JP2017517253A5 - - Google Patents
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- Publication number
- JP2017517253A5 JP2017517253A5 JP2016567889A JP2016567889A JP2017517253A5 JP 2017517253 A5 JP2017517253 A5 JP 2017517253A5 JP 2016567889 A JP2016567889 A JP 2016567889A JP 2016567889 A JP2016567889 A JP 2016567889A JP 2017517253 A5 JP2017517253 A5 JP 2017517253A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- bound
- sequence
- aon
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VHFSLDUNRXEDJJ-WHWKVSFZSA-N B[C@@H](CN(C1)P(N(C)C)(OC[C@H](C2)O[C@@H](B)C[NH+]2[S-])=O)OC1(C1)[C@@H]1O Chemical compound B[C@@H](CN(C1)P(N(C)C)(OC[C@H](C2)O[C@@H](B)C[NH+]2[S-])=O)OC1(C1)[C@@H]1O VHFSLDUNRXEDJJ-WHWKVSFZSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462002296P | 2014-05-23 | 2014-05-23 | |
| US62/002,296 | 2014-05-23 | ||
| PCT/US2015/032142 WO2015179742A1 (en) | 2014-05-23 | 2015-05-22 | Multiple oligonucleotide moieties on peptide carrier |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021003149A Division JP7269968B2 (ja) | 2014-05-23 | 2021-01-13 | ペプチド担体上の多重オリゴヌクレオチド部分 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017517253A JP2017517253A (ja) | 2017-06-29 |
| JP2017517253A5 true JP2017517253A5 (2) | 2019-10-17 |
| JP6825914B2 JP6825914B2 (ja) | 2021-02-03 |
Family
ID=53366294
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016567889A Expired - Fee Related JP6825914B2 (ja) | 2014-05-23 | 2015-05-22 | ペプチド担体上の多重オリゴヌクレオチド部分 |
| JP2021003149A Active JP7269968B2 (ja) | 2014-05-23 | 2021-01-13 | ペプチド担体上の多重オリゴヌクレオチド部分 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021003149A Active JP7269968B2 (ja) | 2014-05-23 | 2021-01-13 | ペプチド担体上の多重オリゴヌクレオチド部分 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20170182171A1 (2) |
| EP (1) | EP3151841B1 (2) |
| JP (2) | JP6825914B2 (2) |
| KR (1) | KR102487942B1 (2) |
| CN (1) | CN106459975B (2) |
| AR (1) | AR101542A1 (2) |
| AU (1) | AU2015263963B2 (2) |
| BR (1) | BR112016027236A2 (2) |
| CA (1) | CA2949104C (2) |
| IL (1) | IL249064B (2) |
| MX (1) | MX381946B (2) |
| RU (2) | RU2020142530A (2) |
| SG (2) | SG10202004611SA (2) |
| TW (1) | TWI726844B (2) |
| WO (1) | WO2015179742A1 (2) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106459975B (zh) | 2014-05-23 | 2020-03-27 | 建新公司 | 肽载体上的多个寡核苷酸部分 |
| EP3808849A1 (en) | 2017-08-03 | 2021-04-21 | Voyager Therapeutics, Inc. | Compositions and methods for delivery of aav |
| JP7441455B2 (ja) * | 2017-09-22 | 2024-03-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイト | 筋ジストロフィーの処置のためのチオモルホリノオリゴヌクレオチド |
| US11897911B2 (en) | 2018-03-07 | 2024-02-13 | Sanofi | Nucleotide precursors, nucleotide analogs and oligomeric compounds containing the same |
| US10758629B2 (en) * | 2018-05-29 | 2020-09-01 | Sarepta Therapeutics, Inc. | Exon skipping oligomer conjugates for muscular dystrophy |
| CN114728999A (zh) * | 2019-09-05 | 2022-07-08 | 赛诺菲 | 含有核苷酸类似物的寡核苷酸 |
| WO2021211572A1 (en) * | 2020-04-14 | 2021-10-21 | Oregon State University | Antisense therapeutics for the treatment of coronavirus |
| US20250011777A1 (en) * | 2021-09-03 | 2025-01-09 | Sarepta Therapeutics, Inc. | Delivery of anitsense oligomers by mirror image peptides |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995006056A1 (en) * | 1993-08-20 | 1995-03-02 | University Of Medicine & Dentistry Of New Jersey | Bridged polycationic polymer-oligonucleotide conjugates and methods for preparing same |
| DE19935302A1 (de) | 1999-07-28 | 2001-02-08 | Aventis Pharma Gmbh | Konjugate und Verfahren zu deren Herstellung sowie deren Verwendung zum Transport von Molekülen über biologische Membranen |
| US7468418B2 (en) | 2003-04-29 | 2008-12-23 | Avi Biopharma., Inc. | Compositions for enhancing transport of molecules into cells |
| WO2009005793A2 (en) | 2007-06-29 | 2009-01-08 | Avi Biopharma, Inc. | Tissue specific peptide conjugates and methods |
| US20100016215A1 (en) * | 2007-06-29 | 2010-01-21 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| WO2009144481A2 (en) | 2008-05-30 | 2009-12-03 | Isis Innovation Limited | Conjugates for delivery of biologically active compounds |
| WO2009147368A1 (en) | 2008-06-04 | 2009-12-10 | Medical Research Council | Peptides |
| BR122020021379B1 (pt) | 2008-10-24 | 2021-05-11 | Sarepta Therapeutics, Inc. | oligômero morfolino fosforodiamidato, composição que compreende o mesmo e uso do dito oligômero para tratar distrofia muscular |
| WO2012177639A2 (en) * | 2011-06-22 | 2012-12-27 | Alnylam Pharmaceuticals, Inc. | Bioprocessing and bioproduction using avian cell lines |
| AU2012308320C1 (en) * | 2011-09-14 | 2018-08-23 | Translate Bio Ma, Inc. | Multimeric oligonucleotide compounds |
| EP2900821B1 (en) * | 2012-09-25 | 2020-04-01 | Genzyme Corporation | Peptide-linked morpholino antisense oligonucleotides for treatment of myotonic dystrophy |
| CA2935426C (en) * | 2014-01-30 | 2023-07-25 | F. Hoffmann-La Roche Ag | Polyoligomer compound with biocleavable conjugates for reducing or inhibiting expression of a nucleic acid target |
| CN106459975B (zh) | 2014-05-23 | 2020-03-27 | 建新公司 | 肽载体上的多个寡核苷酸部分 |
-
2015
- 2015-05-22 CN CN201580027369.4A patent/CN106459975B/zh active Active
- 2015-05-22 EP EP15727795.5A patent/EP3151841B1/en active Active
- 2015-05-22 SG SG10202004611SA patent/SG10202004611SA/en unknown
- 2015-05-22 RU RU2020142530A patent/RU2020142530A/ru unknown
- 2015-05-22 AU AU2015263963A patent/AU2015263963B2/en not_active Ceased
- 2015-05-22 BR BR112016027236A patent/BR112016027236A2/pt not_active Application Discontinuation
- 2015-05-22 JP JP2016567889A patent/JP6825914B2/ja not_active Expired - Fee Related
- 2015-05-22 TW TW104116447A patent/TWI726844B/zh not_active IP Right Cessation
- 2015-05-22 WO PCT/US2015/032142 patent/WO2015179742A1/en not_active Ceased
- 2015-05-22 CA CA2949104A patent/CA2949104C/en active Active
- 2015-05-22 US US15/313,405 patent/US20170182171A1/en not_active Abandoned
- 2015-05-22 KR KR1020167035607A patent/KR102487942B1/ko active Active
- 2015-05-22 MX MX2016015156A patent/MX381946B/es unknown
- 2015-05-22 AR ARP150101604A patent/AR101542A1/es unknown
- 2015-05-22 SG SG11201608880VA patent/SG11201608880VA/en unknown
- 2015-05-22 RU RU2016150629A patent/RU2739987C2/ru active
-
2016
- 2016-11-20 IL IL249064A patent/IL249064B/en unknown
-
2019
- 2019-02-01 US US16/265,883 patent/US11103587B2/en not_active Expired - Fee Related
-
2021
- 2021-01-13 JP JP2021003149A patent/JP7269968B2/ja active Active
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