JP2017507145A5 - - Google Patents
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- Publication number
- JP2017507145A5 JP2017507145A5 JP2016553402A JP2016553402A JP2017507145A5 JP 2017507145 A5 JP2017507145 A5 JP 2017507145A5 JP 2016553402 A JP2016553402 A JP 2016553402A JP 2016553402 A JP2016553402 A JP 2016553402A JP 2017507145 A5 JP2017507145 A5 JP 2017507145A5
- Authority
- JP
- Japan
- Prior art keywords
- delivery system
- substance delivery
- matrix
- polymeric material
- anabolic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14000598.4 | 2014-02-20 | ||
| EP14000598 | 2014-02-20 | ||
| PCT/EP2015/053645 WO2015124739A1 (en) | 2014-02-20 | 2015-02-20 | Implant comprising fgf-18 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017507145A JP2017507145A (ja) | 2017-03-16 |
| JP2017507145A5 true JP2017507145A5 (2) | 2018-02-22 |
| JP6510547B2 JP6510547B2 (ja) | 2019-05-08 |
Family
ID=50151086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553402A Active JP6510547B2 (ja) | 2014-02-20 | 2015-02-20 | Ｆｇｆ−１８を含むインプラント |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US10086112B2 (2) |
| EP (1) | EP3107592B1 (2) |
| JP (1) | JP6510547B2 (2) |
| KR (1) | KR102421950B1 (2) |
| CN (1) | CN106232154A (2) |
| AR (1) | AR099556A1 (2) |
| AU (1) | AU2015220785B2 (2) |
| BR (1) | BR112016018681B1 (2) |
| CA (1) | CA2938796C (2) |
| DK (1) | DK3107592T3 (2) |
| ES (1) | ES2698117T3 (2) |
| HR (1) | HRP20181573T1 (2) |
| IL (1) | IL247106B (2) |
| LT (1) | LT3107592T (2) |
| MX (1) | MX368946B (2) |
| NZ (1) | NZ723177A (2) |
| PL (1) | PL3107592T3 (2) |
| PT (1) | PT3107592T (2) |
| RS (1) | RS58138B1 (2) |
| RU (1) | RU2700414C2 (2) |
| SG (1) | SG11201606697YA (2) |
| SI (1) | SI3107592T1 (2) |
| WO (1) | WO2015124739A1 (2) |
| ZA (1) | ZA201605667B (2) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2684527T3 (es) | 2013-02-14 | 2018-10-03 | Nanopareil, Llc | Fieltro híbrido de nanofibras electrohiladas, método de preparación del mismo y método de purificación de biomoléculas |
| RU2700582C2 (ru) | 2014-02-20 | 2019-09-18 | Мерк Патент Гмбх | Схема применения соединения fgf-18 |
| WO2016120387A1 (en) | 2015-01-29 | 2016-08-04 | Ares Trading S.A. | Immunoassays for high positively charged proteins |
| EP3687558B1 (en) | 2017-09-29 | 2022-03-16 | Merck Patent GmbH | Metabolic biomarkers for predicting responsiveness to fgf-18 compound |
| LT3688468T (lt) | 2017-09-29 | 2022-06-27 | Merck Patent Gmbh | Uždegiminiai biožymenys, skirti atsako į fgf-18 junginį numatymui |
| IL281333B2 (en) | 2018-09-10 | 2025-11-01 | Merck Patent Gmbh | A method for reducing risk in a clinical trial |
| CN117187255B (zh) * | 2023-11-07 | 2024-01-30 | 北京大学第三医院（北京大学第三临床医学院） | 编码FGF18或rhFGF18的mRNA及其在骨关节炎治疗中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0896825B1 (en) * | 1997-08-14 | 2002-07-17 | Sulzer Innotec Ag | Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors |
| US6511958B1 (en) | 1997-08-14 | 2003-01-28 | Sulzer Biologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
| KR100380119B1 (ko) * | 2001-04-19 | 2003-04-11 | 한국항공우주연구원 | 이원화된 통신속도 적응형 베이스 밴드 스위칭 위상시프트 키잉 장치 |
| EP1273365A1 (fr) * | 2001-07-06 | 2003-01-08 | Recherche Et Developpement Du Groupe Cockerill Sambre | Outils rotatifs pour le perçage en ligne de produits profiles |
| AU2003279835B2 (en) * | 2002-10-07 | 2009-09-10 | Zymogenetics, Inc. | Methods of administering FGF18 |
| US8852240B2 (en) * | 2004-10-25 | 2014-10-07 | Kieran Murphy, Llc | Methods and compositions for fostering and preserving bone growth |
| DK1828239T3 (da) * | 2004-12-10 | 2011-12-19 | Zymogenetics Inc | FGF18-produktion i prokaryote værter |
| ZA200900426B (en) * | 2006-08-25 | 2010-04-28 | Ares Trading Sa | Treatment of cartilage disorders with FGF-18 |
| WO2010102266A1 (en) * | 2009-03-05 | 2010-09-10 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects |
| US8431399B2 (en) | 2010-03-02 | 2013-04-30 | Taipei Medical University | Method to restore cartilaginous phenotype of chondrocytes after cultured and expanded in vitro |
| WO2012094511A2 (en) * | 2011-01-05 | 2012-07-12 | Rhode Island Hospital | Compositions and methods for the treatment of orthopedic disease or injury |
| EP2678048B1 (en) * | 2011-02-22 | 2018-11-21 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Nano-reservoirs technology for use in bone and/or cartilage regeneration |
| NZ721597A (en) * | 2013-12-24 | 2022-07-01 | Ares Trading Sa | Fgf-18 formulation in alginate/collagen hydrogels |
| WO2015124735A1 (en) | 2014-02-20 | 2015-08-27 | Merck Patent Gmbh | Fgf-18 in graft transplantation and tissue engineering procedures |
| RU2700582C2 (ru) | 2014-02-20 | 2019-09-18 | Мерк Патент Гмбх | Схема применения соединения fgf-18 |
-
2015
- 2015-02-20 NZ NZ723177A patent/NZ723177A/en unknown
- 2015-02-20 RU RU2016137291A patent/RU2700414C2/ru active
- 2015-02-20 AR ARP150100505A patent/AR099556A1/es not_active Application Discontinuation
- 2015-02-20 WO PCT/EP2015/053645 patent/WO2015124739A1/en not_active Ceased
- 2015-02-20 SG SG11201606697YA patent/SG11201606697YA/en unknown
- 2015-02-20 DK DK15706011.2T patent/DK3107592T3/en active
- 2015-02-20 BR BR112016018681-8A patent/BR112016018681B1/pt active IP Right Grant
- 2015-02-20 PT PT15706011T patent/PT3107592T/pt unknown
- 2015-02-20 ES ES15706011T patent/ES2698117T3/es active Active
- 2015-02-20 RS RS20181404A patent/RS58138B1/sr unknown
- 2015-02-20 KR KR1020167025247A patent/KR102421950B1/ko active Active
- 2015-02-20 US US15/120,137 patent/US10086112B2/en active Active
- 2015-02-20 LT LTEP15706011.2T patent/LT3107592T/lt unknown
- 2015-02-20 CA CA2938796A patent/CA2938796C/en active Active
- 2015-02-20 JP JP2016553402A patent/JP6510547B2/ja active Active
- 2015-02-20 AU AU2015220785A patent/AU2015220785B2/en active Active
- 2015-02-20 SI SI201530409T patent/SI3107592T1/sl unknown
- 2015-02-20 PL PL15706011T patent/PL3107592T3/pl unknown
- 2015-02-20 MX MX2016010874A patent/MX368946B/es active IP Right Grant
- 2015-02-20 CN CN201580020527.3A patent/CN106232154A/zh active Pending
- 2015-02-20 EP EP15706011.2A patent/EP3107592B1/en active Active
- 2015-02-20 HR HRP20181573TT patent/HRP20181573T1/hr unknown
-
2016
- 2016-08-04 IL IL247106A patent/IL247106B/en active IP Right Grant
- 2016-08-16 ZA ZA2016/05667A patent/ZA201605667B/en unknown
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