoxy group Chemical group 0.000 claims 4
125000004093 cyano group Chemical group *C#N 0.000 claims 4
125000004663 dialkyl amino group Chemical group 0.000 claims 4
125000004990 dihydroxyalkyl group Chemical group 0.000 claims 4
IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical compound NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 claims 4
125000004356 hydroxy functional group Chemical group O* 0.000 claims 3
125000004433 nitrogen atom Chemical group N* 0.000 claims 3
XAGZJIQIVXSURR-UHFFFAOYSA-N 1-[4-(trifluoromethyl)phenyl]piperidin-2-one Chemical group C1=CC(C(F)(F)F)=CC=C1N1C(=O)CCCC1 XAGZJIQIVXSURR-UHFFFAOYSA-N 0.000 claims 2
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
125000005518 carboxamido group Chemical group 0.000 claims 2
229910052736 halogen Inorganic materials 0.000 claims 2
150000002367 halogens Chemical class 0.000 claims 2
125000004404 heteroalkyl group Chemical group 0.000 claims 2
BATAKQAIMRZBKK-HSZRJFAPSA-N (1S)-1-[6-(1-cyclohexyl-2,3,4,5-tetrahydro-1-benzazepin-7-yl)pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCCC2)C1CCCCC1 BATAKQAIMRZBKK-HSZRJFAPSA-N 0.000 claims 1
MWVMAOPVOBUOGS-OAQYLSRUSA-N (1S)-1-[6-[1-(2-methylpropyl)-4-methylsulfonyl-3,5-dihydro-2H-1,4-benzodiazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound CC(C)CN1CCN(CC2=C1C=CC(=C2)C1=CC=CC(=N1)[C@H](O)CO)S(C)(=O)=O MWVMAOPVOBUOGS-OAQYLSRUSA-N 0.000 claims 1
UNNIUPFALBGCBG-JOCHJYFZSA-N (1S)-1-[6-[1-(4,4-difluorocyclohexyl)-2,3,4,5-tetrahydro-1-benzazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCCC2)C1CCC(F)(F)CC1 UNNIUPFALBGCBG-JOCHJYFZSA-N 0.000 claims 1
VBRXOOPJTQNXOL-JOCHJYFZSA-N (1S)-1-[6-[1-(oxan-4-yl)-2,3,4,5-tetrahydro-1-benzazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCCC2)C1CCOCC1 VBRXOOPJTQNXOL-JOCHJYFZSA-N 0.000 claims 1
TWCUCOUSUASXSV-JOCHJYFZSA-N (1S)-1-[6-[1-[4-(trifluoromethyl)phenyl]-2,3,4,5-tetrahydro-1,4-benzodiazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCNC2)C1=CC=C(C=C1)C(F)(F)F TWCUCOUSUASXSV-JOCHJYFZSA-N 0.000 claims 1
JBNWTEGHEKINOR-JOCHJYFZSA-N (1S)-1-[6-[1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-4,1-benzoxazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCOC2)C1=CC=C(C=C1)C(F)(F)F JBNWTEGHEKINOR-JOCHJYFZSA-N 0.000 claims 1
BGRZHUXTVWBAQC-HSZRJFAPSA-N (1S)-1-[6-[1-[[4-(trifluoromethyl)phenyl]methyl]-3,4-dihydro-2H-quinolin-6-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CC1=CC=C(C=C1)C(F)(F)F)CCC2 BGRZHUXTVWBAQC-HSZRJFAPSA-N 0.000 claims 1
OTLFVFMAOBMXOK-AREMUKBSSA-N (1S)-1-[6-[4-(cyclopropylmethyl)-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound OC[C@@H](O)C1=NC(=CC=C1)C1=CC2=C(C=C1)N(CCN(CC1CC1)C2)C1=CC=C(C=C1)C(F)(F)F OTLFVFMAOBMXOK-AREMUKBSSA-N 0.000 claims 1
SHPLKCRMHIMWRZ-HSZRJFAPSA-N (1s)-1-[6-[4-methylsulfonyl-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2h-1,4-benzodiazepin-7-yl]pyridin-2-yl]ethane-1,2-diol Chemical compound C12=CC=C(C=3N=C(C=CC=3)[C@H](O)CO)C=C2CN(S(=O)(=O)C)CCN1C1=CC=C(C(F)(F)F)C=C1 SHPLKCRMHIMWRZ-HSZRJFAPSA-N 0.000 claims 1
SQVWEIWPMBSOAY-XMMPIXPASA-N 1-[1-cyclohexyl-7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]ethanone Chemical compound CC(=O)N1CCN(C2CCCCC2)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO SQVWEIWPMBSOAY-XMMPIXPASA-N 0.000 claims 1
NIGAPNKNXARLOG-RUZDIDTESA-N 1-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]-2-(dimethylamino)ethanone Chemical compound CN(C)CC(=O)N1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO NIGAPNKNXARLOG-RUZDIDTESA-N 0.000 claims 1
CMWASHALVKNRRD-HSZRJFAPSA-N 1-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]-2-hydroxyethanone Chemical compound OC[C@@H](O)C1=CC=CC(=N1)C1=CC2=C(C=C1)N(CCN(C2)C(=O)CO)C1=CC=C(C=C1)C(F)(F)F CMWASHALVKNRRD-HSZRJFAPSA-N 0.000 claims 1
DXFJWZMNQMYZKB-XMMPIXPASA-N 1-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]ethanone Chemical compound CC(=O)N1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO DXFJWZMNQMYZKB-XMMPIXPASA-N 0.000 claims 1
UPKZSBXRVJHEDV-UHFFFAOYSA-N 2-[7-(6-methylpyridin-2-yl)-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]acetonitrile Chemical compound C(#N)CN1CCN(C2=C(C1)C=C(C=C2)C2=CC=CC(=N2)C)C2=CC=C(C=C2)C(F)(F)F UPKZSBXRVJHEDV-UHFFFAOYSA-N 0.000 claims 1
PANKKSHDMMARJO-XMMPIXPASA-N 2-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]-N-methylacetamide Chemical compound CNC(=O)CN1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO PANKKSHDMMARJO-XMMPIXPASA-N 0.000 claims 1
ILUPSHMSCWEPQR-XMMPIXPASA-N 2-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]acetonitrile Chemical compound OC[C@@H](O)C1=CC=CC(=N1)C1=CC2=C(C=C1)N(CCN(CC#N)C2)C1=CC=C(C=C1)C(F)(F)F ILUPSHMSCWEPQR-XMMPIXPASA-N 0.000 claims 1
QGXTXYHTRXGFNC-OAQYLSRUSA-N 5-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[[4-(trifluoromethyl)phenyl]methyl]-3H-indol-2-one Chemical compound O[C@H](CO)C1=CC=CC(=N1)C=1C=C2CC(N(C2=CC1)CC1=CC=C(C=C1)C(F)(F)F)=O QGXTXYHTRXGFNC-OAQYLSRUSA-N 0.000 claims 1
GYHQARDUYGKITD-HHHXNRCGSA-N 6-[4-(cyclopropylmethyl)-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-7-yl]-4-[(1S)-1,2-dihydroxyethyl]pyridine-2-carbonitrile Chemical compound C1(CC1)CN1CCN(C2=C(C1)C=C(C=C2)C1=CC(=CC(=N1)C#N)[C@@H](CO)O)C1=CC=C(C=C1)C(F)(F)F GYHQARDUYGKITD-HHHXNRCGSA-N 0.000 claims 1
ZVMHMTHBDNJATF-UHFFFAOYSA-N 7-(6-carbamoylpyridin-2-yl)-N,N-diethyl-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamide Chemical compound CCN(CC)C(=O)N1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)C(N)=O ZVMHMTHBDNJATF-UHFFFAOYSA-N 0.000 claims 1
XVIJUQXXWONJQK-JOCHJYFZSA-N 7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamide Chemical compound NC(=O)N1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO XVIJUQXXWONJQK-JOCHJYFZSA-N 0.000 claims 1
BUSCEHFTSTUANR-XMMPIXPASA-N 7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-N-ethyl-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamide Chemical compound CCNC(=O)N1CCN(C2=CC=C(C=C2)C(F)(F)F)C2=C(C1)C=C(C=C2)C1=NC(=CC=C1)[C@H](O)CO BUSCEHFTSTUANR-XMMPIXPASA-N 0.000 claims 1
208000000094 Chronic Pain Diseases 0.000 claims 1
206010065390 Inflammatory pain Diseases 0.000 claims 1
241000124008 Mammalia Species 0.000 claims 1
SJARHIQQBSXEBV-UHFFFAOYSA-N N-[4-[difluoro-(2-fluorophenyl)methyl]-3,4-dihydro-2H-chromen-7-yl]pyrimidine-4-carboxamide Chemical compound N1=CN=C(C=C1)C(=O)NC1=CC=C2C(CCOC2=C1)C(C1=C(C=CC=C1)F)(F)F SJARHIQQBSXEBV-UHFFFAOYSA-N 0.000 claims 1
208000005298 acute pain Diseases 0.000 claims 1
125000003342 alkenyl group Chemical group 0.000 claims 1
125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
125000000304 alkynyl group Chemical group 0.000 claims 1
150000001408 amides Chemical class 0.000 claims 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
150000003857 carboxamides Chemical class 0.000 claims 1
125000000753 cycloalkyl group Chemical group 0.000 claims 1
239000003814 drug Substances 0.000 claims 1
239000003937 drug carrier Substances 0.000 claims 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
208000004296 neuralgia Diseases 0.000 claims 1
208000021722 neuropathic pain Diseases 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
QLNJFJADRCOGBJ-LBPDFUHNSA-N propanamide Chemical class CC[13C](N)=O QLNJFJADRCOGBJ-LBPDFUHNSA-N 0.000 claims 1
QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 claims 1
BWSRSZUHBXIXAP-UHFFFAOYSA-N tert-butyl 7-(6-carbamoylpyridin-2-yl)-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxylate Chemical compound C(N)(=O)C1=CC=CC(=N1)C1=CC2=C(N(CCN(C2)C(=O)OC(C)(C)C)C2=CC=C(C=C2)C(F)(F)F)C=C1 BWSRSZUHBXIXAP-UHFFFAOYSA-N 0.000 claims 1
CSRFDVVNIVYOQK-INIZCTEOSA-N tert-butyl 7-[4-[[(2S)-1-amino-1-oxopropan-2-yl]amino]-6-carbamoylpyrimidin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxylate Chemical compound NC([C@H](C)NC1=NC(=NC(=C1)C(N)=O)C1=CC2=C(N(CCN(C2)C(=O)OC(C)(C)C)C2=CC=C(C=C2)C(F)(F)F)C=C1)=O CSRFDVVNIVYOQK-INIZCTEOSA-N 0.000 claims 1
NQTHIHLOHIXQGU-RUZDIDTESA-N tert-butyl 7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxylate Chemical compound O[C@H](CO)C1=CC=CC(=N1)C1=CC2=C(N(CCN(C2)C(=O)OC(C)(C)C)C2=CC=C(C=C2)C(F)(F)F)C=C1 NQTHIHLOHIXQGU-RUZDIDTESA-N 0.000 claims 1

JP2016548133A 2014-01-24 2015-01-23 ピリジン類及びピリミジン類並びにその使用 Active JP6526023B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201461931144P	2014-01-24	2014-01-24
US61/931,144		2014-01-24
PCT/US2015/012591 WO2015112801A1 (en)	2014-01-24	2015-01-23	Pyridines and pyrimidines and use thereof

Publications (3)

Publication Number	Publication Date
JP2017503837A JP2017503837A (ja)	2017-02-02
JP2017503837A5 true JP2017503837A5 (2)	2018-03-01
JP6526023B2 JP6526023B2 (ja)	2019-06-05

Family

ID=53681959

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2016548133A Active JP6526023B2 (ja)	2014-01-24	2015-01-23	ピリジン類及びピリミジン類並びにその使用

Country Status (5)

Country	Link
US (1)	US10047075B2 (2)
EP (1)	EP3097078B1 (2)
JP (1)	JP6526023B2 (2)
CN (1)	CN106061944A (2)
WO (1)	WO2015112801A1 (2)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2013531687A (ja)	2010-07-16	2013-08-08	パーデュー、ファーマ、リミテッド、パートナーシップ	ナトリウムチャネル遮断剤としてのピリジン化合物
EP2616441B1 (en)	2010-09-17	2019-08-07	Purdue Pharma L.P.	Pyridine compounds and the uses thereof
CN103429571A (zh)	2010-12-22	2013-12-04	普渡制药公司	作为钠通道阻断剂的取代吡啶
WO2013064883A1 (en)	2011-10-31	2013-05-10	Purdue Pharma L.P.	Heteroaryl compounds as sodium channel blockers
AU2012321111A1 (en)	2011-10-31	2013-05-16	Purdue Pharma L.P.	Quaternized amines as sodium channel blockers
US9133131B2 (en)	2011-11-15	2015-09-15	Purdue Pharma L.P.	Pyrimidine diol amides as sodium channel blockers
WO2013136170A1 (en)	2012-03-16	2013-09-19	Purdue Pharma L.P.	Substituted pyridines as sodium channel blockers
CA2890655A1 (en)	2012-11-09	2014-05-15	Purdue Pharma L.P.	Benzomorphan analogs and the use thereof
WO2014096941A1 (en)	2012-12-20	2014-06-26	Purdue Pharma L.P.	Cyclic sulfonamides as sodium channel blockers
US9120786B2 (en)	2013-03-04	2015-09-01	Purdue Pharma, L.P.	Triazine carboxamides as sodium channel blockers
US9637458B2 (en)	2013-03-04	2017-05-02	Jeffrey Lockman	Pyrimidine carboxamides as sodium channel blockers
CA3082427A1 (en)	2013-03-15	2014-09-25	Purdue Pharma L.P.	Carboxamide derivatives and use thereof
WO2015031036A1 (en)	2013-08-26	2015-03-05	Purdue Pharma L.P.	Azaspiro[4.5] decane derivatives and use thereof
US9828348B2 (en)	2013-11-08	2017-11-28	Purdue Pharma L.P.	Benzimidazole derivatives and use thereof
US9745287B2 (en)	2013-12-20	2017-08-29	Purdue Pharma L.P.	Pyrimidines and use thereof
AU2014370407B2 (en)	2013-12-23	2018-03-29	Purdue Pharma L.P.	Indazoles and use thereof
US9695144B2 (en)	2013-12-23	2017-07-04	Purdue Pharma L.P.	Dibenzazepine derivatives and use thereof
EP3089978B1 (en)	2013-12-30	2018-08-29	Purdue Pharma L.P.	Pyridone-sulfone morphinan analogs as opioid receptor ligands
US10730866B2 (en)	2014-04-07	2020-08-04	Purdue Pharma L.P.	Indole derivatives and use thereof
CA2948144A1 (en)	2014-05-06	2015-11-12	Purdue Pharma L.P.	Benzomorphan analogs and use thereof
WO2015192039A1 (en)	2014-06-13	2015-12-17	Purdue Pharma L.P.	Heterocyclic morphinan derivatives and use thereof
EP3154972A4 (en)	2014-06-13	2017-11-22	Purdue Pharma L.P.	Azamophinan derivatives and use thereof
WO2018125716A1 (en)	2017-01-02	2018-07-05	Purdue Pharma L.P.	Morphinan derivatives and use thereof
US11040958B2 (en)	2017-02-17	2021-06-22	Wuhan Ll Science And Technology Development Co., Ltd.	Triazole antimicrobial derivative, pharmaceutical composition and use thereof

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ500590A (en)	1997-04-22	2001-11-30	Cocensys Inc	Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof
EP2201945B1 (en)	1997-11-21	2013-03-06	Purdue Neuroscience Company	Use of substituted 2-aminoacetamides for treating or ameliorating anxiety
US6281211B1 (en)	1999-02-04	2001-08-28	Euro-Celtique S.A.	Substituted semicarbazides and the use thereof
CA2368631A1 (en)	1999-03-26	2000-10-05	Euro-Celtique S.A.	Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof
DE60022333T2 (de)	1999-04-09	2006-07-06	Euro-Celtique S.A.	Natrium kanalblocker zusammensetzungen und deren verwendung
AU2868601A (en) *	2000-01-27	2001-08-07	Ribotargets Ltd	Biaryl compounds, their preparation and their use in therapy
AR029489A1 (es)	2000-03-10	2003-07-02	Euro Celtique Sa	Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento
NZ520875A (en)	2000-03-24	2005-04-29	Euro Celtique S	Aryl substituted pyrazoles, triazoles and tetrazoles as sodium channel blocker
WO2001074779A1 (en)	2000-03-31	2001-10-11	Euro-Celtique S.A.	Aminopyridines and their use as anticonvulsants and sodium channel blockers
MXPA04000411A (es)	2001-07-16	2004-03-18	Euro Celtique Sa	Tiazolidinonas arilo sustituidas y uso de las mismas.
AR036873A1 (es)	2001-09-07	2004-10-13	Euro Celtique Sa	Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento
AR037233A1 (es)	2001-09-07	2004-11-03	Euro Celtique Sa	Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento
DK1483247T3 (da)	2002-03-13	2009-08-17	Euro Celtique Sa	Arylsubstituerede pyrimidiner og anvendelsen deraf
MXPA05000813A (es)	2002-07-31	2005-04-19	Euro Celtique Sa	Compuestos hidrantoina aril sustituidos y su uso como bloqueadores del canal de sodio.
JP2006504660A (ja)	2002-07-31	2006-02-09	ユーロ−セルティークエス．エイ．	アリール置換ベンゾイミダゾール類およびナトリウムチャネルブロッカーとしてのそれらの使用
US20040152696A1 (en)	2002-08-01	2004-08-05	Euro-Celtique S.A.	2-substituted bicyclic benzoheterocyclic compounds and their use as sodium channel blockers
WO2005014849A2 (en)	2003-07-03	2005-02-17	Euro-Celtique, S.A.	Genes associated with responses to neuropathic pain
TW200616613A (en) *	2004-10-05	2006-06-01	Shionogi & Co	Biaryl derivatives
EP1995242B1 (en)	2006-03-14	2012-11-07	Santen Pharmaceutical Co., Ltd	Novel 1,2,3,4-tetrahydroquinoxaline derivative having glucocorticoid receptor binding activity
WO2009045381A1 (en) *	2007-10-04	2009-04-09	Merck & Co., Inc.	N-substituted oxindoline derivatives as calcium channel blockers
CA2701203A1 (en) *	2007-10-04	2009-04-09	Merck Sharp & Dohme Corp.	N-substituted oxindoline derivatives as calcium channel blockers
EP2338887A4 (en) *	2008-10-15	2012-05-09	Kissei Pharmaceutical	FUSIONED HETEROCYCLIC DERIVATIVE AND ITS USE FOR MEDICAL PURPOSES
RU2561109C2 (ru) *	2008-12-19	2015-08-20	Дженентек, Инк.	Соединения и способы применения
EP2435407B1 (en)	2009-05-29	2019-12-25	RaQualia Pharma Inc.	Aryl substituted carboxamide derivatives as calcium or sodium channel blockers
JP2013530180A (ja)	2010-06-16	2013-07-25	パーデュー、ファーマ、リミテッド、パートナーシップ	アリール置換インドールおよびその使用
JP2013531687A (ja)	2010-07-16	2013-08-08	パーデュー、ファーマ、リミテッド、パートナーシップ	ナトリウムチャネル遮断剤としてのピリジン化合物
EP2616441B1 (en)	2010-09-17	2019-08-07	Purdue Pharma L.P.	Pyridine compounds and the uses thereof
EP2625169B1 (en)	2010-10-05	2015-03-25	Purdue Pharma L.P.	Quinazoline compounds as sodium channel blockers
CN103429571A (zh)	2010-12-22	2013-12-04	普渡制药公司	作为钠通道阻断剂的取代吡啶
SI2750677T1 (sl) *	2011-08-30	2017-10-30	Chdi Foundation, Inc.	Inhibitorji kinurenin-3-monooksigenaze, farmacevtski sestavki in postopki njihove uporabe
WO2013030665A1 (en)	2011-09-02	2013-03-07	Purdue Pharma L.P.	Pyrimidines as sodium channel blockers
WO2013064883A1 (en)	2011-10-31	2013-05-10	Purdue Pharma L.P.	Heteroaryl compounds as sodium channel blockers
AU2012321111A1 (en)	2011-10-31	2013-05-16	Purdue Pharma L.P.	Quaternized amines as sodium channel blockers
US9133131B2 (en)	2011-11-15	2015-09-15	Purdue Pharma L.P.	Pyrimidine diol amides as sodium channel blockers
WO2013136170A1 (en)	2012-03-16	2013-09-19	Purdue Pharma L.P.	Substituted pyridines as sodium channel blockers
WO2013166015A1 (en)	2012-04-30	2013-11-07	Anderson Gaweco	Ror modulators and their uses
WO2014008214A1 (en)	2012-07-02	2014-01-09	Biogen Idec Ma Inc.	Biaryl-containing compounds as inverse agonists of ror-gamma receptors
WO2014096941A1 (en)	2012-12-20	2014-06-26	Purdue Pharma L.P.	Cyclic sulfonamides as sodium channel blockers
US9637458B2 (en)	2013-03-04	2017-05-02	Jeffrey Lockman	Pyrimidine carboxamides as sodium channel blockers
US9120786B2 (en)	2013-03-04	2015-09-01	Purdue Pharma, L.P.	Triazine carboxamides as sodium channel blockers
CA3082427A1 (en)	2013-03-15	2014-09-25	Purdue Pharma L.P.	Carboxamide derivatives and use thereof
US9359330B2 (en)	2013-08-26	2016-06-07	Purdue Pharma L.P.	Substituted piperidines as sodium channel blockers
WO2015031036A1 (en)	2013-08-26	2015-03-05	Purdue Pharma L.P.	Azaspiro[4.5] decane derivatives and use thereof
US9828348B2 (en)	2013-11-08	2017-11-28	Purdue Pharma L.P.	Benzimidazole derivatives and use thereof
US9340504B2 (en)	2013-11-21	2016-05-17	Purdue Pharma L.P.	Pyridine and piperidine derivatives as novel sodium channel blockers
US9745287B2 (en)	2013-12-20	2017-08-29	Purdue Pharma L.P.	Pyrimidines and use thereof
US9695144B2 (en)	2013-12-23	2017-07-04	Purdue Pharma L.P.	Dibenzazepine derivatives and use thereof
AU2014370407B2 (en)	2013-12-23	2018-03-29	Purdue Pharma L.P.	Indazoles and use thereof
WO2015097545A1 (en)	2013-12-26	2015-07-02	Purdue Pharma L.P.	Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
US10738026B2 (en)	2014-02-12	2020-08-11	Purdue Pharma L.P.	Isoquinoline derivatives and use thereof
US10730866B2 (en)	2014-04-07	2020-08-04	Purdue Pharma L.P.	Indole derivatives and use thereof
CN107613965A (zh)	2015-02-19	2018-01-19	普渡制药公司	用于减少胃排空的方法和组合物

2015
- 2015-01-23 US US15/113,493 patent/US10047075B2/en active Active
- 2015-01-23 JP JP2016548133A patent/JP6526023B2/ja active Active
- 2015-01-23 WO PCT/US2015/012591 patent/WO2015112801A1/en not_active Ceased
- 2015-01-23 CN CN201580005580.6A patent/CN106061944A/zh active Pending
- 2015-01-23 EP EP15739774.6A patent/EP3097078B1/en active Active

Publication	Publication Date	Title
JP2017503837A5 (2)	2018-03-01
JP2017530185A5 (2)	2019-10-03
JP2016538313A5 (2)	2017-10-26
HRP20201146T1 (hr)	2020-10-30	Spojevi indol karboksamida korisni kao inhibitori kinaze
JP2021534124A5 (2)	2022-08-18
JP2020521740A5 (2)	2021-07-26
JP2021500345A5 (2)	2021-12-02
JP2016537394A5 (2)	2017-12-07
JP2015514806A5 (2)	2016-03-17
SI3074386T1 (en)	2018-02-28	New aminopyrimidine derivatives
JP2020506946A5 (2)	2021-03-11
RU2017120217A (ru)	2018-12-13	2-амино-5,5-дифтор-6-(фторметил)-6-фенил-3,4,5,6-тетрагидпропиридины в качестве ингибиторов bace1
JP2011520908A5 (2)	2012-06-14
JP2014508175A5 (2)	2015-03-19
RU2018131775A (ru)	2020-03-20	6-арил-4-морфолин-1-илпиридоны, пригодные для лечения рака или диабета
RU2018131766A (ru)	2020-03-20	6-гетероциклил-4-морфолин-4-илпиридин-2-оны, пригодные для лечения рака и диабета
JP2008513516A5 (2)	2008-10-23
JP2017530999A5 (2)	2018-04-05
JP2009534386A5 (2)	2013-09-12
HRP20201469T1 (hr)	2020-12-11	Derivati tetrahidroizokinolina
JP2016517878A5 (2)	2017-06-01
JP2016525076A5 (2)	2017-07-20
JP2006500348A5 (2)	2006-10-26
RU2010116821A (ru)	2011-11-10	N-гетероциклические биарильные карбоксамиды в качестве антагонистов рецептора ccr
RU2015112192A (ru)	2016-11-10	2-оксо-2,3,4,5-тетрагидро-1н-бензо[b]диазепины и их применение при лечении рака