JP2017516104A5 - - Google Patents

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Publication number: JP2017516104A5
Authority: JP; Japan
Prior art keywords: mass spectrometry; amount; norendoxifene; tamoxifen; sample
Prior art date: 2015-05-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP2016567654A

Other languages

English (en)

Japanese (ja)

Other versions

JP6279104B2 (ja

JP2017516104A (ja

Filing date

2015-05-12

Publication date

2017-07-27

2015-05-12 Application filed filed Critical

2015-05-12 Priority claimed from PCT/US2015/030419 external-priority patent/WO2015175561A1/en

2017-06-15 Publication of JP2017516104A publication Critical patent/JP2017516104A/ja

2017-07-27 Publication of JP2017516104A5 publication Critical patent/JP2017516104A5/ja

2018-02-14 Application granted granted Critical

2018-02-14 Publication of JP6279104B2 publication Critical patent/JP6279104B2/ja

Status Active legal-status Critical Current

2035-05-12 Anticipated expiration legal-status Critical

Links

238000000034 method Methods 0.000 claims 34
239000002207 metabolite Substances 0.000 claims 9
238000004949 mass spectrometry Methods 0.000 claims 8
150000002500 ions Chemical class 0.000 claims 7
NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 6
238000000746 purification Methods 0.000 claims 6
MHJBZVSGOZTKRH-IZHYLOQSSA-N 4-Hydroxy-N-desmethyltamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCNC)=CC=1)/C1=CC=C(O)C=C1 MHJBZVSGOZTKRH-IZHYLOQSSA-N 0.000 claims 5
DODQJNMQWMSYGS-QPLCGJKRSA-N 4-[(z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-phenylbut-1-en-2-yl]phenol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 DODQJNMQWMSYGS-QPLCGJKRSA-N 0.000 claims 4
238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims 4
238000004128 high performance liquid chromatography Methods 0.000 claims 4
238000004811 liquid chromatography Methods 0.000 claims 4
229960001603 tamoxifen Drugs 0.000 claims 3
KLPBCGLMGLFHNY-OCOZRVBESA-N 4-[(E)-1-[4-[2-(methylamino)ethoxy]phenyl]-1-phenylbut-1-en-2-yl]phenol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(C=1C=CC(OCCNC)=CC=1)\C1=CC=CC=C1 KLPBCGLMGLFHNY-OCOZRVBESA-N 0.000 claims 2
238000001514 detection method Methods 0.000 claims 2
238000001914 filtration Methods 0.000 claims 2
230000006920 protein precipitation Effects 0.000 claims 2
210000002966 serum Anatomy 0.000 claims 2
238000004885 tandem mass spectrometry Methods 0.000 claims 2
NYDCDZSEEAUOHN-IZHYLOQSSA-N N-Desmethyltamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCNC)=CC=1)/C1=CC=CC=C1 NYDCDZSEEAUOHN-IZHYLOQSSA-N 0.000 claims 1
238000003556 assay Methods 0.000 claims 1

JP2016567654A 2014-05-12 2015-05-12 質量分析によるタモキシフェンおよびその代謝産物の定量化 Active JP6279104B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201461992214P	2014-05-12	2014-05-12
US61/992,214		2014-05-12
PCT/US2015/030419 WO2015175561A1 (en)	2014-05-12	2015-05-12	Quantitation of tamoxifen and metabolites thereof by mass spectrometry

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2018004851A Division JP6821610B2 (ja)	2014-05-12	2018-01-16	質量分析によるタモキシフェンおよびその代謝産物の定量化

Publications (3)

Publication Number	Publication Date
JP2017516104A JP2017516104A (ja)	2017-06-15
JP2017516104A5 true JP2017516104A5 (2)	2017-07-27
JP6279104B2 JP6279104B2 (ja)	2018-02-14

Family

ID=54367635

Family Applications (5)

Application Number	Title	Priority Date	Filing Date
JP2016567654A Active JP6279104B2 (ja)	2014-05-12	2015-05-12	質量分析によるタモキシフェンおよびその代謝産物の定量化
JP2018004851A Active JP6821610B2 (ja)	2014-05-12	2018-01-16	質量分析によるタモキシフェンおよびその代謝産物の定量化
JP2021000689A Pending JP2021073450A (ja)	2014-05-12	2021-01-06	質量分析によるタモキシフェンおよびその代謝産物の定量化
JP2023080724A Pending JP2023109874A (ja)	2014-05-12	2023-05-16	質量分析によるタモキシフェンおよびその代謝産物の定量化
JP2025018885A Pending JP2025081382A (ja)	2014-05-12	2025-02-07	質量分析によるタモキシフェンおよびその代謝産物の定量化

Family Applications After (4)

Application Number	Title	Priority Date	Filing Date
JP2018004851A Active JP6821610B2 (ja)	2014-05-12	2018-01-16	質量分析によるタモキシフェンおよびその代謝産物の定量化
JP2021000689A Pending JP2021073450A (ja)	2014-05-12	2021-01-06	質量分析によるタモキシフェンおよびその代謝産物の定量化
JP2023080724A Pending JP2023109874A (ja)	2014-05-12	2023-05-16	質量分析によるタモキシフェンおよびその代謝産物の定量化
JP2025018885A Pending JP2025081382A (ja)	2014-05-12	2025-02-07	質量分析によるタモキシフェンおよびその代謝産物の定量化

Country Status (9)

Country	Link
US (7)	US9459267B2 (2)
EP (2)	EP3143392B1 (2)
JP (5)	JP6279104B2 (2)
CN (2)	CN106537139B (2)
AU (6)	AU2015259294A1 (2)
BR (1)	BR112016026459B1 (2)
CA (1)	CA2948823C (2)
SA (1)	SA516380291B1 (2)
WO (1)	WO2015175561A1 (2)

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KR20220078610A (ko)	2019-10-10	2022-06-10	리제너론 파마슈티칼스 인코포레이티드	양쪽성 전해질 로트 변형 분석을 위한 액체 크로마토그래피-질량 분석(lc-ms) 방법
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US12105102B2 (en)	2022-03-30	2024-10-01	University Of Utah Research Foundation	Methods for quantifying insulin-like growth factor-1 and insulin-like growth factor-2

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2015
- 2015-05-12 WO PCT/US2015/030419 patent/WO2015175561A1/en not_active Ceased
- 2015-05-12 US US14/710,311 patent/US9459267B2/en active Active
- 2015-05-12 BR BR112016026459-2A patent/BR112016026459B1/pt active IP Right Grant
- 2015-05-12 CN CN201580037630.9A patent/CN106537139B/zh active Active
- 2015-05-12 CA CA2948823A patent/CA2948823C/en active Active
- 2015-05-12 CN CN201910220665.6A patent/CN110044998B/zh active Active
- 2015-05-12 EP EP15793289.8A patent/EP3143392B1/en active Active
- 2015-05-12 EP EP23157017.7A patent/EP4220178A3/en active Pending
- 2015-05-12 JP JP2016567654A patent/JP6279104B2/ja active Active
- 2015-05-12 AU AU2015259294A patent/AU2015259294A1/en not_active Abandoned
2016
- 2016-10-03 US US15/284,248 patent/US9835606B2/en active Active
- 2016-11-13 SA SA516380291A patent/SA516380291B1/ar unknown
2017
- 2017-12-04 US US15/830,812 patent/US10830746B2/en active Active
2018
- 2018-01-16 JP JP2018004851A patent/JP6821610B2/ja active Active
- 2018-12-07 AU AU2018275011A patent/AU2018275011A1/en not_active Abandoned
2020
- 2020-09-23 AU AU2020239700A patent/AU2020239700B2/en active Active
- 2020-11-09 US US17/093,472 patent/US11428682B2/en active Active
2021
- 2021-01-06 JP JP2021000689A patent/JP2021073450A/ja active Pending
2022
- 2022-04-20 AU AU2022202628A patent/AU2022202628B2/en active Active
- 2022-08-23 US US17/893,950 patent/US11835505B2/en active Active
2023
- 2023-05-16 JP JP2023080724A patent/JP2023109874A/ja active Pending
- 2023-07-07 AU AU2023204389A patent/AU2023204389B2/en active Active
- 2023-10-25 US US18/494,030 patent/US12270803B2/en active Active
2024
- 2024-10-09 AU AU2024227191A patent/AU2024227191A1/en active Pending
2025
- 2025-02-07 JP JP2025018885A patent/JP2025081382A/ja active Pending
- 2025-03-07 US US19/074,121 patent/US20260118337A1/en active Pending

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