JP2017505605A5 - - Google Patents
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- Publication number
- JP2017505605A5 JP2017505605A5 JP2016545896A JP2016545896A JP2017505605A5 JP 2017505605 A5 JP2017505605 A5 JP 2017505605A5 JP 2016545896 A JP2016545896 A JP 2016545896A JP 2016545896 A JP2016545896 A JP 2016545896A JP 2017505605 A5 JP2017505605 A5 JP 2017505605A5
- Authority
- JP
- Japan
- Prior art keywords
- mycobacterial
- fusion
- nucleic acid
- hetero
- immunogenic combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 35
- 102000036639 antigens Human genes 0.000 claims 35
- 108091007433 antigens Proteins 0.000 claims 35
- 230000004927 fusion Effects 0.000 claims 22
- 230000002163 immunogen Effects 0.000 claims 22
- 108020004707 nucleic acids Proteins 0.000 claims 15
- 102000039446 nucleic acids Human genes 0.000 claims 15
- 150000007523 nucleic acids Chemical class 0.000 claims 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 229920001184 polypeptide Polymers 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 12
- 239000013598 vector Substances 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 101710088334 Diacylglycerol acyltransferase/mycolyltransferase Ag85B Proteins 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 101150079015 esxB gene Proteins 0.000 claims 6
- 241000186359 Mycobacterium Species 0.000 claims 5
- 101710166488 6 kDa early secretory antigenic target Proteins 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 208000027531 mycobacterial infectious disease Diseases 0.000 claims 3
- 206010062207 Mycobacterial infection Diseases 0.000 claims 2
- 241000186366 Mycobacterium bovis Species 0.000 claims 2
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 2
- 201000008827 tuberculosis Diseases 0.000 claims 2
- 241000701161 unidentified adenovirus Species 0.000 claims 2
- 208000007089 vaccinia Diseases 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000710929 Alphavirus Species 0.000 claims 1
- 241000178270 Canarypox virus Species 0.000 claims 1
- 208000000666 Fowlpox Diseases 0.000 claims 1
- 241000700662 Fowlpox virus Species 0.000 claims 1
- 241000714192 Human spumaretrovirus Species 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 101000612837 Mus musculus Tetraspanin-7 Proteins 0.000 claims 1
- 208000031998 Mycobacterium Infections Diseases 0.000 claims 1
- 241001467553 Mycobacterium africanum Species 0.000 claims 1
- 241001467552 Mycobacterium bovis BCG Species 0.000 claims 1
- 241001312372 Mycobacterium canettii Species 0.000 claims 1
- 241000211133 Mycobacterium caprae Species 0.000 claims 1
- 241000187919 Mycobacterium microti Species 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 230000005867 T cell response Effects 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 241000711975 Vesicular stomatitis virus Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 239000013066 combination product Substances 0.000 claims 1
- 229940127555 combination product Drugs 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- -1 hetero Nucleic acid Chemical class 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 239000013600 plasmid vector Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000007420 reactivation Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14305030 | 2014-01-09 | ||
| EP14305030.0 | 2014-01-09 | ||
| PCT/EP2015/050344 WO2015104380A1 (en) | 2014-01-09 | 2015-01-09 | Fusion of heterooligomeric mycobacterial antigens |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017505605A JP2017505605A (ja) | 2017-02-23 |
| JP2017505605A5 true JP2017505605A5 (2) | 2018-02-22 |
| JP6605480B2 JP6605480B2 (ja) | 2019-11-13 |
Family
ID=49989636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016545896A Expired - Fee Related JP6605480B2 (ja) | 2014-01-09 | 2015-01-09 | ヘテロオリゴマーマイコバクテリア抗原の融合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10765731B2 (2) |
| EP (1) | EP3092000A1 (2) |
| JP (1) | JP6605480B2 (2) |
| KR (1) | KR20160130216A (2) |
| CN (1) | CN106103471B (2) |
| BR (1) | BR112016015936A2 (2) |
| CA (1) | CA2936131A1 (2) |
| IL (1) | IL246659A0 (2) |
| MX (1) | MX2016009072A (2) |
| RU (1) | RU2695462C2 (2) |
| SG (1) | SG11201605595YA (2) |
| WO (1) | WO2015104380A1 (2) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104640564B (zh) * | 2012-07-10 | 2020-08-04 | 特兰斯吉恩股份有限公司 | 分枝杆菌抗原疫苗 |
| WO2016131945A1 (en) | 2015-02-20 | 2016-08-25 | Transgene Sa | Combination product with autophagy modulator |
| CN105218680B (zh) * | 2015-10-21 | 2019-06-25 | 中山大学 | 一种用于诱导外周血单个核细胞产生细胞因子的结核分支杆菌融合蛋白 |
| CN105601747B (zh) * | 2015-10-21 | 2019-05-28 | 中山大学 | 一种结核杆菌融合蛋白及其在诱导外周血单个核细胞产生细胞因子的应用 |
| CA3023022A1 (en) | 2016-05-04 | 2017-11-09 | Transgene Sa | Combination therapy with cpg tlr9 ligand |
| KR20190009308A (ko) * | 2016-05-21 | 2019-01-28 | 인펙셔스 디지즈 리서치 인스티튜트 (아이디알아이) | 2차 결핵 및 비결핵성 마이코박테리아 감염을 치료하기 위한 조성물 및 방법 |
| CA3028827A1 (en) | 2016-06-22 | 2017-12-28 | Aeras | Recombinant cytomegalovirus vectors as vaccines for tuberculosis |
| US20190328869A1 (en) | 2016-10-10 | 2019-10-31 | Transgene Sa | Immunotherapeutic product and mdsc modulator combination therapy |
| US11638749B2 (en) | 2017-10-17 | 2023-05-02 | International Aids Vaccine Initiative, Inc. | Tuberculosis antigen cassettes |
| KR102004902B1 (ko) * | 2017-12-26 | 2019-07-29 | 연세대학교 산학협력단 | 융합 단백질을 포함하는 결핵 예방용 조성물 |
| CN110684116B (zh) * | 2019-08-23 | 2022-04-26 | 成都可恩生物科技有限公司 | 一种结核分枝杆菌eec融合蛋白、制备方法及其应用 |
| CN110590957B (zh) * | 2019-09-11 | 2021-06-01 | 中国人民解放军总医院第八医学中心 | 一种融合蛋白及其在抗结核分枝杆菌的免疫保护中的应用 |
| RU2724896C1 (ru) * | 2019-11-14 | 2020-06-26 | федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации | Полиантигенная вакцина для профилактики и вспомогательного лечения туберкулеза |
| CN111269297B (zh) * | 2020-01-23 | 2021-11-30 | 郑州伊美诺生物技术有限公司 | 一种结核分枝杆菌刺激抗原的制备方法 |
| WO2024027910A1 (en) * | 2022-08-03 | 2024-02-08 | BioNTech SE | Rna for preventing or treating tuberculosis |
| CA3263686A1 (en) * | 2022-08-03 | 2024-02-08 | BioNTech SE | RNA FOR THE PREVENTION OR TREATMENT OF TUBERCULOSIS |
| CN116162141B (zh) * | 2022-11-30 | 2024-04-12 | 中国疾病预防控制中心传染病预防控制所 | 一种结核分枝杆菌抗原epcra013及其应用 |
| CN116063418B (zh) * | 2022-12-08 | 2024-04-12 | 中国疾病预防控制中心传染病预防控制所 | 结核分枝杆菌抗原组合物epdpa015及其制备方法与应用 |
| EP4637810A2 (en) * | 2022-12-22 | 2025-10-29 | Akagera Medicines, Inc. | Lipid nanoparticles for the prevention of tuberculosis or other mycobacterial infections |
| CN116106544A (zh) * | 2023-01-10 | 2023-05-12 | 南京农业大学 | 一种牛分枝杆菌抗体检测试剂盒 |
| WO2025265101A1 (en) * | 2024-06-21 | 2025-12-26 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of vaccine for prevention of tuberculosis |
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| US7045313B1 (en) | 1982-11-30 | 2006-05-16 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| DE69233158T2 (de) | 1991-03-07 | 2004-05-13 | Connaught Technology Corp., Greenville | Gentechnologisch hergestellter stamm für impfstoffe |
| US6013638A (en) | 1991-10-02 | 2000-01-11 | The United States Of America As Represented By The Department Of Health And Human Services | Adenovirus comprising deletions on the E1A, E1B and E3 regions for transfer of genes to the lung |
| US6133028A (en) | 1993-05-28 | 2000-10-17 | Transgene S.A. | Defective adenoviruses and corresponding complementation lines |
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| UA68327C2 (en) | 1995-07-04 | 2004-08-16 | Gsf Forschungszentrum Fur Unwe | A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals |
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| CN101538578B (zh) * | 2009-03-02 | 2011-01-26 | 华中农业大学 | 三基因融合的重组牛结核特异性抗原蛋白及制备方法 |
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| DK2432502T3 (en) | 2009-05-20 | 2018-03-12 | Aeras | STABLE, SPRAY DRIED, IMMUNOGENE, VIRUS COMPOSITIONS |
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| CN101900727A (zh) * | 2010-06-01 | 2010-12-01 | 华中农业大学 | 一种应用Rv3872新型融合蛋白制备的牛结核抗体鉴别检测试纸条 |
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| CN102692509B (zh) * | 2012-05-11 | 2014-11-26 | 中国农业科学院北京畜牧兽医研究所 | 重组蛋白混合物介导的牛结核病诊断方法及其试剂 |
| WO2014009433A1 (en) * | 2012-07-10 | 2014-01-16 | Transgene Sa | Mycobacterium resuscitation promoting factor for use as adjuvant |
| CN104640564B (zh) | 2012-07-10 | 2020-08-04 | 特兰斯吉恩股份有限公司 | 分枝杆菌抗原疫苗 |
| CN102719438B (zh) | 2012-07-12 | 2013-10-30 | 章晓联 | 一种能特异结合结核菌抗原的核酸适配子及其应用 |
| JP6470179B2 (ja) | 2012-10-23 | 2019-02-13 | スタテンス セールム インスティトゥート | 結核菌（ｍ．ｔｕｂｅｒｃｕｌｏｓｉｓ）ワクチン |
| CN103333251B (zh) * | 2013-04-11 | 2014-08-20 | 广西壮族自治区动物疫病预防控制中心 | 基于重组融合抗原蛋白的γ-干扰素夹心ELISA检测方法 |
| CN103204945A (zh) | 2013-05-03 | 2013-07-17 | 扬州大学 | 一种用于牛结核病诊断的真核表达cfp10-esat-6融合蛋白 |
| CN105431166B (zh) | 2013-06-25 | 2020-09-18 | 国际艾滋病疫苗行动组织公司 | 结核病组合物和其使用方法 |
| CN103386128B (zh) | 2013-07-02 | 2017-02-08 | 中国食品药品检定研究院 | 一种含联合佐剂的结核亚单位疫苗 |
-
2015
- 2015-01-09 EP EP15700284.1A patent/EP3092000A1/en not_active Withdrawn
- 2015-01-09 US US15/110,514 patent/US10765731B2/en active Active
- 2015-01-09 WO PCT/EP2015/050344 patent/WO2015104380A1/en not_active Ceased
- 2015-01-09 SG SG11201605595YA patent/SG11201605595YA/en unknown
- 2015-01-09 RU RU2016131853A patent/RU2695462C2/ru not_active IP Right Cessation
- 2015-01-09 JP JP2016545896A patent/JP6605480B2/ja not_active Expired - Fee Related
- 2015-01-09 MX MX2016009072A patent/MX2016009072A/es unknown
- 2015-01-09 CA CA2936131A patent/CA2936131A1/en not_active Abandoned
- 2015-01-09 KR KR1020167020984A patent/KR20160130216A/ko not_active Ceased
- 2015-01-09 CN CN201580012192.0A patent/CN106103471B/zh not_active Expired - Fee Related
- 2015-01-09 BR BR112016015936A patent/BR112016015936A2/pt not_active Application Discontinuation
-
2016
- 2016-07-07 IL IL246659A patent/IL246659A0/en unknown
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